PL3670522T3 - Krystaliczna postać chlorku rybozydu nikotynamidu - Google Patents
Krystaliczna postać chlorku rybozydu nikotynamiduInfo
- Publication number
- PL3670522T3 PL3670522T3 PL20153772T PL20153772T PL3670522T3 PL 3670522 T3 PL3670522 T3 PL 3670522T3 PL 20153772 T PL20153772 T PL 20153772T PL 20153772 T PL20153772 T PL 20153772T PL 3670522 T3 PL3670522 T3 PL 3670522T3
- Authority
- PL
- Poland
- Prior art keywords
- crystalline form
- nicotinamide riboside
- riboside chloride
- chloride
- nicotinamide
- Prior art date
Links
- YABIFCKURFRPPO-IVOJBTPCSA-N 1-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyridin-1-ium-3-carboxamide;chloride Chemical compound [Cl-].NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](CO)O2)O)=C1 YABIFCKURFRPPO-IVOJBTPCSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/048—Pyridine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462028702P | 2014-07-24 | 2014-07-24 | |
| PCT/US2015/041956 WO2016014927A2 (en) | 2014-07-24 | 2015-07-24 | Crystalline form of nicotinamide riboside |
| EP20153772.7A EP3670522B1 (en) | 2014-07-24 | 2015-07-24 | Crystalline form of nicotinamide riboside chloride |
| EP15825253.6A EP3174891B1 (en) | 2014-07-24 | 2015-07-24 | Crystalline form of nicotinamide riboside |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3670522T3 true PL3670522T3 (pl) | 2022-02-21 |
Family
ID=55163976
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL15825253T PL3174891T3 (pl) | 2014-07-24 | 2015-07-24 | Krystaliczna postać rybozydu nikotynamidu |
| PL20153772T PL3670522T3 (pl) | 2014-07-24 | 2015-07-24 | Krystaliczna postać chlorku rybozydu nikotynamidu |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL15825253T PL3174891T3 (pl) | 2014-07-24 | 2015-07-24 | Krystaliczna postać rybozydu nikotynamidu |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10323058B2 (pl) |
| EP (2) | EP3174891B1 (pl) |
| CN (1) | CN106715454B (pl) |
| CA (1) | CA2956163C (pl) |
| ES (2) | ES2908332T3 (pl) |
| PL (2) | PL3174891T3 (pl) |
| WO (1) | WO2016014927A2 (pl) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2963057T3 (es) * | 2015-03-09 | 2024-03-25 | Grace W R & Co | Forma cristalina de ribósido de nicotinamida |
| US9855289B2 (en) | 2015-08-05 | 2018-01-02 | Metro International Biotech, Llc | Nicotinamide mononucleotide derivatives and their uses |
| GB2542881B (en) | 2015-10-02 | 2020-01-01 | Carr Andrew | Crystal forms of ß-nicotinamide mononucleotide |
| EP3429354A4 (en) | 2016-03-16 | 2020-03-25 | Chromadex Inc. | B-VITAMIN AND AMINO ACID CONJUGATES OF NICOTINOYL RIBOSIDES AND REDUCED NICOTINOYL RIBOSIDES, DERIVATIVES THEREOF AND METHOD FOR THE PRODUCTION THEREOF |
| WO2017218580A1 (en) | 2016-06-14 | 2017-12-21 | Rejuvenation Therapeutics Corporation | Synthetic methods for the preparation of nicotinamide riboside and related compounds |
| NZ803738A (en) | 2016-11-11 | 2024-05-31 | Chromadex Inc | Efficient and scalable syntheses of nicotinoyl ribosides and reduced nicotinoyl ribosides, modified derivatives thereof, phosphorylated analogs thereof, adenylyl dinucleotide conjugates thereof, and novel crystalline forms thereof |
| EP3554285A4 (en) | 2016-11-29 | 2021-01-20 | University of Iowa Research Foundation | USE OF NAD PRECURSORS TO IMPROVE THE HEALTH OF MOTHER AND / OR OFFspring |
| US11071747B2 (en) | 2016-11-29 | 2021-07-27 | University Of Iowa Research Foundation | Use of NAD precursors for breast enhancement |
| US20190328761A1 (en) | 2016-12-21 | 2019-10-31 | Newsouth Innovations Pty Limited | Methods for enhancing vascular density |
| US11286274B2 (en) | 2017-06-19 | 2022-03-29 | Mitopower Llc | Nicotinamide riboside derivatives and their uses |
| EP3727400A4 (en) * | 2017-12-22 | 2021-10-20 | Elysium Health, Inc. | CRYSTALLINE FORMS OF NICOTINAMIDE RIBOSIDE CHLORIDE |
| WO2019152416A1 (en) | 2018-01-30 | 2019-08-08 | Metro International Biotech, Llc | Nicotinamide riboside analogs, pharmaceutical compositions, and uses thereof |
| CN112135833A (zh) * | 2018-05-18 | 2020-12-25 | 弗·哈夫曼-拉罗切有限公司 | (硫代)烟酰胺呋喃核糖苷盐及其组合物、制备方法和用途 |
| CN108774278A (zh) * | 2018-09-10 | 2018-11-09 | 张洪喜 | 一种制备尼克酰胺核苷盐的方法 |
| KR20210108400A (ko) | 2018-12-10 | 2021-09-02 | 크로마덱스 아이엔씨. | 니코티노일 리보사이드 및 이의 유도체의 결정질 형태 및 이의 제조 방법 |
| WO2020131578A2 (en) | 2018-12-17 | 2020-06-25 | Mitopower Llc | Nicotinyl riboside compounds and their uses |
| EP3927715A4 (en) | 2019-02-21 | 2023-03-01 | Chromadex, Inc. | USE OF NICOTINAMIDE RIBOSIDE, NICOTINOIC ACID RIBOSIDE, REDUCED NICOTINYL RIBOSIDE COMPOUNDS AND NICOTINYL RIBOSIDE COMPOUNDS IN FORMULATIONS |
| US10618927B1 (en) | 2019-03-22 | 2020-04-14 | Metro International Biotech, Llc | Compositions and methods for modulation of nicotinamide adenine dinucleotide |
| US11939348B2 (en) | 2019-03-22 | 2024-03-26 | Metro International Biotech, Llc | Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide |
| JP7675061B2 (ja) | 2019-07-19 | 2025-05-12 | バイオシント アクチェンゲゼルシャフト | ニコチンアミドリボフラノシド塩の製造方法、ニコチンアミドリボフラノシド塩自体、およびその使用 |
| CN111808156A (zh) * | 2020-07-15 | 2020-10-23 | 许昌远志生物科技有限公司 | 一种β-烟酰胺核糖氯化物的晶型1A、晶型1B及其制备方法 |
| CA3187278A1 (en) * | 2020-09-15 | 2022-03-24 | Societe Des Produits Nestle S.A. | Methods for producing dihydronicotinamide riboside from nicotinamide riboside chloride |
| CA3219033A1 (en) | 2021-05-27 | 2022-12-01 | Metro International Biotech, Llc | Crystalline solids of nicotinic acid mononucleotide and esters thereof and methods of making and use |
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| GB1190080A (en) | 1966-08-08 | 1970-04-29 | Kyowa Hakko Kogyo Company Ltd | Process for producing Nicotinamide Adenine Dinucleotide |
| US3728111A (en) | 1971-09-21 | 1973-04-17 | Asea Ab | Method of manufacturing billets from powder |
| EP0981534B1 (en) | 1997-02-06 | 2006-05-03 | Inspire Pharmaceuticals, Inc. | Dinucleotides and their uses |
| GB9712370D0 (en) | 1997-06-14 | 1997-08-13 | Aepact Ltd | Therapeutic systems |
| JP2005502580A (ja) | 2000-12-15 | 2005-01-27 | フアーマセツト・リミテツド | フラビウィルス感染治療用抗ウィルス薬 |
| US7179791B2 (en) | 2001-01-11 | 2007-02-20 | Duke University | Inhibiting GS-FDH to modulate NO bioactivity |
| US7977049B2 (en) * | 2002-08-09 | 2011-07-12 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
| US20050020587A1 (en) | 2003-07-25 | 2005-01-27 | Pfizer Inc | Nicotinamide derivatives useful as PDE4 inhibitors |
| US8017634B2 (en) | 2003-12-29 | 2011-09-13 | President And Fellows Of Harvard College | Compositions for treating obesity and insulin resistance disorders |
| EP1723227A4 (en) | 2004-02-10 | 2007-09-19 | Dartmouth College | NICOTINAMIDRIBOSIDE KINASE COMPOSITIONS AND METHOD FOR THEIR USE |
| US8114626B2 (en) | 2004-02-10 | 2012-02-14 | Trustees Of Dartmouth College | Yeast strain and method for using the same to produce nicotinamide riboside |
| CN1964627B (zh) | 2004-06-04 | 2011-10-19 | 华盛顿大学 | 治疗神经病变的方法和组合物 |
| ES2430569T3 (es) | 2005-02-18 | 2013-11-21 | Astrazeneca Ab | Compuestos antibacterianos derivados de piperidina |
| EP2805719A1 (en) * | 2005-03-30 | 2014-11-26 | Glaxosmithkline LLC | Nicotinamide riboside and analogues thereof |
| US20070149466A1 (en) | 2005-07-07 | 2007-06-28 | Michael Milburn | Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders |
| WO2007061798A2 (en) * | 2005-11-18 | 2007-05-31 | Cornell Research Foundation, Inc. | Nicotinoyl riboside compositions and methods of use |
| US20070248590A1 (en) | 2005-12-02 | 2007-10-25 | Sirtris Pharmaceuticals, Inc. | Modulators of CDC2-like kinases (CLKS) and methods of use thereof |
| WO2007136744A1 (en) | 2006-05-19 | 2007-11-29 | The Johns Hopkins University | Crystal structure of a substrate complex of nampt/pbef/visfatin |
| JP2010513458A (ja) * | 2006-12-19 | 2010-04-30 | ファイザー・プロダクツ・インク | H−pgdsの阻害剤としてのニコチンアミド誘導体、およびプロスタグランジンd2の仲介による疾患を治療するためのその使用 |
| CA2676609A1 (en) | 2007-01-26 | 2008-07-31 | Washington University | Methods and compositions for treating neuropathies |
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| US20100015072A1 (en) | 2008-06-30 | 2010-01-21 | Christopher Polla | Topical Compositions Comprising Isonicotinamide |
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| WO2011005289A2 (en) | 2009-06-23 | 2011-01-13 | President And Fellows Of Harvard College | Methods and kits for measuring enzyme activity |
| WO2011011721A2 (en) | 2009-07-24 | 2011-01-27 | Amazentis Sa | Compounds, compositions and methods for protecting brain health in neurodegenerative disorders |
| US8507251B2 (en) | 2009-09-28 | 2013-08-13 | Robert J. Greenstein | Medium and method for culturing Mycobacterium avium subspecies paratuberculosis |
| WO2011081942A1 (en) * | 2009-12-14 | 2011-07-07 | Cornell University | Activation and activators of sirt5 |
| EP2464249B1 (de) | 2010-03-29 | 2013-03-13 | Johannes Huber | Konzentrationssteigerndes getränk |
| US8481711B2 (en) | 2010-07-06 | 2013-07-09 | Hidenori Kamanishi | Neurite outgrowth agent |
| WO2012114204A2 (en) | 2011-02-15 | 2012-08-30 | Ecole Polytechnique Federale De Lausanne (Epfl) Epfl-Tto | Methods of treating mitochondrial dysfunction |
| US20120107888A1 (en) | 2011-02-17 | 2012-05-03 | Qteros, Inc. | Modulation of fermentation products through vitamin supplementation |
| US20120328526A1 (en) | 2011-06-27 | 2012-12-27 | University Of Maryland, Baltimore | Modulation of Nad+ Activity in Neuropathophysiological Conditions and Uses Thereof |
| EP3345901A3 (en) | 2011-06-29 | 2018-09-12 | President and Fellows of Harvard College | Small molecules as antiaging agents |
| EP2726601B1 (en) | 2011-06-29 | 2018-12-26 | The General Hospital Corporation | Compositions and methods for enhancing bioenergetic status in female germ cells |
| US20140256760A1 (en) | 2012-07-09 | 2014-09-11 | Noglo Llc | Reduction or prevention of alcohol reaction with dietary supplements |
| EP2869717B8 (en) | 2012-07-09 | 2018-07-25 | NoGlo, Inc. | Prevention of alcohol reaction with dietary supplements |
| EP2872128B1 (en) | 2012-07-16 | 2020-02-19 | Cornell University | Nicotinamide riboside to treat hearing loss |
| WO2014059029A1 (en) | 2012-10-09 | 2014-04-17 | President And Fellows Of Harvard College | Treatment of age-related and mitochondrial diseases by inhibition of hif-1 alpha function |
| WO2014111906A1 (en) | 2013-01-21 | 2014-07-24 | Ecole Polytechnique Federale De Lausanne (Epfl) | Bioluminescence imaging of small biomolecules |
| SG11201507046UA (en) | 2013-03-15 | 2015-10-29 | Nusirt Sciences Inc | Leucine and nicotinic acid reduces lipid levels |
| GB201313465D0 (en) * | 2013-07-29 | 2013-09-11 | Queens University Of The Belfast | Methods of preparing nicotinamide riboside and derivatives thereof |
| WO2015061512A1 (en) | 2013-10-24 | 2015-04-30 | The Procter & Gamble Company | Skin lightening cosmetic compositions and methods |
| WO2015064988A1 (ko) | 2013-10-29 | 2015-05-07 | 한림대학교 산학협력단 | 니코틴아마이드 라이보사이드를 유효성분으로 포함하는 패혈증 치료 또는 예방용 약제학적 조성물 |
| JP6509844B2 (ja) | 2013-10-30 | 2019-05-08 | クロマデックス, インコーポレイテッドChromaDex, Inc. | 皮膚症状の治療において局所使用されるニコチンアミドリボシド組成物 |
| BR112016010422B1 (pt) | 2013-11-12 | 2021-08-31 | Ortho-Nutra, Llc | Suplemento dietético e método de tratamento para melhorar o desempenho ou energia física em um indivíduo |
| WO2015099842A1 (en) | 2013-12-23 | 2015-07-02 | Abbott Laboratories | Hot beverage fortifier |
| JP2017511304A (ja) | 2014-03-13 | 2017-04-20 | ソーク インスティチュート フォー バイオロジカル スタディーズ | フェキサラミン類似体ならびに作製方法および使用方法 |
| CA2942403A1 (en) | 2014-03-13 | 2015-09-17 | Salk Institute For Biological Studies | Fxr agonists and methods for making and using |
| US20150297508A1 (en) | 2014-04-21 | 2015-10-22 | William Andriette | Topical Formulation to Enhance Genital Sensation and Function |
| US10316054B2 (en) * | 2014-06-02 | 2019-06-11 | Glaxosmithkline Intellectual Property (No. 2) Limited | Preparation and use of crystalline beta-D-nicotinamide riboside |
| RU2016149767A (ru) | 2014-06-06 | 2018-07-16 | Глэксосмитклайн Интеллекчуал Проперти (Но.2) Лимитед | Аналоги никотинамидрибозида и фармацевтические композиции и их применение |
| WO2016011360A1 (en) | 2014-07-17 | 2016-01-21 | The Scripps Research Institute | Methods and compositions for enhancing cancer therapy |
| ES2963057T3 (es) | 2015-03-09 | 2024-03-25 | Grace W R & Co | Forma cristalina de ribósido de nicotinamida |
-
2015
- 2015-07-24 CA CA2956163A patent/CA2956163C/en active Active
- 2015-07-24 EP EP15825253.6A patent/EP3174891B1/en active Active
- 2015-07-24 ES ES20153772T patent/ES2908332T3/es active Active
- 2015-07-24 US US15/328,664 patent/US10323058B2/en active Active
- 2015-07-24 ES ES15825253T patent/ES2776395T3/es active Active
- 2015-07-24 EP EP20153772.7A patent/EP3670522B1/en active Active
- 2015-07-24 PL PL15825253T patent/PL3174891T3/pl unknown
- 2015-07-24 PL PL20153772T patent/PL3670522T3/pl unknown
- 2015-07-24 WO PCT/US2015/041956 patent/WO2016014927A2/en not_active Ceased
- 2015-07-24 CN CN201580051724.1A patent/CN106715454B/zh active Active
-
2017
- 2017-10-23 US US15/791,097 patent/US10233207B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20170210774A1 (en) | 2017-07-27 |
| ES2908332T3 (es) | 2022-04-28 |
| EP3174891A4 (en) | 2018-05-30 |
| ES2776395T3 (es) | 2020-07-30 |
| CN106715454A (zh) | 2017-05-24 |
| US10323058B2 (en) | 2019-06-18 |
| PL3174891T3 (pl) | 2020-08-10 |
| US10233207B2 (en) | 2019-03-19 |
| EP3670522A1 (en) | 2020-06-24 |
| EP3174891B1 (en) | 2020-01-29 |
| EP3174891A2 (en) | 2017-06-07 |
| CA2956163A1 (en) | 2016-01-28 |
| EP3670522B1 (en) | 2022-01-19 |
| WO2016014927A2 (en) | 2016-01-28 |
| WO2016014927A3 (en) | 2016-09-15 |
| CA2956163C (en) | 2023-01-10 |
| CN106715454B (zh) | 2020-06-16 |
| US20180086783A1 (en) | 2018-03-29 |
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