PL316528A1 - Pharmaceutic compositions and drugs for prevetion and treatment of endothelial disorders - Google Patents

Pharmaceutic compositions and drugs for prevetion and treatment of endothelial disorders

Info

Publication number
PL316528A1
PL316528A1 PL95316528A PL31652895A PL316528A1 PL 316528 A1 PL316528 A1 PL 316528A1 PL 95316528 A PL95316528 A PL 95316528A PL 31652895 A PL31652895 A PL 31652895A PL 316528 A1 PL316528 A1 PL 316528A1
Authority
PL
Poland
Prior art keywords
prevetion
drugs
treatment
endothelial disorders
pharmaceutic compositions
Prior art date
Application number
PL95316528A
Inventor
Eike Albrecht Noack
Georg Kojda
Original Assignee
Isis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharma Gmbh filed Critical Isis Pharma Gmbh
Publication of PL316528A1 publication Critical patent/PL316528A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/556—Angiotensin converting enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL95316528A 1994-03-30 1995-03-28 Pharmaceutic compositions and drugs for prevetion and treatment of endothelial disorders PL316528A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4410997A DE4410997A1 (en) 1994-03-30 1994-03-30 Pharmaceutical preparations and drugs for the prevention and treatment of endothelial dysfunctions

Publications (1)

Publication Number Publication Date
PL316528A1 true PL316528A1 (en) 1997-01-20

Family

ID=6514213

Family Applications (1)

Application Number Title Priority Date Filing Date
PL95316528A PL316528A1 (en) 1994-03-30 1995-03-28 Pharmaceutic compositions and drugs for prevetion and treatment of endothelial disorders

Country Status (19)

Country Link
EP (1) EP0752858A1 (en)
JP (1) JPH09510979A (en)
CN (1) CN1150387A (en)
BG (1) BG63073B1 (en)
CA (1) CA2186783A1 (en)
CZ (1) CZ283696A3 (en)
DE (2) DE4410997A1 (en)
EE (1) EE9600139A (en)
FI (1) FI963883A7 (en)
HU (1) HU220165B (en)
IS (1) IS4365A (en)
LT (1) LT4310B (en)
LV (1) LV11666B (en)
MX (1) MX9604434A (en)
NO (1) NO964102D0 (en)
PL (1) PL316528A1 (en)
SI (1) SI9520047A (en)
SK (1) SK121896A3 (en)
WO (1) WO1995026725A1 (en)

Families Citing this family (22)

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GB9423868D0 (en) * 1994-11-25 1995-01-11 Wellcome Found Compounds for use in medicine
DE19654895C2 (en) * 1996-02-07 2000-07-27 Sanol Arznei Schwarz Gmbh Detection method
DE19604361C2 (en) * 1996-02-07 1999-01-14 Sanol Arznei Schwarz Gmbh Use of gas-tight primary packaging for pharmaceutical compositions
DE19726812A1 (en) * 1997-06-25 1999-01-07 Isis Pharma Gmbh New nitryl-oxy-methyl derivatives derived from pentaerythritol
US5958926A (en) 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
USRE37234E1 (en) 1996-11-01 2001-06-19 Nitromed, Inc. Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses
US6331543B1 (en) 1996-11-01 2001-12-18 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
ZA989356B (en) * 1997-10-16 1998-11-16 Isis Pharma Gmbh Pharmaceutical preparations
DE19745622A1 (en) * 1997-10-16 1999-04-22 Isis Pharma Gmbh New nitric acid ester derivatives of pentaerythritol
ES2238770T5 (en) * 1997-10-17 2012-01-17 Ark Therapeutics Limited USE OF INHIBITORS OF THE RENIN-ANGIOTENSIN SYSTEM FOR THE TREATMENT OF HYPOXIA OR DECREASE OF METABOLIC FUNCTION.
US6472425B1 (en) 1997-10-31 2002-10-29 Nitromed, Inc. Methods for treating female sexual dysfunctions
WO1999067430A2 (en) * 1998-06-24 1999-12-29 Alpharma-Isis Gmbh & Co. Kg Analytic substrates and antioxidative agents
AU7365900A (en) 1999-09-08 2001-04-10 Nitromed, Inc. Methods of treating and preventing congestive heart failure with hydralazine compounds and isosorbide dinitrate or isosorbide mononitrate
US7235237B2 (en) 1999-10-29 2007-06-26 Nitromed, Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
US7708989B2 (en) 1999-10-29 2010-05-04 Nitromed, Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
US6635273B1 (en) 1999-10-29 2003-10-21 Trustees Of Boston University Methods of treating vascular diseases characterized by nitric oxide insufficiency
US7537785B2 (en) 1999-10-29 2009-05-26 Nitromed, Inc. Composition for treating vascular diseases characterized by nitric oxide insufficiency
ES2258365B1 (en) * 2003-10-03 2007-12-01 Lacer, S.A. DERIVATIVES OF DISULFIDE, SULFIDE, SULFOXIDE AND SULFONE OF CYCLING SUGARS AND THEIR USES.
WO2008124505A2 (en) * 2007-04-05 2008-10-16 Ironwood Pharmaceuticals,Inc. Soluble guanylate cyclase (sgc) modulators for treatment of lipid related disorders
UA107112C2 (en) * 2010-05-27 2014-11-25 Мерк Шарп Енд Доме Корп. ACTIVATORS OF SOLUTION GUANILATE CYCLES
RU2467748C1 (en) * 2011-08-08 2012-11-27 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Белгородский государственный национальный исследовательский университет" 3-(2,2,2-trimethylhydrazinium) propionate derivative - 3-(2,2,2-trimethylhydrazinium) potassium propionate glycinate exhibiting endothelioprotective activity
JP5360939B2 (en) * 2011-09-28 2013-12-04 国立大学法人徳島大学 A therapeutic agent for arteriosclerosis comprising a nitrosonifedipine derivative as an active ingredient

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR984523A (en) * 1949-02-10 1951-07-06 Trinitro-triethanolamine phosphate and method of preparation
DE1695897C3 (en) * 1966-07-04 1979-02-15 Takeda Chemical Industries Ltd N-acyl-sydnonimines, their salts, processes for their preparation and medicaments containing these compounds
GB1356374A (en) * 1971-04-29 1974-06-12 American Home Prod Mononitrate esters of 1,3 3,6-dianhydro-d-glucitol
US3886186A (en) * 1971-04-29 1975-05-27 American Home Prod Mononitrate esters of 1,4:3,6-dianhydro-d-glucitol
DE2532124C3 (en) * 1975-07-18 1979-04-19 Cassella Ag, 6000 Frankfurt Process for the production of 4-amino-morpholine
US4200640A (en) * 1976-04-02 1980-04-29 Chugai Seiyaku Kabushiki Kaisha Nitric ester of N-(2-hydroxyethyl)nicotinamide and pharmaceutical use
DE2623800C3 (en) * 1976-05-28 1978-11-23 Sanol Schwarz-Monheim Gmbh, 4000 Duesseldorf Super-saturated aqueous isosorbide dinitrate solution, manufacturing process and use
US4065488A (en) * 1977-02-24 1977-12-27 American Home Products Corporation Process for preparing 1,4:3,6-dianhydro-D-glucitol 2-nitrate
DE2903927C2 (en) * 1979-02-02 1981-03-12 Sanol Schwarz-Monheim Gmbh, 4019 Monheim Process for the selective production of isosorbide-5-nitrate
DE3028873C2 (en) * 1980-07-30 1983-10-27 Boehringer Mannheim Gmbh, 6800 Mannheim Process for the preparation of 1,4 to 3,6-dianhydro-D-glucitol-5-nitrate (isosorbide-5-nitrate)
DE3102947A1 (en) * 1981-01-29 1982-09-02 Heinrich Mack Nachf., 7918 Illertissen METHOD FOR PRODUCING ISOSORBIDE 5-NITRATE
FR2500835A1 (en) * 1981-02-27 1982-09-03 Poudres & Explosifs Ste Nale PROCESS FOR THE SYNTHESIS OF MONONITRATES OF ISOSORBIDE
DE3117612A1 (en) * 1981-05-05 1982-11-25 Cassella Ag, 6000 Frankfurt METHOD FOR PRODUCING ISOSORBIDE 5-NITRATE
DE3124410A1 (en) * 1981-06-22 1983-01-05 Heinrich Mack Nachf., 7918 Illertissen METHOD FOR PRODUCING ISOSORBIDE-2-NITRATE
JPS5910513A (en) * 1982-07-12 1984-01-20 Nitto Electric Ind Co Ltd Pharmaceutical preparation of drug
DE3325652A1 (en) * 1983-07-15 1985-01-24 Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim Solid, stable pharmaceutical formulations containing isosorbide 5-mononitrate, and process for the production thereof
DE3328094A1 (en) * 1983-08-04 1985-02-21 H. Trommsdorff GmbH & Co, 5110 Alsdorf Desensitised pharmaceutical formulation of explosive nitric acid esters
EP0143507B1 (en) * 1983-11-25 1989-09-20 TOSHIN CHEMICAL CO., Ltd. A method for the preparation of isosorbide-5-nitrate and sodium isosorbide-5-nitrate hydrate as a precursor thereof
DD244980A1 (en) * 1985-12-18 1987-04-22 Isis Chemie Zwickau Veb PROCESS FOR PREPARING N-MORPHOLINOAMINOACETONITRILE AND ITS HYDROCHLORIDE
DD293492A5 (en) * 1987-11-26 1991-09-05 Isis-Chemie Gmbh,De METHOD FOR THE PRODUCTION OF A GLYCEROLTRINITRATE DRUG FILM WITH SIMILARLY DELAYED DRUG RELEASE
US5284872A (en) * 1989-09-12 1994-02-08 Schwarz Pharma Ag Nitrato alkanoic acid derivatives, methods for their production, pharmaceutical compositions containing the derivatives and medicinal uses thereof
DE4007705C1 (en) * 1990-03-10 1991-09-26 G. Pohl-Boskamp Gmbh & Co. Chemisch-Pharmazeutische Fabrik, 2214 Hohenlockstedt, De
DE4038203A1 (en) * 1990-11-30 1992-06-04 Kali Chemie Pharma Gmbh Pharmaceutical spray-prepn. for admin. of nitrate(s) - esp. for treatment of cardiovascular, disorders, asthma, migraine and colic
US5385937A (en) * 1991-04-10 1995-01-31 Brigham & Women's Hospital Nitrosation of homocysteine as a method for treating homocysteinemia

Also Published As

Publication number Publication date
LV11666A (en) 1997-02-20
EE9600139A (en) 1997-04-15
SI9520047A (en) 1997-06-30
AU698359B2 (en) 1998-10-29
FI963883L (en) 1996-09-27
EP0752858A1 (en) 1997-01-15
NO964102L (en) 1996-09-27
HU9602671D0 (en) 1996-11-28
DE19580261D2 (en) 1997-05-28
CN1150387A (en) 1997-05-21
FI963883A0 (en) 1996-09-27
CZ283696A3 (en) 1998-03-18
JPH09510979A (en) 1997-11-04
FI963883A7 (en) 1996-09-27
CA2186783A1 (en) 1995-10-12
HU220165B (en) 2001-11-28
SK121896A3 (en) 1998-10-07
LV11666B (en) 1997-06-20
HUT76676A (en) 1997-10-28
LT4310B (en) 1998-03-25
WO1995026725A1 (en) 1995-10-12
AU2134595A (en) 1995-10-23
NO964102D0 (en) 1996-09-27
IS4365A (en) 1996-09-25
DE4410997A1 (en) 1995-10-26
MX9604434A (en) 1997-12-31
LT96148A (en) 1997-12-29
BG100930A (en) 1997-07-31
BG63073B1 (en) 2001-03-30

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