PL3106459T3 - Podstawiona pirolem pochodna indolonu, sposób jej wytwarzania, zawierająca ją kompozycja i jej zastosowanie - Google Patents

Podstawiona pirolem pochodna indolonu, sposób jej wytwarzania, zawierająca ją kompozycja i jej zastosowanie

Info

Publication number
PL3106459T3
PL3106459T3 PL15746066T PL15746066T PL3106459T3 PL 3106459 T3 PL3106459 T3 PL 3106459T3 PL 15746066 T PL15746066 T PL 15746066T PL 15746066 T PL15746066 T PL 15746066T PL 3106459 T3 PL3106459 T3 PL 3106459T3
Authority
PL
Poland
Prior art keywords
pyrrole
preparation
composition
same
method therefor
Prior art date
Application number
PL15746066T
Other languages
English (en)
Inventor
Lihong Hu
Shaohua Zhao
Peng Liu
Xiangjun Li
Junyong An
Mengxia ZHOU
Lili Zhang
Zijian YAO
Original Assignee
Shijiazhuang Yiling Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shijiazhuang Yiling Pharmaceutical Co., Ltd. filed Critical Shijiazhuang Yiling Pharmaceutical Co., Ltd.
Publication of PL3106459T3 publication Critical patent/PL3106459T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL15746066T 2014-02-10 2015-02-04 Podstawiona pirolem pochodna indolonu, sposób jej wytwarzania, zawierająca ją kompozycja i jej zastosowanie PL3106459T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201410046278.2A CN104829596B (zh) 2014-02-10 2014-02-10 吡咯取代吲哚酮类衍生物、其制备方法、包含该衍生物的组合物、及其用途
PCT/CN2015/072230 WO2015117551A1 (zh) 2014-02-10 2015-02-04 吡咯取代吲哚酮类衍生物、其制备方法、包含该衍生物的组合物、及其用途
EP15746066.8A EP3106459B1 (en) 2014-02-10 2015-02-04 Pyrrole-substituted indolone derivative, preparation method therefor, composition comprising same and use thereof

Publications (1)

Publication Number Publication Date
PL3106459T3 true PL3106459T3 (pl) 2018-11-30

Family

ID=53777341

Family Applications (1)

Application Number Title Priority Date Filing Date
PL15746066T PL3106459T3 (pl) 2014-02-10 2015-02-04 Podstawiona pirolem pochodna indolonu, sposób jej wytwarzania, zawierająca ją kompozycja i jej zastosowanie

Country Status (17)

Country Link
US (1) US9556154B2 (pl)
EP (1) EP3106459B1 (pl)
JP (1) JP6211205B2 (pl)
KR (1) KR101805693B1 (pl)
CN (1) CN104829596B (pl)
AU (1) AU2015215335B2 (pl)
BR (1) BR112016018371B1 (pl)
CA (1) CA2939012C (pl)
ES (1) ES2687418T3 (pl)
MX (1) MX369473B (pl)
MY (1) MY176521A (pl)
PL (1) PL3106459T3 (pl)
PT (1) PT3106459T (pl)
RU (1) RU2650682C2 (pl)
SA (1) SA516371644B1 (pl)
SG (1) SG11201606545SA (pl)
WO (1) WO2015117551A1 (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10462491B2 (en) 2015-11-02 2019-10-29 Dolby Laboratories Licensing Corporation Layered representation and delivery of high dynamic range video
CN108727341B (zh) * 2017-04-13 2021-02-19 勤浩医药(苏州)有限公司 一种吡咯取代吲哚酮类衍生物或其药学上可接受的盐、及它们的制备方法和用途
CN108191835A (zh) * 2018-01-09 2018-06-22 中国药科大学 一类新型的含吡咯环和吲哚啉结构rip1激酶抑制剂及其用途
KR20210060461A (ko) * 2018-09-19 2021-05-26 수저우 젠하우스 파마슈티컬 컴퍼니 리미티드 피롤 치환된 인돌리논계 유도체 또는 이의 약학적으로 허용 가능한 염, 및 이의 제조 방법 및 이의 용도
CN109232580A (zh) * 2018-11-14 2019-01-18 南阳师范学院 一种1H-吡咯并[1,2-a]吲哚-2(3-H)-酮的合成方法
CN112321568B (zh) * 2020-09-22 2023-02-17 南京中医药大学 4-甲基吡咯取代的吲哚酮衍生物、其制备方法及其医药用途
WO2025035486A1 (zh) * 2023-08-11 2025-02-20 勤浩医药(苏州)有限公司 一种酪氨酸激酶抑制剂的可药用盐、结晶形式及其制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR034118A1 (es) 2000-02-15 2004-02-04 Sugen Inc Compuestos de 2-indolinonas sustituidas con pirroles inhibidoras de proteinquinasas; sus composiciones farmaceuticas e intermediarios de sintesis
AR035721A1 (es) * 2000-12-20 2004-07-07 Sugen Inc Indolinonas 4-aril sustituidas; sus composiciones farmaceuticas y metodo para modular la actividad catalitica de una proteina quinasa
WO2002081466A1 (en) * 2001-04-09 2002-10-17 Sugen, Inc. Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
MXPA04003385A (es) * 2001-10-10 2005-04-11 Sugen Inc Derivados de 3-?4-substituido con heterociclilo)-pirrol-2-ilmetilidene?-2-indolinona como inhibidores de cinasa.
CA2466807A1 (en) * 2001-11-21 2003-06-05 Sugen, Inc. Pharmaceutical formulations comprising indolinone derivatives
TW200418836A (en) * 2002-09-10 2004-10-01 Pharmacia Italia Spa Formulations comprising an indolinone compound
CN101007801A (zh) * 2006-01-27 2007-08-01 上海恒瑞医药有限公司 吡咯取代的2-二氢吲哚酮衍生物、其制法与医药上的用途
WO2008033562A2 (en) * 2006-09-15 2008-03-20 Xcovery, Inc. Kinase inhibitor compounds
WO2009071523A1 (en) * 2007-12-03 2009-06-11 Boehringer Ingelheim International Gmbh Process for the manufacture of an indolinone derivative
US8829039B2 (en) * 2008-05-23 2014-09-09 Shanghai Institute Of Pharmaceutical Industry Dihydroindolinone derivatives
CN102276584A (zh) * 2010-06-08 2011-12-14 齐鲁制药有限公司 吡咯取代的2-二氢吲哚酮衍生物、其制备方法及用途
CN103130744B (zh) 2012-08-28 2014-10-15 沈阳药科大学 一种硒唑甲酸类化合物及其制备方法和用途

Also Published As

Publication number Publication date
AU2015215335B2 (en) 2017-07-27
SA516371644B1 (ar) 2019-08-29
EP3106459A4 (en) 2017-07-12
EP3106459B1 (en) 2018-07-04
US9556154B2 (en) 2017-01-31
JP2017505803A (ja) 2017-02-23
CA2939012C (en) 2018-11-06
JP6211205B2 (ja) 2017-10-11
ES2687418T3 (es) 2018-10-25
RU2016136351A3 (pl) 2018-03-15
WO2015117551A1 (zh) 2015-08-13
CN104829596A (zh) 2015-08-12
BR112016018371A2 (pt) 2017-10-17
CA2939012A1 (en) 2015-08-13
MX2016010272A (es) 2017-02-06
KR101805693B1 (ko) 2017-12-06
EP3106459A1 (en) 2016-12-21
RU2650682C2 (ru) 2018-04-17
RU2016136351A (ru) 2018-03-15
AU2015215335A1 (en) 2016-09-01
MY176521A (en) 2020-08-13
SG11201606545SA (en) 2016-09-29
MX369473B (es) 2019-11-08
CN104829596B (zh) 2017-02-01
BR112016018371B1 (pt) 2022-06-14
KR20160117605A (ko) 2016-10-10
US20160347740A1 (en) 2016-12-01
PT3106459T (pt) 2018-10-18

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