PL3019177T3 - Kompozycje hialuronianu o dużej sprężystości i ich zastosowania - Google Patents

Kompozycje hialuronianu o dużej sprężystości i ich zastosowania

Info

Publication number
PL3019177T3
PL3019177T3 PL14745299T PL14745299T PL3019177T3 PL 3019177 T3 PL3019177 T3 PL 3019177T3 PL 14745299 T PL14745299 T PL 14745299T PL 14745299 T PL14745299 T PL 14745299T PL 3019177 T3 PL3019177 T3 PL 3019177T3
Authority
PL
Poland
Prior art keywords
applications
high flexibility
hyaluronate compositions
hyaluronate
compositions
Prior art date
Application number
PL14745299T
Other languages
English (en)
Inventor
Endre A. Balazs
Carlos Belmonte
Original Assignee
Matrix Biology Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matrix Biology Institute filed Critical Matrix Biology Institute
Publication of PL3019177T3 publication Critical patent/PL3019177T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728Hyaluronic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PL14745299T 2013-07-10 2014-07-09 Kompozycje hialuronianu o dużej sprężystości i ich zastosowania PL3019177T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361844645P 2013-07-10 2013-07-10
EP14745299.9A EP3019177B1 (en) 2013-07-10 2014-07-09 Compositions of hyaluronan with high elasticity and uses thereof
PCT/US2014/045973 WO2015006460A1 (en) 2013-07-10 2014-07-09 Compositions of hyaluronan with high elasticity and uses thereof

Publications (1)

Publication Number Publication Date
PL3019177T3 true PL3019177T3 (pl) 2021-04-19

Family

ID=51261252

Family Applications (2)

Application Number Title Priority Date Filing Date
PL19202082.4T PL3613423T3 (pl) 2013-07-10 2014-07-09 Kompozycje hialuronanu o dużej sprężystości i ich zastosowanie
PL14745299T PL3019177T3 (pl) 2013-07-10 2014-07-09 Kompozycje hialuronianu o dużej sprężystości i ich zastosowania

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL19202082.4T PL3613423T3 (pl) 2013-07-10 2014-07-09 Kompozycje hialuronanu o dużej sprężystości i ich zastosowanie

Country Status (8)

Country Link
US (5) US9492474B2 (pl)
EP (3) EP4137139A1 (pl)
JP (5) JP6357228B2 (pl)
AR (2) AR096875A1 (pl)
ES (2) ES2933549T3 (pl)
PL (2) PL3613423T3 (pl)
PT (2) PT3019177T (pl)
WO (1) WO2015006460A1 (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4137139A1 (en) 2013-07-10 2023-02-22 Matrix Biology Institute Compositions of hyaluronan with high elasticity and uses thereof
ES2871199T3 (es) 2015-09-24 2021-10-28 Matrix Biology Inst Composiciones de hialuronano de alta elasticidad y métodos de uso de las mismas
WO2020144372A1 (en) 2019-01-10 2020-07-16 The Provost, Fellows, Scholars And Other Members Of Board Of Trinity College Dublin Composite viscoelastic hydrogel, and uses thereof for sealing a channel in tissue
ES2976202T3 (es) 2018-01-10 2024-07-26 The Provost Fellows Scholars And Other Members Of Board Of Trinity College Dublin Sistema para sellar un canal en tejido
EP3781175A1 (en) 2018-04-18 2021-02-24 i.com Medical GmbH High molecular weight hyaluronic acid for treatment and prevention of severe ocular surface disease
US12268706B2 (en) 2019-01-31 2025-04-08 i.com medical GmbH Hyaluronic acid for relief of idiopathic ocular pain
EP3969057B1 (en) * 2019-05-17 2025-12-17 The Governing Council of the University of Toronto Sustained release local anesthetic hydrogel composition

Family Cites Families (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4141973A (en) 1975-10-17 1979-02-27 Biotrics, Inc. Ultrapure hyaluronic acid and the use thereof
US4517295A (en) 1983-02-18 1985-05-14 Diagnostic, Inc. Hyaluronic acid from bacterial culture
IN163192B (pl) 1983-10-11 1988-08-20 Fidia Spa
IT1198449B (it) 1986-10-13 1988-12-21 F I D I Farmaceutici Italiani Esteri di alcoli polivalenti di acido ialuronico
US5403592A (en) 1987-08-25 1995-04-04 Macnaught Pty Limited Lubricant composition for rheumatism
AU620821B2 (en) 1987-08-25 1992-02-27 Macnaught Pty Limited Hyaluronic acid lubricating compounds
EP0414373B2 (en) * 1989-07-24 2001-04-25 Allergan Pharmaceuticals (Ireland) Limited Stable solution of hyaluronate in a balanced salt medium
AU652022B2 (en) 1991-02-12 1994-08-11 C.R. Bard Inc. Injectable medical device
US5234914A (en) 1991-06-11 1993-08-10 Patent Biopharmaceutics, Inc. Methods of treating hemorrhoids and anorecial disease
AU682670B2 (en) 1993-02-05 1997-10-16 Becton Dickinson & Company Syringe needle isolation device
US5624915A (en) 1993-08-04 1997-04-29 Patent Biopharmaceutics, Inc. Hyaluronic acid-urea pharmaceutical compositions and uses
US5607400A (en) 1995-05-19 1997-03-04 Becton, Dickinson And Company Pre-fillable syringe and stopper assembly therefor
IT1277707B1 (it) 1995-12-22 1997-11-11 Chemedica Sa Formulazione oftalmica a base di ialuronato di sodio per uso nella chirurgia oculare
JPH09173450A (ja) 1995-12-26 1997-07-08 Nissho Corp プレフィルドシリンジ
JP3293122B2 (ja) 1996-12-13 2002-06-17 ニプロ株式会社 プレフィルドシリンジ
SE9700827D0 (sv) * 1997-03-07 1997-03-07 Pharmacia & Upjohn Ab Ophthalmic composition
RU2126669C1 (ru) 1997-04-25 1999-02-27 Новокузнецкий государственный институт усовершенствования врачей Способ лечения синдрома сухого глаза
SE9703425D0 (sv) 1997-09-23 1997-09-23 Pharmacia & Upjohn Ab Prefilled ampooules and manufacture thereof
DE19751219A1 (de) 1997-11-19 1999-05-27 Vetter & Co Apotheker Spritze, insbesondere vorgefüllte Spritze, oder Karpule
JP4216467B2 (ja) 1998-03-13 2009-01-28 ベクトン・ディキンソン・アンド・カンパニー 医療装置の組立ておよび包装方法
ITPD980169A1 (it) 1998-07-06 2000-01-06 Fidia Advanced Biopolymers Srl Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione.
JP3591636B2 (ja) 2000-04-03 2004-11-24 ニプロ株式会社 プレフィルドシリンジ
DE60100866T2 (de) 2000-04-07 2004-07-29 Laboratoire Medidom S.A. Cyklosporin, Hyaluronsäure und Polysorbate enthaltenes Augenarzneimittel
US7635489B2 (en) 2001-05-18 2009-12-22 Leneau Holdings, Llc Ingestion of hyaluronic acid for improved joint health
JP2003119147A (ja) * 2001-10-10 2003-04-23 Raku:Kk ヒアルロン酸化合物の水溶液組成物
ATE547122T1 (de) 2001-11-21 2012-03-15 Novartis Pharma Gmbh Zusammensetzung zur stabilisierung von hyaluronsäure
US7820194B2 (en) 2001-12-21 2010-10-26 Alcon, Inc. Combinations of viscoelastics for use during surgery
JP4141156B2 (ja) 2002-03-15 2008-08-27 日本ベクトン・ディッキンソン株式会社 プランジャ後退制限機構付きプレフィルドシリンジ
US7081107B2 (en) 2002-07-02 2006-07-25 Terumo Kabushiki Kaisha Syringe and prefilled syringe
RU2005102604A (ru) 2002-07-03 2005-09-10 Перикор Сайенс, Инк. (Us) Композиция гиалуроновой кислоты и способы применения
WO2004028536A1 (en) 2002-09-30 2004-04-08 Babizhayev Mark A Method for topical treatment of eye disease and composition and device for said treatment
DE10254321A1 (de) 2002-11-21 2004-06-17 Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg Vorgefüllte Spritze
JP2004229750A (ja) 2003-01-28 2004-08-19 Nipro Corp プレフィルドシリンジ及びそのバレルの製造方法
US20040167480A1 (en) 2003-02-21 2004-08-26 Advanced Medical Optics, Inc. Administration of multiple viscoelastic solutions with a multi-compartment syringe
JP2004262777A (ja) 2003-02-27 2004-09-24 Shiseido Co Ltd アセチル化ヒアルロン酸含有眼用医薬組成物
FR2861734B1 (fr) 2003-04-10 2006-04-14 Corneal Ind Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus
AR044302A1 (es) 2003-05-13 2005-09-07 Ares Trading Sa Formulaciones con proteinas liquidas estabilizadas en recipientes farmaceuticos
US20050059639A1 (en) 2003-09-11 2005-03-17 Wei Edward T. Ophthalmic compositions and method for treating eye discomfort and pain
US20050075611A1 (en) 2003-10-01 2005-04-07 Hetzler Kevin G. Low extractable, thermoplastic syringe and tip cap
US20090148527A1 (en) 2007-12-07 2009-06-11 Robinson Michael R Intraocular formulation
US7544671B2 (en) 2004-05-07 2009-06-09 S.K. Pharmaceuticals, Inc. Stabilized hyaluronan preparations and related methods
US8372814B2 (en) 2004-06-07 2013-02-12 Ista Pharmaceuticals, Inc. Ophthalmic formulations and uses thereof
WO2006067608A1 (en) 2004-12-22 2006-06-29 Laboratoire Medidom S.A. Aqueous formulations based on sodium hyaluronate for parenteral use
EP2664334B1 (en) * 2004-12-30 2015-03-04 Genzyme Corporation Regimens for intra-articular viscosupplementation
US9238003B2 (en) 2005-02-04 2016-01-19 Auburn University Extended or continuous wear silicone hydrogel contact lenses for the extended release of comfort molecules
US8388995B1 (en) 2006-02-03 2013-03-05 Auburn University Controlled and extended delivery of hyaluronic acid and comfort molecules via a contact lens platform
ITPD20050056A1 (it) 2005-03-02 2006-09-03 Fidia Farmaceutici Derivati ammidici del'acido ialuronico in osteoartrosi
US7767710B2 (en) 2005-05-25 2010-08-03 Calosyn Pharma, Inc. Method for treating osteoarthritis
DE102005055275A1 (de) 2005-11-17 2007-05-24 Ursapharm Arzneimittel Gmbh & Co. Kg Phosphatfreie pharmazeutische Zusammensetzung sowie deren Verwendung
WO2007059890A1 (en) * 2005-11-22 2007-05-31 Centre National De Recherche Scientifique New derivatives of hyaluronic acid, their preparation process and their uses
US7988675B2 (en) 2005-12-08 2011-08-02 West Pharmaceutical Services Of Delaware, Inc. Automatic injection and retraction devices for use with pre-filled syringe cartridges
EP1968614A2 (en) 2005-12-14 2008-09-17 Anika Therapeutics Inc. Treatment of arthritis and other musculoskeletal disorders with crosslinked hyaluronic acid
JP4682850B2 (ja) 2006-01-12 2011-05-11 ニプロ株式会社 プレフィルドシリンジ
US20070254841A1 (en) 2006-01-25 2007-11-01 Ophthalmic Research Associates, Inc. Formulations and methods for treating dry eye
US7674781B2 (en) 2006-04-28 2010-03-09 Heather Sheardown Hyaluronic acid-retaining polymers
AR062046A1 (es) 2006-07-25 2008-08-10 Osmotica Pharmaceutical Argentina S A Soluciones oftalmicas
BRPI0716270A2 (pt) 2006-08-28 2013-08-13 Rexaderm Inc bandagem de ferida seca e sistema de distribuiÇço de fÁrmaco
ITMI20061668A1 (it) * 2006-09-01 2008-03-02 Schiena Michele Giuseppe Di Composizione a base di acido ialuronico e suoi sali per il trattamento di lesioni epiteliali
AU2007320123A1 (en) 2006-11-17 2008-05-22 Agency For Science, Technology And Research Porous polymeric material with cross-linkable wetting agent
CN101389342B (zh) 2006-12-05 2012-08-08 株式会社糖质科学研究所 用于变性关节炎的治疗剂
FR2918276B1 (fr) * 2007-07-02 2010-01-22 Anteis Sa "utilisation d'un gel de polysaccharide(s)naturel(s)pour la preparation d'une formulation injectable de traitement des degenerescences articulaires"
WO2009111159A2 (en) 2008-03-03 2009-09-11 New York University Biocompatible materials containing stable complexes of tsg-6 and hyaluronan and method of using same
WO2009122541A1 (ja) * 2008-03-31 2009-10-08 Inui Hiroaki ヒト胚の体外受精及び培養用培養液及びヒト胚の体外受精及び培養方法
JP5758797B2 (ja) 2008-04-04 2015-08-05 ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション アルキル化半合成グリコサミノグリカンエーテルならびにその製造および使用方法
FR2938187B1 (fr) 2008-11-07 2012-08-17 Anteis Sa Composition injectable a base d'acide hyaluronique ou l'un de ses sels, de polyols et de lidocaine, sterilisee a la chaleur
AU2010204445B2 (en) * 2009-01-07 2015-09-03 2405871 Ontario Inc. Treatment of soft tissue injury using hyaluronic acid and botulinum toxin
US20100178317A1 (en) 2009-01-09 2010-07-15 Burke Susan E Lens Care Solutions with Hyaluronic Acid
US8979821B2 (en) 2009-04-14 2015-03-17 Fezza Family Properties, Llc Lacrimal filler
US20100303915A1 (en) 2009-06-02 2010-12-02 Abbott Medical Optics Inc. Therapeutic opthalmic emulsions
US20120128754A1 (en) 2009-06-05 2012-05-24 Edward Tak Wei Treatment of eye discomfort by topical administration of a cooling agent to the external surface of the eyelid
US8673340B2 (en) 2009-09-10 2014-03-18 Boston Foundation For Sight Sodium channel blocker delivery system with scleral lens
US20120264689A1 (en) 2009-10-07 2012-10-18 Genogen, Inc. Methods and compositions for skin regeneration
US20110171310A1 (en) 2010-01-13 2011-07-14 Allergan Industrie, Sas Hydrogel compositions comprising vasoconstricting and anti-hemorrhagic agents for dermatological use
HUE030138T2 (en) 2010-03-22 2017-04-28 Allergan Inc Polysaccharide and protein-polysaccharide cross-linked hydrogels for soft tissue augmentation
US20130209531A1 (en) 2010-06-08 2013-08-15 University Of Utah Research Foundation Applications of partially and fully sulfated hyaluronan
WO2012027834A1 (en) 2010-09-02 2012-03-08 Mcmaster University Hyaluronic acid-containing biopolymers
WO2012033189A1 (ja) 2010-09-10 2012-03-15 参天製薬株式会社 P2y2受容体作動薬およびヒアルロン酸またはその塩を組み合わせたことを特徴とするドライアイ治療剤、ドライアイの治療方法、ならびにその使用
US8455436B2 (en) 2010-12-28 2013-06-04 Depuy Mitek, Llc Compositions and methods for treating joints
US8524662B2 (en) 2010-12-28 2013-09-03 Depuy Mitek, Llc Compositions and methods for treating joints
US8398611B2 (en) 2010-12-28 2013-03-19 Depuy Mitek, Inc. Compositions and methods for treating joints
US20140038917A1 (en) * 2011-04-19 2014-02-06 Anteis S.A. Sterile and injectable aqueous formulation for administration in the intra-articular space of an intra-articular joint
GB201118586D0 (en) 2011-10-27 2011-12-07 Turzi Antoine New A-PRP medical device, manufacturing machine and process
RS53135B (sr) 2011-11-24 2014-06-30 Quimera Ingenieria Biomedica, S.L. Kompleks dobijen iz hijaluronske kiseline ili njene soli i smeša hondroitin sulfata
US20150037422A1 (en) 2012-02-22 2015-02-05 Trustees Of Tufts College Compositions and methods for ocular delivery of a therapeutic agent
US20150018305A1 (en) 2012-02-22 2015-01-15 Hyaluronan Research Institute, Inc. Sirtuin inducer, tissue repairing agent, hepatocyte growth factor inducer, tissue homeostasis maintenance agent, and tlr4 agonist, having hyaluronic acid fragment as active ingredient
UA113434C2 (uk) 2012-05-04 2017-01-25 Алкон Рісерч, Лтд. Офтальмологічна композиція з поліпшеним захистом від зневоднювання й утриманням
FR2991876B1 (fr) 2012-06-13 2014-11-21 Vivacy Lab Composition, en milieu aqueux, comprenant au moins un acide hyaluronique et au moins un sel hydrosoluble de sucrose octasulfate
FR2994846B1 (fr) 2012-08-29 2014-12-26 Vivacy Lab Composition, sterilisee, comprenant au moins un acide hyaluronique et de l'ascorbyl phosphate de magnesium
LT2950783T (lt) 2013-02-01 2019-10-25 Allergan Inc Dirbtinės ašaros, kurių sudėtyje yra natrio hialuronato ir karboksimetilceliuliozės
US9226938B2 (en) 2013-03-14 2016-01-05 RMG Rehabilitation Management Group, LP Combinatorial therapy for treatment of osteoarthritis of the knee
EP2979539B1 (en) 2013-03-25 2017-12-20 National University Corporation Tokyo University Of Agriculture and Technology Plant cultivation method
ITMI20130883A1 (it) 2013-05-30 2014-12-01 Eurores S R L Composizioni farmaceutiche comprendenti collagene e sodio ialuronato
EP4137139A1 (en) 2013-07-10 2023-02-22 Matrix Biology Institute Compositions of hyaluronan with high elasticity and uses thereof
ES2784229T3 (es) 2013-11-20 2020-09-23 Panag Pharma Inc Composiciones y procedimientos para el tratamiento de la inflamación y el dolor ocular
US9187576B2 (en) 2013-11-25 2015-11-17 Deuteria Biomaterials, Llc Deuterium-enriched hyaluronan
FR3015290B1 (fr) 2013-12-23 2017-01-13 Lab Vivacy Compositions d'acide hyaluronique compreant de la mepivacaine
ES2871199T3 (es) 2015-09-24 2021-10-28 Matrix Biology Inst Composiciones de hialuronano de alta elasticidad y métodos de uso de las mismas

Also Published As

Publication number Publication date
PL3613423T3 (pl) 2023-02-13
JP2018138622A (ja) 2018-09-06
WO2015006460A1 (en) 2015-01-15
AR130403A2 (es) 2024-12-04
AR096875A1 (es) 2016-02-03
JP2024028669A (ja) 2024-03-04
US11524027B2 (en) 2022-12-13
US10933085B2 (en) 2021-03-02
JP6598929B2 (ja) 2019-10-30
US20210161947A1 (en) 2021-06-03
PT3019177T (pt) 2020-12-30
JP2022058871A (ja) 2022-04-12
JP2019214632A (ja) 2019-12-19
US20200030363A1 (en) 2020-01-30
ES2933549T3 (es) 2023-02-10
EP3613423B1 (en) 2022-10-26
EP3613423A1 (en) 2020-02-26
US10383890B2 (en) 2019-08-20
EP3019177A1 (en) 2016-05-18
US9492474B2 (en) 2016-11-15
JP7025039B2 (ja) 2022-02-24
US20150018303A1 (en) 2015-01-15
ES2837626T3 (es) 2021-07-01
EP3019177B1 (en) 2020-11-04
US20170071974A1 (en) 2017-03-16
JP2016526573A (ja) 2016-09-05
EP4137139A1 (en) 2023-02-22
JP6357228B2 (ja) 2018-07-11
US20250352572A1 (en) 2025-11-20
PT3613423T (pt) 2022-12-07

Similar Documents

Publication Publication Date Title
PL3352766T3 (pl) Kompozycie z hialuronanem o dużej elastyczności i sposoby ich użycia
PL3328199T3 (pl) Kompozycje przeciwdrobnoustrojowe i ich zastosowania
BR112015028459A2 (pt) composições e comestíveis
PL3043803T3 (pl) Kompozycje nukleotydowe i nukleozydowe oraz ich zastosowanie
EP2953474A4 (en) COMPOSITIONS AND METHODS
PL3035936T3 (pl) Pewne jednostki chemiczne, kompozycje i sposoby
PL3265448T3 (pl) Proleki riluzolu i ich zastosowanie
PT3066201T (pt) Métodos e composições relacionadas com crispr com arng reguladores
PL3058936T3 (pl) Kompozycja peptydów i jej zastosowania
PL3030519T3 (pl) Trójpierścieniowe związki benzoksaborolu i ich zastosowania
EP2970569A4 (en) PERSISTENT CARBENE AND COMPOSITIONS WITH IT
DK3027750T3 (da) Biokatalytisk sammensætning
DE202014011212U8 (de) Superabsorberpolymerzusammensetzung
EP2968107A4 (en) COSMETIC COMPOSITIONS AND USES THEREOF
HUE043417T2 (hu) Krémesítõ kompozíciók és alkalmazásuk
DK2893929T3 (da) Antibiotisk ceftolozansammensætninger
DK3060200T3 (da) Tyrosinderivater og sammensætninger dermed
PL3393485T3 (pl) Kompozycje probiotyczne i ich zastosowanie
PL3154515T3 (pl) Udoskonalenia kompozycji donosowych i sposób ich stosowania
DK3013921T3 (da) Fleksibelt visir med dugfri egenskaber og dugfri belægningssammensætninger
DK3071053T3 (da) Præbiotisk sammensætning
IL276126B (en) Preparations containing l-4-chloroquinonerine and their uses
PL3337506T3 (pl) Kombinacje i ich zastosowania
PL3613423T3 (pl) Kompozycje hialuronanu o dużej sprężystości i ich zastosowanie
EP2995308A4 (en) ANTI-HYPOXIC PHARMACEUTICAL COMPOSITION AND USE THEREOF