PL2850060T3 - Fluorowane pochodne zmostkowanego spiro[2.4]heptanu jako agoniści receptora alx - Google Patents
Fluorowane pochodne zmostkowanego spiro[2.4]heptanu jako agoniści receptora alxInfo
- Publication number
- PL2850060T3 PL2850060T3 PL13731938T PL13731938T PL2850060T3 PL 2850060 T3 PL2850060 T3 PL 2850060T3 PL 13731938 T PL13731938 T PL 13731938T PL 13731938 T PL13731938 T PL 13731938T PL 2850060 T3 PL2850060 T3 PL 2850060T3
- Authority
- PL
- Poland
- Prior art keywords
- receptor agonists
- heptane derivatives
- alx receptor
- bridged spiro
- fluorinated bridged
- Prior art date
Links
- 239000000018 receptor agonist Substances 0.000 title 1
- 229940044601 receptor agonist Drugs 0.000 title 1
- HEMCGZPSGYRIOL-UHFFFAOYSA-N spiro[2.4]heptane Chemical class C1CC11CCCC1 HEMCGZPSGYRIOL-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12168322 | 2012-05-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2850060T3 true PL2850060T3 (pl) | 2017-01-31 |
Family
ID=48699893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL13731938T PL2850060T3 (pl) | 2012-05-16 | 2013-05-15 | Fluorowane pochodne zmostkowanego spiro[2.4]heptanu jako agoniści receptora alx |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US9139524B2 (pl) |
| EP (1) | EP2850060B1 (pl) |
| JP (1) | JP6101789B2 (pl) |
| KR (1) | KR20150013285A (pl) |
| CN (1) | CN104321309B (pl) |
| AR (1) | AR091059A1 (pl) |
| AU (1) | AU2013261091B2 (pl) |
| BR (1) | BR112014028358A2 (pl) |
| CA (1) | CA2871336A1 (pl) |
| CL (1) | CL2014002918A1 (pl) |
| EA (1) | EA025264B1 (pl) |
| ES (1) | ES2595219T3 (pl) |
| HK (1) | HK1208441A1 (pl) |
| IL (1) | IL235660A0 (pl) |
| MA (1) | MA37618B1 (pl) |
| MX (1) | MX355221B (pl) |
| NZ (1) | NZ702971A (pl) |
| PH (1) | PH12014502465A1 (pl) |
| PL (1) | PL2850060T3 (pl) |
| SG (1) | SG11201406971WA (pl) |
| TW (1) | TWI579269B (pl) |
| WO (1) | WO2013171694A1 (pl) |
| ZA (1) | ZA201409249B (pl) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012066488A2 (en) | 2010-11-17 | 2012-05-24 | Actelion Pharmaceuticals Ltd | Bridged spiro[2.4]heptane ester derivatives |
| EP2648724B1 (en) | 2010-12-07 | 2016-09-21 | Actelion Pharmaceuticals Ltd. | Hydroxylated aminotriazole derivatives as alx receptor agonists |
| EP2850058B1 (en) | 2012-05-16 | 2016-07-13 | Actelion Pharmaceuticals Ltd. | 1-(p-tolyl)cyclopropyl substituted bridged spiro[2.4]heptane derivatives as alx receptor agonists |
| AR096686A1 (es) | 2013-06-25 | 2016-01-27 | Actelion Pharmaceuticals Ltd | Derivados de espiro[2.4]heptano puenteados sustituidos con difluoroetil-oxazol como agonistas del receptor de alx |
| BR112016001106A8 (pt) * | 2013-07-18 | 2017-12-26 | Actelion Pharmaceuticals Ltd | Derivados de espiro [2,4] heptano interligados piperazina substituídos como agonistas do receptor de alx |
| AR097279A1 (es) | 2013-08-09 | 2016-03-02 | Actelion Pharmaceuticals Ltd | Derivados de benzimidazolil-metil urea como agonistas del receptor de alx |
| HRP20241236T1 (hr) | 2014-05-13 | 2024-12-06 | Novartis Ag | Spojevi i pripravci za induciranje hondrogeneze |
| AU2016266190A1 (en) | 2015-05-27 | 2018-01-18 | Kyorin Pharmaceutical Co., Ltd. | Urea derivative or pharmacologically acceptable salt thereof |
| WO2016189877A1 (en) | 2015-05-27 | 2016-12-01 | Kyorin Pharmaceutical Co., Ltd. | Urea derivative or pharmacologically acceptable salt thereof |
| CN111233751B (zh) * | 2020-03-25 | 2021-02-02 | 丽水绿氟科技有限公司 | 一种3,3-二氟-4-氨基哌啶类化合物及其衍生物的制备方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5686454A (en) * | 1993-07-16 | 1997-11-11 | Merck & Co., Inc. | Camphorcarbonyl |
| JP2005536187A (ja) | 2002-04-03 | 2005-12-02 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | N−ホルミルペプチド受容体様1(fprl1)に関連する疾患の診断および治療 |
| CN1863773A (zh) | 2003-10-09 | 2006-11-15 | 埃科特莱茵药品有限公司 | 四氢吡啶衍生物 |
| WO2005047899A2 (en) | 2003-11-07 | 2005-05-26 | Acadia Pharmaceuticals Inc. | Use of the lipoxin receptor, fprl1, as a tool for identifying compounds effective in the treatment of pain and inflammation |
| TW200538098A (en) | 2004-03-22 | 2005-12-01 | Astrazeneca Ab | Therapeutic agents |
| US7820699B2 (en) | 2005-04-27 | 2010-10-26 | Hoffmann-La Roche Inc. | Cyclic amines |
| JP2010522765A (ja) | 2007-03-28 | 2010-07-08 | アレイ バイオファーマ、インコーポレイテッド | 受容体チロシンキナーゼとしてのイミダゾ[1,2−a]ピリジン化合物 |
| AR069650A1 (es) | 2007-12-14 | 2010-02-10 | Actelion Pharmaceuticals Ltd | Derivados de aminopirazol como agonistas no peptidicos del receptor alx humano |
| BRPI0821115A8 (pt) | 2007-12-18 | 2017-12-26 | Actelion Pharmaceuticals Ltd | Composto derivado de aminotriazol, medicamento, composição farmacêutica e uso do composto |
| JP5510945B2 (ja) * | 2009-05-18 | 2014-06-04 | アクテリオン ファーマシューティカルズ リミテッド | Alx受容体及び/又はfprl2アゴニストとしての架橋スピロ[2.4]ヘプタン誘導体 |
| NZ597453A (en) | 2009-06-09 | 2013-03-28 | Actelion Pharmaceuticals Ltd | Fluorinated aminotriazole derivatives as alxr agonists |
| CA2760887A1 (en) | 2009-06-12 | 2010-12-16 | Actelion Pharmaceuticals Ltd | Oxazole and thiazole derivatives as alx receptor agonists |
| EP2585054A1 (en) * | 2010-06-24 | 2013-05-01 | Allergan, Inc. | Derivatives of cycloalkyl- and cycloalkenyl-1,2-dicarboxylic acid compounds having formyl peptide receptor like-1 (fprl-1) agonist or antagonist activity |
| WO2012066488A2 (en) * | 2010-11-17 | 2012-05-24 | Actelion Pharmaceuticals Ltd | Bridged spiro[2.4]heptane ester derivatives |
| EP2648724B1 (en) | 2010-12-07 | 2016-09-21 | Actelion Pharmaceuticals Ltd. | Hydroxylated aminotriazole derivatives as alx receptor agonists |
| PL2649068T3 (pl) | 2010-12-07 | 2015-03-31 | Idorsia Pharmaceuticals Ltd | Pochodne eteru oksazolilowo-metylowego jako agoniści receptora ALX |
| EP2731931A1 (en) | 2011-07-11 | 2014-05-21 | Allergan, Inc. | Polycyclic pyrrolidine-2,5-dione derivatives as -formyl peptide receptor like-1 (fprl-1) receptor modulators |
| EP2850058B1 (en) | 2012-05-16 | 2016-07-13 | Actelion Pharmaceuticals Ltd. | 1-(p-tolyl)cyclopropyl substituted bridged spiro[2.4]heptane derivatives as alx receptor agonists |
| EP2964213B1 (en) | 2013-03-06 | 2020-11-04 | Allergan, Inc. | Use of agonists of formyl peptide receptor 2 for treating ocular inflammatory diseases |
| AU2014226001B2 (en) | 2013-03-06 | 2018-12-06 | Allergan, Inc. | Use of agonists of Formyl peptide receptor 2 for treating dermatological diseases |
-
2013
- 2013-05-14 MA MA37618A patent/MA37618B1/fr unknown
- 2013-05-15 CN CN201380025040.5A patent/CN104321309B/zh not_active Expired - Fee Related
- 2013-05-15 SG SG11201406971WA patent/SG11201406971WA/en unknown
- 2013-05-15 AR ARP130101686 patent/AR091059A1/es unknown
- 2013-05-15 NZ NZ702971A patent/NZ702971A/en not_active IP Right Cessation
- 2013-05-15 CA CA2871336A patent/CA2871336A1/en not_active Abandoned
- 2013-05-15 HK HK15108959.5A patent/HK1208441A1/xx unknown
- 2013-05-15 EA EA201401259A patent/EA025264B1/ru not_active IP Right Cessation
- 2013-05-15 MX MX2014013829A patent/MX355221B/es active IP Right Grant
- 2013-05-15 KR KR20147034766A patent/KR20150013285A/ko not_active Ceased
- 2013-05-15 EP EP13731938.0A patent/EP2850060B1/en not_active Not-in-force
- 2013-05-15 WO PCT/IB2013/053976 patent/WO2013171694A1/en not_active Ceased
- 2013-05-15 JP JP2015512184A patent/JP6101789B2/ja not_active Expired - Fee Related
- 2013-05-15 ES ES13731938.0T patent/ES2595219T3/es active Active
- 2013-05-15 US US14/401,769 patent/US9139524B2/en not_active Expired - Fee Related
- 2013-05-15 BR BR112014028358-3A patent/BR112014028358A2/pt not_active IP Right Cessation
- 2013-05-15 TW TW102117256A patent/TWI579269B/zh not_active IP Right Cessation
- 2013-05-15 AU AU2013261091A patent/AU2013261091B2/en not_active Ceased
- 2013-05-15 PL PL13731938T patent/PL2850060T3/pl unknown
-
2014
- 2014-10-28 CL CL2014002918A patent/CL2014002918A1/es unknown
- 2014-11-05 PH PH12014502465A patent/PH12014502465A1/en unknown
- 2014-11-12 IL IL235660A patent/IL235660A0/en unknown
- 2014-12-15 ZA ZA2014/09249A patent/ZA201409249B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP6101789B2 (ja) | 2017-03-22 |
| MA37618A1 (fr) | 2016-12-30 |
| CN104321309B (zh) | 2016-06-22 |
| TWI579269B (zh) | 2017-04-21 |
| MX2014013829A (es) | 2015-02-04 |
| EP2850060B1 (en) | 2016-07-13 |
| SG11201406971WA (en) | 2014-11-27 |
| NZ702971A (en) | 2016-09-30 |
| TW201348198A (zh) | 2013-12-01 |
| ES2595219T3 (es) | 2016-12-28 |
| AU2013261091B2 (en) | 2017-04-06 |
| PH12014502465A1 (en) | 2014-12-22 |
| US20150118258A1 (en) | 2015-04-30 |
| MA37618B1 (fr) | 2017-08-31 |
| ZA201409249B (en) | 2016-09-28 |
| KR20150013285A (ko) | 2015-02-04 |
| MX355221B (es) | 2018-04-10 |
| WO2013171694A1 (en) | 2013-11-21 |
| AU2013261091A1 (en) | 2015-01-22 |
| EA201401259A1 (ru) | 2015-04-30 |
| HK1208441A1 (en) | 2016-03-04 |
| US9139524B2 (en) | 2015-09-22 |
| CN104321309A (zh) | 2015-01-28 |
| IL235660A0 (en) | 2015-02-01 |
| BR112014028358A2 (pt) | 2020-07-21 |
| CL2014002918A1 (es) | 2015-02-06 |
| EA025264B1 (ru) | 2016-12-30 |
| EP2850060A1 (en) | 2015-03-25 |
| AR091059A1 (es) | 2014-12-30 |
| CA2871336A1 (en) | 2013-11-21 |
| JP2015516463A (ja) | 2015-06-11 |
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