PL2991988T3 - Pochodne pirolo[2,3-d]pirymidyny jako agoniści receptora cb2 - Google Patents
Pochodne pirolo[2,3-d]pirymidyny jako agoniści receptora cb2Info
- Publication number
- PL2991988T3 PL2991988T3 PL14720136T PL14720136T PL2991988T3 PL 2991988 T3 PL2991988 T3 PL 2991988T3 PL 14720136 T PL14720136 T PL 14720136T PL 14720136 T PL14720136 T PL 14720136T PL 2991988 T3 PL2991988 T3 PL 2991988T3
- Authority
- PL
- Poland
- Prior art keywords
- pyrrolo
- receptor agonists
- pyrimidine derivatives
- pyrimidine
- derivatives
- Prior art date
Links
- 150000004943 pyrrolo[2,3-d]pyrimidines Chemical class 0.000 title 1
- 239000000018 receptor agonist Substances 0.000 title 1
- 229940044601 receptor agonist Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13166296 | 2013-05-02 | ||
| PCT/EP2014/058648 WO2014177527A1 (en) | 2013-05-02 | 2014-04-29 | Pyrrolo[2,3-d]pyrimidine derivatives as cb2 receptor agonists |
| EP14720136.2A EP2991988B1 (en) | 2013-05-02 | 2014-04-29 | Pyrrolo[2,3-d]pyrimidine derivatives as cb2 receptor agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2991988T3 true PL2991988T3 (pl) | 2017-10-31 |
Family
ID=48190401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL14720136T PL2991988T3 (pl) | 2013-05-02 | 2014-04-29 | Pochodne pirolo[2,3-d]pirymidyny jako agoniści receptora cb2 |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US9580435B2 (pl) |
| EP (1) | EP2991988B1 (pl) |
| JP (1) | JP6454689B2 (pl) |
| KR (1) | KR20160002857A (pl) |
| CN (1) | CN105164133B (pl) |
| AR (1) | AR096153A1 (pl) |
| AU (1) | AU2014261546B2 (pl) |
| BR (1) | BR112015027394A8 (pl) |
| CA (1) | CA2907691A1 (pl) |
| CL (1) | CL2015003196A1 (pl) |
| CR (1) | CR20150555A (pl) |
| CY (1) | CY1119114T1 (pl) |
| DK (1) | DK2991988T3 (pl) |
| EA (1) | EA028123B1 (pl) |
| ES (1) | ES2635632T3 (pl) |
| HR (1) | HRP20171099T1 (pl) |
| HU (1) | HUE035333T2 (pl) |
| IL (1) | IL242162B (pl) |
| LT (1) | LT2991988T (pl) |
| MA (1) | MA38555B1 (pl) |
| MX (1) | MX373855B (pl) |
| MY (1) | MY182237A (pl) |
| NZ (1) | NZ712030A (pl) |
| PE (1) | PE20160039A1 (pl) |
| PH (1) | PH12015502409A1 (pl) |
| PL (1) | PL2991988T3 (pl) |
| PT (1) | PT2991988T (pl) |
| RS (1) | RS56313B1 (pl) |
| SG (1) | SG11201509029PA (pl) |
| SI (1) | SI2991988T1 (pl) |
| TW (1) | TWI680129B (pl) |
| UA (1) | UA116801C2 (pl) |
| WO (1) | WO2014177527A1 (pl) |
| ZA (1) | ZA201507008B (pl) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3041843T3 (pl) | 2013-09-06 | 2019-06-28 | F. Hoffmann-La Roche Ag | Pochodne triazolo[4,5-d]pirymidyny jako antagoniści receptora cb2 |
| AU2015341811A1 (en) * | 2014-11-07 | 2017-03-30 | F. Hoffmann-La Roche Ag | Triazolo[4,5-d]pyrimidines as agonists of the cannabinoid receptor 2 |
| WO2017220544A1 (en) | 2016-06-23 | 2017-12-28 | F. Hoffmann-La Roche Ag | Novel[1,2,3]triazolo[4,5-d]pyrimidine derivatives |
| WO2017220516A1 (en) | 2016-06-23 | 2017-12-28 | F. Hoffmann-La Roche Ag | Novel [1,2,3]triazolo[4,5-d]pyrimidine derivatives |
| MA45442A (fr) | 2016-06-23 | 2019-05-01 | Hoffmann La Roche | Dérivés de [1,2,3]triazolo[4,5-d]pyrimidine ayant une affinité pour le récepteur cannabinoïde de type 2 |
| CN109311886B (zh) | 2016-06-23 | 2021-11-09 | 豪夫迈·罗氏有限公司 | [1,2,3]三唑并[4,5-d]嘧啶衍生物 |
| JP2023541601A (ja) | 2020-09-10 | 2023-10-03 | プレシリックス・ナームローゼ・ベンノートシヤープ | Ｆａｐに対する抗体フラグメント |
| WO2023203135A1 (en) | 2022-04-22 | 2023-10-26 | Precirix N.V. | Improved radiolabelled antibody |
| AU2023264245A1 (en) | 2022-05-02 | 2024-12-19 | Precirix N.V. | Pre-targeting |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001058869A2 (en) | 2000-02-11 | 2001-08-16 | Bristol-Myers Squibb Company | Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators in treating respiratory and non-respiratory diseases |
| EP1492784A4 (en) | 2002-03-28 | 2006-03-29 | Merck & Co Inc | SUBSTITUTED 2,3-DIPHENYLPYRIDINES |
| DE10219435A1 (de) | 2002-05-02 | 2003-11-13 | Bayer Cropscience Ag | Substituierte Pyrazolo-pyrimidin-4-one |
| TWI270549B (en) * | 2002-12-26 | 2007-01-11 | Taisho Pharmaceutical Co Ltd | Pyrrolopyrimidine and pyrrolopyridine derivatives substituted with cyclic amino group |
| AR051596A1 (es) | 2004-10-26 | 2007-01-24 | Irm Llc | Compuestos heterociclicos condensados nitrogenados como inhibidores de la actividad del receptor canabinoide 1; composiciones farmaceuticas que los contienen y su empleo en la preparacion de medicamentos para el tratamiento de trastornos alimentarios |
| WO2007120454A1 (en) * | 2006-03-30 | 2007-10-25 | Irm Llc | Azolopyrimidines as inhibitors of cannabinoid 1 activity |
| ES2395583T3 (es) * | 2007-05-10 | 2013-02-13 | Ge Healthcare Limited | IMIDAZOL (1,2-A)PIRIDINAS y compuestos relacionados con actividad frente a los receptores cannabinoides CB2 |
| US20090062253A1 (en) * | 2007-08-31 | 2009-03-05 | Kalypsys, Inc. | Heterocyclodiazepine cannabinoid receptor modulators for treatment of disease |
| WO2009051705A1 (en) | 2007-10-18 | 2009-04-23 | Merck & Co., Inc. | Substituted 1,2,4-oxadiazoles and analogs thereof as cb2 receptor modulators, useful in the treatment of pain, respiratory and non-respiratory diseases |
| UA104010C2 (en) * | 2008-12-18 | 2013-12-25 | Эли Лилли Энд Компани | Purine compounds |
| WO2010118367A2 (en) | 2009-04-10 | 2010-10-14 | Progenics Pharmaceuticals, Inc. | Antiviral pyrimidines |
| ES2426407T3 (es) * | 2009-10-15 | 2013-10-23 | Pfizer Inc. | Compuestos de pirrolo[2,3-d]pirimidina |
| US9321727B2 (en) | 2011-06-10 | 2016-04-26 | Hoffmann-La Roche Inc. | Pyridine derivatives as agonists of the CB2 receptor |
| UA111640C2 (uk) | 2011-11-08 | 2016-05-25 | Ф. Хоффманн-Ля Рош Аг | ПОХІДНІ [1,2,3]ТРИАЗОЛО[4,5-d]ПІРИМІДИНУ ЯК АГОНІСТИ КАНАБІНОЇДНОГО РЕЦЕПТОРА 2 |
| BR112014032996A2 (pt) | 2012-07-04 | 2018-05-15 | Hoffmann La Roche | derivados de adamantil como agonistas do receptor de canabinoide 2 |
| JP6426619B2 (ja) | 2012-12-07 | 2018-11-21 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｃｂ２アゴニストとして有用なピリジン−２−アミド |
| HRP20180672T1 (hr) | 2012-12-07 | 2018-06-01 | F. Hoffmann - La Roche Ag | Novi derivati piridina |
| SI2928882T1 (sl) | 2012-12-07 | 2017-05-31 | F. Hoffmann-La Roche Ag | Pirazinski derivati kot agonisti receptorja CB2 |
| HRP20171459T1 (hr) | 2012-12-07 | 2017-11-03 | F. Hoffmann - La Roche Ag | Piridin-2-amidi korisni kao agonisti cb2 |
| EA027935B1 (ru) | 2013-03-07 | 2017-09-29 | Ф. Хоффманн-Ля Рош Аг | Новые производные пиразола |
| CN105209466B (zh) | 2013-05-02 | 2018-05-18 | 豪夫迈·罗氏有限公司 | 作为cb2受体激动剂的嘌呤衍生物 |
-
2014
- 2014-04-29 HU HUE14720136A patent/HUE035333T2/en unknown
- 2014-04-29 PT PT147201362T patent/PT2991988T/pt unknown
- 2014-04-29 PE PE2015002323A patent/PE20160039A1/es active IP Right Grant
- 2014-04-29 SI SI201430317T patent/SI2991988T1/sl unknown
- 2014-04-29 EP EP14720136.2A patent/EP2991988B1/en active Active
- 2014-04-29 HR HRP20171099TT patent/HRP20171099T1/hr unknown
- 2014-04-29 ES ES14720136.2T patent/ES2635632T3/es active Active
- 2014-04-29 BR BR112015027394A patent/BR112015027394A8/pt not_active IP Right Cessation
- 2014-04-29 DK DK14720136.2T patent/DK2991988T3/en active
- 2014-04-29 UA UAA201510730A patent/UA116801C2/uk unknown
- 2014-04-29 MX MX2015014081A patent/MX373855B/es active IP Right Grant
- 2014-04-29 WO PCT/EP2014/058648 patent/WO2014177527A1/en not_active Ceased
- 2014-04-29 MA MA38555A patent/MA38555B1/fr unknown
- 2014-04-29 CN CN201480024215.5A patent/CN105164133B/zh active Active
- 2014-04-29 PL PL14720136T patent/PL2991988T3/pl unknown
- 2014-04-29 EA EA201591939A patent/EA028123B1/ru not_active IP Right Cessation
- 2014-04-29 LT LTEP14720136.2T patent/LT2991988T/lt unknown
- 2014-04-29 CA CA2907691A patent/CA2907691A1/en not_active Abandoned
- 2014-04-29 SG SG11201509029PA patent/SG11201509029PA/en unknown
- 2014-04-29 RS RS20170752A patent/RS56313B1/sr unknown
- 2014-04-29 JP JP2016511035A patent/JP6454689B2/ja active Active
- 2014-04-29 AU AU2014261546A patent/AU2014261546B2/en not_active Ceased
- 2014-04-29 KR KR1020157031006A patent/KR20160002857A/ko not_active Ceased
- 2014-04-29 NZ NZ712030A patent/NZ712030A/en unknown
- 2014-04-29 MY MYPI2015703900A patent/MY182237A/en unknown
- 2014-04-30 TW TW103115663A patent/TWI680129B/zh not_active IP Right Cessation
- 2014-04-30 AR ARP140101784A patent/AR096153A1/es unknown
-
2015
- 2015-09-21 ZA ZA2015/07008A patent/ZA201507008B/en unknown
- 2015-10-14 CR CR20150555A patent/CR20150555A/es unknown
- 2015-10-16 PH PH12015502409A patent/PH12015502409A1/en unknown
- 2015-10-19 IL IL242162A patent/IL242162B/en active IP Right Grant
- 2015-10-26 US US14/923,186 patent/US9580435B2/en active Active
- 2015-10-30 CL CL2015003196A patent/CL2015003196A1/es unknown
-
2017
- 2017-07-24 CY CY20171100785T patent/CY1119114T1/el unknown
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