PL2819982T3 - Proleki witaminy k - Google Patents
Proleki witaminy kInfo
- Publication number
- PL2819982T3 PL2819982T3 PL13709348T PL13709348T PL2819982T3 PL 2819982 T3 PL2819982 T3 PL 2819982T3 PL 13709348 T PL13709348 T PL 13709348T PL 13709348 T PL13709348 T PL 13709348T PL 2819982 T3 PL2819982 T3 PL 2819982T3
- Authority
- PL
- Poland
- Prior art keywords
- vitamine
- prodrugs
- Prior art date
Links
- WIGIZIANZCJQQY-UHFFFAOYSA-N 4-ethyl-3-methyl-N-[2-[4-[[[(4-methylcyclohexyl)amino]-oxomethyl]sulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide Chemical compound O=C1C(CC)=C(C)CN1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCC(C)CC2)C=C1 WIGIZIANZCJQQY-UHFFFAOYSA-N 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
- 239000011782 vitamin Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/017—Esters of hydroxy compounds having the esterified hydroxy group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/12—Acetic acid esters
- C07C69/16—Acetic acid esters of dihydroxylic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
- C07C69/28—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with dihydroxylic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
- C07C69/40—Succinic acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/78—Benzoic acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/098—Esters of polyphosphoric acids or anhydrides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1203705.7A GB201203705D0 (en) | 2012-03-02 | 2012-03-02 | Prodrugs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2819982T3 true PL2819982T3 (pl) | 2017-01-31 |
Family
ID=46003017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL13709348T PL2819982T3 (pl) | 2012-03-02 | 2013-03-04 | Proleki witaminy k |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9512153B2 (pl) |
| EP (1) | EP2819982B1 (pl) |
| CN (1) | CN104395273A (pl) |
| AU (1) | AU2013224857B2 (pl) |
| DK (1) | DK2819982T3 (pl) |
| GB (1) | GB201203705D0 (pl) |
| HU (1) | HUE029261T2 (pl) |
| IN (1) | IN2014MN01778A (pl) |
| PL (1) | PL2819982T3 (pl) |
| WO (1) | WO2013128037A1 (pl) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201203705D0 (en) | 2012-03-02 | 2012-04-18 | Kappa Bioscience As | Prodrugs |
| GB201314245D0 (en) * | 2013-08-08 | 2013-09-25 | Kappa Bioscience As | Provitamins |
| KR102500913B1 (ko) | 2014-05-05 | 2023-02-16 | 바스프 에스이 | 지용성 비타민 제형 |
| CN107660202B (zh) | 2015-03-27 | 2021-12-24 | 大日本住友制药肿瘤公司 | 水溶性前药 |
| WO2019059344A1 (ja) | 2017-09-22 | 2019-03-28 | 大日本住友製薬株式会社 | 化学活性化型水溶性プロドラッグ |
| AU2019282421B2 (en) | 2018-06-08 | 2025-01-09 | Epizon Pharma, Inc. | Methods and compositions for preventing or treating calciphylaxis |
| WO2019237053A1 (en) | 2018-06-08 | 2019-12-12 | Epizon Pharma, Inc. | Methods and compositions for preventing or treating tissue calcification |
| CA3111108A1 (en) | 2018-09-12 | 2020-03-19 | Epizon Pharma, Inc. | Menaquinol compositions and methods of treatment |
| JP7394433B2 (ja) * | 2019-03-19 | 2023-12-08 | 学校法人福岡大学 | 光曝露下に適用されるビタミンｋ剤及びそれを用いた皮膚外用剤、点眼剤、眼軟膏剤 |
| CA3140115A1 (en) | 2019-05-23 | 2020-11-26 | Massachusetts Institute Of Technology | Ligand discovery and gene delivery via retroviral surface display |
| US12103914B2 (en) * | 2020-12-30 | 2024-10-01 | Epizon Pharma, Inc. | Compositions of biologically active menaquinol derivatives and methods of treatment |
| US11912654B2 (en) | 2021-09-03 | 2024-02-27 | Synergia Life Sciences Pvt. Ltd. | Process for stereospecific synthesis of vitamin K2 and its novel intermediates |
| WO2023119230A1 (en) | 2021-12-22 | 2023-06-29 | L'oreal | Coagulation pathway and nicotinamide-adenine dinucleotide pathway modulating compositions and methods of their use |
| WO2023129141A1 (en) * | 2021-12-28 | 2023-07-06 | Epizon, Inc. | Compositions of biologically active menaquinol derivatives and methods of treatment |
| CN119630636A (zh) * | 2022-05-30 | 2025-03-14 | 埃皮松制药公司 | 聚乙二醇化甲萘酚组合物和治疗方法 |
| KR20250019094A (ko) | 2022-05-31 | 2025-02-07 | 레지온 시드단마크 | 관상동맥 석회화(cac) 치료용 비타민 k2 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2456686A (en) | 1944-05-11 | 1948-12-21 | President & Board Of Trustees | Process for obtaining vitamink compounds |
| US3127434A (en) * | 1959-10-20 | 1964-03-31 | Hoffmann La Roche | Dihydrovitamin k monophosphate compounds and preparation thereof |
| GB893172A (en) | 1959-10-20 | 1962-04-04 | Roche Products Ltd | A process for the manufacture of phosphoric acid esters and novel phosphoric acid esters |
| CH575904A5 (pl) | 1972-02-16 | 1976-05-31 | Eisai Co Ltd | |
| GB1426769A (en) * | 1972-12-04 | 1976-03-03 | Eisai Co Ltd | Process for the production of hydroquinone derivatives |
| US6746678B1 (en) | 1991-02-22 | 2004-06-08 | Howard K. Shapiro | Method of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with medicaments |
| US20050090553A1 (en) | 1992-06-30 | 2005-04-28 | Shapiro Howard K. | Compositions and method for treatment of chronic inflammatory diseases |
| US8178516B2 (en) | 1992-06-30 | 2012-05-15 | Sylvan Labs, LLC | Compositions and method for treatment of chronic inflammatory diseases |
| DE69501421T2 (de) | 1994-04-28 | 1998-04-23 | Eisai Co Ltd | Hematetrenome Derivat als antiarteriosklerotisches Mittel |
| JPH1035256A (ja) | 1996-07-18 | 1998-02-10 | Denso Corp | 車両用暖房装置 |
| DE19964116A1 (de) | 1999-12-30 | 2001-07-05 | Liebscher Dierck H | Verfahren zur Erhöhung der Bioverfügbarkeit von Magnesiumionen im Organismus sowie eine pharmazeutische Verpackungseinheit auf dieser Basis |
| JP4040082B2 (ja) * | 2005-01-28 | 2008-01-30 | 学校法人福岡大学 | ビタミンｋヒドロキノン誘導体を用いる癌治療剤および再発予防剤 |
| US20080220094A1 (en) | 2006-11-01 | 2008-09-11 | Wyeth | Compositions and methods for the treatment and/or prevention of osteoporosis |
| EP2060256A1 (en) * | 2007-11-16 | 2009-05-20 | Gnosis S.p.A. | Pharmaceutical and nutraceutical compositions based on menaquinols |
| GB0817528D0 (en) * | 2008-09-24 | 2008-10-29 | Syntavit As | Process |
| WO2011152810A1 (en) | 2010-06-03 | 2011-12-08 | Bilgic Mahmut | Formulations comprising calcium, vitamin d and vitamin k for osteoporosis |
| WO2012161572A1 (en) | 2011-05-20 | 2012-11-29 | Friesland Brands B.V. | Composition comprising vitamin k2 |
| GB201203705D0 (en) | 2012-03-02 | 2012-04-18 | Kappa Bioscience As | Prodrugs |
| CN103142568B (zh) | 2013-03-11 | 2015-03-11 | 昆明邦宇制药有限公司 | 一种醋酸钙维生素k药物制剂及其制备方法 |
-
2012
- 2012-03-02 GB GBGB1203705.7A patent/GB201203705D0/en not_active Ceased
-
2013
- 2013-03-04 US US14/382,225 patent/US9512153B2/en active Active
- 2013-03-04 PL PL13709348T patent/PL2819982T3/pl unknown
- 2013-03-04 EP EP13709348.0A patent/EP2819982B1/en active Active
- 2013-03-04 WO PCT/EP2013/054298 patent/WO2013128037A1/en not_active Ceased
- 2013-03-04 IN IN1778MUN2014 patent/IN2014MN01778A/en unknown
- 2013-03-04 AU AU2013224857A patent/AU2013224857B2/en active Active
- 2013-03-04 HU HUE13709348A patent/HUE029261T2/en unknown
- 2013-03-04 DK DK13709348.0T patent/DK2819982T3/en active
- 2013-03-04 CN CN201380023420.5A patent/CN104395273A/zh active Pending
-
2016
- 2016-12-05 US US15/369,060 patent/US10159687B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| GB201203705D0 (en) | 2012-04-18 |
| AU2013224857B2 (en) | 2016-03-17 |
| AU2013224857A1 (en) | 2014-09-25 |
| DK2819982T3 (en) | 2016-11-14 |
| HUE029261T2 (en) | 2017-02-28 |
| WO2013128037A1 (en) | 2013-09-06 |
| EP2819982A1 (en) | 2015-01-07 |
| US20170079994A1 (en) | 2017-03-23 |
| CN104395273A (zh) | 2015-03-04 |
| IN2014MN01778A (pl) | 2015-07-03 |
| US9512153B2 (en) | 2016-12-06 |
| US10159687B2 (en) | 2018-12-25 |
| EP2819982B1 (en) | 2016-09-14 |
| US20150031651A1 (en) | 2015-01-29 |
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