PL3308791T3 - Karboksylowane pochodne glikozaminoglikanów i zastosowanie jako leki - Google Patents

Karboksylowane pochodne glikozaminoglikanów i zastosowanie jako leki

Info

Publication number
PL3308791T3
PL3308791T3 PL17205232T PL17205232T PL3308791T3 PL 3308791 T3 PL3308791 T3 PL 3308791T3 PL 17205232 T PL17205232 T PL 17205232T PL 17205232 T PL17205232 T PL 17205232T PL 3308791 T3 PL3308791 T3 PL 3308791T3
Authority
PL
Poland
Prior art keywords
glycosaminoglycans
drugs
carboxylated derivatives
carboxylated
derivatives
Prior art date
Application number
PL17205232T
Other languages
English (en)
Inventor
Giangiacomo Torri
Annamaria Naggi
Original Assignee
Novahealth Biosystems Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novahealth Biosystems Llc filed Critical Novahealth Biosystems Llc
Publication of PL3308791T3 publication Critical patent/PL3308791T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PL17205232T 2013-11-06 2014-10-22 Karboksylowane pochodne glikozaminoglikanów i zastosowanie jako leki PL3308791T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IT000006A ITLO20130006A1 (it) 2013-11-06 2013-11-06 Derivati carbossilati di glucosamminoglicani e loro uso come farmaci
EP14790560.8A EP3065747B1 (en) 2013-11-06 2014-10-22 Carboxylated derivatives of glucosaminoglycans and use as drugs
PCT/EP2014/072676 WO2015067471A1 (en) 2013-11-06 2014-10-22 Carboxylated derivatives of glucosaminoglycans and use as drugs
EP17205232.6A EP3308791B1 (en) 2013-11-06 2014-10-22 Carboxylated derivatives of glycosaminoglycans and use as drugs

Publications (1)

Publication Number Publication Date
PL3308791T3 true PL3308791T3 (pl) 2019-07-31

Family

ID=49683858

Family Applications (3)

Application Number Title Priority Date Filing Date
PL14790560T PL3065747T3 (pl) 2013-11-06 2014-10-22 Karboksylowane pochodne glikozaminoglikanów i zastosowanie jako leki
PL19164954T PL3520797T3 (pl) 2013-11-06 2014-10-22 Karboksylowane pochodne glikozaminoglikanów i zastosowanie jako leki
PL17205232T PL3308791T3 (pl) 2013-11-06 2014-10-22 Karboksylowane pochodne glikozaminoglikanów i zastosowanie jako leki

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PL14790560T PL3065747T3 (pl) 2013-11-06 2014-10-22 Karboksylowane pochodne glikozaminoglikanów i zastosowanie jako leki
PL19164954T PL3520797T3 (pl) 2013-11-06 2014-10-22 Karboksylowane pochodne glikozaminoglikanów i zastosowanie jako leki

Country Status (13)

Country Link
US (3) US10822430B2 (pl)
EP (3) EP3520797B1 (pl)
JP (1) JP6784454B2 (pl)
KR (1) KR102113905B1 (pl)
CN (2) CN110218268B (pl)
CY (2) CY1120221T1 (pl)
DK (3) DK3520797T3 (pl)
ES (3) ES2835173T3 (pl)
IT (1) ITLO20130006A1 (pl)
PL (3) PL3065747T3 (pl)
PT (3) PT3520797T (pl)
TR (2) TR201802314T4 (pl)
WO (1) WO2015067471A1 (pl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111670038B (zh) * 2018-02-02 2024-01-26 深圳市海普瑞药业集团股份有限公司 糖胺聚糖衍生物及其制备方法和用途
CN114689722A (zh) * 2020-12-31 2022-07-01 深圳市海普瑞药业集团股份有限公司 一种用于检测样品中糖胺聚糖羧酸化衍生物含量的方法及其应用
WO2025098378A1 (zh) * 2023-11-07 2025-05-15 深圳市海普瑞药业集团股份有限公司 一种化学修饰的糖胺聚糖及其制备方法和用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA928218A (en) * 1969-06-17 1973-06-12 Recherche Et Industrie Therapeutiques R.I.T. Antiinfectious compositions and process for their preparation
GB1295666A (pl) * 1969-06-17 1972-11-08
IT1230582B (it) 1988-10-21 1991-10-28 Opocrin S P A Lab Farmabiologi Oliogosaccaridi di dermatan solfato ed eparina aventi attivita' antiaterosclerotica
SE466779B (sv) 1991-02-13 1992-03-30 L T S I Soederkoeping Ab Anordning vid ett kylsystem foer kylning av teleteknisk utrustning
US5250519A (en) 1991-03-29 1993-10-05 Glycomed Incorporated Non-anticoagulant heparin derivatives
IL131074A0 (en) * 1999-07-23 2001-03-19 Polygene Ltd A biodegradable polycation composition for delivery of an anionic macromolecule
US7781416B2 (en) 2000-01-25 2010-08-24 Sigma-Tau Research Switzerland S.A. Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
IT1316986B1 (it) 2000-01-25 2003-05-26 Sigma Tau Ind Farmaceuti Derivati glicosamminoglicani parzialmente desolfatati nonanticoagulanti ad attivita' antiangiogenica.
US20020062019A1 (en) * 2000-03-30 2002-05-23 Pasqua Oreste Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation
EP1427427B1 (en) * 2001-09-12 2011-06-08 SIGMA-TAU Research Switzerland S.A. Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
SG185925A1 (en) * 2007-11-02 2012-12-28 Momenta Pharmaceuticals Inc Non-anticoagulant polysaccharide compositions

Also Published As

Publication number Publication date
US11332548B2 (en) 2022-05-17
US20160297896A1 (en) 2016-10-13
US20200190224A1 (en) 2020-06-18
CY1120221T1 (el) 2018-12-12
KR20160106559A (ko) 2016-09-12
EP3065747A1 (en) 2016-09-14
CN105744940A (zh) 2016-07-06
EP3308791B1 (en) 2019-03-27
US11370848B2 (en) 2022-06-28
ES2835173T3 (es) 2021-06-22
US20170233501A9 (en) 2017-08-17
JP6784454B2 (ja) 2020-11-11
CN105744940B (zh) 2019-06-25
EP3308791A1 (en) 2018-04-18
US20200172636A1 (en) 2020-06-04
ES2724475T3 (es) 2019-09-11
TR201802314T4 (tr) 2018-03-21
PT3520797T (pt) 2020-11-24
DK3308791T3 (en) 2019-04-29
TR201906180T4 (tr) 2019-05-21
DK3065747T3 (en) 2018-02-12
ES2660777T3 (es) 2018-03-26
EP3520797A1 (en) 2019-08-07
CY1121569T1 (el) 2020-05-29
PT3308791T (pt) 2019-05-28
JP2017508836A (ja) 2017-03-30
CN110218268A (zh) 2019-09-10
PT3065747T (pt) 2018-02-28
WO2015067471A1 (en) 2015-05-14
CN110218268B (zh) 2021-10-15
PL3520797T3 (pl) 2021-02-08
EP3065747B1 (en) 2017-12-06
PL3065747T3 (pl) 2018-05-30
EP3520797B1 (en) 2020-10-21
DK3520797T3 (da) 2020-11-09
ITLO20130006A1 (it) 2015-05-07
US10822430B2 (en) 2020-11-03
KR102113905B1 (ko) 2020-05-22
HK1222797A1 (zh) 2017-07-14

Similar Documents

Publication Publication Date Title
IL240290A0 (en) History of pyridazinone-amide and pharmaceutical preparations containing them
EP2968307A4 (en) Carboxamide derivatives and use thereof
IL240291A0 (en) History of pyridazinone and pharmaceutical preparations containing them
IL243608A0 (en) Substances with antiviral activity, preparations containing them and their uses
ZA201604502B (en) Use of benzimidazole-proline derivatives
ZA201602198B (en) Preparation of hydroxy-benzylbenzene derivatives
IL244084B (en) Uncialamycin derivatives, methods for their synthesis and their use as antitumor agents
PL3064491T3 (pl) Pochodna sulfonamidowa i jej zastosowanie medyczne
IL243227A0 (en) History of diaminocyclopentane carboxamide, their preparation and pharmaceutical preparations containing them
IL240292B (en) History of quinazoline and pharmaceutical preparations containing them
PL3063177T3 (pl) Pochodne N-odsiarczanowanych glikozaminoglikanów i ich zastosowanie jako leki
PT3082869T (pt) Combinação de glicosaminoglicanos e ciclodextrinas
PT3520797T (pt) Derivados carboxilados de glicosaminoglicanos e utilização como fármacos
IL240447A0 (en) Propionic-biaryl acid derivatives and their use as pharmaceutical preparations
EP3052475A4 (en) Pharmaceutical use of 3-benzylsulfonylpropionitrile
HUE041663T2 (hu) Myxopyronin és származékai elõállítása
IL240422B (en) Bi-aryl derivatives of propionic acid and their use as medicinal preparations
GB201319595D0 (en) Combination of Analgesic drugs
GB201316468D0 (en) Combination of analgesic drugs
GB201308608D0 (en) Mixtures of haloalkylsufonanilide derivatives and safeners
GB201308611D0 (en) Mixtures of haloalkylsulnanilide derivatives and safeners