PL3023100T3 - Lek przeciwnowotworowy do okresowego podawania inhibitora FGFR - Google Patents
Lek przeciwnowotworowy do okresowego podawania inhibitora FGFRInfo
- Publication number
- PL3023100T3 PL3023100T3 PL14826652T PL14826652T PL3023100T3 PL 3023100 T3 PL3023100 T3 PL 3023100T3 PL 14826652 T PL14826652 T PL 14826652T PL 14826652 T PL14826652 T PL 14826652T PL 3023100 T3 PL3023100 T3 PL 3023100T3
- Authority
- PL
- Poland
- Prior art keywords
- antitumor drug
- fgfr inhibitor
- intermittent administration
- intermittent
- administration
- Prior art date
Links
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 229940041181 antineoplastic drug Drugs 0.000 title 1
- 229940125829 fibroblast growth factor receptor inhibitor Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013149963 | 2013-07-18 | ||
| EP14826652.1A EP3023100B1 (en) | 2013-07-18 | 2014-07-17 | Antitumor drug for intermittent administration of fgfr inhibitor |
| PCT/JP2014/069086 WO2015008839A1 (ja) | 2013-07-18 | 2014-07-17 | Ｆｇｆｒ阻害剤の間歇投与用抗腫瘍剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3023100T3 true PL3023100T3 (pl) | 2019-07-31 |
Family
ID=52346281
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL14826652T PL3023100T3 (pl) | 2013-07-18 | 2014-07-17 | Lek przeciwnowotworowy do okresowego podawania inhibitora FGFR |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20160193210A1 (pl) |
| EP (1) | EP3023100B1 (pl) |
| JP (1) | JP6084291B2 (pl) |
| KR (1) | KR101974254B1 (pl) |
| AU (1) | AU2014291161B2 (pl) |
| DK (1) | DK3023100T3 (pl) |
| ES (1) | ES2724929T3 (pl) |
| HU (1) | HUE044273T2 (pl) |
| PL (1) | PL3023100T3 (pl) |
| PT (1) | PT3023100T (pl) |
| RU (1) | RU2664118C2 (pl) |
| TR (1) | TR201907147T4 (pl) |
| TW (1) | TWI574691B (pl) |
| WO (1) | WO2015008839A1 (pl) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10124003B2 (en) | 2013-07-18 | 2018-11-13 | Taiho Pharmaceutical Co., Ltd. | Therapeutic agent for FGFR inhibitor-resistant cancer |
| AU2014291161B2 (en) | 2013-07-18 | 2018-04-26 | Taiho Pharmaceutical Co., Ltd. | Antitumor drug for intermittent administration of FGFR inhibitor |
| CN105837575B (zh) * | 2015-01-13 | 2019-01-15 | 四川大学 | 3-乙炔基吡唑并嘧啶衍生物及其制备方法和用途 |
| PT3279202T (pt) | 2015-03-31 | 2020-08-31 | Taiho Pharmaceutical Co Ltd | Cristal de composto de alquinilo de benzeno 3,5-dissubstituído |
| EP3424505A4 (en) | 2016-03-04 | 2019-10-16 | Taiho Pharmaceutical Co., Ltd. | PREPARATION AND COMPOSITION FOR THE TREATMENT OF MALIGNANT TUMORS |
| US11883404B2 (en) | 2016-03-04 | 2024-01-30 | Taiho Pharmaceuticals Co., Ltd. | Preparation and composition for treatment of malignant tumors |
| CN107698593A (zh) * | 2016-08-09 | 2018-02-16 | 南京天印健华医药科技有限公司 | 作为fgfr抑制剂的杂环化合物 |
| CN107840842A (zh) * | 2016-09-19 | 2018-03-27 | 北京天诚医药科技有限公司 | 炔代杂环化合物、其制备方法及其在医药学上的应用 |
| JP6918204B2 (ja) | 2018-03-19 | 2021-08-11 | 大鵬薬品工業株式会社 | アルキル硫酸ナトリウムを含む医薬組成物 |
| TW202027749A (zh) * | 2018-10-12 | 2020-08-01 | 日商富士軟片股份有限公司 | 急性骨髓性白血病用抗腫瘤劑 |
| KR102742083B1 (ko) | 2018-11-09 | 2024-12-16 | 다이호야쿠힌고교 가부시키가이샤 | 디메톡시벤젠 화합물의 제조 방법 |
| US20210388002A1 (en) | 2018-11-09 | 2021-12-16 | Taiho Pharmaceutical Co., Ltd. | Dimethoxybenzene compound analogs, methods for analyzing said compounds and standard products of said compounds |
| WO2020110974A1 (ja) * | 2018-11-26 | 2020-06-04 | 大鵬薬品工業株式会社 | 線維芽細胞増殖因子受容体阻害剤と内分泌療法との併用による内分泌療法が適用される腫瘍の治療及び予防方法 |
| WO2020170355A1 (ja) * | 2019-02-20 | 2020-08-27 | 大鵬薬品工業株式会社 | Ｆｇｆｒ１変異腫瘍の治療方法 |
| EP4134081A4 (en) * | 2020-04-10 | 2024-05-01 | Taiho Pharmaceutical Co., Ltd. | Cancer therapy using 3,5-disubstituted benzene alkynyl compound and mek inhibitor |
| US11345681B1 (en) * | 2020-06-05 | 2022-05-31 | Kinnate Biopharma Inc. | Inhibitors of fibroblast growth factor receptor kinases |
| CN116096707A (zh) * | 2020-06-05 | 2023-05-09 | 金耐特生物制药公司 | 成纤维细胞生长因子受体激酶的抑制剂 |
| TWI797711B (zh) * | 2020-08-13 | 2023-04-01 | 大陸商上海和譽生物醫藥科技有限公司 | 一種fgfr及其突變抑制劑，其製備方法和應用 |
| CN114805359B (zh) * | 2021-01-28 | 2023-10-27 | 药雅科技(上海)有限公司 | 炔代杂环化合物fgfr抑制剂的制备方法和用途 |
| CN115028634B (zh) * | 2021-03-08 | 2023-11-28 | 药雅科技(上海)有限公司 | 一种炔代吡嗪并杂环类fgfr抑制剂及其制备方法和用途 |
| CN115785103A (zh) * | 2022-12-28 | 2023-03-14 | 北京康立生医药技术开发有限公司 | 一种治疗胆管癌药物福巴替尼的合成方法 |
| CN120172981B (zh) * | 2025-05-20 | 2025-07-25 | 南京工业大学 | 一类以fgfr2为靶点的小分子降解剂及其药物组合物和应用 |
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| WO2005007083A2 (en) | 2003-06-18 | 2005-01-27 | Smithkline Beecham Corporation | Chemical compounds |
| CA2542776A1 (en) | 2003-10-27 | 2005-05-12 | Genelabs Technologies, Inc. | Nucleoside compounds for treating viral infections |
| JP5052518B2 (ja) * | 2005-10-06 | 2012-10-17 | シェーリング コーポレイション | プロテインキナーゼインヒビターとしてのピラゾロピリミジン |
| ATE446294T1 (de) * | 2005-11-15 | 2009-11-15 | Array Biopharma Inc | N4-phenyl-chinazolin-4-aminderivate und verwandte verbindungen als inhibitoren der erbb-typ-i- rezeptortyrosinkinase zur behandlung hyperproliferativer krankheiten |
| TW200738725A (en) * | 2006-01-25 | 2007-10-16 | Osi Pharm Inc | Unsaturated mTOR inhibitors |
| WO2007095223A2 (en) | 2006-02-14 | 2007-08-23 | Vertex Pharmaceuticals Incorporated | Pyrrolo(3,2-c) pyridines useful as inhibitors of protein kinases |
| US20100273776A1 (en) | 2006-03-29 | 2010-10-28 | FOLDRx PHARMACEUTICALS, INC | Inhibition of alpha-synuclein toxicity |
| EP1939197A1 (en) | 2006-12-22 | 2008-07-02 | Schwarz Pharma Ag | 8-ethinylxanthine derivatives as selective A2A receptor antagonists |
| SG10202107066WA (en) | 2007-03-28 | 2021-07-29 | Pharmacyclics Llc | Inhibitors of bruton's tyrosine kinase |
| CA2728063A1 (en) | 2008-06-19 | 2009-12-23 | Astrazeneca Ab | Pyrazole compounds 436 |
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| CA2759083A1 (en) | 2009-04-30 | 2010-11-04 | Novartis Ag | Imidazole derivatives and their use as modulators of cyclin dependent kinases |
| KR101483215B1 (ko) * | 2010-01-29 | 2015-01-16 | 한미약품 주식회사 | 단백질 키나아제 저해활성을 갖는 비시클릭 헤테로아릴 유도체 |
| US9140689B2 (en) | 2010-03-14 | 2015-09-22 | Translational Genomics Research Institute | Methods of determining susceptibility of tumors to tyrosine kinase inhibitors |
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| CA3007787C (en) * | 2010-06-03 | 2020-03-10 | Pharmacyclics Llc | The use of inhibitors of bruton's tyrosine kinase (btk) |
| SG193327A1 (en) | 2011-04-06 | 2013-10-30 | Taiho Pharmaceutical Co Ltd | Novel imidazo-oxazine compound or salt thereof |
| UY34484A (es) | 2011-12-15 | 2013-07-31 | Bayer Ip Gmbh | Benzotienilo-pirrolotriazinas disustituidas y sus usos |
| MY171055A (en) * | 2012-01-19 | 2019-09-23 | Taiho Pharmaceutical Co Ltd | 3,5-disubstituted alkynylbenzene compound and salt thereof |
| JP6082033B2 (ja) | 2012-02-23 | 2017-02-15 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | 置換ベンゾチエニル−ピロロトリアジンおよびその使用 |
| WO2014007217A1 (ja) | 2012-07-02 | 2014-01-09 | 大鵬薬品工業株式会社 | イミダゾオキサジン化合物による抗腫瘍効果増強剤 |
| EP2692740A1 (en) | 2012-07-30 | 2014-02-05 | Le Centre National De La Recherche Scientifique | Glycan compositions, processes for preparing the same and their uses as a drug |
| CN103570725B (zh) | 2012-08-01 | 2017-03-22 | 中国科学院上海药物研究所 | 哌嗪并三唑类化合物及其制备方法和用途 |
| MX2015011428A (es) | 2013-03-06 | 2016-02-03 | Genentech Inc | Metodos para tratar y prevenir la resistencia a los farmacos para el cancer. |
| PH12015502383B1 (en) | 2013-04-19 | 2023-02-03 | Incyte Holdings Corp | Bicyclic heterocycles as fgfr inhibitors |
| JP6289459B2 (ja) | 2013-06-20 | 2018-03-07 | 大鵬薬品工業株式会社 | ＰＨＬＤＡ１又はＰＩＫ３Ｃ２Ｂの発現に基づくＰＩ３Ｋ／ＡＫＴ／ｍＴＯＲ阻害剤の治療効果の予測方法 |
| AU2014291161B2 (en) | 2013-07-18 | 2018-04-26 | Taiho Pharmaceutical Co., Ltd. | Antitumor drug for intermittent administration of FGFR inhibitor |
| US10124003B2 (en) | 2013-07-18 | 2018-11-13 | Taiho Pharmaceutical Co., Ltd. | Therapeutic agent for FGFR inhibitor-resistant cancer |
| TWI831128B (zh) | 2014-04-25 | 2024-02-01 | 日商中外製藥股份有限公司 | 以高用量含有４環性化合物的製劑 |
| CN105017256A (zh) | 2014-04-29 | 2015-11-04 | 浙江导明医药科技有限公司 | 多氟化合物作为布鲁顿酪氨酸激酶抑制剂 |
| CN105859721B (zh) | 2015-01-22 | 2018-04-17 | 浙江京新药业股份有限公司 | 一种伊布鲁替尼的制备方法 |
| US10323044B2 (en) | 2015-02-27 | 2019-06-18 | Taiho Pharmaceutical Co., Ltd. | Crystal of imidazo-oxazine, pharmaceutical composition containing said crystal, and method for producing said crystal |
| PT3279202T (pt) | 2015-03-31 | 2020-08-31 | Taiho Pharmaceutical Co Ltd | Cristal de composto de alquinilo de benzeno 3,5-dissubstituído |
| US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
| US10532056B2 (en) | 2015-06-29 | 2020-01-14 | Verastem, Inc. | Therapeutic compositions, combinations, and methods of use |
| US10149887B2 (en) | 2015-10-23 | 2018-12-11 | Canbas Co., Ltd. | Peptides and peptidomimetics in combination with t cell activating and/or checkpoint inhibiting agents for cancer treatment |
| EP3424505A4 (en) | 2016-03-04 | 2019-10-16 | Taiho Pharmaceutical Co., Ltd. | PREPARATION AND COMPOSITION FOR THE TREATMENT OF MALIGNANT TUMORS |
-
2014
- 2014-07-17 AU AU2014291161A patent/AU2014291161B2/en active Active
- 2014-07-17 TR TR2019/07147T patent/TR201907147T4/tr unknown
- 2014-07-17 JP JP2015527336A patent/JP6084291B2/ja active Active
- 2014-07-17 RU RU2016105133A patent/RU2664118C2/ru active
- 2014-07-17 WO PCT/JP2014/069086 patent/WO2015008839A1/ja not_active Ceased
- 2014-07-17 ES ES14826652T patent/ES2724929T3/es active Active
- 2014-07-17 EP EP14826652.1A patent/EP3023100B1/en active Active
- 2014-07-17 HU HUE14826652 patent/HUE044273T2/hu unknown
- 2014-07-17 DK DK14826652.1T patent/DK3023100T3/da active
- 2014-07-17 TW TW103124539A patent/TWI574691B/zh active
- 2014-07-17 PT PT14826652T patent/PT3023100T/pt unknown
- 2014-07-17 PL PL14826652T patent/PL3023100T3/pl unknown
- 2014-07-17 KR KR1020167003764A patent/KR101974254B1/ko active Active
- 2014-07-17 US US14/905,420 patent/US20160193210A1/en not_active Abandoned
-
2019
- 2019-02-13 US US16/274,573 patent/US10894048B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| PT3023100T (pt) | 2019-05-29 |
| EP3023100A1 (en) | 2016-05-25 |
| US20190183897A1 (en) | 2019-06-20 |
| JPWO2015008839A1 (ja) | 2017-03-02 |
| WO2015008839A1 (ja) | 2015-01-22 |
| TW201536294A (zh) | 2015-10-01 |
| RU2016105133A3 (pl) | 2018-02-28 |
| RU2016105133A (ru) | 2017-08-23 |
| HUE044273T2 (hu) | 2019-10-28 |
| KR101974254B1 (ko) | 2019-04-30 |
| US20160193210A1 (en) | 2016-07-07 |
| AU2014291161A1 (en) | 2016-02-25 |
| TWI574691B (zh) | 2017-03-21 |
| ES2724929T3 (es) | 2019-09-17 |
| AU2014291161B2 (en) | 2018-04-26 |
| DK3023100T3 (da) | 2019-05-27 |
| KR20160032186A (ko) | 2016-03-23 |
| JP6084291B2 (ja) | 2017-02-22 |
| TR201907147T4 (tr) | 2019-06-21 |
| US10894048B2 (en) | 2021-01-19 |
| RU2664118C2 (ru) | 2018-08-15 |
| EP3023100A4 (en) | 2017-01-04 |
| EP3023100B1 (en) | 2019-03-13 |
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