TR201907147T4 - Fgfr inhibitörünün aralıklı uygulanmasına yönelik anti-tümör ilaç. - Google Patents
Fgfr inhibitörünün aralıklı uygulanmasına yönelik anti-tümör ilaç. Download PDFInfo
- Publication number
- TR201907147T4 TR201907147T4 TR2019/07147T TR201907147T TR201907147T4 TR 201907147 T4 TR201907147 T4 TR 201907147T4 TR 2019/07147 T TR2019/07147 T TR 2019/07147T TR 201907147 T TR201907147 T TR 201907147T TR 201907147 T4 TR201907147 T4 TR 201907147T4
- Authority
- TR
- Turkey
- Prior art keywords
- fgfr inhibitor
- tumor drug
- intermittent administration
- present
- salt
- Prior art date
Links
- 239000002246 antineoplastic agent Substances 0.000 title abstract 3
- 229940125829 fibroblast growth factor receptor inhibitor Drugs 0.000 title abstract 3
- 229940041181 antineoplastic drug Drugs 0.000 title 1
- -1 3,5-disubstituted benzene alkynyl compound Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052698 phosphorus Inorganic materials 0.000 abstract 1
- 239000011574 phosphorus Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Mevcut buluş aracılığıyla çözülecek problem, FGFR inhibitörünün antitümör etkisi muhafaza edilirken yüksek kan fosfor seviyeleri gibi azaltılmış yan etkilere sahip olan güçlü ve yüksek derecede seçici yeni bir FGFR inhibitörü ve bir antitümör ajan sağlamaktır. Mevcut buluş, Formül (I) ile temsil edilen bir 3,5-disübstitüe benzen alkinil bileşiğini veya kullanılan bir tuzunu içeren bir antitümör ajanı sağlar böylece 3,5-disübstitüe benzen alkinil bileşiği veya bunun bir tuzu, haftada en az iki kere ve en az bir günlük bir dozlama aralığı olmak üzere bir uygulama programıyla uygulanır.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013149963 | 2013-07-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR201907147T4 true TR201907147T4 (tr) | 2019-06-21 |
Family
ID=52346281
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2019/07147T TR201907147T4 (tr) | 2013-07-18 | 2014-07-17 | Fgfr inhibitörünün aralıklı uygulanmasına yönelik anti-tümör ilaç. |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20160193210A1 (tr) |
| EP (1) | EP3023100B1 (tr) |
| JP (1) | JP6084291B2 (tr) |
| KR (1) | KR101974254B1 (tr) |
| AU (1) | AU2014291161B2 (tr) |
| DK (1) | DK3023100T3 (tr) |
| ES (1) | ES2724929T3 (tr) |
| HU (1) | HUE044273T2 (tr) |
| PL (1) | PL3023100T3 (tr) |
| PT (1) | PT3023100T (tr) |
| RU (1) | RU2664118C2 (tr) |
| TR (1) | TR201907147T4 (tr) |
| TW (1) | TWI574691B (tr) |
| WO (1) | WO2015008839A1 (tr) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR201907147T4 (tr) | 2013-07-18 | 2019-06-21 | Taiho Pharmaceutical Co Ltd | Fgfr inhibitörünün aralıklı uygulanmasına yönelik anti-tümör ilaç. |
| WO2015008844A1 (ja) | 2013-07-18 | 2015-01-22 | 大鵬薬品工業株式会社 | Ｆｇｆｒ阻害剤耐性癌の治療薬 |
| CN105837575B (zh) | 2015-01-13 | 2019-01-15 | 四川大学 | 3-乙炔基吡唑并嘧啶衍生物及其制备方法和用途 |
| MY196077A (en) * | 2015-03-31 | 2023-03-13 | Taiho Pharmaceutical Co Ltd | Crystal Of 3,5-Disubstituted Benzene Alkynyl Compound |
| US11883404B2 (en) | 2016-03-04 | 2024-01-30 | Taiho Pharmaceuticals Co., Ltd. | Preparation and composition for treatment of malignant tumors |
| EP3424505A4 (en) | 2016-03-04 | 2019-10-16 | Taiho Pharmaceutical Co., Ltd. | PREPARATION AND COMPOSITION FOR THE TREATMENT OF MALIGNANT TUMORS |
| CN107698593A (zh) | 2016-08-09 | 2018-02-16 | 南京天印健华医药科技有限公司 | 作为fgfr抑制剂的杂环化合物 |
| CN107840842A (zh) | 2016-09-19 | 2018-03-27 | 北京天诚医药科技有限公司 | 炔代杂环化合物、其制备方法及其在医药学上的应用 |
| SG11202008435SA (en) | 2018-03-19 | 2020-10-29 | Taiho Pharmaceutical Co Ltd | Pharmaceutical composition including sodium alkyl sulfate |
| WO2020095452A1 (ja) * | 2018-11-09 | 2020-05-14 | 大鵬薬品工業株式会社 | ジメトキシベンゼン化合物の製造方法 |
| CN113260618A (zh) | 2018-11-09 | 2021-08-13 | 大鹏药品工业株式会社 | 二甲氧基苯化合物类似物、分析所述化合物的方法和所述化合物的标准品 |
| US20220023300A1 (en) * | 2018-11-26 | 2022-01-27 | Taiho Pharmaceutical Co., Ltd. | Therapeutic and prophylactic method for tumor treatable with endocrine therapy by combined use of fibroblast growth factor receptor inhibitor with endocrine therapy |
| WO2020170355A1 (ja) * | 2019-02-20 | 2020-08-27 | 大鵬薬品工業株式会社 | Ｆｇｆｒ１変異腫瘍の治療方法 |
| JP7805285B2 (ja) * | 2020-04-10 | 2026-01-23 | 大鵬薬品工業株式会社 | ３，５－二置換ベンゼンアルキニル化合物とｍｅｋ阻害剤とを用いた癌治療法 |
| EP4161657A1 (en) * | 2020-06-05 | 2023-04-12 | Kinnate Biopharma Inc. | Inhibitors of fibroblast growth factor receptor kinases |
| IL298760A (en) | 2020-06-05 | 2023-02-01 | Kinnate Biopharma Inc | Fibroblast growth factor receptor kinase inhibitors |
| TWI797711B (zh) * | 2020-08-13 | 2023-04-01 | 大陸商上海和譽生物醫藥科技有限公司 | 一種fgfr及其突變抑制劑，其製備方法和應用 |
| CN114805359B (zh) * | 2021-01-28 | 2023-10-27 | 药雅科技(上海)有限公司 | 炔代杂环化合物fgfr抑制剂的制备方法和用途 |
| CN115028634B (zh) * | 2021-03-08 | 2023-11-28 | 药雅科技(上海)有限公司 | 一种炔代吡嗪并杂环类fgfr抑制剂及其制备方法和用途 |
| CN115785103A (zh) * | 2022-12-28 | 2023-03-14 | 北京康立生医药技术开发有限公司 | 一种治疗胆管癌药物福巴替尼的合成方法 |
| CN120172981B (zh) * | 2025-05-20 | 2025-07-25 | 南京工业大学 | 一类以fgfr2为靶点的小分子降解剂及其药物组合物和应用 |
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| WO2005007083A2 (en) | 2003-06-18 | 2005-01-27 | Smithkline Beecham Corporation | Chemical compounds |
| JP2007509939A (ja) | 2003-10-27 | 2007-04-19 | ジェネラブズ テクノロジーズ インコーポレーティッド | ウイルス感染を治療するためのヌクレオシド化合物 |
| CN101321760A (zh) * | 2005-10-06 | 2008-12-10 | 先灵公司 | 作为蛋白激酶抑制剂的吡唑并嘧啶 |
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| US7659274B2 (en) * | 2006-01-25 | 2010-02-09 | Osi Pharmaceuticals, Inc. | Unsaturated mTOR inhibitors |
| US7659283B2 (en) | 2006-02-14 | 2010-02-09 | Vertex Pharmaceuticals Incorporated | Pyrrolo [3,2-C] pyridines useful as inhibitors of protein kinases |
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| UY34484A (es) | 2011-12-15 | 2013-07-31 | Bayer Ip Gmbh | Benzotienilo-pirrolotriazinas disustituidas y sus usos |
| DK2657233T3 (da) | 2012-01-19 | 2014-09-22 | Taiho Pharmaceutical Co Ltd | 3,5-disubstitueret alkynylbenzenforbindelse og salt deraf |
| EP2817311B1 (en) | 2012-02-23 | 2016-04-06 | Bayer Intellectual Property GmbH | Substituted benzothienyl-pyrrolotriazines and uses thereof |
| NO2868660T3 (tr) | 2012-07-02 | 2018-05-26 | ||
| EP2692740A1 (en) | 2012-07-30 | 2014-02-05 | Le Centre National De La Recherche Scientifique | Glycan compositions, processes for preparing the same and their uses as a drug |
| CN103570725B (zh) | 2012-08-01 | 2017-03-22 | 中国科学院上海药物研究所 | 哌嗪并三唑类化合物及其制备方法和用途 |
| KR20150123250A (ko) | 2013-03-06 | 2015-11-03 | 제넨테크, 인크. | 암 약물 내성의 치료 및 예방 방법 |
| EA035095B1 (ru) | 2013-04-19 | 2020-04-27 | Инсайт Холдингс Корпорейшн | Бициклические гетероциклы в качестве ингибиторов fgfr |
| JP6289459B2 (ja) | 2013-06-20 | 2018-03-07 | 大鵬薬品工業株式会社 | ＰＨＬＤＡ１又はＰＩＫ３Ｃ２Ｂの発現に基づくＰＩ３Ｋ／ＡＫＴ／ｍＴＯＲ阻害剤の治療効果の予測方法 |
| WO2015008844A1 (ja) | 2013-07-18 | 2015-01-22 | 大鵬薬品工業株式会社 | Ｆｇｆｒ阻害剤耐性癌の治療薬 |
| TR201907147T4 (tr) | 2013-07-18 | 2019-06-21 | Taiho Pharmaceutical Co Ltd | Fgfr inhibitörünün aralıklı uygulanmasına yönelik anti-tümör ilaç. |
| WO2015163448A1 (ja) | 2014-04-25 | 2015-10-29 | 中外製薬株式会社 | ４環性化合物を高用量含有する製剤 |
| CN105017256A (zh) | 2014-04-29 | 2015-11-04 | 浙江导明医药科技有限公司 | 多氟化合物作为布鲁顿酪氨酸激酶抑制剂 |
| CN105859721B (zh) | 2015-01-22 | 2018-04-17 | 浙江京新药业股份有限公司 | 一种伊布鲁替尼的制备方法 |
| CN111943962A (zh) | 2015-02-27 | 2020-11-17 | 大鹏药品工业株式会社 | 咪唑并噁嗪晶体、含有所述晶体的药物组合物和制备所述晶体的方法 |
| MY196077A (en) | 2015-03-31 | 2023-03-13 | Taiho Pharmaceutical Co Ltd | Crystal Of 3,5-Disubstituted Benzene Alkynyl Compound |
| US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
| JP2018519327A (ja) | 2015-06-29 | 2018-07-19 | ベラステム・インコーポレーテッドＶｅｒａｓｔｅｍ，Ｉｎｃ． | 治療用組成物、組合せ物および使用の方法 |
| US10149887B2 (en) | 2015-10-23 | 2018-12-11 | Canbas Co., Ltd. | Peptides and peptidomimetics in combination with t cell activating and/or checkpoint inhibiting agents for cancer treatment |
| EP3424505A4 (en) | 2016-03-04 | 2019-10-16 | Taiho Pharmaceutical Co., Ltd. | PREPARATION AND COMPOSITION FOR THE TREATMENT OF MALIGNANT TUMORS |
-
2014
- 2014-07-17 TR TR2019/07147T patent/TR201907147T4/tr unknown
- 2014-07-17 US US14/905,420 patent/US20160193210A1/en not_active Abandoned
- 2014-07-17 RU RU2016105133A patent/RU2664118C2/ru active
- 2014-07-17 JP JP2015527336A patent/JP6084291B2/ja active Active
- 2014-07-17 EP EP14826652.1A patent/EP3023100B1/en active Active
- 2014-07-17 WO PCT/JP2014/069086 patent/WO2015008839A1/ja not_active Ceased
- 2014-07-17 HU HUE14826652 patent/HUE044273T2/hu unknown
- 2014-07-17 TW TW103124539A patent/TWI574691B/zh active
- 2014-07-17 PL PL14826652T patent/PL3023100T3/pl unknown
- 2014-07-17 DK DK14826652.1T patent/DK3023100T3/da active
- 2014-07-17 ES ES14826652T patent/ES2724929T3/es active Active
- 2014-07-17 KR KR1020167003764A patent/KR101974254B1/ko active Active
- 2014-07-17 PT PT14826652T patent/PT3023100T/pt unknown
- 2014-07-17 AU AU2014291161A patent/AU2014291161B2/en active Active
-
2019
- 2019-02-13 US US16/274,573 patent/US10894048B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| TWI574691B (zh) | 2017-03-21 |
| ES2724929T3 (es) | 2019-09-17 |
| EP3023100A4 (en) | 2017-01-04 |
| US20160193210A1 (en) | 2016-07-07 |
| AU2014291161B2 (en) | 2018-04-26 |
| EP3023100B1 (en) | 2019-03-13 |
| JP6084291B2 (ja) | 2017-02-22 |
| RU2664118C2 (ru) | 2018-08-15 |
| JPWO2015008839A1 (ja) | 2017-03-02 |
| RU2016105133A (ru) | 2017-08-23 |
| EP3023100A1 (en) | 2016-05-25 |
| TW201536294A (zh) | 2015-10-01 |
| US20190183897A1 (en) | 2019-06-20 |
| KR101974254B1 (ko) | 2019-04-30 |
| RU2016105133A3 (tr) | 2018-02-28 |
| US10894048B2 (en) | 2021-01-19 |
| HUE044273T2 (hu) | 2019-10-28 |
| PL3023100T3 (pl) | 2019-07-31 |
| AU2014291161A1 (en) | 2016-02-25 |
| PT3023100T (pt) | 2019-05-29 |
| DK3023100T3 (da) | 2019-05-27 |
| WO2015008839A1 (ja) | 2015-01-22 |
| KR20160032186A (ko) | 2016-03-23 |
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