PL3065747T3 - Karboksylowane pochodne glikozaminoglikanów i zastosowanie jako leki - Google Patents

Karboksylowane pochodne glikozaminoglikanów i zastosowanie jako leki

Info

Publication number
PL3065747T3
PL3065747T3 PL14790560T PL14790560T PL3065747T3 PL 3065747 T3 PL3065747 T3 PL 3065747T3 PL 14790560 T PL14790560 T PL 14790560T PL 14790560 T PL14790560 T PL 14790560T PL 3065747 T3 PL3065747 T3 PL 3065747T3
Authority
PL
Poland
Prior art keywords
glucosaminoglycans
drugs
carboxylated derivatives
carboxylated
derivatives
Prior art date
Application number
PL14790560T
Other languages
English (en)
Inventor
Giangiacomo Torri
Annamaria Naggi
Original Assignee
Novahealth Biosystems Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novahealth Biosystems Llc filed Critical Novahealth Biosystems Llc
Publication of PL3065747T3 publication Critical patent/PL3065747T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PL14790560T 2013-11-06 2014-10-22 Karboksylowane pochodne glikozaminoglikanów i zastosowanie jako leki PL3065747T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT000006A ITLO20130006A1 (it) 2013-11-06 2013-11-06 Derivati carbossilati di glucosamminoglicani e loro uso come farmaci
PCT/EP2014/072676 WO2015067471A1 (en) 2013-11-06 2014-10-22 Carboxylated derivatives of glucosaminoglycans and use as drugs
EP14790560.8A EP3065747B1 (en) 2013-11-06 2014-10-22 Carboxylated derivatives of glucosaminoglycans and use as drugs

Publications (1)

Publication Number Publication Date
PL3065747T3 true PL3065747T3 (pl) 2018-05-30

Family

ID=49683858

Family Applications (3)

Application Number Title Priority Date Filing Date
PL17205232T PL3308791T3 (pl) 2013-11-06 2014-10-22 Karboksylowane pochodne glikozaminoglikanów i zastosowanie jako leki
PL14790560T PL3065747T3 (pl) 2013-11-06 2014-10-22 Karboksylowane pochodne glikozaminoglikanów i zastosowanie jako leki
PL19164954T PL3520797T3 (pl) 2013-11-06 2014-10-22 Karboksylowane pochodne glikozaminoglikanów i zastosowanie jako leki

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL17205232T PL3308791T3 (pl) 2013-11-06 2014-10-22 Karboksylowane pochodne glikozaminoglikanów i zastosowanie jako leki

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL19164954T PL3520797T3 (pl) 2013-11-06 2014-10-22 Karboksylowane pochodne glikozaminoglikanów i zastosowanie jako leki

Country Status (13)

Country Link
US (3) US10822430B2 (pl)
EP (3) EP3520797B1 (pl)
JP (1) JP6784454B2 (pl)
KR (1) KR102113905B1 (pl)
CN (2) CN110218268B (pl)
CY (2) CY1120221T1 (pl)
DK (3) DK3520797T3 (pl)
ES (3) ES2724475T3 (pl)
IT (1) ITLO20130006A1 (pl)
PL (3) PL3308791T3 (pl)
PT (3) PT3308791T (pl)
TR (2) TR201802314T4 (pl)
WO (1) WO2015067471A1 (pl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11225531B2 (en) 2018-02-02 2022-01-18 Shenzhen Hepalink Pharmaceutical Group Co., Ltd. Glycosaminoglycan derivative and preparation method therefor and use thereof
CN114689722A (zh) * 2020-12-31 2022-07-01 深圳市海普瑞药业集团股份有限公司 一种用于检测样品中糖胺聚糖羧酸化衍生物含量的方法及其应用
CN119954986A (zh) * 2023-11-07 2025-05-09 深圳市海普瑞药业集团股份有限公司 一种化学修饰的糖胺聚糖及其制备方法和用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA928218A (en) * 1969-06-17 1973-06-12 Recherche Et Industrie Therapeutiques R.I.T. Antiinfectious compositions and process for their preparation
GB1295666A (pl) * 1969-06-17 1972-11-08
IT1230582B (it) 1988-10-21 1991-10-28 Opocrin S P A Lab Farmabiologi Oliogosaccaridi di dermatan solfato ed eparina aventi attivita' antiaterosclerotica
SE466779B (sv) 1991-02-13 1992-03-30 L T S I Soederkoeping Ab Anordning vid ett kylsystem foer kylning av teleteknisk utrustning
US5250519A (en) 1991-03-29 1993-10-05 Glycomed Incorporated Non-anticoagulant heparin derivatives
IL131074A0 (en) * 1999-07-23 2001-03-19 Polygene Ltd A biodegradable polycation composition for delivery of an anionic macromolecule
IT1316986B1 (it) * 2000-01-25 2003-05-26 Sigma Tau Ind Farmaceuti Derivati glicosamminoglicani parzialmente desolfatati nonanticoagulanti ad attivita' antiangiogenica.
US7781416B2 (en) 2000-01-25 2010-08-24 Sigma-Tau Research Switzerland S.A. Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
US20020062019A1 (en) * 2000-03-30 2002-05-23 Pasqua Oreste Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation
CA2457719C (en) 2001-09-12 2012-01-03 Benito Casu Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
KR101561860B1 (ko) * 2007-11-02 2015-10-20 모멘타 파머슈티컬스 인코포레이티드 비항응고성 다당류 조성물

Also Published As

Publication number Publication date
US11332548B2 (en) 2022-05-17
WO2015067471A1 (en) 2015-05-14
CN110218268B (zh) 2021-10-15
EP3065747A1 (en) 2016-09-14
HK1222797A1 (zh) 2017-07-14
ES2835173T3 (es) 2021-06-22
JP6784454B2 (ja) 2020-11-11
PT3520797T (pt) 2020-11-24
DK3308791T3 (en) 2019-04-29
TR201906180T4 (tr) 2019-05-21
PT3308791T (pt) 2019-05-28
PL3308791T3 (pl) 2019-07-31
ES2724475T3 (es) 2019-09-11
ES2660777T3 (es) 2018-03-26
US10822430B2 (en) 2020-11-03
CN105744940B (zh) 2019-06-25
KR20160106559A (ko) 2016-09-12
TR201802314T4 (tr) 2018-03-21
US20160297896A1 (en) 2016-10-13
CN105744940A (zh) 2016-07-06
US11370848B2 (en) 2022-06-28
CY1121569T1 (el) 2020-05-29
DK3065747T3 (en) 2018-02-12
US20200190224A1 (en) 2020-06-18
DK3520797T3 (da) 2020-11-09
EP3065747B1 (en) 2017-12-06
KR102113905B1 (ko) 2020-05-22
EP3520797B1 (en) 2020-10-21
ITLO20130006A1 (it) 2015-05-07
EP3308791A1 (en) 2018-04-18
PT3065747T (pt) 2018-02-28
JP2017508836A (ja) 2017-03-30
EP3308791B1 (en) 2019-03-27
EP3520797A1 (en) 2019-08-07
CY1120221T1 (el) 2018-12-12
US20200172636A1 (en) 2020-06-04
CN110218268A (zh) 2019-09-10
PL3520797T3 (pl) 2021-02-08
US20170233501A9 (en) 2017-08-17

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