PL3158054T3 - Bakterie zmodyfikowane genetycznie i sposoby modyfikacji genetycznej bakterii - Google Patents

Bakterie zmodyfikowane genetycznie i sposoby modyfikacji genetycznej bakterii

Info

Publication number
PL3158054T3
PL3158054T3 PL15809700.6T PL15809700T PL3158054T3 PL 3158054 T3 PL3158054 T3 PL 3158054T3 PL 15809700 T PL15809700 T PL 15809700T PL 3158054 T3 PL3158054 T3 PL 3158054T3
Authority
PL
Poland
Prior art keywords
bacteria
methods
genetically modified
genetic modification
modified bacteria
Prior art date
Application number
PL15809700.6T
Other languages
English (en)
Other versions
PL3158054T4 (pl
Inventor
Thomas HITCHCOCK
Mun Su Rhee
Original Assignee
Crown Laboratories, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crown Laboratories, Inc. filed Critical Crown Laboratories, Inc.
Publication of PL3158054T4 publication Critical patent/PL3158054T4/pl
Publication of PL3158054T3 publication Critical patent/PL3158054T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/746—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
PL15809700.6T 2014-06-17 2015-06-17 Bakterie zmodyfikowane genetycznie i sposoby modyfikacji genetycznej bakterii PL3158054T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462013159P 2014-06-17 2014-06-17
PCT/US2015/036306 WO2015195845A1 (en) 2014-06-17 2015-06-17 Genetically modified bacteria and methods for genetic modification of bacteria

Publications (2)

Publication Number Publication Date
PL3158054T4 PL3158054T4 (pl) 2025-07-21
PL3158054T3 true PL3158054T3 (pl) 2025-07-21

Family

ID=54835648

Family Applications (1)

Application Number Title Priority Date Filing Date
PL15809700.6T PL3158054T3 (pl) 2014-06-17 2015-06-17 Bakterie zmodyfikowane genetycznie i sposoby modyfikacji genetycznej bakterii

Country Status (12)

Country Link
US (3) US10584344B2 (pl)
EP (1) EP3158054B1 (pl)
JP (3) JP2017521059A (pl)
CN (2) CN118979001A (pl)
BR (1) BR112016029581B1 (pl)
CA (1) CA2950945A1 (pl)
DK (1) DK3158054T3 (pl)
ES (1) ES3025685T3 (pl)
HU (1) HUE071447T2 (pl)
PL (1) PL3158054T3 (pl)
SI (1) SI3158054T1 (pl)
WO (1) WO2015195845A1 (pl)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011130729A2 (en) 2010-04-16 2011-10-20 Salk Institute For Biological Studies Methods for treating metabolic disorders using fgf
US10245288B2 (en) 2011-02-04 2019-04-02 Joseph E. Kovarik Method and system for reducing the likelihood of developing NASH in an individual diagnosed with non-alcoholic fatty liver disease
US10085938B2 (en) 2011-02-04 2018-10-02 Joseph E. Kovarik Method and system for preventing sore throat in humans
US10842834B2 (en) 2016-01-06 2020-11-24 Joseph E. Kovarik Method and system for reducing the likelihood of developing liver cancer in an individual diagnosed with non-alcoholic fatty liver disease
US10940169B2 (en) 2015-11-30 2021-03-09 Joseph E. Kovarik Method for reducing the likelihood of developing cancer in an individual human being
US10687975B2 (en) 2011-02-04 2020-06-23 Joseph E. Kovarik Method and system to facilitate the growth of desired bacteria in a human's mouth
US12279989B2 (en) 2011-02-04 2025-04-22 Seed Health, Inc. Method and system for increasing beneficial bacteria and decreasing pathogenic bacteria in the oral cavity
US10835560B2 (en) 2013-12-20 2020-11-17 Joseph E. Kovarik Reducing the likelihood of skin cancer in an individual human being
US12257272B2 (en) 2015-12-24 2025-03-25 Seed Health, Inc. Method and system for reducing the likelihood of developing depression in an individual
US11951139B2 (en) 2015-11-30 2024-04-09 Seed Health, Inc. Method and system for reducing the likelihood of osteoporosis
US12533312B2 (en) 2011-02-04 2026-01-27 Seed Health, Inc. Method and system for preventing sore throat in humans
US9987224B2 (en) 2011-02-04 2018-06-05 Joseph E. Kovarik Method and system for preventing migraine headaches, cluster headaches and dizziness
US11951140B2 (en) 2011-02-04 2024-04-09 Seed Health, Inc. Modulation of an individual's gut microbiome to address osteoporosis and bone disease
US11844720B2 (en) 2011-02-04 2023-12-19 Seed Health, Inc. Method and system to reduce the likelihood of dental caries and halitosis
US10086018B2 (en) 2011-02-04 2018-10-02 Joseph E. Kovarik Method and system for reducing the likelihood of colorectal cancer in a human being
US11357722B2 (en) 2011-02-04 2022-06-14 Seed Health, Inc. Method and system for preventing sore throat in humans
US11273187B2 (en) 2015-11-30 2022-03-15 Joseph E. Kovarik Method and system for reducing the likelihood of developing depression in an individual
US10512661B2 (en) 2011-02-04 2019-12-24 Joseph E. Kovarik Method and system for reducing the likelihood of developing liver cancer in an individual diagnosed with non-alcoholic fatty liver disease
US11191665B2 (en) 2011-02-04 2021-12-07 Joseph E. Kovarik Method and system for reducing the likelihood of a porphyromonas gingivalis infection in a human being
US10583033B2 (en) 2011-02-04 2020-03-10 Katherine Rose Kovarik Method and system for reducing the likelihood of a porphyromonas gingivalis infection in a human being
US10548761B2 (en) 2011-02-04 2020-02-04 Joseph E. Kovarik Method and system for reducing the likelihood of colorectal cancer in a human being
US10111913B2 (en) 2011-02-04 2018-10-30 Joseph E. Kovarik Method of reducing the likelihood of skin cancer in an individual human being
US10010568B2 (en) 2011-02-04 2018-07-03 Katherine Rose Kovarik Method and system for reducing the likelihood of a spirochetes infection in a human being
US11998479B2 (en) 2011-02-04 2024-06-04 Seed Health, Inc. Method and system for addressing adverse effects on the oral microbiome and restoring gingival health caused by sodium lauryl sulphate exposure
US11419903B2 (en) 2015-11-30 2022-08-23 Seed Health, Inc. Method and system for reducing the likelihood of osteoporosis
US11523934B2 (en) 2011-02-04 2022-12-13 Seed Health, Inc. Method and system to facilitate the growth of desired bacteria in a human's mouth
EP2825676B1 (en) 2012-03-17 2017-12-20 The Regents of The University of California Fast diagnosis and personalized treatments for acne
US12329783B2 (en) 2013-12-20 2025-06-17 Seed Health, Inc. Method and system to improve the health of a person's skin microbiome
US11642382B2 (en) 2013-12-20 2023-05-09 Seed Health, Inc. Method for treating an individual suffering from bladder cancer
US11833177B2 (en) 2013-12-20 2023-12-05 Seed Health, Inc. Probiotic to enhance an individual's skin microbiome
US11529379B2 (en) 2013-12-20 2022-12-20 Seed Health, Inc. Method and system for reducing the likelihood of developing colorectal cancer in an individual human being
US12246043B2 (en) 2013-12-20 2025-03-11 Seed Health, Inc. Topical application to treat acne vulgaris
US12005085B2 (en) 2013-12-20 2024-06-11 Seed Health, Inc. Probiotic method and composition for maintaining a healthy vaginal microbiome
US11839632B2 (en) 2013-12-20 2023-12-12 Seed Health, Inc. Topical application of CRISPR-modified bacteria to treat acne vulgaris
US11980643B2 (en) 2013-12-20 2024-05-14 Seed Health, Inc. Method and system to modify an individual's gut-brain axis to provide neurocognitive protection
US11969445B2 (en) 2013-12-20 2024-04-30 Seed Health, Inc. Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH
US11213552B2 (en) 2015-11-30 2022-01-04 Joseph E. Kovarik Method for treating an individual suffering from a chronic infectious disease and cancer
US11998574B2 (en) 2013-12-20 2024-06-04 Seed Health, Inc. Method and system for modulating an individual's skin microbiome
US11026982B2 (en) 2015-11-30 2021-06-08 Joseph E. Kovarik Method for reducing the likelihood of developing bladder or colorectal cancer in an individual human being
US12318377B2 (en) 2013-12-20 2025-06-03 Seed Health, Inc. Method and system for reducing the likelihood of a porphyromonas gingivalis infection in a human being
US11826388B2 (en) 2013-12-20 2023-11-28 Seed Health, Inc. Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation
US11672835B2 (en) 2013-12-20 2023-06-13 Seed Health, Inc. Method for treating individuals having cancer and who are receiving cancer immunotherapy
SI3158054T1 (sl) 2014-06-17 2025-06-30 Crown Laboratories, Inc. Genetsko modificirane bakterije in postopki za genetsko modifikacijo bakterij
WO2016124239A1 (en) 2015-02-04 2016-08-11 Aurealis Oy Recombinant probiotic bacteria for use in the treatment of a skin dysfunction
EP3285872A4 (en) 2015-04-20 2019-02-20 S-Biomedic NV METHOD AND COMPOSITIONS FOR CHANGING THE COMPOSITION OF SKIN MICROBIOMA WITH COMPLEX MIXTURES OF BACTERIAL BARS
EP3368059A4 (en) 2015-10-30 2019-03-27 Salk Institute for Biological Studies TREATMENT OF STEROID-INDUCED HYPERGLYCEMIA WITH FIBROBLAST GROWTH FACTOR (FGF) -1 ANALOGUE
US10086024B2 (en) 2015-11-30 2018-10-02 Joseph E. Kovarik Method and system for protecting honey bees, bats and butterflies from neonicotinoid pesticides
US10675347B2 (en) 2015-11-30 2020-06-09 Joseph E. Kovarik Method and system for protecting honey bees from fipronil pesticides
US10568916B2 (en) 2015-11-30 2020-02-25 Joseph E. Kovarik Method and system for protecting honey bees, bats and butterflies from neonicotinoid pesticides
US11529412B2 (en) 2015-11-30 2022-12-20 Seed Health, Inc. Method and system for protecting honey bees from pesticides
US10933128B2 (en) 2015-11-30 2021-03-02 Joseph E. Kovarik Method and system for protecting honey bees from pesticides
US12239706B2 (en) 2015-11-30 2025-03-04 Seed Health, Inc. Method and system for protecting monarch butterflies from pesticides
WO2017147507A1 (en) * 2016-02-24 2017-08-31 Xycrobe Therapeutics, Inc. Skin probiotic formulation
US9889165B2 (en) 2016-04-21 2018-02-13 Naked Biome, Inc. Compositions and methods for treatment of skin disorders
WO2017185018A1 (en) * 2016-04-21 2017-10-26 Naked Biome, Inc. Synthetic bacteria and methods of use
WO2018018010A1 (en) * 2016-07-21 2018-01-25 Metacrine, Inc. Fgf mutants and uses thereof
US11541081B2 (en) 2016-10-19 2023-01-03 S-Biomedic Nv Methods and compositions for changing the composition of the skin microbiome using complex mixtures of bacterial strains
EP3538119A4 (en) * 2016-11-08 2020-07-01 The Regents of The University of California COMPOSITIONS AND METHODS FOR TREATING SKIN DISEASES AND MAINTAINING HEALTHY SKIN
WO2018195180A1 (en) * 2017-04-18 2018-10-25 University Of Florida Research Foundation, Incorporated Materials and methods for the treatment of enteric bacterial infections and associated pathologies including colorectal cancer
WO2019018270A1 (en) * 2017-07-21 2019-01-24 Conagen, Inc. PLASMID DEPENDENCE SYSTEM FOR DIRECTING THE EXPRESSION OF A DESIRED GENE
WO2019079618A2 (en) * 2017-10-20 2019-04-25 Naked Biome, Inc. FORMULATIONS FOR THE TREATMENT OF SKIN DISEASES
WO2020055547A2 (en) 2018-08-18 2020-03-19 Seed Health, Inc. Methods and compositions for honey bee health
KR101927988B1 (ko) * 2018-08-23 2018-12-12 주식회사 지놈앤컴퍼니 신규의 큐티박테리움 그래뉼로섬 균주, 및 이러한 균주 또는 이의 배양물을 포함하는 여드름 예방 또는 치료용 조성물
CN109628533A (zh) * 2019-01-18 2019-04-16 重庆派金生物科技有限公司 成纤维细胞生长因子蛋白可溶性高效重组表达的方法
WO2020237246A1 (en) * 2019-05-23 2020-11-26 University Of Maryland, Baltimore Live attenuated non-transmissible vaccines
CN110244047B (zh) * 2019-06-10 2023-11-03 广州市妇女儿童医疗中心 肺癌血清诊断标志物及其应用、肺癌相关可溶性蛋白的分离鉴定方法
US11542309B2 (en) 2019-07-31 2023-01-03 Salk Institute For Biological Studies Fibroblast growth factor 1 (FGF1) mutant proteins that selectively activate FGFR1B to reduce blood glucose
CN113092774B (zh) * 2020-01-09 2022-08-19 中国科学院生物物理研究所 mtEF4蛋白作为毛发生长和脱发的生物标志物的用途
CN111440755B (zh) * 2020-04-10 2023-03-10 西北农林科技大学 一株布鲁氏菌S2疫苗株DnaA基因条件性诱导缺失菌株、其构建方法及应用
KR102197174B1 (ko) * 2020-05-08 2020-12-31 코스맥스 주식회사 큐티박테리움 그래뉼로섬 균주 및 그의 피부 상태 개선 용도
US12102710B2 (en) * 2020-06-23 2024-10-01 Crown Laboratories, Inc. Probiotic skin formulations
CN112342152B (zh) * 2020-06-28 2022-05-20 南昌大学 一种表达脂肪酶的山羊葡萄球菌株ncu s6
CN114262683B (zh) * 2022-03-01 2022-06-17 中国科学院动物研究所 一种表达vegfr3 d2多肽的细菌制剂及其构建方法和应用
EP4656649A1 (en) * 2023-03-10 2025-12-03 WestVac Biopharma Co., Ltd. Anti-acne recombinant protein vaccine, preparation method, and use
WO2025114477A1 (en) * 2023-11-28 2025-06-05 Epigenica Ab Adaptors for ligation
CN120173837B (zh) * 2025-05-21 2025-12-05 杭州微致生物科技有限公司 痤疮丙酸杆菌vb208基因编辑方法及其应用

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4663306A (en) 1983-09-23 1987-05-05 Ribi Immunochem Research, Inc. Pyridine-soluble extract-refined detoxified endotoxin composition and use
EP0569604A1 (en) * 1992-04-07 1993-11-18 Societe Des Produits Nestle S.A. Integrative gene-expression in Streptococcus salivarius ssp.thermophilus
US5837509A (en) * 1992-12-30 1998-11-17 Bioteknologisk Institut Recombinant lactic acid bacterium containing an inserted promoter and method of constructing same
US20020072089A1 (en) * 1999-11-23 2002-06-13 Holtzman Douglas A. Novel ITALY, Lor-2, STRIFE, TRASH, BDSF, LRSG, and STMST protein and nucleic acid molecules and uses therefor
HUP0102820A3 (en) 1998-06-25 2003-09-29 Dsm Ip Assets Bv Propionibacterium vector
EP1110555A1 (fr) 1999-12-22 2001-06-27 Societe Des Produits Nestle S.A. Agent anti-adhesion de la flore pathogene de la peau
US20020063763A1 (en) * 2000-11-29 2002-05-30 Mantell David Allen Apparatus and method for removing air bubbles from an ink jet printhead
JP2004520803A (ja) 2000-04-21 2004-07-15 コリクサ コーポレイション 尋常性挫瘡の治療および診断のための組成物および方法
AUPQ899700A0 (en) 2000-07-25 2000-08-17 Borody, Thomas Julius Probiotic recolonisation therapy
WO2002014468A2 (en) * 2000-08-15 2002-02-21 Phage Biotechnology Corporation Phage-dependent superproduction of biologically active protein and peptides
JP2004536579A (ja) * 2001-04-13 2004-12-09 ヒューマン　ジノーム　サイエンシーズ，　インコーポレイテッド 血管内皮増殖因子２
WO2003033515A1 (en) 2001-10-15 2003-04-24 Corixa Corporation Compositions and methods for the therapy and diagnosis of acne vulgaris
WO2004007695A2 (en) 2002-03-08 2004-01-22 Osel, Inc. Lactobacilli expressing biologically active polypeptides and uses thereof
US20050100531A1 (en) * 2002-06-13 2005-05-12 John Bienenstock Probiotic therapies
JP4521687B2 (ja) 2002-06-21 2010-08-11 ニューキャッスル イノベーション リミテッド プロバイオティクス、プロピオニバクテリウム・イエンセニー７０２
CN101172091B (zh) 2007-09-25 2011-04-27 北京美福源生物医药科技有限公司 含人血清白蛋白与皮肤细胞生长因子的融合蛋白护肤产品制备工艺和用途
TWI328612B (en) * 2002-07-25 2010-08-11 Dsm Ip Assets Bv Genes and their encoded polypeptides involved in the biosynthetic pathway of vitamin b12, vectors and host cells comprising the genes, and process for producing vitamin b12
WO2006058243A2 (en) 2004-11-24 2006-06-01 Yale University Leishmania antigens and related compositions and uses
GB0514262D0 (en) * 2005-07-12 2005-08-17 Renovo Ltd Promotion of epithelial regeneration
FR2889057B1 (fr) 2005-08-01 2008-07-18 Oreal Composition cosmetique et/ou dermatologique pour la prevention et/ou le traitement des peaux sensibles ou seches
CN1869238A (zh) * 2006-06-24 2006-11-29 中国人民解放军兰州军区兰州总医院 一种修复溃疡的生物制剂
CN100490941C (zh) 2006-12-19 2009-05-27 丽珠医药集团股份有限公司 一种干燥剂在活菌制剂干燥中的应用
DE502007004849D1 (de) 2007-02-02 2010-10-07 May Amadeus Alexander Produkt mit lebenden probiotischen Mikroorganismen
FR2915388B1 (fr) 2007-04-27 2010-12-24 Oreal Film hydrosoluble cosmetique
UA99147C2 (ru) 2007-10-02 2012-07-25 Кус Гмбх Косметическая или фармацевтическая композиция местного применения
KR101489723B1 (ko) 2008-03-14 2015-02-06 인하대학교 산학협력단 전기천공법을 이용한 프로피오니박테리움 아크네스의형질전환 조건의 최적화
FR2938437B1 (fr) 2008-11-19 2020-03-27 Société des Produits Nestlé S.A. Utilisation cosmetique de microorganisme pour le traitement des peaux grasses
WO2010054322A1 (en) 2008-11-07 2010-05-14 Solazyme, Inc. Cosmetic compositions comprising microalgal components
GB0821729D0 (en) * 2008-11-28 2008-12-31 Plant Bioscience Ltd Composition and method for enhanced secretion of peptides and proteins from bacteria
FR2942719B1 (fr) 2009-03-04 2011-08-19 Oreal Utilisation de microorganismes probiotiques pour limiter les irritations cutanees
US8496917B2 (en) 2009-11-13 2013-07-30 Sytheon Ltd Compositions and methods for improving skin appearance
JP2013511261A (ja) * 2009-11-18 2013-04-04 マリー ゴールバーン シーオー−オペレイティブ シーオー．リミテッド 組換え微生物
FR2953408B1 (fr) 2009-12-08 2013-02-08 Oreal Microorganismes probiotiques a titre d'actif pour l'eclat du teint de la peau
DK2364712T3 (da) 2010-03-11 2013-05-21 Kloarys Invest Ltd Topisk, kosmetisk eller farmaceutisk sammensætning, der omfatter probiotiske Lactobacillus-stammer, og anvendelse heraf
FR2960001A1 (fr) * 2010-05-12 2011-11-18 Univ Rennes Vecteur recombinant pour la production et la secretion de sequences d'acides amines d'interet par les bacteries propioniques et ses applications
JP5954828B2 (ja) * 2010-05-21 2016-07-20 株式会社明治 皮膚状態の改善用組成物
WO2012106551A1 (en) 2011-02-02 2012-08-09 Unigen, Inc. Bakuchiol compositions for treatment of post inflammatory hyperpigmentation
US20140065209A1 (en) 2011-05-03 2014-03-06 Dupont Nutrition Biosciences Aps Probiotic bacteria for the topical treatment of skin disorders
KR101749485B1 (ko) 2011-05-31 2017-06-22 코오롱글로텍주식회사 인조잔디 구조체 및 이의 제조방법 및 제조장치
CA2863568A1 (en) 2012-02-14 2013-08-22 The Procter & Gamble Company Topical use of a skin-commensal prebiotic agent and compositions containing the same
EP2825676B1 (en) 2012-03-17 2017-12-20 The Regents of The University of California Fast diagnosis and personalized treatments for acne
US20140023618A1 (en) 2012-07-23 2014-01-23 Applied Biology Systems and methods for treatment of androgenetic skin conditions by microbial organisms
MX2015001751A (es) * 2012-08-07 2015-11-13 Topgenix Inc Composicion topica comprendiendo bacterias transformadas que expresan un compuesto de interes.
PT3889181T (pt) * 2012-09-07 2024-05-29 Regeneron Pharma Um anticorpo antagonista de il-4r para utilização no tratamento da dermatite atópica por administração
US9295723B2 (en) 2013-03-01 2016-03-29 Envy Medical, Inc. Acne solution
GB201306536D0 (en) 2013-04-10 2013-05-22 Gt Biolog Ltd Polypeptide and immune modulation
CA2910044A1 (en) * 2013-04-26 2014-10-30 Philogen S.P.A. Il4 conjugated to antibodies against extracellular matrix components
EP2813242A1 (en) * 2013-06-13 2014-12-17 PLS-Design GmbH Low molecular weight immune-modulators as adjuvants for specific immunotherapy
WO2015012532A1 (ko) * 2013-07-26 2015-01-29 전남대학교산학협력단 아미노클레이를 이용한 원핵 또는 진핵생물의 형질전환 방법
EP4299122A3 (en) 2014-05-07 2024-03-27 The Regents of The University of California Compositions and methods for treating skin and mucous membrane diseases
SI3158054T1 (sl) 2014-06-17 2025-06-30 Crown Laboratories, Inc. Genetsko modificirane bakterije in postopki za genetsko modifikacijo bakterij
US10471035B2 (en) 2014-10-20 2019-11-12 Sunny BioDiscovery Compositions and methods for using esters of meroterpenes and of other resveratrol analogues
US10597402B2 (en) 2015-03-27 2020-03-24 Sytheon Limited Compositions and methods for restoring epidermal integrity and function and treating dermatological diseases
US9636292B2 (en) 2015-07-30 2017-05-02 Truth Aesthetics LLC Topical skin care composition for night use
WO2017044835A1 (en) 2015-09-10 2017-03-16 Xycrobe Therapeutics, Inc. Genetically modified bacteria, compositions and methods of making and using
WO2017147507A1 (en) 2016-02-24 2017-08-31 Xycrobe Therapeutics, Inc. Skin probiotic formulation
US9889165B2 (en) 2016-04-21 2018-02-13 Naked Biome, Inc. Compositions and methods for treatment of skin disorders
WO2017185018A1 (en) 2016-04-21 2017-10-26 Naked Biome, Inc. Synthetic bacteria and methods of use
EP4299077A3 (en) 2016-10-31 2024-04-17 Sytheon Limited Skin enhancing compositions and methods
US10293237B1 (en) * 2017-08-17 2019-05-21 Callaway Golf Company Putter with alignment aid
CA3118524A1 (en) 2018-11-16 2020-05-22 S-biomedic N.v. Compositions for treating oxidative stress-associated skin diseases and skin ageing and diagnosis of oxidative stress-associated skin diseases

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JP6913216B2 (ja) 2021-08-04
US20150361436A1 (en) 2015-12-17
US10584344B2 (en) 2020-03-10
DK3158054T3 (da) 2025-05-26
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EP3158054A4 (en) 2017-11-15
BR112016029581A2 (pt) 2017-10-24
US20250002924A1 (en) 2025-01-02
EP3158054A1 (en) 2017-04-26
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US12049633B2 (en) 2024-07-30
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