PL3049055T3 - Sposób otrzymywania hydrożelu do wstrzykiwań na bazie kwasu hialuronowego zawierającego lidokainę dodaną w postaci proszku oraz środek alkaliczny, sterylizowanego ciepłem - Google Patents

Sposób otrzymywania hydrożelu do wstrzykiwań na bazie kwasu hialuronowego zawierającego lidokainę dodaną w postaci proszku oraz środek alkaliczny, sterylizowanego ciepłem

Info

Publication number: PL3049055T3
Authority: PL; Poland
Prior art keywords: sterilized; obtaining; heat; hyaluronic acid; powder form
Prior art date: 2013-09-27

Application number

PL14777521T

Other languages

English (en)

Inventor

Samuel GAVARD

Original Assignee

Anteis Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-09-27

Filing date

2014-09-26

Publication date

2019-05-31

2014-09-26 Application filed by Anteis Sa filed Critical Anteis Sa

2019-05-31 Publication of PL3049055T3 publication Critical patent/PL3049055T3/pl

Links

KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title 1
NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 title 1
239000003795 chemical substances by application Substances 0.000 title 1
229920002674 hyaluronan Polymers 0.000 title 1
229960003160 hyaluronic acid Drugs 0.000 title 1
239000000017 hydrogel Substances 0.000 title 1
229960004194 lidocaine Drugs 0.000 title 1
239000000843 powder Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/91—Injection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/22—Materials or treatment for tissue regeneration for reconstruction of hollow organs, e.g. bladder, esophagus, urether, uterus
- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Dermatology (AREA)
Pharmacology & Pharmacy (AREA)
Transplantation (AREA)
Oral & Maxillofacial Surgery (AREA)
Birds (AREA)
Biomedical Technology (AREA)
Engineering & Computer Science (AREA)
Dispersion Chemistry (AREA)
Molecular Biology (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Neurosurgery (AREA)
Organic Chemistry (AREA)
Gerontology & Geriatric Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Ophthalmology & Optometry (AREA)
Inorganic Chemistry (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Materials For Medical Uses (AREA)
Polymers & Plastics (AREA)

PL14777521T 2013-09-27 2014-09-26 Sposób otrzymywania hydrożelu do wstrzykiwań na bazie kwasu hialuronowego zawierającego lidokainę dodaną w postaci proszku oraz środek alkaliczny, sterylizowanego ciepłem PL3049055T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR1359338		2013-09-27
EP14777521.7A EP3049055B1 (en)	2013-09-27	2014-09-26	Method for obtaining an injectable hydrogel based on hyaluronic acid containing lidocaine added in powder form, and an alkaline agent, sterilized with heat
PCT/EP2014/002628 WO2015043757A1 (en)	2013-09-27	2014-09-26	Method for obtaining an injectable hydrogel based on hyaluronic acid containing lidocaine added in powder form, and an alkaline agent, sterilized with heat

Publications (1)

Publication Number	Publication Date
PL3049055T3 true PL3049055T3 (pl)	2019-05-31

Family

ID=49876829

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL14777521T PL3049055T3 (pl)	2013-09-27	2014-09-26	Sposób otrzymywania hydrożelu do wstrzykiwań na bazie kwasu hialuronowego zawierającego lidokainę dodaną w postaci proszku oraz środek alkaliczny, sterylizowanego ciepłem

Country Status (11)

Country	Link
US (1)	US10272181B2 (pl)
EP (1)	EP3049055B1 (pl)
KR (1)	KR102277655B1 (pl)
CN (1)	CN105705137B (pl)
BR (1)	BR112016006684B1 (pl)
CA (1)	CA2923742C (pl)
ES (1)	ES2668981T3 (pl)
LT (1)	LT3049055T (pl)
PL (1)	PL3049055T3 (pl)
RU (1)	RU2671837C2 (pl)
WO (1)	WO2015043757A1 (pl)

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ES2953928T5 (en)	2015-11-24	2025-11-27	Bmi Korea Co Ltd	Composition for injection of hyaluronic acid, containing hyaluronic acid derivative and dna fraction, and use thereof
ES2962687T3 (es)	2015-12-29	2024-03-20	Galderma Holding SA	Reticulación de carbohidratos
JP7862118B2 (ja) *	2017-04-12	2026-05-19	ウリゲンファーマシューティカルズ、インコーポレイテッド	改善された安定性を備えた注射器中に局所麻酔薬、緩衝液、およびグルコサミノグリカンを含む製品
WO2019001784A1 (en) *	2017-06-28	2019-01-03	Nestlé Skin Health Sa	Hyaluronic acid gel with a divalent cation
IT201800001890A1 (it) *	2018-01-25	2019-07-25	Fidia Farm Spa	Composizioni farmaceutiche per il trattamento del dolore postoperatorio
EP3900750A4 (en)	2018-12-21	2022-02-16	LG Chem, Ltd.	FILLER WITH HYALURONIC ACID HYDROGEL WITH EXCELLENT FILLING PROPERTIES
WO2020232539A1 (en)	2019-05-17	2020-11-26	The Governing Council Of The University Of Toronto	Sustained release local anesthetic hydrogel composition
US12414917B2 (en)	2019-09-13	2025-09-16	University Of Utah Research Foundation	Opioid independent surgical anesthetic
US11235087B2 (en)	2019-10-28	2022-02-01	Galderma Holding SA	Ready-to-use esthetic compositions
AU2020395955A1 (en)	2019-12-02	2022-07-14	Galderma Holding SA	High molecular weight esthetic compositions
US11439537B2 (en)	2020-04-10	2022-09-13	Paul Phillips	Opthalmic cannulated wound-stabilizing blade and method of using same
KR20240125432A (ko) *	2020-09-29	2024-08-19	지로파, 인코포레이티드	통증 완화 및 마취를 위한 조성물 및 방법
KR102348467B1 (ko) *	2021-07-14	2022-01-07	주식회사 휴메딕스	Dna 분획물을 포함하는 필러 제조방법 및 이로부터 제조된 필러
CN115671030A (zh) *	2021-07-21	2023-02-03	杭州协合医疗用品有限公司	一种能用水光针注射的含黑素细胞的透明质酸钠水凝胶、制备方法及应用
CN116297887A (zh) *	2021-12-20	2023-06-23	上海创始医疗科技(集团)股份有限公司	一种水凝胶中利多卡因含量的检测方法
CN114404355B (zh) *	2021-12-28	2024-05-24	常州药物研究所有限公司	透明质酸钠凝胶及其制备方法、应用
CN114712530B (zh) *	2022-04-18	2023-10-24	哈尔滨敷尔佳科技股份有限公司	提高重组胶原蛋白填充剂稳定性的湿热灭菌方法
KR102493003B1 (ko) *	2022-05-09	2023-01-27	구태훈	히알루론산과 리도카인을 포함하는 관절활액 보충재용 조성물
CN116983212A (zh) *	2023-08-01	2023-11-03	海雅美生物技术(珠海)有限公司	一种注射用透明质酸钠复合冻干纤维制备方法及其制得的复合冻干纤维和应用
CN119564503B (zh) *	2025-02-08	2025-04-11	北京茗泽中和药物研究有限公司	一种盐酸利多卡因凝胶的制备工艺
CN121754729A (zh) *	2026-03-04	2026-03-31	上海白衣缘生物工程有限公司	一种注射用透明质酸钠凝胶再生填充剂及其制备方法和应用

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SE9202128D0 (sv) *	1992-07-09	1992-07-09	Astra Ab	Precipitation of one or more active compounds in situ
CN1829743B (zh)	2003-07-30	2010-06-30	安特易斯有限公司	生物医用的复合基质
US8124120B2 (en) *	2003-12-22	2012-02-28	Anika Therapeutics, Inc.	Crosslinked hyaluronic acid compositions for tissue augmentation
FR2865737B1 (fr)	2004-02-03	2006-03-31	Anteis Sa	Gel reticule biocompatible
EP1817347B1 (en) *	2004-11-24	2017-05-17	Albumedix A/S	Method of cross-linking hyaluronic acid with divinylsulfone
US20120071437A1 (en) *	2007-07-30	2012-03-22	Allergan, Inc.	Tunable crosslinked polysaccharide compositions
US8357795B2 (en) *	2008-08-04	2013-01-22	Allergan, Inc.	Hyaluronic acid-based gels including lidocaine
FR2938187B1 (fr) *	2008-11-07	2012-08-17	Anteis Sa	Composition injectable a base d'acide hyaluronique ou l'un de ses sels, de polyols et de lidocaine, sterilisee a la chaleur

2014
- 2014-09-26 PL PL14777521T patent/PL3049055T3/pl unknown
- 2014-09-26 CN CN201480053531.5A patent/CN105705137B/zh active Active
- 2014-09-26 ES ES14777521.7T patent/ES2668981T3/es active Active
- 2014-09-26 KR KR1020167010936A patent/KR102277655B1/ko active Active
- 2014-09-26 US US15/024,433 patent/US10272181B2/en active Active
- 2014-09-26 EP EP14777521.7A patent/EP3049055B1/en active Active
- 2014-09-26 RU RU2016110605A patent/RU2671837C2/ru active
- 2014-09-26 WO PCT/EP2014/002628 patent/WO2015043757A1/en not_active Ceased
- 2014-09-26 CA CA2923742A patent/CA2923742C/en active Active
- 2014-09-26 BR BR112016006684-7A patent/BR112016006684B1/pt active IP Right Grant
- 2014-09-26 LT LTEP14777521.7T patent/LT3049055T/lt unknown

Also Published As

Publication number	Publication date
US20160228613A1 (en)	2016-08-11
CA2923742A1 (en)	2015-04-02
LT3049055T (lt)	2018-07-25
RU2016110605A (ru)	2017-11-01
CN105705137B (zh)	2020-03-27
CN105705137A (zh)	2016-06-22
ES2668981T3 (es)	2018-05-23
RU2016110605A3 (pl)	2018-06-28
WO2015043757A1 (en)	2015-04-02
EP3049055B1 (en)	2018-04-25
CA2923742C (en)	2021-02-16
US10272181B2 (en)	2019-04-30
KR20160075535A (ko)	2016-06-29
EP3049055A1 (en)	2016-08-03
KR102277655B1 (ko)	2021-07-15
BR112016006684A2 (pt)	2017-08-01
BR112016006684B1 (pt)	2022-11-29
RU2671837C2 (ru)	2018-11-07

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