PL3064498T3 - Pirazolopirymidon lub pochodne pirolotriazonu, sposób ich otrzymywania i ich zastosowania farmaceutyczne - Google Patents

Pirazolopirymidon lub pochodne pirolotriazonu, sposób ich otrzymywania i ich zastosowania farmaceutyczne

Info

Publication number
PL3064498T3
PL3064498T3 PL14858090T PL14858090T PL3064498T3 PL 3064498 T3 PL3064498 T3 PL 3064498T3 PL 14858090 T PL14858090 T PL 14858090T PL 14858090 T PL14858090 T PL 14858090T PL 3064498 T3 PL3064498 T3 PL 3064498T3
Authority
PL
Poland
Prior art keywords
pyrazolopyrimidone
pharmaceutical applications
preparing same
pyrrolotriazone
derivatives
Prior art date
Application number
PL14858090T
Other languages
English (en)
Inventor
Hejun Lu
Piaoyang Sun
Bin GUI
Qing Dong
Original Assignee
Shanghai Hengrui Pharmaceutical Co. Ltd.
Jiangsu Hengrui Medicine Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Hengrui Pharmaceutical Co. Ltd., Jiangsu Hengrui Medicine Co., Ltd. filed Critical Shanghai Hengrui Pharmaceutical Co. Ltd.
Publication of PL3064498T3 publication Critical patent/PL3064498T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18Feminine contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/02Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32Antioestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pregnancy & Childbirth (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PL14858090T 2013-10-30 2014-09-30 Pirazolopirymidon lub pochodne pirolotriazonu, sposób ich otrzymywania i ich zastosowania farmaceutyczne PL3064498T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201310525956 2013-10-30
PCT/CN2014/087906 WO2015062391A1 (zh) 2013-10-30 2014-09-30 吡唑并嘧啶酮类或吡咯并三嗪酮类衍生物、其制备方法及其在医药上的应用
EP14858090.5A EP3064498B1 (en) 2013-10-30 2014-09-30 Pyrazolopyrimidone or pyrrolotriazone derivatives, method of preparing same, and pharmaceutical applications thereof

Publications (1)

Publication Number Publication Date
PL3064498T3 true PL3064498T3 (pl) 2020-03-31

Family

ID=53003302

Family Applications (1)

Application Number Title Priority Date Filing Date
PL14858090T PL3064498T3 (pl) 2013-10-30 2014-09-30 Pirazolopirymidon lub pochodne pirolotriazonu, sposób ich otrzymywania i ich zastosowania farmaceutyczne

Country Status (22)

Country Link
US (3) US10005781B2 (pl)
EP (1) EP3064498B1 (pl)
JP (1) JP6412563B2 (pl)
CN (1) CN104884457B (pl)
AU (1) AU2014344504C1 (pl)
BR (1) BR112016008799B1 (pl)
CA (1) CA2927641C (pl)
CY (1) CY1122196T1 (pl)
DK (1) DK3064498T3 (pl)
ES (1) ES2747839T3 (pl)
HR (1) HRP20191679T1 (pl)
HU (1) HUE046314T2 (pl)
LT (1) LT3064498T (pl)
MX (1) MX380546B (pl)
PL (1) PL3064498T3 (pl)
PT (1) PT3064498T (pl)
RS (1) RS59457B1 (pl)
RU (1) RU2674977C2 (pl)
SI (1) SI3064498T1 (pl)
SM (1) SMT201900573T1 (pl)
TW (1) TWI675838B (pl)
WO (1) WO2015062391A1 (pl)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX380546B (es) * 2013-10-30 2025-03-12 Shanghai hengrui pharmaceutical co ltd Derivados de pirazolopirimidona o pirrolotriazona, metodo y preparacion de los mismos y aplicaciones farmaceuticas de los mismos.
TWI751220B (zh) * 2016-11-07 2022-01-01 大陸商江蘇恆瑞醫藥股份有限公司 一種GnRH受體拮抗劑的多晶型及其製備方法
KR102516017B1 (ko) * 2016-11-14 2023-03-30 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 GnRH 수용체 길항제의 결정질 형태 및 그의 제조 방법
JP2020528060A (ja) * 2017-07-28 2020-09-17 江蘇恒瑞医薬股▲ふん▼有限公司 ピリミドンヘテロアリール誘導体の製造方法およびピリミドンヘテロアリール誘導体の中間体
CN109970662B (zh) * 2017-12-27 2023-06-30 上海科胜药物研发有限公司 一种制备噁拉戈利中间体的方法
TW202302592A (zh) * 2021-04-02 2023-01-16 大陸商江蘇恒瑞醫藥股份有限公司 GnRH受體拮抗劑的結晶形式及其製備方法
CN115260211B (zh) * 2021-04-29 2024-02-06 长春金赛药业有限责任公司 含噻吩稠环类衍生物、药物组合物及其制备方法和应用
TW202315622A (zh) * 2021-08-30 2023-04-16 大陸商江蘇恆瑞醫藥股份有限公司 一種GnRH受體拮抗劑的結晶工藝
CN115141809B (zh) * 2022-08-30 2023-05-02 南京诺唯赞生物科技股份有限公司 一种检测gnrh结合蛋白生物学活性的方法及试剂盒
TW202448887A (zh) * 2023-02-24 2024-12-16 日商日本煙草產業股份有限公司 取代吡唑并嘧啶化合物及其醫藥用途
CN120731207A (zh) * 2023-02-24 2025-09-30 日本烟草产业株式会社 6-烷氧基吡唑并嘧啶化合物及其药学用途

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US5171835A (en) 1988-10-21 1992-12-15 The Administrators Of The Tulane Educational Fund LHRH antagonists
US20020065309A1 (en) 1999-08-04 2002-05-30 Ge Peng Novel Bicyclic and tricyclic pyrrolidine derivatives as GnRH antagonists
WO2003064429A1 (en) * 2002-01-30 2003-08-07 Takeda Chemical Industries, Ltd. Thienopyrimidines, process for preparing the same and use thereof
JP5072166B2 (ja) * 2002-01-30 2012-11-14 武田薬品工業株式会社 チエノピリミジン化合物、その製造法および用途
AU2003253165A1 (en) 2002-08-13 2004-02-25 Warner-Lambert Company Llc Pyrimidine fused bicyclic metalloproteinase inhibitors
JP4039574B2 (ja) * 2003-01-29 2008-01-30 武田薬品工業株式会社 チエノピリミジン化合物およびその用途
RU2007115522A (ru) * 2004-10-12 2008-10-27 Декод Дженетикс Ехф (Is) Пери-замещенные бициклические карбоновые кислоты для лечения окклюзионного заболевания артерий
EP1841448A2 (en) * 2004-12-30 2007-10-10 Diakine Therapeutics, Inc. Pharmaceutical compositions and methods for restoring beta-cell mass and function
EP1847541A4 (en) * 2005-02-03 2009-12-30 Takeda Pharmaceutical CONDENSED PYRIMIDINE DERIVATIVE AND USE THEREOF
CA2601978A1 (en) 2005-03-07 2006-09-14 Wyeth Quinoxaline dihydrohalide dihydrates and synthetic methods therefor
CN101468988A (zh) * 2007-12-26 2009-07-01 上海恒瑞医药有限公司 哌嗪类衍生物,其制备方法及其在医药上的应用
WO2010026993A1 (ja) 2008-09-03 2010-03-11 武田薬品工業株式会社 製剤における吸収性改善方法および吸収性が改善された製剤
EA023857B1 (ru) * 2009-03-23 2016-07-29 Гленмарк Фармасеутикалс С.А. Сочлененные производные пиримидиндионов в качестве модуляторов trpa1
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EP2525659B1 (en) 2010-01-19 2019-02-27 Merck Sharp & Dohme Corp. PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS
CN102807568B (zh) * 2011-05-31 2015-11-25 正大天晴药业集团股份有限公司 噻二唑衍生物类dpp-iv抑制剂
WO2012175514A1 (en) 2011-06-21 2012-12-27 Bayer Intellectual Property Gmbh Pyridinone derivatives and pharmaceutical compositions thereof
ES2665580T3 (es) * 2011-11-11 2018-04-26 Gilead Apollo, Llc Inhibidores de ACC y usos de los mismos
MX357841B (es) * 2012-02-28 2018-07-26 Tiumbio Co Ltd Antagonistas de los receptores de la hormona liberadora de gonadotropina, método para la preparación de éstos y composición farmacéutica que los contienen.
CN102807569B (zh) * 2012-08-21 2015-02-25 四川大学 一种镇静催眠的化合物及其制备方法和用途
MX380546B (es) * 2013-10-30 2025-03-12 Shanghai hengrui pharmaceutical co ltd Derivados de pirazolopirimidona o pirrolotriazona, metodo y preparacion de los mismos y aplicaciones farmaceuticas de los mismos.

Also Published As

Publication number Publication date
BR112016008799B1 (pt) 2023-02-23
HUE046314T2 (hu) 2020-02-28
JP2016534989A (ja) 2016-11-10
RU2016119135A (ru) 2017-12-04
JP6412563B2 (ja) 2018-10-24
EP3064498A1 (en) 2016-09-07
TWI675838B (zh) 2019-11-01
MX380546B (es) 2025-03-12
BR112016008799A8 (pt) 2020-03-24
MX2016005142A (es) 2016-10-28
US10005781B2 (en) 2018-06-26
US10344034B2 (en) 2019-07-09
RU2016119135A3 (pl) 2018-05-18
DK3064498T3 (da) 2019-10-07
CA2927641A1 (en) 2015-05-07
WO2015062391A1 (zh) 2015-05-07
PT3064498T (pt) 2019-10-14
CA2927641C (en) 2023-03-14
SI3064498T1 (sl) 2019-11-29
TW201536787A (zh) 2015-10-01
US10633388B2 (en) 2020-04-28
AU2014344504A1 (en) 2016-05-12
CN104884457A (zh) 2015-09-02
EP3064498B1 (en) 2019-07-17
CN104884457B (zh) 2016-12-07
US20190270748A1 (en) 2019-09-05
RU2674977C2 (ru) 2018-12-14
LT3064498T (lt) 2019-10-10
EP3064498A4 (en) 2017-03-22
RS59457B1 (sr) 2019-11-29
HRP20191679T1 (hr) 2019-12-13
AU2014344504B2 (en) 2018-07-19
SMT201900573T1 (it) 2019-11-13
CY1122196T1 (el) 2020-11-25
ES2747839T3 (es) 2020-03-11
US20160264578A1 (en) 2016-09-15
US20180244679A1 (en) 2018-08-30
AU2014344504C1 (en) 2018-11-01

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