PL3189839T3 - Pochodne n-piperydyloacetamidu jako blokery kanału wapniowego - Google Patents

Pochodne n-piperydyloacetamidu jako blokery kanału wapniowego

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Publication number
PL3189839T3
PL3189839T3 PL17155716T PL17155716T PL3189839T3 PL 3189839 T3 PL3189839 T3 PL 3189839T3 PL 17155716 T PL17155716 T PL 17155716T PL 17155716 T PL17155716 T PL 17155716T PL 3189839 T3 PL3189839 T3 PL 3189839T3
Authority
PL
Poland
Prior art keywords
calcium channel
channel blockers
acetamide derivatives
piperidinyl acetamide
piperidinyl
Prior art date
Application number
PL17155716T
Other languages
English (en)
Inventor
Hassan Pajouhesh
Ramesh Kaul
Yanbing Ding
Yongbao Zhu
Lingyun Zhang
Nagasree Chakka
Mike Grimwood
Jason Tan
Yuanxi Zhou
Original Assignee
Praxis Precision Medicines, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Praxis Precision Medicines, Inc. filed Critical Praxis Precision Medicines, Inc.
Publication of PL3189839T3 publication Critical patent/PL3189839T3/pl

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
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Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8362021B2 (en) * 2006-05-11 2013-01-29 Zalicus Pharmaceuticals Ltd. Method for increasing the bioavailability of benzhydryl piperazine containing compounds
AU2010291834A1 (en) * 2009-09-04 2012-03-15 Zalicus Pharmaceuticals Ltd. Substituted heterocyclic derivatives for the treatment of pain and epilepsy
US20120220564A1 (en) * 2009-09-18 2012-08-30 Zalicus Pharmaceuticals Ltd. Selective calcium channel modulators
US8591944B2 (en) 2011-03-08 2013-11-26 Zalicus Pharmaceuticals Ltd. Solid dispersion formulations and methods of use thereof
US8409560B2 (en) 2011-03-08 2013-04-02 Zalicus Pharmaceuticals Ltd. Solid dispersion formulations and methods of use thereof
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
AU2013224302B2 (en) * 2012-02-21 2017-03-30 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. 1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors
JP6304492B2 (ja) 2012-03-30 2018-04-04 日産化学工業株式会社 トリアジノン化合物及びｔ型カルシウムチャネル阻害剤
EP2961403A4 (en) 2013-03-01 2016-11-30 Zalicus Pharmaceuticals Ltd HETEROCYCLIC INHIBITORS OF SODIUM CHANNEL
JPWO2015050212A1 (ja) 2013-10-02 2017-03-09 日産化学工業株式会社 Ｔ型カルシウムチャネル阻害剤
EP3085695A1 (en) 2013-12-17 2016-10-26 Nissan Chemical Industries, Ltd. Substituted triazinone compound and t-type calcium channel inhibitor
DK3364993T3 (da) 2015-10-22 2023-01-09 Cavion Inc Fremgangsmåder til behandling af angelman syndrom
EP3340988B1 (en) 2015-11-12 2025-04-09 Afasci, Inc. Ion channel inhibitory compounds, pharmaceutical formulations and uses
WO2018118101A1 (en) * 2016-12-21 2018-06-28 Praxis Precision Medicines, Inc. T-type calcium channel modulators and methods of use thereof
CN110545806A (zh) 2017-02-15 2019-12-06 卡维昂公司 钙通道抑制剂
CN110770221B (zh) 2017-04-26 2023-09-08 卡维昂公司 用于改善记忆和认知以及用于治疗记忆和认知障碍的方法
EP3615010B1 (en) * 2017-04-26 2024-08-21 Cavion, Inc. Methods for treating dravet syndrome
TWI879741B (zh) 2018-10-03 2025-04-11 美商卡凡恩公司 以(r)-2-(4-異丙基苯基)-n-(1-(5-(2,2,2-三氟乙氧基)吡啶-2-基)乙基)乙醯胺治療自發性震顫
EP3996746A4 (en) * 2019-07-11 2023-08-23 Praxis Precision Medicines, Inc. T-TYPE CALCIUM CHANNEL MODULATOR FORMULATIONS AND METHODS OF USE THEREOF
IL297642A (en) * 2020-04-29 2022-12-01 Praxis Prec Medicines Inc Methods for using t-type calcium channel modulators
US20240025852A1 (en) * 2020-11-09 2024-01-25 Praxis Precision Medicines, Inc. T-type calcium channel modulators and methods of use thereof
CN116669724A (zh) * 2020-11-09 2023-08-29 普拉西斯精密医药公司 T型钙通道调节剂和其使用方法
EP4329751A4 (en) * 2021-04-26 2025-03-19 Praxis Precision Medicines, Inc. Methods of treatment with neuroactive steroids
CN114518425B (zh) * 2022-02-11 2023-03-10 中国科学技术大学 同时检测单个免疫细胞胞浆和细胞膜的代谢物的分析方法
EP4504170A4 (en) * 2022-04-01 2026-04-08 Praxis Prec Medicines Inc T-TYPE CALCIUM CHANNEL MODULATORS COMPRISING A DIAZASPIROHEPTANE CORE AND THEIR METHODS OF USE
WO2023192665A2 (en) * 2022-04-01 2023-10-05 Praxis Precision Medicines, Inc. T-type calcium channel modulators and methods of use thereof
AU2023245572A1 (en) * 2022-04-01 2024-10-17 Praxis Precision Medicines, Inc. T-type calcium channel modulators comprising an azaspirononane core and methods of use thereof
US20250295646A1 (en) * 2022-05-09 2025-09-25 Praxis Precision Medicines, Inc. Methods of use of t-type calcium channel modulators
KR20250165616A (ko) * 2023-03-02 2025-11-26 프락시스 프리시젼 메디신즈, 인크. 고함량 단일 투여 단위 제형 및 이의 사용 방법
JP2026507197A (ja) * 2023-03-02 2026-02-27 プラクシス プレシジョン メディシンズ， インコーポレイテッド 本態性振戦の治療方法
WO2025188619A1 (en) * 2024-03-04 2025-09-12 Praxis Precision Medicines, Inc. Methods of treating parkinson's disease with t-type calcium channel modulators
WO2025255502A1 (en) 2024-06-07 2025-12-11 Cavion, Inc. PYRIDYL AMIDE Cav3 CHANNEL MODULATORS

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5852014A (en) 1992-03-12 1998-12-22 Smithkline Beecham P.L.C. Condensed indole derivatives as 5HT4 -receptor antagonists
US5624677A (en) 1995-06-13 1997-04-29 Pentech Pharmaceuticals, Inc. Controlled release of drugs delivered by sublingual or buccal administration
JPH11513382A (ja) * 1995-10-20 1999-11-16 ドクトル カルル トーマエ ゲゼルシャフト ミット ベシュレンクテル ハフツング ５員複素環化合物、これらの化合物を含む医薬品、それらの使用及びそれらの調製方法
IT1291569B1 (it) 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici
IL125658A0 (en) 1997-08-18 1999-04-11 Hoffmann La Roche Ccr-3 receptor antagonists
FR2769914B1 (fr) 1997-10-21 2000-02-04 Synthelabo Derives d'indazole tricycliques leur preparation et leur application en therapeutique
US20030125269A1 (en) 1998-08-26 2003-07-03 Ming Li T-type calcium channel
TW570920B (en) 1998-12-22 2004-01-11 Janssen Pharmaceutica Nv 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders
GR20000100283A (el) * 2000-08-17 2002-05-24 Κωνσταντινος Αλεξοπουλος Μη-πεπτιδικοι μιμητες της δραστικης αλληλουχιας s42fllr46 του υποδοχεα της θρομβινης για την θεραπεια της θρομβωσης και του καρκινου
EP1217000A1 (en) 2000-12-23 2002-06-26 Aventis Pharma Deutschland GmbH Inhibitors of factor Xa and factor VIIa
CA2443108A1 (en) 2001-04-03 2002-10-17 Merck & Co. Inc. N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists
WO2003007953A1 (en) 2001-07-18 2003-01-30 Washington University Methods and compositions for modulating t-type calcium channels
KR100534556B1 (ko) 2001-10-26 2005-12-08 주식회사 오리엔트바이오 알파１ｇ 단백질의 기능을 억제하여 간질을 일으키지 않게하는 방법
KR20030037081A (ko) 2001-11-02 2003-05-12 한국과학기술연구원 Ｔ 타입 칼슘채널을 조절하여 복통을 억제하는 방법
GB0126781D0 (en) 2001-11-07 2002-01-02 Medical Res Council Modulation
DE10227511A1 (de) 2002-06-19 2004-01-08 Max-Delbrück-Centrum für Molekulare Medizin Mittel zur medikamentösen Behandlung von akuten und chronischen Schmerzen
WO2004035000A2 (en) 2002-10-17 2004-04-29 Merck & Co., Inc. Enhancement of sleep with t-type calcium channel antagonists
WO2004046110A1 (ja) 2002-11-15 2004-06-03 Yamanouchi Pharmaceutical Co., Ltd. メラニン凝集ホルモン受容体拮抗剤
EP1583821A4 (en) 2003-01-15 2007-07-18 Millennium Pharm Inc METHODS AND COMPOSITIONS FOR TREATING UROLOGICAL DISORDERS USING GENES 44390, 54181, 211, 5687, 884, 1405, 636, 4421, 5410, 30905, 2045, 16405, 18560, 2047, 33751, 52872, 14063, 20739, 32544, 43239, 44373, 51164, 53010, 16852, 1587, 2207, 22245, 2387, 52908, 69112, 14990, 18547, 115, 579
WO2004105750A1 (en) 2003-05-30 2004-12-09 Neuromed Technologies, Inc. 3-aminomethyl-pyrrolidines as n-type calcium channel blockers
US7507760B2 (en) 2004-01-22 2009-03-24 Neuromed Pharmaceuticals Ltd. N-type calcium channel blockers
JP2008501633A (ja) 2004-02-11 2008-01-24 ユニバーシティ オブ ヴァージニア パテント ファウンデーション 癌の診断及び治療のためのＣａｖ３アイソフォーム及びそのδ２５スプライスバリアントの阻害
WO2005092882A1 (en) 2004-03-01 2005-10-06 Pfizer Japan, Inc. 4-amino-5-halogeno-benzamide derivatives as 5-ht4 receptor agonists for the treatment of gastrointestinal, cns, neurological and cardiovascular disorders
US20060003020A1 (en) 2004-03-11 2006-01-05 The Regents Of The University Of Michigan Anti-metastatic ability of mibefradil and gadolinium
US7888374B2 (en) * 2005-01-28 2011-02-15 Abbott Laboratories Inhibitors of c-jun N-terminal kinases
US20100222387A1 (en) 2005-06-23 2010-09-02 Barrow James C 3-Fluoro-Piperidine T-Type Calcium Channel Antagonists
JP2009500340A (ja) 2005-06-29 2009-01-08 メルク エンド カムパニー インコーポレーテッド ４−フルオロ−ピペリジンｔ型カルシウムチャネルアンタゴニスト
EP1943215A2 (en) 2005-10-31 2008-07-16 Brystol-Myers Squibb Company Pyrrolidinyl beta-amino amide-based inhibitors of dipeptidyl peptidase iv and methods
CA2669736C (en) * 2005-11-03 2017-02-21 Chembridge Research Laboratories, Inc. Heterocyclic compounds as tyrosine kinase modulators
UA96283C2 (uk) 2005-12-23 2011-10-25 Зіланд Фарма А/С Модифіковані міметики лізину
US20090156465A1 (en) 2005-12-30 2009-06-18 Sattigeri Jitendra A Derivatives of beta-amino acid as dipeptidyl peptidase-iv inhibitors
CA2663280A1 (en) 2006-09-14 2008-03-20 Neuromed Pharmaceuticals Ltd. Diaryl piperidine compounds as calcium channel blockers
US20090298834A1 (en) 2008-06-02 2009-12-03 Hassan Pajouhesh 4-(aminomethyl)cyclohexanamine derivatives as calcium channel blockers
US20120220564A1 (en) 2009-09-18 2012-08-30 Zalicus Pharmaceuticals Ltd. Selective calcium channel modulators

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