PL3209698T3 - Mysz transgeniczna - Google Patents

Mysz transgeniczna

Info

Publication number: PL3209698T3
Authority: PL; Poland
Prior art keywords: transgenic mice; transgenic; mice
Prior art date: 2014-10-22

Application number

PL14790686T

Other languages

English (en)

Other versions

PL3209698T5 (pl

Inventor

Yumin TENG

Joyce YOUNG

Brian Mcguinness

Mike ROMANOS

Marianne Brueggemann

Original Assignee

Crescendo Biologics Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-10-22

Filing date

2014-10-22

Publication date

2019-03-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51842672&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL3209698(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2014-10-22 Application filed by Crescendo Biologics Limited filed Critical Crescendo Biologics Limited

2019-03-29 Publication of PL3209698T3 publication Critical patent/PL3209698T3/pl

2022-04-25 Publication of PL3209698T5 publication Critical patent/PL3209698T5/pl

Links

Classifications

- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- C12N2015/8518—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic expressing industrially exogenous proteins, e.g. for pharmaceutical use, human insulin, blood factors, immunoglobulins, pseudoparticles
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/20—Pseudochromosomes, minichrosomosomes
- C12N2800/206—Pseudochromosomes, minichrosomosomes of yeast origin, e.g. YAC, 2u
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/30—Vector systems having a special element relevant for transcription being an enhancer not forming part of the promoter region

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Biotechnology (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Immunology (AREA)
Environmental Sciences (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Animal Husbandry (AREA)
Biodiversity & Conservation Biology (AREA)
Animal Behavior & Ethology (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines Containing Plant Substances (AREA)
Eye Examination Apparatus (AREA)

PL14790686T 2014-10-22 2014-10-22 Mysz transgeniczna PL3209698T5 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
PCT/GB2014/053146 WO2016062990A1 (en)	2014-10-22	2014-10-22	Transgenic mice
EP14790686.1A EP3209698B2 (en)	2014-10-22	2014-10-22	Transgenic mice

Publications (2)

Publication Number	Publication Date
PL3209698T3 true PL3209698T3 (pl)	2019-03-29
PL3209698T5 PL3209698T5 (pl)	2022-04-25

Family

ID=51842672

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL14790686T PL3209698T5 (pl)	2014-10-22	2014-10-22	Mysz transgeniczna

Country Status (16)

Country	Link
US (2)	US11547099B2 (pl)
EP (2)	EP3209698B2 (pl)
JP (1)	JP6641379B2 (pl)
KR (1)	KR20170073647A (pl)
CN (2)	CN107002092A (pl)
AU (1)	AU2014409276A1 (pl)
CA (1)	CA2963752A1 (pl)
DK (1)	DK3209698T4 (pl)
ES (1)	ES2701061T5 (pl)
GB (1)	GB2547587B (pl)
HR (1)	HRP20181892T4 (pl)
IL (1)	IL251010B2 (pl)
PL (1)	PL3209698T5 (pl)
PT (1)	PT3209698T (pl)
SG (1)	SG11201702502XA (pl)
WO (1)	WO2016062990A1 (pl)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB201500463D0 (en)	2015-01-12	2015-02-25	Cresendo Biolog Ltd	Therapeutic molecules
JP2019506155A (ja)	2016-01-12	2019-03-07	クレッシェンド、バイオロジックス、リミテッドＣｒｅｓｃｅｎｄｏＢｉｏｌｏｇｉｃｓＬｉｍｉｔｅｄ	治療分子
IL299221A (en)	2016-06-21	2023-02-01	Teneobio Inc	Cd3 binding antibodies
GB201612043D0 (en)	2016-07-11	2016-08-24	Crescendo Biologics Ltd	Composition for treatment of disorders
CR20220578A (es)	2016-09-14	2023-01-17	Teneobio Inc	Anticuerpos de unión a cd3
EP3559035A1 (en)	2016-12-21	2019-10-30	TeneoBio, Inc.	Anti-bcma heavy chain-only antibodies
EP3565842A1 (en)	2017-01-06	2019-11-13	Crescendo Biologics Limited	Single domain antibodies to programmed cell death (pd-1)
CN110891971B (zh)	2017-06-20	2024-01-12	特尼奥生物股份有限公司	仅有重链的抗bcma抗体
JP7240335B2 (ja)	2017-06-20	2023-03-15	テネオワン，インコーポレイテッド	抗ｂｃｍａ重鎖のみ抗体
GB201711068D0 (en)	2017-07-10	2017-08-23	Crescendo Biologics Ltd	Therapeutic molecules binding PSMA
CA3082297A1 (en)	2017-11-13	2019-05-16	Crescendo Biologics Limited	Molecules that bind to cd137 and psma
GB201802573D0 (en)	2018-02-16	2018-04-04	Crescendo Biologics Ltd	Therapeutic molecules that bind to LAG3
CN108486125B (zh) *	2018-03-27	2024-01-05	重庆金迈博生物科技有限公司	一种核酸分子及其在制备人源单域抗体中的应用
GB201818460D0 (en)	2018-11-13	2018-12-26	Crescendo Biologics Ltd	Single domain antibodies that bind human serum albumin
CA3133654A1 (en)	2019-04-05	2020-10-08	Teneobio, Inc.	Heavy chain antibodies binding to psma
US20220220215A1 (en)	2019-05-15	2022-07-14	Crescendo Biologics Limited	Binding molecules
CN114206927B (zh)	2019-06-14	2025-03-21	特尼奥生物股份有限公司	与cd22和cd3结合的多特异性重链抗体
GB201914468D0 (en)	2019-10-07	2019-11-20	Crescendo Biologics Ltd	Binding Molecules
WO2021188599A1 (en)	2020-03-16	2021-09-23	University Of Southern California	Novel antigen binding domains and synthetic antigen receptors incorporating the same
CN114134144A (zh) *	2020-09-04	2022-03-04	北京仁源欣生生物科技有限公司	一种非人哺乳动物或其子代的制备方法及其应用
US20220090060A1 (en)	2020-09-11	2022-03-24	Regeneron Pharmaceuticals, Inc.	Identification and production of antigen-specific antibodies
EP4262373A1 (en)	2020-12-16	2023-10-25	Regeneron Pharmaceuticals, Inc.	Mice expressing humanized fc alpha receptors
WO2023199069A1 (en)	2022-04-14	2023-10-19	Crescendo Biologics Limited	Chimeric antigen receptor that binds mesothelin
GB202205589D0 (en)	2022-04-14	2022-06-01	Crescendo Biologics Ltd	Mesothelin binders
WO2026030428A2 (en)	2024-08-01	2026-02-05	Regeneron Pharmaceuticals, Inc.	Prostate-specific antigen peptides and uses thereof
US20260123608A1 (en)	2024-08-06	2026-05-07	Regeneron Pharmaceuticals, Inc.	Non-human animals having modified immunoglobulin heavy chain constant region locus and uses thereof
WO2026096736A1 (en)	2024-10-31	2026-05-07	Regeneron Pharmaceuticals, Inc.	Rodents expressing humanized polymeric immunoglobulin receptor

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2495083A (en) *	1947-09-19	1950-01-17	Ashaway Line & Twine Mfg	Vise for tying leader ends
US6833268B1 (en)	1999-06-10	2004-12-21	Abgenix, Inc.	Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions
GB0115256D0 (en)	2001-06-21	2001-08-15	Babraham Inst	Mouse light chain locus
JP4149748B2 (ja)	2002-06-24	2008-09-17	三菱商事プラスチック株式会社	ロータリー型量産用ｃｖｄ成膜装置及びプラスチック容器内表面へのｃｖｄ膜成膜方法
GB2398784B (en) *	2003-02-26	2005-07-27	Babraham Inst	Removal and modification of the immunoglobulin constant region gene cluster of a non-human mammal
EP1776383B1 (en)	2004-07-22	2014-08-20	Erasmus University Medical Center Rotterdam	Binding molecules
WO2011072204A1 (en) *	2009-12-10	2011-06-16	Regeneron Pharmaceuticals, Inc.	Mice that make heavy chain antibodies
GB2495083A (en)	2011-09-26	2013-04-03	Kymab Ltd	Human VpreB and chimaeric surrogate light chains in transgenic non-human vertebrates
WO2013045916A1 (en)	2011-09-26	2013-04-04	Kymab Limited	Chimaeric surrogate light chains (slc) comprising human vpreb
GB2502127A (en) *	2012-05-17	2013-11-20	Kymab Ltd	Multivalent antibodies and in vivo methods for their production
WO2014093908A2 (en)	2012-12-14	2014-06-19	Omt, Inc.	Polynucleotides encoding rodent antibodies with human idiotypes and animals comprising same
US10993420B2 (en)	2013-03-15	2021-05-04	Erasmus University Medical Center	Production of heavy chain only antibodies in transgenic mammals
US9788534B2 (en) *	2013-03-18	2017-10-17	Kymab Limited	Animal models and therapeutic molecules
AU2015230938C1 (en)	2014-03-21	2021-10-14	Regeneron Pharmaceuticals, Inc.	Non-human animals that make single domain binding proteins

2014
- 2014-10-22 PL PL14790686T patent/PL3209698T5/pl unknown
- 2014-10-22 CN CN201480082416.0A patent/CN107002092A/zh active Pending
- 2014-10-22 HR HRP20181892TT patent/HRP20181892T4/hr unknown
- 2014-10-22 ES ES14790686T patent/ES2701061T5/es active Active
- 2014-10-22 CN CN202210143798.XA patent/CN114774466A/zh active Pending
- 2014-10-22 PT PT14790686T patent/PT3209698T/pt unknown
- 2014-10-22 AU AU2014409276A patent/AU2014409276A1/en not_active Abandoned
- 2014-10-22 US US15/520,627 patent/US11547099B2/en active Active
- 2014-10-22 DK DK14790686.1T patent/DK3209698T4/da active
- 2014-10-22 EP EP14790686.1A patent/EP3209698B2/en active Active
- 2014-10-22 JP JP2017541172A patent/JP6641379B2/ja active Active
- 2014-10-22 SG SG11201702502XA patent/SG11201702502XA/en unknown
- 2014-10-22 IL IL251010A patent/IL251010B2/en unknown
- 2014-10-22 CA CA2963752A patent/CA2963752A1/en not_active Abandoned
- 2014-10-22 EP EP18192313.7A patent/EP3461848B1/en active Active
- 2014-10-22 WO PCT/GB2014/053146 patent/WO2016062990A1/en not_active Ceased
- 2014-10-22 GB GB1708074.8A patent/GB2547587B/en active Active
- 2014-10-22 KR KR1020177013704A patent/KR20170073647A/ko not_active Withdrawn
2022
- 2022-10-19 US US18/047,673 patent/US20230133028A1/en not_active Abandoned

Also Published As

Publication number	Publication date
AU2014409276A1 (en)	2017-04-06
IL251010B2 (en)	2024-01-01
EP3461848B1 (en)	2023-10-11
US20230133028A1 (en)	2023-05-04
EP3461848A1 (en)	2019-04-03
PL3209698T5 (pl)	2022-04-25
CN114774466A (zh)	2022-07-22
DK3209698T3 (en)	2019-01-07
SG11201702502XA (en)	2017-05-30
EP3209698B2 (en)	2022-02-09
IL251010A0 (en)	2017-04-30
IL251010B1 (en)	2023-09-01
GB2547587A (en)	2017-08-23
GB201708074D0 (en)	2017-07-05
HRP20181892T4 (hr)	2022-04-15
PT3209698T (pt)	2018-12-14
EP3209698A1 (en)	2017-08-30
GB2547587B (en)	2020-12-09
ES2701061T5 (es)	2022-05-09
CA2963752A1 (en)	2016-04-28
JP6641379B2 (ja)	2020-02-05
CN107002092A (zh)	2017-08-01
HRP20181892T1 (hr)	2019-01-11
US11547099B2 (en)	2023-01-10
ES2701061T3 (es)	2019-02-20
KR20170073647A (ko)	2017-06-28
WO2016062990A1 (en)	2016-04-28
DK3209698T4 (da)	2022-04-04
EP3209698B1 (en)	2018-09-05
JP2017537653A (ja)	2017-12-21
EP3461848C0 (en)	2023-10-11
US20180362666A1 (en)	2018-12-20

Publication	Publication Date	Title
IL251010A0 (en)	2017-04-30	transgenic mice
DK3236972T3 (en)	2021-10-04	Antivirale N4-hydroxycytidin-derivativer
GB201413019D0 (en)	2014-09-03	Beyond 1B
AU361515S (en)	2015-04-30	Dishrack
AU362944S (en)	2015-07-28	Lapboard
ZA201702491B (en)	2018-08-29	Optimized braid construction
DK3191586T3 (en)	2020-02-10	Cellobiosephosphorylase
EP3261432A4 (en)	2018-07-25	Transgenic mice
LT3237349T (lt)	2019-09-25	Patobulintas biologinis rišiklis
DK3178931T3 (en)	2021-03-22	Anti-orai1-antistof
DK3002465T3 (en)	2020-02-03	Hydrauliksystem
SG11201702187XA (en)	2017-04-27	Mice
DK3145380T3 (en)	2020-02-03	Toiletventilationssystem
GB2559497B (en)	2019-05-15	Functional wall-tie
DK3234061T3 (en)	2020-08-17	Nano-inhibitorer
GB2584219B (en)	2021-03-24	Transgenic Mice
AU5592P (en)	2015-03-05	Lanmichigan Mandevilla boliviensis x sanderi
AU5593P (en)	2015-03-05	Lanmissouri Mandevilla sanderi
AU5598P (en)	2015-03-05	Lanidaho Mandevilla sanderi
AU5584P (en)	2015-03-05	Laniowa Mandevilla sanderi
AU5597P (en)	2015-03-05	Lancalifornia Mandevilla sanderi
AU5596P (en)	2015-03-05	Lannevada Mandevilla sanderi
AU5583P (en)	2015-03-05	Lanminnesota Mandevilla sanderi
AU5287P (en)	2016-11-18	FLOMANPIW Mandevilla sanderi
AU5286P (en)	2016-11-11	FLOMANWHW Mandevilla sanderi