PL2989100T3 - Pochodne naftyrydyny użyteczne jako antagoniści integryny alfa-v-beta-6 - Google Patents

Pochodne naftyrydyny użyteczne jako antagoniści integryny alfa-v-beta-6

Info

Publication number
PL2989100T3
PL2989100T3 PL14712666T PL14712666T PL2989100T3 PL 2989100 T3 PL2989100 T3 PL 2989100T3 PL 14712666 T PL14712666 T PL 14712666T PL 14712666 T PL14712666 T PL 14712666T PL 2989100 T3 PL2989100 T3 PL 2989100T3
Authority
PL
Poland
Prior art keywords
beta
alpha
derivatives useful
integrin antagonists
naphthyridine derivatives
Prior art date
Application number
PL14712666T
Other languages
English (en)
Inventor
Niall Andrew ANDERSON
Brendan John FALLON
John Martin Pritchard
Original Assignee
Glaxosmithkline Intellectual Property Development Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Intellectual Property Development Limited filed Critical Glaxosmithkline Intellectual Property Development Limited
Publication of PL2989100T3 publication Critical patent/PL2989100T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL14712666T 2013-03-28 2014-03-26 Pochodne naftyrydyny użyteczne jako antagoniści integryny alfa-v-beta-6 PL2989100T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1305668.4A GB201305668D0 (en) 2013-03-28 2013-03-28 Avs6 Integrin Antagonists
PCT/EP2014/056013 WO2014154725A1 (en) 2013-03-28 2014-03-26 Naphthyridine derivatives useful as alpha-v-beta-6 integrin antagonists
EP14712666.8A EP2989100B1 (en) 2013-03-28 2014-03-26 Naphthyridine derivatives useful as alpha-v-beta-6 integrin antagonists

Publications (1)

Publication Number Publication Date
PL2989100T3 true PL2989100T3 (pl) 2018-07-31

Family

ID=48444909

Family Applications (1)

Application Number Title Priority Date Filing Date
PL14712666T PL2989100T3 (pl) 2013-03-28 2014-03-26 Pochodne naftyrydyny użyteczne jako antagoniści integryny alfa-v-beta-6

Country Status (38)

Country Link
US (2) US10023568B2 (pl)
EP (2) EP3360876A1 (pl)
JP (1) JP6095847B2 (pl)
KR (2) KR101775085B1 (pl)
CN (1) CN105189499B (pl)
AR (1) AR095768A1 (pl)
AU (1) AU2014243068C1 (pl)
BR (1) BR112015024530A8 (pl)
CA (1) CA2903358A1 (pl)
CL (1) CL2015002860A1 (pl)
CR (1) CR20150509A (pl)
CY (1) CY1120188T1 (pl)
DK (1) DK2989100T3 (pl)
DO (1) DOP2015000251A (pl)
EA (1) EA027305B1 (pl)
ES (1) ES2665597T3 (pl)
GB (1) GB201305668D0 (pl)
HR (1) HRP20180528T1 (pl)
HU (1) HUE036750T2 (pl)
IL (1) IL241184A0 (pl)
LT (1) LT2989100T (pl)
MA (1) MA38540B1 (pl)
ME (1) ME02987B (pl)
MX (1) MX363288B (pl)
NO (1) NO2989100T3 (pl)
NZ (1) NZ629025A (pl)
PE (1) PE20151606A1 (pl)
PH (1) PH12015502232B1 (pl)
PL (1) PL2989100T3 (pl)
PT (1) PT2989100T (pl)
RS (1) RS57220B1 (pl)
SG (1) SG11201506813QA (pl)
SI (1) SI2989100T1 (pl)
SM (1) SMT201800247T1 (pl)
TW (1) TWI632143B (pl)
UA (1) UA114952C2 (pl)
UY (1) UY35505A (pl)
WO (1) WO2014154725A1 (pl)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3929196T3 (da) 2013-09-24 2023-09-25 Fujifilm Corp Farmaceutisk sammensætning af en nitrogenholdig forbindelse eller salt deraf, eller metalkompleks deraf
GB201417011D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201417094D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201417002D0 (en) * 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compound
GB201417018D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
CN107428828A (zh) 2015-03-11 2017-12-01 葛兰素史密斯克莱知识产权发展有限公司 Tslp结合蛋白
GB201615588D0 (en) 2016-09-14 2016-10-26 Glaxosmithkline Ip Dev Ltd TSLP Binding Proteins
GB201604589D0 (en) * 2016-03-18 2016-05-04 Glaxosmithkline Ip Dev Ltd Chemical compound
GB201604681D0 (en) 2016-03-21 2016-05-04 Glaxosmithkline Ip Dev Ltd Chemical Compounds
GB201604680D0 (en) * 2016-03-21 2016-05-04 Glaxosmithkline Ip Dev Ltd Chemical Compounds
CN110167934B (zh) 2016-11-08 2022-06-10 百时美施贵宝公司 作为αV整联蛋白抑制剂的含有环丁烷和含有氮杂环丁烷的单环和螺环化合物
AU2017359028A1 (en) 2016-11-08 2019-06-20 Bristol-Myers Squibb Company Azole amides and amines as alpha V integrin inhibitors
EP3538528B1 (en) 2016-11-08 2020-12-23 Bristol-Myers Squibb Company Pyrrole amides as alpha v integrin inhibitors
PT3538525T (pt) 2016-11-08 2022-08-16 Bristol Myers Squibb Co Ácidos propiónicos 3-substituídos por inibidores de alfa v integrina
EA201991123A1 (ru) 2016-11-08 2019-11-29 ИНДАЗОЛОВЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ АНТАГОНИСТОВ ИНТЕГРИНА αV
US10696672B2 (en) 2016-12-23 2020-06-30 Pliant Therapeutics, Inc. Amino acid compounds and methods of use
EP4159727B1 (en) 2017-02-28 2026-04-08 Morphic Therapeutic, Inc. Inhibitors of (alpha-v)(beta-6) integrin
US11046685B2 (en) 2017-02-28 2021-06-29 Morphic Therapeutic, Inc. Inhibitors of (α-v)(β-6) integrin
JP7291696B2 (ja) 2017-11-07 2023-06-15 ブリストル-マイヤーズ スクイブ カンパニー アルファvインテグリン阻害剤としてのピロロピラジン誘導体
CU24684B1 (es) 2018-03-07 2023-10-06 Pliant Therapeutics Inc Compuestos de aminoácidos como inhibidores de la integrina
TWI841573B (zh) * 2018-06-27 2024-05-11 美商普萊恩醫療公司 具有未分支連接子之胺基酸化合物及使用方法
EP3843728B1 (en) * 2018-08-29 2025-04-30 Morphic Therapeutic, Inc. Inhibitors of (alpha-v)(beta-6) integrin
AU2019327475B2 (en) 2018-08-29 2025-06-05 Morphic Therapeutic, Inc. INHIBITING αV β6 INTEGRIN
PT3844162T (pt) 2018-08-29 2025-03-28 Morphic Therapeutic Inc Inibidores da integrina alfa v beta6
WO2020047208A1 (en) * 2018-08-29 2020-03-05 Morphic Therapeutic, Inc. Inhibitors of (alpha-v)(beta-6) integrin
GB202010626D0 (en) 2020-07-10 2020-08-26 Univ Nottingham Compound
WO2022183360A1 (en) * 2021-03-02 2022-09-09 Tsao Yeou Ping Short synthetic peptide and their uses for treating dry eye disease
KR20250120424A (ko) * 2022-12-14 2025-08-08 알닐람 파마슈티칼스 인코포레이티드 간외 전달을 위한 알파-v 베타-6(αvβ6) 인테그린 리간드
WO2024145245A2 (en) * 2022-12-27 2024-07-04 Pliant Therapeutics, Inc. Alpha-v-beta-8 integrin inhibitors and uses thereof
TW202615058A (zh) 2024-06-12 2026-04-16 美商艾拉倫製藥股份有限公司 失養強直性肌肉蛋白質激酶(dmpk)irna組成物及其使用方法
WO2025259743A1 (en) 2024-06-12 2025-12-18 Alnylam Pharmaceuticals, Inc. Dual conjugate compounds for extrahepatic delivery
TW202615060A (zh) * 2024-06-21 2026-04-16 美商艾拉倫製藥公司 用於肝外遞送之整合素配體

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9004781D0 (en) 1990-03-02 1990-04-25 Glaxo Group Ltd Device
EP1047425A4 (en) * 1997-12-17 2009-04-22 Merck & Co Inc INTEGRIN RECEPTOR ANTAGONISTS
SK9192000A3 (en) 1997-12-17 2001-03-12 Merck & Co Inc Integrin receptor antagonists
DE60035779T2 (de) 1999-06-02 2008-04-30 Merck & Co., Inc. Alpha v integrin-rezeptor antagonisten
EP1194151A4 (en) 1999-06-23 2003-01-15 Merck & Co Inc ANTAGONISTS OF THE INTEGRIN RECEPTORS
EP1229910A4 (en) 1999-10-04 2003-10-01 Merck & Co Inc integrin
YU32502A (sh) * 1999-11-08 2004-12-31 Merck & Co.Inc. Postupak i intermedijeri za proizvodnju imidazolidinonskih antagonista alfa v integrina
JP2004511434A (ja) 2000-06-15 2004-04-15 ファルマシア・コーポレーション インテグリン受容体アンタゴニストとしてのヘテロアリールアルカン酸
AU7793501A (en) 2000-07-26 2002-02-05 Merck & Co Inc Alpha v integrin receptor antagonists
AU2001290772A1 (en) 2000-09-14 2002-03-26 Merck And Co., Inc. Alpha v integrin receptor antagonists
AU2002246757B2 (en) 2001-01-03 2006-02-02 Merck & Co., Inc. Methods and compositions for treating periodontal disease
DE10112771A1 (de) * 2001-03-16 2002-09-26 Merck Patent Gmbh Inhibitoren des Integrins alpha¶v¶beta¶6¶
AR037517A1 (es) 2001-11-05 2004-11-17 Novartis Ag Derivados de naftiridinas, un proceso para su preparacion, composicion farmaceutica y el uso de los mismos para la preparacion de un medicamento para el tratamiento de una enfermedad inflamatoria
MY147019A (en) 2002-03-13 2012-10-15 Biogen Idec Inc Anti-alpha v beta 6 antibodies
US20040224986A1 (en) 2002-08-16 2004-11-11 Bart De Corte Piperidinyl targeting compounds that selectively bind integrins
BR0317600A (pt) 2002-12-20 2005-11-29 Pharmacia Corp ácidos heteroarilalcanóicos como derivados de antagonistas de receptor de integrina
US6932865B2 (en) 2003-04-11 2005-08-23 Lockheed Martin Corporation System and method of making single-crystal structures through free-form fabrication techniques
BRPI0416128B8 (pt) 2003-11-03 2021-06-22 Glaxo Group Ltd dispositivo de dispensação de fluido
MX2009010050A (es) 2007-03-23 2009-10-12 Amgen Inc Derivados de quinolina o quinoxalina 3-sustituidos y su uso como inhibidores de fosfotidilinositol 3-cinasa (p13k).
US8563566B2 (en) 2007-08-01 2013-10-22 Valeant Pharmaceuticals International Naphthyridine derivatives as potassium channel modulators
JP2011500823A (ja) 2007-10-22 2011-01-06 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー Pi3キナーゼ阻害物質としてのピリドスルホンアミド誘導体
WO2011111880A1 (ko) 2010-03-08 2011-09-15 주식회사 메디젠텍 세포핵에서 세포질로의 gsk3의 이동을 억제하는 화합물을 함유하는 세포핵에서 세포질로의 gsk3 이동에 의해 발생되는 질환의 치료 또는 예방용 약학적 조성물
AU2014324426A1 (en) 2013-09-30 2016-04-21 The Regents Of The University Of California Anti-alphavbeta1 integrin compounds and methods
GB201417094D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201417011D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201417018D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201417002D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compound
EP3925959A1 (en) 2015-02-19 2021-12-22 OcuTerra Therapeutics, Inc. Fluorinated derivatives of 3-(2-oxo-3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl)imidazolidin-1-yl)propanoic acid and uses thereof
AU2016228852A1 (en) 2015-03-10 2017-10-19 The Regents Of The University Of California Anti-alphavbeta1 integrin inhibitors and methods of use
GB201604589D0 (en) 2016-03-18 2016-05-04 Glaxosmithkline Ip Dev Ltd Chemical compound
GB201604680D0 (en) 2016-03-21 2016-05-04 Glaxosmithkline Ip Dev Ltd Chemical Compounds
GB201604681D0 (en) 2016-03-21 2016-05-04 Glaxosmithkline Ip Dev Ltd Chemical Compounds

Also Published As

Publication number Publication date
SI2989100T1 (en) 2018-06-29
MA38540A1 (fr) 2017-02-28
CN105189499B (zh) 2016-09-28
RS57220B1 (sr) 2018-07-31
KR20150135790A (ko) 2015-12-03
MX2015013742A (es) 2016-02-29
HUE036750T2 (hu) 2018-07-30
GB201305668D0 (en) 2013-05-15
EP2989100A1 (en) 2016-03-02
DK2989100T3 (en) 2018-04-23
PH12015502232B1 (en) 2018-09-26
BR112015024530A8 (pt) 2019-12-10
LT2989100T (lt) 2018-05-25
KR101775085B1 (ko) 2017-09-05
EP2989100B1 (en) 2018-02-28
UA114952C2 (uk) 2017-08-28
KR102042141B1 (ko) 2019-11-07
TW201533042A (zh) 2015-09-01
US10023568B2 (en) 2018-07-17
CL2015002860A1 (es) 2016-03-28
WO2014154725A1 (en) 2014-10-02
JP6095847B2 (ja) 2017-03-15
CY1120188T1 (el) 2018-12-12
PE20151606A1 (es) 2015-11-24
MX363288B (es) 2019-03-19
CR20150509A (es) 2016-03-04
TWI632143B (zh) 2018-08-11
EP3360876A1 (en) 2018-08-15
UY35505A (es) 2014-10-31
AU2014243068A1 (en) 2015-10-08
MA38540B1 (fr) 2017-10-31
PT2989100T (pt) 2018-05-18
US20160280705A1 (en) 2016-09-29
KR20170103033A (ko) 2017-09-12
CN105189499A (zh) 2015-12-23
CA2903358A1 (en) 2014-10-02
HK1214262A1 (en) 2016-07-22
JP2016515557A (ja) 2016-05-30
ES2665597T3 (es) 2018-04-26
DOP2015000251A (es) 2016-02-29
HRP20180528T1 (hr) 2018-05-04
EA027305B1 (ru) 2017-07-31
ME02987B (me) 2018-10-20
BR112015024530A2 (pt) 2017-07-18
AU2014243068C1 (en) 2017-05-25
US20180291022A1 (en) 2018-10-11
AU2014243068B2 (en) 2017-01-05
IL241184A0 (en) 2015-11-30
SMT201800247T1 (it) 2018-07-17
PH12015502232A1 (en) 2016-02-01
AR095768A1 (es) 2015-11-11
EA201591503A1 (ru) 2016-04-29
SG11201506813QA (en) 2015-10-29
NZ629025A (en) 2017-05-26
US10450312B2 (en) 2019-10-22
NO2989100T3 (pl) 2018-07-28

Similar Documents

Publication Publication Date Title
SG11201506813QA (en) Naphthyridine derivatives useful as alpha-v-beta-6 integrin antagonists
IL240863A0 (en) Amatoxin derivatives
SG11201506100XA (en) Pyridazinone-amides derivatives
PT2951177T (pt) Compostos imidazopiridina e suas utilizações
IL244609B (en) History of 4-azaindole
ZA201505575B (en) Fluorinated integrin antagonists
ZA201601333B (en) Oxoquinazolinyl-butanamide derivatives
PL3022210T3 (pl) Nowy pochodne azabenzimidazolu
HUP1300139A2 (en) Phenoxypiperidine h3 antagonists
SG11201600862YA (en) Piperidine urea derivatives
SG11201605189YA (en) Imidazopyrazinone derivatives
GB201306657D0 (en) Trestle
GB201300306D0 (en) Heterocyclic derivatives
GB201309912D0 (en) Duvelope