PL3083620T4 - Modulatory tetrahydropirydopirazynowe GPR6 - Google Patents

Modulatory tetrahydropirydopirazynowe GPR6

Info

Publication number: PL3083620T4
Authority: PL; Poland
Prior art keywords: tetrahydropyridopyrazines; gpr6; modulators; tetrahydropyridopyrazines modulators
Prior art date: 2013-12-20

Application number

PL14833425T

Other languages

English (en)

Other versions

PL3083620T3 (pl

Inventor

Jason Brown

Stephen Hitchcock

Maria HOPKINS

Shota Kikuchi

Holger Monenschein

Holly REICHARD

Kristin SCHLEICHER

Hukai SUN

Todd MACKLIN

Original Assignee

Takeda Pharmaceutical Company Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-12-20

Filing date

2014-12-19

Publication date

2019-09-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52440811&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL3083620(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2014-12-19 Application filed by Takeda Pharmaceutical Company Limited filed Critical Takeda Pharmaceutical Company Limited

2019-09-30 Publication of PL3083620T4 publication Critical patent/PL3083620T4/pl

2019-09-30 Publication of PL3083620T3 publication Critical patent/PL3083620T3/pl

Links

HOFCYSNYAFJTSI-UHFFFAOYSA-N 1,2,3,4-tetrahydropyrido[2,3-b]pyrazine Chemical class C1=CC=C2NCCNC2=N1 HOFCYSNYAFJTSI-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Psychology (AREA)
Epidemiology (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Nutrition Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

PL14833425T 2013-12-20 2014-12-19 Modulatory tetrahydropirydopirazynowe GPR6 PL3083620T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201361919661P	2013-12-20	2013-12-20
PCT/US2014/071543 WO2015095728A1 (en)	2013-12-20	2014-12-19	Tetrahydropyridopyrazines modulators of gpr6
EP14833425.3A EP3083620B1 (en)	2013-12-20	2014-12-19	Tetrahydropyridopyrazines modulators of gpr6

Publications (2)

Publication Number	Publication Date
PL3083620T4 true PL3083620T4 (pl)	2019-09-30
PL3083620T3 PL3083620T3 (pl)	2019-09-30

Family

ID=52440811

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL14833425T PL3083620T3 (pl)	2013-12-20	2014-12-19	Modulatory tetrahydropirydopirazynowe GPR6

Country Status (42)

Country	Link
US (4)	US9181249B2 (pl)
EP (2)	EP3083620B1 (pl)
JP (1)	JP6538697B2 (pl)
KR (1)	KR102441531B1 (pl)
CN (2)	CN105829309B (pl)
AR (2)	AR098872A1 (pl)
AU (1)	AU2014368992C1 (pl)
BR (1)	BR112016014020B1 (pl)
CA (1)	CA2934247C (pl)
CL (1)	CL2016001595A1 (pl)
CR (1)	CR20160321A (pl)
CY (1)	CY1121395T1 (pl)
DK (1)	DK3083620T3 (pl)
DO (1)	DOP2016000144A (pl)
EA (1)	EA032443B1 (pl)
EC (1)	ECSP16061758A (pl)
ES (1)	ES2702187T3 (pl)
GE (1)	GEP201706783B (pl)
HR (1)	HRP20182004T1 (pl)
HU (1)	HUE042443T2 (pl)
IL (1)	IL246177B (pl)
JO (1)	JO3466B1 (pl)
LT (1)	LT3083620T (pl)
MA (1)	MA39193B1 (pl)
MX (1)	MX2016008188A (pl)
MY (1)	MY177031A (pl)
NZ (1)	NZ721723A (pl)
PE (1)	PE20160751A1 (pl)
PH (1)	PH12016501192A1 (pl)
PL (1)	PL3083620T3 (pl)
PT (1)	PT3083620T (pl)
RS (1)	RS58092B1 (pl)
SG (1)	SG11201604921TA (pl)
SI (1)	SI3083620T1 (pl)
SM (1)	SMT201800668T1 (pl)
TN (1)	TN2016000244A1 (pl)
TR (1)	TR201900038T4 (pl)
TW (2)	TWI809395B (pl)
UA (1)	UA120427C2 (pl)
UY (1)	UY35908A (pl)
WO (1)	WO2015095728A1 (pl)
ZA (1)	ZA201604703B (pl)

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EA037918B1 (ru)	2011-12-21	2021-06-07	Новира Терапьютикс, Инк.	Противовирусные агенты против гепатита в
WO2014028479A1 (en)	2012-08-13	2014-02-20	Envoy Therapeutics, Inc.	Quinoxaline derivatives as gpr6 modulators
HK1208465A1 (en)	2012-08-28	2016-03-04	Janssen Sciences Ireland Uc	Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b
DK2961732T3 (en)	2013-02-28	2017-07-10	Janssen Sciences Ireland Uc	SULFAMOYLARYLAMIDS AND USE THEREOF AS MEDICINES TO TREAT HEPATITIS B
WO2014161888A1 (en)	2013-04-03	2014-10-09	Janssen R&D Ireland	N-phenyl-carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
RS57999B1 (sr)	2013-05-17	2019-01-31	Janssen Sciences Ireland Uc	Derivati sulfamoiltiofenamida i njihova primena kao lekovi za tretman hepatitisa b
JO3603B1 (ar)	2013-05-17	2020-07-05	Janssen Sciences Ireland Uc	مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي
ES2774749T3 (es)	2013-07-25	2020-07-22	Janssen Sciences Ireland Unlimited Co	Derivados de pirrolamida sustituidos con glioxamida y su uso como medicamentos para el tratamiento de la hepatitis B
KR102290189B1 (ko)	2013-10-23	2021-08-17	얀센 사이언시즈 아일랜드 언리미티드 컴퍼니	카르복스아미드 유도체 및 ｂ형 간염 치료용 의약으로서의 이의 용도
JO3466B1 (ar) *	2013-12-20	2020-07-05	Takeda Pharmaceuticals Co	مواد ضابطة لتترا هيدرو بيريدوبيرازينات من gpr6
US10392349B2 (en)	2014-01-16	2019-08-27	Novira Therapeutics, Inc.	Azepane derivatives and methods of treating hepatitis B infections
US9169212B2 (en)	2014-01-16	2015-10-27	Novira Therapeutics, Inc.	Azepane derivatives and methods of treating hepatitis B infections
KR20160128305A (ko)	2014-02-05	2016-11-07	노비라 테라퓨틱스, 인코포레이티드	Hbv 감염의 치료를 위한 병용 요법
DK3102572T3 (en)	2014-02-06	2019-02-04	Janssen Sciences Ireland Uc	SULFAMOYLPYRROLAMIDE DERIVATIVES AND THEIR USE AS MEDICINES TO TREAT HEPATITIS B
EP3105230B1 (en) *	2014-02-14	2021-04-07	Takeda Pharmaceutical Company Limited	Pyridopyrazines modulators of gpr6
WO2016149581A1 (en)	2015-03-19	2016-09-22	Novira Therapeutics, Inc.	Azocane and azonane derivatives and methods of treating hepatitis b infections
US10875876B2 (en)	2015-07-02	2020-12-29	Janssen Sciences Ireland Uc	Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
HK1259410A1 (zh)	2015-09-29	2019-11-29	诺维拉治疗公司	乙型肝炎抗病毒剂的晶体形式
EP3442524A2 (en)	2016-04-15	2019-02-20	Novira Therapeutics Inc.	Combinations and methods comprising a capsid assembly inhibitor
JOP20180057A1 (ar) *	2017-06-15	2019-01-30	Takeda Pharmaceuticals Co	مركبات رابع هيدروبيريدو بيرازين والتي تعمل كمعدلات gpr6
EA202092171A1 (ru)	2018-03-14	2020-12-01	Янссен Сайенсиз Айрлэнд Анлимитед Компани	Схема дозирования модулятора сборки капсида
MA55020A (fr)	2019-02-22	2021-12-29	Janssen Sciences Ireland Unlimited Co	Dérivés d'amide utiles dans le traitement d'une infection par le virus de l'hépatite b ou de maladies induites par le virus de l'hépatite b
BR112021021454A2 (pt)	2019-05-06	2021-12-21	Janssen Sciences Ireland Unlimited Co	Derivados de amida úteis no tratamento da infecção por hbv ou doenças induzidas por hbv

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2014
- 2014-12-18 JO JOP/2014/0369A patent/JO3466B1/ar active
- 2014-12-19 SG SG11201604921TA patent/SG11201604921TA/en unknown
- 2014-12-19 AR ARP140104807A patent/AR098872A1/es active IP Right Grant
- 2014-12-19 SI SI201430995T patent/SI3083620T1/sl unknown
- 2014-12-19 TR TR2019/00038T patent/TR201900038T4/tr unknown
- 2014-12-19 NZ NZ721723A patent/NZ721723A/en unknown
- 2014-12-19 MX MX2016008188A patent/MX2016008188A/es active IP Right Grant
- 2014-12-19 SM SM20180668T patent/SMT201800668T1/it unknown
- 2014-12-19 WO PCT/US2014/071543 patent/WO2015095728A1/en not_active Ceased
- 2014-12-19 EP EP14833425.3A patent/EP3083620B1/en active Active
- 2014-12-19 PT PT14833425T patent/PT3083620T/pt unknown
- 2014-12-19 LT LTEP14833425.3T patent/LT3083620T/lt unknown
- 2014-12-19 MY MYPI2016001142A patent/MY177031A/en unknown
- 2014-12-19 DK DK14833425.3T patent/DK3083620T3/en active
- 2014-12-19 KR KR1020167019644A patent/KR102441531B1/ko active Active
- 2014-12-19 JP JP2016541330A patent/JP6538697B2/ja active Active
- 2014-12-19 CA CA2934247A patent/CA2934247C/en active Active
- 2014-12-19 PL PL14833425T patent/PL3083620T3/pl unknown
- 2014-12-19 TN TN2016000244A patent/TN2016000244A1/en unknown
- 2014-12-19 EP EP18187138.5A patent/EP3453709A1/en not_active Withdrawn
- 2014-12-19 RS RS20181548A patent/RS58092B1/sr unknown
- 2014-12-19 AU AU2014368992A patent/AU2014368992C1/en active Active
- 2014-12-19 CN CN201480069550.7A patent/CN105829309B/zh active Active
- 2014-12-19 EA EA201691272A patent/EA032443B1/ru unknown
- 2014-12-19 CN CN201810356710.6A patent/CN108658978A/zh active Pending
- 2014-12-19 ES ES14833425T patent/ES2702187T3/es active Active
- 2014-12-19 TW TW110118089A patent/TWI809395B/zh active
- 2014-12-19 TW TW103144660A patent/TWI730937B/zh active
- 2014-12-19 HR HRP20182004TT patent/HRP20182004T1/hr unknown
- 2014-12-19 US US14/577,480 patent/US9181249B2/en active Active
- 2014-12-19 UY UY0001035908A patent/UY35908A/es not_active Application Discontinuation
- 2014-12-19 GE GEAP201414210A patent/GEP201706783B/en unknown
- 2014-12-19 UA UAA201606659A patent/UA120427C2/uk unknown
- 2014-12-19 MA MA39193A patent/MA39193B1/fr unknown
- 2014-12-19 CR CR20160321A patent/CR20160321A/es unknown
- 2014-12-19 HU HUE14833425A patent/HUE042443T2/hu unknown
- 2014-12-19 BR BR112016014020-6A patent/BR112016014020B1/pt active IP Right Grant
- 2014-12-19 PE PE2016000838A patent/PE20160751A1/es unknown
2015
- 2015-10-14 US US14/883,174 patent/US9708313B2/en active Active
2016
- 2016-06-13 IL IL24617716A patent/IL246177B/en active IP Right Grant
- 2016-06-17 DO DO2016000144A patent/DOP2016000144A/es unknown
- 2016-06-17 PH PH12016501192A patent/PH12016501192A1/en unknown
- 2016-06-20 CL CL2016001595A patent/CL2016001595A1/es unknown
- 2016-07-08 ZA ZA2016/04703A patent/ZA201604703B/en unknown
- 2016-07-20 EC ECIEPI201661758A patent/ECSP16061758A/es unknown
2017
- 2017-06-13 US US15/621,761 patent/US10077266B2/en active Active
2018
- 2018-08-07 US US16/057,350 patent/US10738046B2/en active Active
2019
- 2019-01-03 CY CY20191100008T patent/CY1121395T1/el unknown
2023
- 2023-06-15 AR ARP230101544A patent/AR129635A2/es unknown

Also Published As

Publication number	Publication date
CR20160321A (es)	2016-09-28
EP3083620A1 (en)	2016-10-26
US9708313B2 (en)	2017-07-18
PT3083620T (pt)	2019-01-17
ZA201604703B (en)	2018-11-28
CN105829309B (zh)	2018-05-15
PH12016501192B1 (en)	2016-08-15
TR201900038T4 (tr)	2019-01-21
JP2017502027A (ja)	2017-01-19
EA032443B1 (ru)	2019-05-31
TN2016000244A1 (en)	2017-10-06
CA2934247C (en)	2023-01-17
UY35908A (es)	2015-07-31
MY177031A (en)	2020-09-02
AU2014368992C1 (en)	2019-02-21
BR112016014020A8 (pt)	2018-01-30
CA2934247A1 (en)	2015-06-25
IL246177A0 (en)	2016-08-02
KR20160099705A (ko)	2016-08-22
EA201691272A1 (ru)	2017-05-31
SI3083620T1 (sl)	2019-02-28
TWI730937B (zh)	2021-06-21
AU2014368992B2 (en)	2018-09-13
ECSP16061758A (es)	2018-02-28
BR112016014020B1 (pt)	2023-02-28
US20160031881A1 (en)	2016-02-04
WO2015095728A1 (en)	2015-06-25
LT3083620T (lt)	2019-02-11
JO3466B1 (ar)	2020-07-05
NZ721723A (en)	2021-07-30
AU2014368992A1 (en)	2016-07-07
AR098872A1 (es)	2016-06-22
EP3453709A1 (en)	2019-03-13
BR112016014020A2 (pt)	2017-08-08
MX2016008188A (es)	2016-09-29
EP3083620B1 (en)	2018-10-03
IL246177B (en)	2019-11-28
SG11201604921TA (en)	2016-07-28
CL2016001595A1 (es)	2017-01-13
MA39193B1 (fr)	2018-04-30
CN108658978A (zh)	2018-10-16
US10738046B2 (en)	2020-08-11
DOP2016000144A (es)	2016-08-15
AR129635A2 (es)	2024-09-11
HUE042443T2 (hu)	2019-06-28
RS58092B1 (sr)	2019-02-28
MA39193A1 (fr)	2017-06-30
US20170283414A1 (en)	2017-10-05
US10077266B2 (en)	2018-09-18
SMT201800668T1 (it)	2019-01-11
TW201605854A (zh)	2016-02-16
US20150175602A1 (en)	2015-06-25
PH12016501192A1 (en)	2016-08-15
JP6538697B2 (ja)	2019-07-03
PL3083620T3 (pl)	2019-09-30
CY1121395T1 (el)	2020-05-29
UA120427C2 (uk)	2019-12-10
TWI809395B (zh)	2023-07-21
US9181249B2 (en)	2015-11-10
GEP201706783B (en)	2017-11-27
HRP20182004T1 (hr)	2019-02-08
ES2702187T3 (es)	2019-02-27
CN105829309A (zh)	2016-08-03
TW202202497A (zh)	2022-01-16
KR102441531B1 (ko)	2022-09-07
DK3083620T3 (en)	2019-01-14
PE20160751A1 (es)	2016-08-01
US20180346464A1 (en)	2018-12-06

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AU351857S (en)	2013-11-04	Watch
GB201305708D0 (en)	2013-05-15	Novel use
IL245020A0 (en)	2016-05-31	Methylene-linked quinolinyls are ror–gamma–t modulators
TWI560487B (en)	2016-12-01	Electro-optical modulator
EP3065944A4 (en)	2017-06-21	Modification of polyamides
GB201312800D0 (en)	2013-08-28	mGlu5 modulators
GB201321601D0 (en)	2014-01-22	Modulator
GB201312727D0 (en)	2013-08-28	Modulators
TWM475821U (en)	2014-04-11	Structure of mosquito-catch
GB201318298D0 (en)	2013-11-27	Modulators
GB201317988D0 (en)	2013-11-27	Modulators
GB201304473D0 (en)	2013-04-24	Modulators
GB201314051D0 (en)	2013-09-18	Novel DRAK modulators
TWM475524U (en)	2014-04-01	Structure of rivet-pulling
GB201304608D0 (en)	2013-05-01	BenTime of Yisrael operable arrangement
GB201318284D0 (en)	2013-11-27	Construction of surfaces
GB201306008D0 (en)	2013-05-15	Modulators of miRNA-184 mediated pathways
GB201313171D0 (en)	2013-09-04	Novel use of aggregates
GB201301990D0 (en)	2013-03-20	Novel Timepiece