PL2079727T3 - Inhibitory kinazy - Google Patents
Inhibitory kinazyInfo
- Publication number
- PL2079727T3 PL2079727T3 PL07838410T PL07838410T PL2079727T3 PL 2079727 T3 PL2079727 T3 PL 2079727T3 PL 07838410 T PL07838410 T PL 07838410T PL 07838410 T PL07838410 T PL 07838410T PL 2079727 T3 PL2079727 T3 PL 2079727T3
- Authority
- PL
- Poland
- Prior art keywords
- kinase inhibitor
- inhibitor compounds
- compounds
- kinase
- inhibitor
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84490206P | 2006-09-15 | 2006-09-15 | |
| PCT/US2007/020193 WO2008033562A2 (en) | 2006-09-15 | 2007-09-14 | Kinase inhibitor compounds |
| EP07838410.4A EP2079727B1 (en) | 2006-09-15 | 2007-09-14 | Kinase inhibitor compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2079727T3 true PL2079727T3 (pl) | 2016-08-31 |
Family
ID=39184421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL07838410T PL2079727T3 (pl) | 2006-09-15 | 2007-09-14 | Inhibitory kinazy |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US7683057B2 (pl) |
| EP (1) | EP2079727B1 (pl) |
| JP (1) | JP5568304B2 (pl) |
| KR (1) | KR101507375B1 (pl) |
| CN (1) | CN101553482B (pl) |
| AU (1) | AU2007294686B2 (pl) |
| CA (1) | CA2662902C (pl) |
| ES (1) | ES2565683T3 (pl) |
| PL (1) | PL2079727T3 (pl) |
| WO (1) | WO2008033562A2 (pl) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008033562A2 (en) * | 2006-09-15 | 2008-03-20 | Xcovery, Inc. | Kinase inhibitor compounds |
| US8829039B2 (en) | 2008-05-23 | 2014-09-09 | Shanghai Institute Of Pharmaceutical Industry | Dihydroindolinone derivatives |
| WO2011032320A1 (en) | 2009-09-21 | 2011-03-24 | F. Hoffmann-La Roche Ag | Novel alkene oxindole derivatives |
| CN102666485A (zh) * | 2009-09-21 | 2012-09-12 | 霍夫曼-拉罗奇有限公司 | 烯烃羟吲哚衍生物及其用于治疗肥胖症，糖尿病和高脂血症的应用 |
| TWI487486B (zh) | 2009-12-01 | 2015-06-11 | Syngenta Participations Ag | 以異唑啉衍生物為主之殺蟲化合物 |
| CN102858739A (zh) | 2010-03-10 | 2013-01-02 | 斯索恩有限公司 | 酰胺化吡咯甲酸酯化合物的方法 |
| KR102015402B1 (ko) | 2010-05-20 | 2019-08-28 | 어레이 바이오파마 인크. | Trk 키나제 저해제로서의 매크로시클릭 화합물 |
| CN102115469A (zh) * | 2011-03-21 | 2011-07-06 | 浙江大学 | 吲哚啉-2-酮类衍生物的制备和用途 |
| US8791112B2 (en) | 2011-03-30 | 2014-07-29 | Arrien Pharmaceuticals Llc | Substituted 5-(pyrazin-2-yl)-1H-pyrazolo [3, 4-B] pyridine and pyrazolo [3, 4-B] pyridine derivatives as protein kinase inhibitors |
| UY34104A (es) | 2011-05-31 | 2013-01-03 | Syngenta Participations Ag | ?compuestos derivados benzamídicos heterocíclicos, procesos e intermedios para su preparación, composiciones y métodos para su uso?. |
| CN102295594B (zh) * | 2011-07-12 | 2016-01-20 | 上海医药工业研究院 | 4-n-取代-1-(3-甲氧基丙基)-4-哌啶胺类化合物及制备和应用 |
| WO2013030138A1 (en) | 2011-09-01 | 2013-03-07 | F. Hoffmann-La Roche Ag | Pyrrolopyrazine kinase inhibitors |
| AR091023A1 (es) * | 2012-05-11 | 2014-12-30 | Abbvie Inc | Inhibidores del nampt |
| WO2014031445A1 (en) * | 2012-08-22 | 2014-02-27 | Merck Sharp & Dohme Corp. | Novel benzimidazole tetrahydropyran derivatives |
| WO2014180908A1 (en) * | 2013-05-08 | 2014-11-13 | Deutsches Krebsforschungszentrum | Acip/peptide-based inhibition of cancer cachexia |
| JP6535007B2 (ja) * | 2013-12-20 | 2019-06-26 | インスティテュート オブ ファーマコロジー アンド トキシコロジー アカデミー オブ ミリタリー メディカル サイエンシズ ピー．エル．エー．チャイナ | 新規ピペリジンカルボキサミド化合物、その調製方法及び使用 |
| CN104829596B (zh) * | 2014-02-10 | 2017-02-01 | 石家庄以岭药业股份有限公司 | 吡咯取代吲哚酮类衍生物、其制备方法、包含该衍生物的组合物、及其用途 |
| AU2015313841B2 (en) * | 2014-09-10 | 2018-03-08 | Glaxosmithkline Intellectual Property Development Limited | Pyridone derivatives as rearranged during transfection (RET) kinase inhibitors |
| CN104341374A (zh) * | 2014-11-11 | 2015-02-11 | 联化科技（德州）有限公司 | 一种吗啉碳酰氯类化合物的制备方法 |
| HUE053067T2 (hu) | 2015-07-16 | 2021-06-28 | Array Biopharma Inc | Helyettesített pirazolo[1,5-A]piridin vegyületek, mint RET kináz inhibitorok |
| CN105622680B (zh) * | 2015-12-22 | 2018-01-19 | 杭州卢普生物科技有限公司 | 一种舒尼替尼衍生物及其制备方法和应用 |
| CN106928114B (zh) * | 2015-12-31 | 2020-07-28 | 韶远科技（上海)有限公司 | 含有脲基的环状手性氨基类化合物及其可放大工艺和用途 |
| AU2017336889B2 (en) | 2016-09-29 | 2021-11-25 | Equinox Sciences, Llc | Polymorphic form of kinase inhibitor compound, pharmaceutical composition containing same, and preparation method therefor and use thereof |
| TWI752098B (zh) | 2016-10-10 | 2022-01-11 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| WO2018136663A1 (en) | 2017-01-18 | 2018-07-26 | Array Biopharma, Inc. | Ret inhibitors |
| US11168090B2 (en) | 2017-01-18 | 2021-11-09 | Array Biopharma Inc. | Substituted pyrazolo[1,5-a]pyrazines as RET kinase inhibitors |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| TWI812649B (zh) | 2017-10-10 | 2023-08-21 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
| TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
| CN108191835A (zh) * | 2018-01-09 | 2018-06-22 | 中国药科大学 | 一类新型的含吡咯环和吲哚啉结构rip1激酶抑制剂及其用途 |
| EP3740490A1 (en) | 2018-01-18 | 2020-11-25 | Array Biopharma, Inc. | Substituted pyrazolo[3,4-d]pyrimidine compounds as ret kinase inhibitors |
| EP3740491A1 (en) | 2018-01-18 | 2020-11-25 | Array Biopharma, Inc. | Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors |
| CA3087972C (en) | 2018-01-18 | 2023-01-10 | Array Biopharma Inc. | Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors |
| US10589264B2 (en) * | 2018-08-10 | 2020-03-17 | Uop Llc | Processes for controlling the partial regeneration of spent catalyst from an MTO reaction |
| JP2022500383A (ja) | 2018-09-10 | 2022-01-04 | アレイ バイオファーマ インコーポレイテッド | Ｒｅｔキナーゼ阻害剤としての縮合複素環式化合物 |
| KR102933784B1 (ko) | 2019-04-03 | 2026-03-06 | 알리고스 테라퓨틱스 인코포레이티드 | 피롤 화합물 |
| US12435059B2 (en) | 2019-07-03 | 2025-10-07 | The Regents Of The University Of Colorado, A Body Corporate | AMP-activated protein kinase inhibitors and methods of making and using the same |
| EP4065576A1 (en) * | 2019-11-27 | 2022-10-05 | Captor Therapeutics S.A. | Piperidine-2, 6-dione derivatives which bind to cereblon, and methods of use thereof |
| PT3884929T (pt) | 2020-03-25 | 2023-08-09 | Ocular Therapeutix Inc | Implante ocular contendo um inibidor da tirosina cinase |
| WO2022006412A2 (en) * | 2020-07-02 | 2022-01-06 | The Regents Of The University Of Colorado, A Body Corporate | Conjugates of ampk inhibitors and protac degraders and related uses |
| EP4210682B1 (en) | 2020-09-14 | 2026-03-25 | EyePoint, Inc. | Bioerodible ocular drug delivery insert and therapeutic method |
| WO2023173095A1 (en) | 2022-03-11 | 2023-09-14 | EyePoint Pharmaceuticals, Inc. | Method of treating wet age-related macular degeneration |
| IL315331A (en) | 2022-03-11 | 2024-10-01 | Eyepoint Pharmaceuticals Inc | A method of preventing age-related ocular degeneration by providing a drug entry mechanism into the eye |
| EP4489750A1 (en) | 2022-03-11 | 2025-01-15 | EyePoint Pharmaceuticals, Inc. | Continuous dosing regimen for treatment of a condition of the eye |
| WO2024033374A1 (en) | 2022-08-11 | 2024-02-15 | Syngenta Crop Protection Ag | Novel arylcarboxamide or arylthioamide compounds |
| WO2024089216A1 (en) | 2022-10-27 | 2024-05-02 | Syngenta Crop Protection Ag | Novel sulfur-containing heteroaryl carboxamide compounds |
| EP4634152A1 (en) | 2022-12-15 | 2025-10-22 | Syngenta Crop Protection AG | Novel bicyclic-carboxamide compounds useful as pesticides |
| AU2024251447A1 (en) | 2023-04-11 | 2025-08-21 | Ocular Therapeutix, Inc. | Ocular implant comprising axitinib polymorph iv |
| WO2025007853A1 (zh) * | 2023-07-05 | 2025-01-09 | 远森制药（杭州）有限公司 | 作为VEGFR和PKa双靶点抑制剂的2-吲哚酮类化合物，其制备方法，及其用途 |
| CN117143083B (zh) * | 2023-08-30 | 2026-02-27 | 沈阳药科大学 | VEGFR抑制剂Vorolanib的合成方法 |
| WO2025102002A1 (en) * | 2023-11-10 | 2025-05-15 | Purdue Research Foundation | Keto-amide-based fibroblast activation protein-targeted ligand linked to a pi3k inhibitor, compositions and methods of use |
| WO2025240868A1 (en) * | 2024-05-16 | 2025-11-20 | Purdue Research Foundation | Method of using chemically stable keto-amide fibroblast activation protein-targeted conjugates and compositions comprising same to treat fibrosis |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR034118A1 (es) | 2000-02-15 | 2004-02-04 | Sugen Inc | Compuestos de 2-indolinonas sustituidas con pirroles inhibidoras de proteinquinasas; sus composiciones farmaceuticas e intermediarios de sintesis |
| US6635640B2 (en) * | 2000-06-30 | 2003-10-21 | Sugen, Inc. | 4-heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors |
| AR035721A1 (es) * | 2000-12-20 | 2004-07-07 | Sugen Inc | Indolinonas 4-aril sustituidas; sus composiciones farmaceuticas y metodo para modular la actividad catalitica de una proteina quinasa |
| AR042586A1 (es) | 2001-02-15 | 2005-06-29 | Sugen Inc | 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa |
| WO2002096361A2 (en) * | 2001-05-30 | 2002-12-05 | Sugen, Inc. | 5-aralkylsulfonyl-3- (pyrrol-2-ylmethylidene)-2-indolinone derivatives as kinase inhibitors |
| MXPA04003385A (es) | 2001-10-10 | 2005-04-11 | Sugen Inc | Derivados de 3-?4-substituido con heterociclilo)-pirrol-2-ilmetilidene?-2-indolinona como inhibidores de cinasa. |
| US7105563B2 (en) | 2003-10-24 | 2006-09-12 | Schering Aktiengesellschaft | Indolinone derivatives and their use in treating disease-states such as cancer |
| MXPA06006049A (es) | 2003-11-26 | 2007-05-24 | Scripps Research Inst | Inhibidores de proteina quinasa avanzados a base de indolinona. |
| EP1696906A1 (en) | 2003-12-16 | 2006-09-06 | Leo Pharma A/S | Novel therapeutic use of indolinone derivatives |
| GT200500321A (es) * | 2004-11-09 | 2006-09-04 | Compuestos y composiciones como inhibidores de proteina kinase. | |
| US20060287381A1 (en) | 2004-11-26 | 2006-12-21 | The Scripps Research Institute | Enhanced indolinone based protein kinase inhibitors |
| BRPI0616378A2 (pt) | 2005-09-22 | 2011-06-21 | Scripps Research Inst | inibidores de proteìna cinase baseados em alcóxi indolinona e métodos para modulação da atividade catalìtica |
| CA2635360A1 (en) | 2005-12-29 | 2007-07-19 | The Scripps Research Institute | Amino acid derivatives of indolinone based protein kinase inhibitors |
| CN101007801A (zh) | 2006-01-27 | 2007-08-01 | 上海恒瑞医药有限公司 | 吡咯取代的2－二氢吲哚酮衍生物、其制法与医药上的用途 |
| US20080221132A1 (en) * | 2006-09-11 | 2008-09-11 | Xiong Cai | Multi-Functional Small Molecules as Anti-Proliferative Agents |
| EP2061758A4 (en) * | 2006-09-11 | 2011-11-30 | Curis Inc | A ZINC BINDING GROUP CONTAINING SUBSTITUTED 2-INDOLINONE AS PTK INHIBITORS |
| CN101535254A (zh) * | 2006-09-11 | 2009-09-16 | 柯瑞斯公司 | 包含锌-结合基团的取代的2-二氢吲哚酮作为ptk抑制剂 |
| WO2008033562A2 (en) * | 2006-09-15 | 2008-03-20 | Xcovery, Inc. | Kinase inhibitor compounds |
-
2007
- 2007-09-14 WO PCT/US2007/020193 patent/WO2008033562A2/en not_active Ceased
- 2007-09-14 ES ES07838410.4T patent/ES2565683T3/es active Active
- 2007-09-14 KR KR1020097007660A patent/KR101507375B1/ko active Active
- 2007-09-14 CN CN2007800421920A patent/CN101553482B/zh active Active
- 2007-09-14 PL PL07838410T patent/PL2079727T3/pl unknown
- 2007-09-14 CA CA2662902A patent/CA2662902C/en active Active
- 2007-09-14 AU AU2007294686A patent/AU2007294686B2/en active Active
- 2007-09-14 EP EP07838410.4A patent/EP2079727B1/en active Active
- 2007-09-14 JP JP2009528335A patent/JP5568304B2/ja active Active
- 2007-12-28 US US12/005,872 patent/US7683057B2/en active Active
-
2010
- 2010-01-28 US US12/657,887 patent/US8039470B2/en active Active
-
2011
- 2011-05-16 US US13/108,598 patent/US20110224212A1/en not_active Abandoned
-
2012
- 2012-01-12 US US13/349,222 patent/US8524709B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN101553482B (zh) | 2013-11-20 |
| EP2079727A2 (en) | 2009-07-22 |
| JP2010503686A (ja) | 2010-02-04 |
| US7683057B2 (en) | 2010-03-23 |
| KR101507375B1 (ko) | 2015-04-07 |
| US8524709B2 (en) | 2013-09-03 |
| HK1133641A1 (zh) | 2010-04-01 |
| KR20090058563A (ko) | 2009-06-09 |
| EP2079727A4 (en) | 2010-11-10 |
| AU2007294686B2 (en) | 2013-10-31 |
| CA2662902A1 (en) | 2008-03-20 |
| US20110224212A1 (en) | 2011-09-15 |
| CN101553482A (zh) | 2009-10-07 |
| WO2008033562A2 (en) | 2008-03-20 |
| US8039470B2 (en) | 2011-10-18 |
| WO2008033562A3 (en) | 2008-08-21 |
| US20100261665A1 (en) | 2010-10-14 |
| JP5568304B2 (ja) | 2014-08-06 |
| US20120115866A1 (en) | 2012-05-10 |
| CA2662902C (en) | 2015-11-24 |
| ES2565683T3 (es) | 2016-04-06 |
| EP2079727B1 (en) | 2016-02-17 |
| AU2007294686A1 (en) | 2008-03-20 |
| US20090076005A1 (en) | 2009-03-19 |
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