PL3174891T3 - Krystaliczna postać rybozydu nikotynamidu - Google Patents
Krystaliczna postać rybozydu nikotynamiduInfo
- Publication number
- PL3174891T3 PL3174891T3 PL15825253T PL15825253T PL3174891T3 PL 3174891 T3 PL3174891 T3 PL 3174891T3 PL 15825253 T PL15825253 T PL 15825253T PL 15825253 T PL15825253 T PL 15825253T PL 3174891 T3 PL3174891 T3 PL 3174891T3
- Authority
- PL
- Poland
- Prior art keywords
- crystalline form
- nicotinamide riboside
- riboside
- nicotinamide
- crystalline
- Prior art date
Links
- JLEBZPBDRKPWTD-TURQNECASA-O N-ribosylnicotinamide Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](CO)O2)O)=C1 JLEBZPBDRKPWTD-TURQNECASA-O 0.000 title 1
- 235000020956 nicotinamide riboside Nutrition 0.000 title 1
- 239000011618 nicotinamide riboside Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/048—Pyridine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462028702P | 2014-07-24 | 2014-07-24 | |
| PCT/US2015/041956 WO2016014927A2 (en) | 2014-07-24 | 2015-07-24 | Crystalline form of nicotinamide riboside |
| EP15825253.6A EP3174891B1 (en) | 2014-07-24 | 2015-07-24 | Crystalline form of nicotinamide riboside |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3174891T3 true PL3174891T3 (pl) | 2020-08-10 |
Family
ID=55163976
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL20153772T PL3670522T3 (pl) | 2014-07-24 | 2015-07-24 | Krystaliczna postać chlorku rybozydu nikotynamidu |
| PL15825253T PL3174891T3 (pl) | 2014-07-24 | 2015-07-24 | Krystaliczna postać rybozydu nikotynamidu |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL20153772T PL3670522T3 (pl) | 2014-07-24 | 2015-07-24 | Krystaliczna postać chlorku rybozydu nikotynamidu |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10323058B2 (pl) |
| EP (2) | EP3670522B1 (pl) |
| CN (1) | CN106715454B (pl) |
| CA (1) | CA2956163C (pl) |
| ES (2) | ES2908332T3 (pl) |
| PL (2) | PL3670522T3 (pl) |
| WO (1) | WO2016014927A2 (pl) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102629310B1 (ko) * | 2015-03-09 | 2024-01-24 | 더블유.알. 그레이스 앤드 캄파니-콘. | 니코틴아미드 리보사이드의 결정 형태 |
| JP6949002B6 (ja) | 2015-08-05 | 2021-11-17 | メトロ インターナショナル バイオテック,エルエルシー | ニコチンアミドモノヌクレオチド誘導体及びそれらの使用 |
| GB2542881B (en) | 2015-10-02 | 2020-01-01 | Carr Andrew | Crystal forms of ß-nicotinamide mononucleotide |
| CA3017254C (en) | 2016-03-16 | 2023-08-22 | ChromaDex Inc. | B-vitamin and amino acid conjugates of nicotinoyl ribosides and reduced nicotinoyl ribosides, derivatives thereof, and methods of preparation thereof |
| WO2017218580A1 (en) | 2016-06-14 | 2017-12-21 | Rejuvenation Therapeutics Corporation | Synthetic methods for the preparation of nicotinamide riboside and related compounds |
| CA3045876A1 (en) | 2016-11-11 | 2018-05-17 | The Queen's University Of Belfast | Scalable syntheses of nicotinoyl ribosides and reduced nic otinoyl ribosides, modified derivatives thereof, phosphorylated analogs thereof, adenylyl dinucleotide conjugates thereof, and novel crystalline forms thereof |
| MX2019006278A (es) | 2016-11-29 | 2019-08-21 | Univ Iowa Res Found | Uso de precursores de nad para mejorar la salud materna y/o salud de la descendencia. |
| US11071747B2 (en) | 2016-11-29 | 2021-07-27 | University Of Iowa Research Foundation | Use of NAD precursors for breast enhancement |
| EP3642214A2 (en) | 2017-06-19 | 2020-04-29 | Gangadhara Ganapati | Nicotinamide riboside derivatives and their uses |
| EP3727400A4 (en) * | 2017-12-22 | 2021-10-20 | Elysium Health, Inc. | CRYSTALLINE FORMS OF NICOTINAMIDE RIBOSIDE CHLORIDE |
| US11180521B2 (en) | 2018-01-30 | 2021-11-23 | Metro International Biotech, Llc | Nicotinamide riboside analogs, pharmaceutical compositions, and uses thereof |
| BR112020023588A2 (pt) * | 2018-05-18 | 2021-02-09 | F. Hoffmann-La Roche Ag | método para a produção de brometo de b-d-ribofuranosídeo de nicotinamida cristalino de fórmula o-ia, método, para a produção de sais de ¿-d-ribofuranosídeo de (tio)nicotinamida cristalinos, método para a produção de uma composição compreendendo um sal amorfo de ¿-d-ribofuranosídeo de (tio)nicotinamida, brometo de 2,3,5-tri-o-acetil-¿-d-ribofuranosídeo de nicotinamida cristalino de fórmula o-va, brometo de ¿-d-ribofuranosídeo de nicotinamida ou de tionicotinamida cristalino de fórmulas o-ia e s-ia, composição, uso de um composto ¿-d-ribofuranosídeo de (tio)nicotinamida cristalino, composição farmacêutica, método para a produção de brometo de tri-o-acil-¿-d-ribofuranosídeo de fórmula iii, método para remoção de grupos acila de brometo de 2,3,5-tri-o-acil-¿-d-ribofuranosídeo de nicotinamida de fórmula o-va ou de cloreto de 2,3,5-tri-o-acil-¿-d-ribofuranosídeo de nicotinamida de fórmula o-vb |
| CN108774278A (zh) * | 2018-09-10 | 2018-11-09 | 张洪喜 | 一种制备尼克酰胺核苷盐的方法 |
| JP2022512126A (ja) * | 2018-12-10 | 2022-02-02 | クロマデックス,インコーポレイテッド | ニコチノイルリボシド及びその誘導体の結晶形態、並びにその調製方法 |
| EP3897666A2 (en) | 2018-12-17 | 2021-10-27 | Mitopower LLC | Nicotinyl riboside compounds and their uses |
| KR20220013540A (ko) | 2019-02-21 | 2022-02-04 | 크로마덱스 아이엔씨. | 니코틴아미드 리보사이드, 니코틴산 리보사이드, 환원 니코티닐 리보사이드 화합물, 및 니코티닐 리보사이드 화합물 유도체의 제형에서의 용도 |
| US10618927B1 (en) | 2019-03-22 | 2020-04-14 | Metro International Biotech, Llc | Compositions and methods for modulation of nicotinamide adenine dinucleotide |
| US11939348B2 (en) | 2019-03-22 | 2024-03-26 | Metro International Biotech, Llc | Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide |
| EP3999518A2 (en) | 2019-07-19 | 2022-05-25 | Biosynth AG | Method of making nicotinamide ribofuranoside salts, nicotinamide ribofuranoside salts as such, and uses thereof |
| CN111808156A (zh) * | 2020-07-15 | 2020-10-23 | 许昌远志生物科技有限公司 | 一种β-烟酰胺核糖氯化物的晶型1A、晶型1B及其制备方法 |
| BR112023003217A2 (pt) * | 2020-09-15 | 2023-03-28 | Nestle Sa | Métodos para produzir ribosídeo de di-hidronicotinamida a partir do cloreto de ribosídeo de nicotinamida |
| WO2022251491A1 (en) | 2021-05-27 | 2022-12-01 | Metro International Biotech, Llc | Crystalline solids of nicotinic acid mononucleotide and esters thereof and methods of making and use |
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| GB1190080A (en) | 1966-08-08 | 1970-04-29 | Kyowa Hakko Kogyo Company Ltd | Process for producing Nicotinamide Adenine Dinucleotide |
| US3728111A (en) | 1971-09-21 | 1973-04-17 | Asea Ab | Method of manufacturing billets from powder |
| CN1262556C (zh) | 1997-02-06 | 2006-07-05 | 印斯拜尔药品股份有限公司 | 特定的二核苷酸和它们作为粘膜纤毛清除和纤毛颤动频率调节剂的应用 |
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| WO2002048165A2 (en) | 2000-12-15 | 2002-06-20 | Pharmasset Ltd. | Antiviral agents for treatment of flaviviridae infections |
| US7179791B2 (en) | 2001-01-11 | 2007-02-20 | Duke University | Inhibiting GS-FDH to modulate NO bioactivity |
| US7977049B2 (en) | 2002-08-09 | 2011-07-12 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
| US20050020587A1 (en) * | 2003-07-25 | 2005-01-27 | Pfizer Inc | Nicotinamide derivatives useful as PDE4 inhibitors |
| US8017634B2 (en) | 2003-12-29 | 2011-09-13 | President And Fellows Of Harvard College | Compositions for treating obesity and insulin resistance disorders |
| US8114626B2 (en) | 2004-02-10 | 2012-02-14 | Trustees Of Dartmouth College | Yeast strain and method for using the same to produce nicotinamide riboside |
| EP1723227A4 (en) | 2004-02-10 | 2007-09-19 | Dartmouth College | NICOTINAMIDRIBOSIDE KINASE COMPOSITIONS AND METHOD FOR THEIR USE |
| CN1964627B (zh) | 2004-06-04 | 2011-10-19 | 华盛顿大学 | 治疗神经病变的方法和组合物 |
| JP4058106B2 (ja) | 2005-02-18 | 2008-03-05 | アストラゼネカ アクチボラグ | 抗菌性のピペリジン誘導体 |
| EP2805719A1 (en) | 2005-03-30 | 2014-11-26 | Glaxosmithkline LLC | Nicotinamide riboside and analogues thereof |
| US20070149466A1 (en) | 2005-07-07 | 2007-06-28 | Michael Milburn | Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders |
| CN101360421B (zh) | 2005-11-18 | 2014-06-18 | 康乃尔研究基金会有限公司 | 烟酰核苷组合物及其使用方法 |
| AU2006339607A1 (en) | 2005-12-02 | 2007-09-13 | Sirtris Pharmaceuticals, Inc. | Modulators of Cdc2-like kinases (Clks) and methods of use thereof |
| WO2007136744A1 (en) | 2006-05-19 | 2007-11-29 | The Johns Hopkins University | Crystal structure of a substrate complex of nampt/pbef/visfatin |
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| US20100047177A1 (en) | 2007-01-26 | 2010-02-25 | Washington University | Methods and compositions for treating neuropathies |
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| WO2010002586A2 (en) | 2008-06-30 | 2010-01-07 | Elc Management Llc | Topical compositions comprising isonicotinamide |
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| US20120164670A1 (en) | 2009-06-23 | 2012-06-28 | President And Fellows Of Harvard College | Methods and kits for measuring enzyme activity |
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| US8507251B2 (en) | 2009-09-28 | 2013-08-13 | Robert J. Greenstein | Medium and method for culturing Mycobacterium avium subspecies paratuberculosis |
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| US20130165398A1 (en) | 2010-03-29 | 2013-06-27 | Paul Hochegger | Concentration-enhancing drink |
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| WO2012114204A2 (en) | 2011-02-15 | 2012-08-30 | Ecole Polytechnique Federale De Lausanne (Epfl) Epfl-Tto | Methods of treating mitochondrial dysfunction |
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| US20120328526A1 (en) | 2011-06-27 | 2012-12-27 | University Of Maryland, Baltimore | Modulation of Nad+ Activity in Neuropathophysiological Conditions and Uses Thereof |
| EA201490050A1 (ru) | 2011-06-29 | 2014-07-30 | Зе Дженерэл Хоспитэл Корпорейшн | Композиции и способы повышения биоэнергетического состояния женских зародышевых клеток |
| CA2840516A1 (en) | 2011-06-29 | 2013-01-03 | President And Fellows Of Harvard College | Small molecule cd38 inhibitors and methods of using same |
| CN110051672A (zh) | 2012-07-09 | 2019-07-26 | 诺格罗有限责任公司 | 使用膳食补充剂预防酒精反应 |
| US20140256760A1 (en) | 2012-07-09 | 2014-09-11 | Noglo Llc | Reduction or prevention of alcohol reaction with dietary supplements |
| EP2872128B1 (en) | 2012-07-16 | 2020-02-19 | Cornell University | Nicotinamide riboside to treat hearing loss |
| WO2014059029A1 (en) | 2012-10-09 | 2014-04-17 | President And Fellows Of Harvard College | Treatment of age-related and mitochondrial diseases by inhibition of hif-1 alpha function |
| WO2014111906A1 (en) | 2013-01-21 | 2014-07-24 | Ecole Polytechnique Federale De Lausanne (Epfl) | Bioluminescence imaging of small biomolecules |
| CN105228627B (zh) | 2013-03-15 | 2018-07-13 | 纽斯尔特科学公司 | 亮氨酸和烟酸降低脂质水平 |
| GB201313465D0 (en) * | 2013-07-29 | 2013-09-11 | Queens University Of The Belfast | Methods of preparing nicotinamide riboside and derivatives thereof |
| KR101914844B1 (ko) | 2013-10-24 | 2018-11-02 | 더 프록터 앤드 갬블 캄파니 | 피부 미백 화장 조성물 및 방법 |
| KR20150050406A (ko) | 2013-10-29 | 2015-05-08 | 한림대학교 산학협력단 | 니코틴아마이드 라이보사이드를 유효성분으로 포함하는 패혈증 치료 또는 예방용 약제학적 조성물 |
| CA2928656C (en) | 2013-10-30 | 2020-07-28 | ChromaDex Inc. | Nicotinamide riboside compositions for topical use in treating skin conditions |
| MX373132B (es) | 2013-11-12 | 2020-05-25 | Ortho Nutra Llc | Suplemento a base de teacrina y método de uso del mismo. |
| WO2015099842A1 (en) | 2013-12-23 | 2015-07-02 | Abbott Laboratories | Hot beverage fortifier |
| EP3116878A4 (en) | 2014-03-13 | 2018-02-14 | Salk Institute for Biological Studies | Fxr agonists and methods for making and using |
| AU2015229055B2 (en) | 2014-03-13 | 2019-09-12 | Salk Institute For Biological Studies | Analogs of fexaramine and methods of making and using |
| US20150297508A1 (en) | 2014-04-21 | 2015-10-22 | William Andriette | Topical Formulation to Enhance Genital Sensation and Function |
| KR20170012449A (ko) | 2014-06-02 | 2017-02-02 | 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 | 결정질 베타-d-니코틴아미드 리보시드의 제조 및 용도 |
| CA2951287A1 (en) | 2014-06-06 | 2015-12-10 | Glaxosmithkline Intellectual Property (No. 2) Limited | Nicotinamide riboside analogs and pharmaceutical compositions and uses thereof |
| CN107073027A (zh) | 2014-07-17 | 2017-08-18 | 斯克利普斯研究院 | 增强癌症疗法的方法和组合物 |
| KR102629310B1 (ko) | 2015-03-09 | 2024-01-24 | 더블유.알. 그레이스 앤드 캄파니-콘. | 니코틴아미드 리보사이드의 결정 형태 |
-
2015
- 2015-07-24 CN CN201580051724.1A patent/CN106715454B/zh active Active
- 2015-07-24 WO PCT/US2015/041956 patent/WO2016014927A2/en not_active Ceased
- 2015-07-24 CA CA2956163A patent/CA2956163C/en active Active
- 2015-07-24 ES ES20153772T patent/ES2908332T3/es active Active
- 2015-07-24 US US15/328,664 patent/US10323058B2/en active Active
- 2015-07-24 PL PL20153772T patent/PL3670522T3/pl unknown
- 2015-07-24 EP EP20153772.7A patent/EP3670522B1/en active Active
- 2015-07-24 EP EP15825253.6A patent/EP3174891B1/en active Active
- 2015-07-24 ES ES15825253T patent/ES2776395T3/es active Active
- 2015-07-24 PL PL15825253T patent/PL3174891T3/pl unknown
-
2017
- 2017-10-23 US US15/791,097 patent/US10233207B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20180086783A1 (en) | 2018-03-29 |
| WO2016014927A3 (en) | 2016-09-15 |
| CN106715454B (zh) | 2020-06-16 |
| EP3670522B1 (en) | 2022-01-19 |
| CA2956163A1 (en) | 2016-01-28 |
| CN106715454A (zh) | 2017-05-24 |
| ES2908332T3 (es) | 2022-04-28 |
| EP3174891B1 (en) | 2020-01-29 |
| US10233207B2 (en) | 2019-03-19 |
| PL3670522T3 (pl) | 2022-02-21 |
| US20170210774A1 (en) | 2017-07-27 |
| WO2016014927A2 (en) | 2016-01-28 |
| EP3670522A1 (en) | 2020-06-24 |
| CA2956163C (en) | 2023-01-10 |
| EP3174891A2 (en) | 2017-06-07 |
| EP3174891A4 (en) | 2018-05-30 |
| US10323058B2 (en) | 2019-06-18 |
| ES2776395T3 (es) | 2020-07-30 |
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