PL3064579T3 - Kompozycje farmaceutyczne i zastosowania medyczne uzyskanych metodami inżynierii ludzkich arginaz - Google Patents

Kompozycje farmaceutyczne i zastosowania medyczne uzyskanych metodami inżynierii ludzkich arginaz

Info

Publication number
PL3064579T3
PL3064579T3 PL16163214T PL16163214T PL3064579T3 PL 3064579 T3 PL3064579 T3 PL 3064579T3 PL 16163214 T PL16163214 T PL 16163214T PL 16163214 T PL16163214 T PL 16163214T PL 3064579 T3 PL3064579 T3 PL 3064579T3
Authority
PL
Poland
Prior art keywords
pharmaceutical compositions
medical uses
engineered human
human arginases
arginases
Prior art date
Application number
PL16163214T
Other languages
English (en)
Inventor
George Georgiou
Everett Stone
Original Assignee
Aerase, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aerase, Inc. filed Critical Aerase, Inc.
Publication of PL3064579T3 publication Critical patent/PL3064579T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/50Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/78Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y305/00Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/03Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amidines (3.5.3)
    • C12Y305/03001Arginase (3.5.3.1)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
PL16163214T 2008-10-31 2009-11-02 Kompozycje farmaceutyczne i zastosowania medyczne uzyskanych metodami inżynierii ludzkich arginaz PL3064579T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11021808P 2008-10-31 2008-10-31
EP16163214.6A EP3064579B1 (en) 2008-10-31 2009-11-02 Pharmaceutical compositions and medical uses of engineered human arginases
EP09824219.1A EP2350273B1 (en) 2008-10-31 2009-11-02 Compositions of engineered human arginases and methods for treating cancer
PCT/US2009/062969 WO2010051533A2 (en) 2008-10-31 2009-11-02 Compositions of engineered human arginases and methods for treating cancer

Publications (1)

Publication Number Publication Date
PL3064579T3 true PL3064579T3 (pl) 2021-07-05

Family

ID=42129584

Family Applications (3)

Application Number Title Priority Date Filing Date
PL20171935.8T PL3778885T3 (pl) 2008-10-31 2009-11-02 Kompozycje modyfikowanych ludzkich arginaz i sposoby leczenia raka
PL09824219.1T PL2350273T3 (pl) 2008-10-31 2009-11-02 Kompozycje modyfikowanych ludzkich arginaz i sposoby leczenia nowotworu złośliwego
PL16163214T PL3064579T3 (pl) 2008-10-31 2009-11-02 Kompozycje farmaceutyczne i zastosowania medyczne uzyskanych metodami inżynierii ludzkich arginaz

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PL20171935.8T PL3778885T3 (pl) 2008-10-31 2009-11-02 Kompozycje modyfikowanych ludzkich arginaz i sposoby leczenia raka
PL09824219.1T PL2350273T3 (pl) 2008-10-31 2009-11-02 Kompozycje modyfikowanych ludzkich arginaz i sposoby leczenia nowotworu złośliwego

Country Status (15)

Country Link
US (8) US8440184B2 (pl)
EP (5) EP3957727A1 (pl)
JP (2) JP5695570B2 (pl)
CA (1) CA2742497C (pl)
DK (3) DK3064579T3 (pl)
ES (3) ES2945580T3 (pl)
FI (1) FI3778885T3 (pl)
HR (1) HRP20230484T1 (pl)
HU (1) HUE062354T2 (pl)
LT (1) LT3778885T (pl)
PL (3) PL3778885T3 (pl)
PT (1) PT3778885T (pl)
SI (1) SI3778885T1 (pl)
SM (1) SMT202300162T1 (pl)
WO (1) WO2010051533A2 (pl)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3957727A1 (en) * 2008-10-31 2022-02-23 AERase, Inc. Compositions of engineered human arginases and methods for treating cancer
US8679479B2 (en) * 2009-06-29 2014-03-25 Aerase, Inc. Methods for purifying pegylated arginase
WO2012061015A2 (en) * 2010-11-03 2012-05-10 Scott & White Healthcare L-citrulline supplementation during arginine depletion therapy with arginase
CN102234624B (zh) * 2011-04-25 2013-03-06 武汉远大弘元股份有限公司 一种表达产生枯草芽孢杆菌精氨酸酶的基因工程菌及构建方法
CN103184209B (zh) * 2011-12-27 2015-09-16 拜奥生物科技(上海)有限公司 人精氨酸酶和聚乙二醇化人精氨酸酶及其应用
US9011845B2 (en) 2012-06-26 2015-04-21 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Methods for treatment of inflammatory and infectious viral diseases
US8877183B2 (en) 2012-06-26 2014-11-04 National Institutes Of Health (Nih) Methods for treatment of ocular diseases
US20160074515A1 (en) 2014-06-20 2016-03-17 Reform Biologics, Llc Viscosity-reducing excipient compounds for protein formulations
US11357857B2 (en) 2014-06-20 2022-06-14 Comera Life Sciences, Inc. Excipient compounds for protein processing
US10478498B2 (en) 2014-06-20 2019-11-19 Reform Biologics, Llc Excipient compounds for biopolymer formulations
WO2016007625A1 (en) 2014-07-08 2016-01-14 Tdw Group Antibodies to argininosuccinate synthase and related methods
HRP20220406T1 (hr) 2016-08-08 2022-05-27 Aerase, Inc. Pripravci i metode za liječenje raka deplecijom arginina i imunoonkološkim sredstvima
DK3522905T3 (da) 2016-10-07 2024-10-21 Io Biotech Aps Immunogene arginasepeptider
WO2018167780A1 (en) 2017-03-12 2018-09-20 Yeda Research And Development Co. Ltd. Methods of prognosing and treating cancer
EP3596469A1 (en) 2017-03-12 2020-01-22 Yeda Research and Development Co., Ltd. Methods of diagnosing and prognosing cancer
TW201910513A (zh) * 2017-08-16 2019-03-16 香港商鎧耀波麗堂(香港)有限公司 胺基酸耗竭治療的組合物及方法
CN111787941A (zh) * 2017-12-05 2020-10-16 艾瑞思有限公司 用于治疗精氨酸酶1缺乏症的方法和组合物
WO2020009740A2 (en) 2018-04-25 2020-01-09 Washington University Compositions and methods of use thereof for treatment of metabolic diseases and related disorders
CN112513099A (zh) 2018-05-31 2021-03-16 香港理工大学 用于癌症、肥胖症、代谢紊乱和相关并发症及合并症的精氨酸耗竭剂的组合物和应用
GB201815549D0 (en) 2018-09-24 2018-11-07 Io Biotech Aps Arginase1 polypeptides
EP3866837A1 (en) 2018-10-19 2021-08-25 AERase, Inc. Arginine depletion therapy for treatment of gamt deficiency
GB201818576D0 (en) * 2018-11-14 2018-12-26 Io Biotech Aps Arginase 2 polypeptides
MX2022002437A (es) 2019-08-30 2022-06-02 Aeglea Biotherapeutics Inc Metodos para la produccion de arginasa humana recombinante 1 y sus usos.
WO2022195629A1 (en) * 2021-03-18 2022-09-22 National Institute Of Pharmaceutical Education And Research (Niper) Engineered arginase constructs, method of generation and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02117383A (ja) * 1988-10-26 1990-05-01 Tosoh Corp ヒトアルギナーゼの製造方法
US5780286A (en) * 1996-03-14 1998-07-14 Smithkline Beecham Corporation Arginase II
WO2003063780A2 (en) * 2002-01-25 2003-08-07 Cancer Treatments International Therapeutic composition for treatment of cancer by arginine depletion
HK1053577A2 (en) 2002-06-20 2003-10-10 Bio-Cancer Treatment International Limited Pharmaceutical composition and method of treatment of human malignanices with arginine deprivation
CN1745847A (zh) * 2004-09-08 2006-03-15 康达医药科技有限公司 用精氨酸酶治疗肝炎的药物组合物和方法
EP3957727A1 (en) * 2008-10-31 2022-02-23 AERase, Inc. Compositions of engineered human arginases and methods for treating cancer

Also Published As

Publication number Publication date
DK3064579T3 (da) 2020-12-21
EP3064579A1 (en) 2016-09-07
US20190000939A1 (en) 2019-01-03
USRE46423E1 (en) 2017-06-06
EP3778885A1 (en) 2021-02-17
ES2574139T3 (es) 2016-06-15
HUE062354T2 (hu) 2023-10-28
US20210128703A1 (en) 2021-05-06
WO2010051533A2 (en) 2010-05-06
US20240009283A1 (en) 2024-01-11
WO2010051533A3 (en) 2010-08-19
ES2838848T3 (es) 2021-07-02
SMT202300162T1 (it) 2023-07-20
US20100111925A1 (en) 2010-05-06
PT3778885T (pt) 2023-05-31
DK3778885T5 (da) 2024-08-19
EP3957727A1 (en) 2022-02-23
DK3778885T3 (da) 2023-05-30
JP5695570B2 (ja) 2015-04-08
US20130273022A1 (en) 2013-10-17
FI3778885T3 (fi) 2023-05-23
US20140242060A1 (en) 2014-08-28
JP2014036676A (ja) 2014-02-27
PL2350273T3 (pl) 2016-10-31
EP3957728A1 (en) 2022-02-23
HK1160165A1 (zh) 2012-08-10
PL3778885T3 (pl) 2023-07-03
EP2350273A4 (en) 2012-06-27
US10098933B2 (en) 2018-10-16
LT3778885T (lt) 2023-06-12
EP3064579B1 (en) 2020-09-30
US8440184B2 (en) 2013-05-14
DK2350273T3 (en) 2016-06-13
SI3778885T1 (sl) 2023-07-31
JP2012507301A (ja) 2012-03-29
CA2742497C (en) 2024-01-23
CA2742497A1 (en) 2010-05-06
US9050340B2 (en) 2015-06-09
HRP20230484T1 (hr) 2023-07-21
US20170128553A1 (en) 2017-05-11
EP3778885B1 (en) 2023-03-08
EP2350273A2 (en) 2011-08-03
EP2350273B1 (en) 2016-04-06
ES2945580T3 (es) 2023-07-04

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