PL3174891T3 - Krystaliczna postać rybozydu nikotynamidu - Google Patents
Krystaliczna postać rybozydu nikotynamiduInfo
- Publication number
- PL3174891T3 PL3174891T3 PL15825253T PL15825253T PL3174891T3 PL 3174891 T3 PL3174891 T3 PL 3174891T3 PL 15825253 T PL15825253 T PL 15825253T PL 15825253 T PL15825253 T PL 15825253T PL 3174891 T3 PL3174891 T3 PL 3174891T3
- Authority
- PL
- Poland
- Prior art keywords
- crystalline form
- nicotinamide riboside
- riboside
- nicotinamide
- crystalline
- Prior art date
Links
- JLEBZPBDRKPWTD-TURQNECASA-O N-ribosylnicotinamide Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](CO)O2)O)=C1 JLEBZPBDRKPWTD-TURQNECASA-O 0.000 title 1
- 235000020956 nicotinamide riboside Nutrition 0.000 title 1
- 239000011618 nicotinamide riboside Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/048—Pyridine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462028702P | 2014-07-24 | 2014-07-24 | |
| EP15825253.6A EP3174891B1 (en) | 2014-07-24 | 2015-07-24 | Crystalline form of nicotinamide riboside |
| PCT/US2015/041956 WO2016014927A2 (en) | 2014-07-24 | 2015-07-24 | Crystalline form of nicotinamide riboside |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3174891T3 true PL3174891T3 (pl) | 2020-08-10 |
Family
ID=55163976
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL20153772T PL3670522T3 (pl) | 2014-07-24 | 2015-07-24 | Krystaliczna postać chlorku rybozydu nikotynamidu |
| PL15825253T PL3174891T3 (pl) | 2014-07-24 | 2015-07-24 | Krystaliczna postać rybozydu nikotynamidu |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL20153772T PL3670522T3 (pl) | 2014-07-24 | 2015-07-24 | Krystaliczna postać chlorku rybozydu nikotynamidu |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10323058B2 (pl) |
| EP (2) | EP3670522B1 (pl) |
| CN (1) | CN106715454B (pl) |
| CA (1) | CA2956163C (pl) |
| ES (2) | ES2776395T3 (pl) |
| PL (2) | PL3670522T3 (pl) |
| WO (1) | WO2016014927A2 (pl) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2963057T3 (es) * | 2015-03-09 | 2024-03-25 | Grace W R & Co | Forma cristalina de ribósido de nicotinamida |
| KR102354784B1 (ko) | 2015-08-05 | 2022-01-25 | 메트로 인터내셔널 바이오테크 엘엘씨 | 니코틴아미드 모노뉴클레오티드 유도체 및 그 용도 |
| GB2542881B (en) | 2015-10-02 | 2020-01-01 | Carr Andrew | Crystal forms of ß-nicotinamide mononucleotide |
| CA3017254C (en) | 2016-03-16 | 2023-08-22 | ChromaDex Inc. | B-vitamin and amino acid conjugates of nicotinoyl ribosides and reduced nicotinoyl ribosides, derivatives thereof, and methods of preparation thereof |
| WO2017218580A1 (en) | 2016-06-14 | 2017-12-21 | Rejuvenation Therapeutics Corporation | Synthetic methods for the preparation of nicotinamide riboside and related compounds |
| NZ803738A (en) | 2016-11-11 | 2024-05-31 | Chromadex Inc | Efficient and scalable syntheses of nicotinoyl ribosides and reduced nicotinoyl ribosides, modified derivatives thereof, phosphorylated analogs thereof, adenylyl dinucleotide conjugates thereof, and novel crystalline forms thereof |
| JP7136795B2 (ja) | 2016-11-29 | 2022-09-13 | ユニバーシティー オブ アイオワ リサーチ ファウンデーション | 母体の健康および/または子の健康を向上させるためのnad前駆体の使用 |
| US11071747B2 (en) | 2016-11-29 | 2021-07-27 | University Of Iowa Research Foundation | Use of NAD precursors for breast enhancement |
| WO2018236814A2 (en) | 2017-06-19 | 2018-12-27 | Gangadhara Ganapati | NICOTINAMIDE RIBOSID DERIVATIVES AND USES THEREOF |
| JP2021506898A (ja) * | 2017-12-22 | 2021-02-22 | エリシウム ヘルス,インコーポレーテッド | ニコチンアミドリボシドクロリドの結晶形態 |
| AU2019214858B2 (en) | 2018-01-30 | 2023-02-02 | Metro International Biotech, Llc | Nicotinamide riboside analogs, pharmaceutical compositions, and uses thereof |
| WO2019219895A1 (en) | 2018-05-18 | 2019-11-21 | Roche Diagnostics Gmbh | (thio)nicotinamide ribofuranoside salts and compositions, methods of making, and uses thereof |
| CN108774278A (zh) * | 2018-09-10 | 2018-11-09 | 张洪喜 | 一种制备尼克酰胺核苷盐的方法 |
| CN113301898B (zh) * | 2018-12-10 | 2022-11-18 | 可劳迈戴斯有限公司 | 烟酰核苷及其衍生物的晶型,及其制备方法 |
| EP3897666A2 (en) | 2018-12-17 | 2021-10-27 | Mitopower LLC | Nicotinyl riboside compounds and their uses |
| WO2020172629A1 (en) * | 2019-02-21 | 2020-08-27 | ChromaDex Inc. | Use of nicotinamide riboside, nicotinic acid riboside, reduced nicotinyl riboside compounds, and nicotinyl riboside compound derivatives in formulations |
| US10618927B1 (en) | 2019-03-22 | 2020-04-14 | Metro International Biotech, Llc | Compositions and methods for modulation of nicotinamide adenine dinucleotide |
| US11939348B2 (en) | 2019-03-22 | 2024-03-26 | Metro International Biotech, Llc | Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide |
| IL289941B2 (en) | 2019-07-19 | 2025-07-01 | Biosynth Ag | Method of making nicotinamide ribofuranoside salts, nicotinamide ribofuranoside salts as such, and uses thereof |
| CN111808156A (zh) * | 2020-07-15 | 2020-10-23 | 许昌远志生物科技有限公司 | 一种β-烟酰胺核糖氯化物的晶型1A、晶型1B及其制备方法 |
| WO2022058312A1 (en) * | 2020-09-15 | 2022-03-24 | Société des Produits Nestlé S.A. | Methods for producing dihydronicotinamide riboside from nicotinamide riboside chloride |
| MX2023013903A (es) | 2021-05-27 | 2023-12-11 | Metro Int Biotech Llc | Solidos cristalinos de mononucleotido de acido nicotinico y esteres de estos y metodos de elaboracion y uso. |
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|---|---|---|---|---|
| GB1190080A (en) | 1966-08-08 | 1970-04-29 | Kyowa Hakko Kogyo Company Ltd | Process for producing Nicotinamide Adenine Dinucleotide |
| US3728111A (en) | 1971-09-21 | 1973-04-17 | Asea Ab | Method of manufacturing billets from powder |
| EP0981534B1 (en) | 1997-02-06 | 2006-05-03 | Inspire Pharmaceuticals, Inc. | Dinucleotides and their uses |
| GB9712370D0 (en) | 1997-06-14 | 1997-08-13 | Aepact Ltd | Therapeutic systems |
| EP1366055A2 (en) | 2000-12-15 | 2003-12-03 | Pharmasset Limited | Antiviral agents for treatment of flaviviridae infections |
| US7179791B2 (en) | 2001-01-11 | 2007-02-20 | Duke University | Inhibiting GS-FDH to modulate NO bioactivity |
| US7977049B2 (en) | 2002-08-09 | 2011-07-12 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
| US20050020587A1 (en) | 2003-07-25 | 2005-01-27 | Pfizer Inc | Nicotinamide derivatives useful as PDE4 inhibitors |
| US8017634B2 (en) | 2003-12-29 | 2011-09-13 | President And Fellows Of Harvard College | Compositions for treating obesity and insulin resistance disorders |
| US8114626B2 (en) | 2004-02-10 | 2012-02-14 | Trustees Of Dartmouth College | Yeast strain and method for using the same to produce nicotinamide riboside |
| CA2555675A1 (en) | 2004-02-10 | 2005-08-25 | Trustees Of Dartmouth College | Nicotinamide riboside kinase compositions and methods for using the same |
| US7776326B2 (en) | 2004-06-04 | 2010-08-17 | Washington University | Methods and compositions for treating neuropathies |
| ES2430569T3 (es) | 2005-02-18 | 2013-11-21 | Astrazeneca Ab | Compuestos antibacterianos derivados de piperidina |
| CA2610854A1 (en) * | 2005-03-30 | 2006-10-05 | Sirtris Pharmaceuticals, Inc. | Nicotinamide riboside and analogues thereof |
| US20070149466A1 (en) | 2005-07-07 | 2007-06-28 | Michael Milburn | Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders |
| DK1957086T3 (en) | 2005-11-18 | 2018-06-06 | Cornell Res Foundation Inc | NICOTINOYL RIBOSIDE COMPOSITIONS AND METHODS OF USE |
| AU2006339607A1 (en) | 2005-12-02 | 2007-09-13 | Sirtris Pharmaceuticals, Inc. | Modulators of Cdc2-like kinases (Clks) and methods of use thereof |
| WO2007136744A1 (en) | 2006-05-19 | 2007-11-29 | The Johns Hopkins University | Crystal structure of a substrate complex of nampt/pbef/visfatin |
| JP2010513458A (ja) | 2006-12-19 | 2010-04-30 | ファイザー・プロダクツ・インク | H−pgdsの阻害剤としてのニコチンアミド誘導体、およびプロスタグランジンd2の仲介による疾患を治療するためのその使用 |
| CA2676609A1 (en) | 2007-01-26 | 2008-07-31 | Washington University | Methods and compositions for treating neuropathies |
| CA2725481A1 (en) * | 2008-06-18 | 2009-12-23 | Pfizer Limited | Nicotinamide derivatives |
| US20100015072A1 (en) | 2008-06-30 | 2010-01-21 | Christopher Polla | Topical Compositions Comprising Isonicotinamide |
| US20100035354A1 (en) | 2008-08-06 | 2010-02-11 | Ettore Bigatti | Process for preparing azacytidine intermediate |
| US20120164670A1 (en) | 2009-06-23 | 2012-06-28 | President And Fellows Of Harvard College | Methods and kits for measuring enzyme activity |
| MX364173B (es) | 2009-07-24 | 2019-04-15 | Amazentis Sa Star | Compuestos, composiciones y metodos para proteger la salud cerebral en trastornos neurodegenerativos. |
| US8507251B2 (en) | 2009-09-28 | 2013-08-13 | Robert J. Greenstein | Medium and method for culturing Mycobacterium avium subspecies paratuberculosis |
| US9603862B2 (en) * | 2009-12-14 | 2017-03-28 | Cornell University | Activation and activators of SIRT5 |
| US20130165398A1 (en) | 2010-03-29 | 2013-06-27 | Paul Hochegger | Concentration-enhancing drink |
| WO2012004917A1 (ja) | 2010-07-06 | 2012-01-12 | Kaminishi Hidenori | 神経突起伸長剤 |
| US20140065099A1 (en) | 2011-02-15 | 2014-03-06 | Ecole Polytechnique Federale De Lausanne (Epfl) | Methods of Treating Mitochondrial Dysfunction |
| US20120107888A1 (en) | 2011-02-17 | 2012-05-03 | Qteros, Inc. | Modulation of fermentation products through vitamin supplementation |
| US20120328526A1 (en) | 2011-06-27 | 2012-12-27 | University Of Maryland, Baltimore | Modulation of Nad+ Activity in Neuropathophysiological Conditions and Uses Thereof |
| CA2847292A1 (en) | 2011-06-29 | 2013-01-03 | The General Hospital Corporation | Compositions and methods for enhancing bioenergetic status in female germ cells |
| EP3345901A3 (en) | 2011-06-29 | 2018-09-12 | President and Fellows of Harvard College | Small molecules as antiaging agents |
| US20140045874A1 (en) | 2012-07-09 | 2014-02-13 | Noglo Llc | Prevention of alcohol reaction with dietary supplements |
| US20140256760A1 (en) | 2012-07-09 | 2014-09-11 | Noglo Llc | Reduction or prevention of alcohol reaction with dietary supplements |
| ES2785303T3 (es) | 2012-07-16 | 2020-10-06 | Univ Cornell | Nicotinamida ribósido para tratar la pérdida auditiva |
| AU2013329312A1 (en) | 2012-10-09 | 2015-05-28 | Massachusetts Institute Of Technology | Treatment of age-related and mitochondrial diseases by inhibition of HIF-1 alpha function |
| WO2014111906A1 (en) | 2013-01-21 | 2014-07-24 | Ecole Polytechnique Federale De Lausanne (Epfl) | Bioluminescence imaging of small biomolecules |
| CA2902879C (en) | 2013-03-15 | 2023-09-26 | Nusirt Sciences, Inc. | Leucine and nicotinic acid reduces lipid levels |
| GB201313465D0 (en) * | 2013-07-29 | 2013-09-11 | Queens University Of The Belfast | Methods of preparing nicotinamide riboside and derivatives thereof |
| EP3060311B1 (en) | 2013-10-24 | 2019-05-22 | The Procter and Gamble Company | Skin lightening cosmetic compositions and methods |
| KR20150050406A (ko) | 2013-10-29 | 2015-05-08 | 한림대학교 산학협력단 | 니코틴아마이드 라이보사이드를 유효성분으로 포함하는 패혈증 치료 또는 예방용 약제학적 조성물 |
| KR20160067195A (ko) | 2013-10-30 | 2016-06-13 | 크로마덱스 아이엔씨. | 피부 질환 치료에서의 국소적 사용을 위한 니코틴아미드 리보사이드 조성물 |
| CN105992521A (zh) | 2013-11-12 | 2016-10-05 | 奥索努特拉有限责任公司 | 基于特咖宁的补充剂及其使用方法 |
| WO2015099842A1 (en) | 2013-12-23 | 2015-07-02 | Abbott Laboratories | Hot beverage fortifier |
| AU2015229055B2 (en) | 2014-03-13 | 2019-09-12 | Salk Institute For Biological Studies | Analogs of fexaramine and methods of making and using |
| JP2017510572A (ja) | 2014-03-13 | 2017-04-13 | ソーク インスティチュート フォー バイオロジカル スタディーズ | Fxrアゴニストならびに作製および使用のための方法 |
| US20150297508A1 (en) | 2014-04-21 | 2015-10-22 | William Andriette | Topical Formulation to Enhance Genital Sensation and Function |
| EP3149016A1 (en) * | 2014-06-02 | 2017-04-05 | Glaxosmithkline Intellectual Property (No. 2) Limited | Preparation and use of crystalline beta-d-nicotinamide riboside |
| AU2015270090A1 (en) | 2014-06-06 | 2016-12-22 | Glaxosmithkline Intellectual Property (No.2) Limited | Nicotinamide riboside analogs and pharmaceutical compositions and uses thereof |
| JP2017522314A (ja) | 2014-07-17 | 2017-08-10 | ザ スクリプス リサーチ インスティテュート | がん治療を向上させるための方法および組成物 |
| ES2963057T3 (es) * | 2015-03-09 | 2024-03-25 | Grace W R & Co | Forma cristalina de ribósido de nicotinamida |
-
2015
- 2015-07-24 WO PCT/US2015/041956 patent/WO2016014927A2/en not_active Ceased
- 2015-07-24 EP EP20153772.7A patent/EP3670522B1/en active Active
- 2015-07-24 US US15/328,664 patent/US10323058B2/en active Active
- 2015-07-24 ES ES15825253T patent/ES2776395T3/es active Active
- 2015-07-24 PL PL20153772T patent/PL3670522T3/pl unknown
- 2015-07-24 CA CA2956163A patent/CA2956163C/en active Active
- 2015-07-24 EP EP15825253.6A patent/EP3174891B1/en active Active
- 2015-07-24 ES ES20153772T patent/ES2908332T3/es active Active
- 2015-07-24 PL PL15825253T patent/PL3174891T3/pl unknown
- 2015-07-24 CN CN201580051724.1A patent/CN106715454B/zh active Active
-
2017
- 2017-10-23 US US15/791,097 patent/US10233207B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3174891A4 (en) | 2018-05-30 |
| US10323058B2 (en) | 2019-06-18 |
| PL3670522T3 (pl) | 2022-02-21 |
| WO2016014927A2 (en) | 2016-01-28 |
| CA2956163C (en) | 2023-01-10 |
| CN106715454B (zh) | 2020-06-16 |
| CA2956163A1 (en) | 2016-01-28 |
| ES2776395T3 (es) | 2020-07-30 |
| ES2908332T3 (es) | 2022-04-28 |
| EP3670522B1 (en) | 2022-01-19 |
| CN106715454A (zh) | 2017-05-24 |
| EP3174891B1 (en) | 2020-01-29 |
| US10233207B2 (en) | 2019-03-19 |
| EP3670522A1 (en) | 2020-06-24 |
| US20180086783A1 (en) | 2018-03-29 |
| EP3174891A2 (en) | 2017-06-07 |
| WO2016014927A3 (en) | 2016-09-15 |
| US20170210774A1 (en) | 2017-07-27 |
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