PL3226888T3 - Podawanie selektywnego transsygnałowego inhibitora IL-6 - Google Patents

Podawanie selektywnego transsygnałowego inhibitora IL-6

Info

Publication number: PL3226888T3
Authority: PL; Poland
Prior art keywords: transsignal; inhibitor; administration; selective; transsignal inhibitor
Prior art date: 2014-12-01

Application number

PL15832692T

Other languages

English (en)

Inventor

Ian Cottingham

Niclas Axel Petri

Original Assignee

Ferring B.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-12-01

Filing date

2015-12-01

Publication date

2021-11-02

2015-12-01 Application filed by Ferring B.V. filed Critical Ferring B.V.

2021-11-02 Publication of PL3226888T3 publication Critical patent/PL3226888T3/pl

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5412—IL-6
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/606—Salicylic acid; Derivatives thereof having amino groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Toxicology (AREA)
Rheumatology (AREA)
Cell Biology (AREA)
Epidemiology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Oncology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Communicable Diseases (AREA)
Pulmonology (AREA)
Ophthalmology & Optometry (AREA)

PL15832692T 2014-12-01 2015-12-01 Podawanie selektywnego transsygnałowego inhibitora IL-6 PL3226888T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201462086054P	2014-12-01	2014-12-01
PCT/IB2015/002459 WO2016087941A1 (en)	2014-12-01	2015-12-01	Administration of a selective il-6-trans-signalling inhibitor
EP15832692.6A EP3226888B1 (en)	2014-12-01	2015-12-01	Administration of a selective il-6-trans-signalling inhibitor

Publications (1)

Publication Number	Publication Date
PL3226888T3 true PL3226888T3 (pl)	2021-11-02

Family

ID=55305021

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL15832692T PL3226888T3 (pl)	2014-12-01	2015-12-01	Podawanie selektywnego transsygnałowego inhibitora IL-6

Country Status (19)

Country	Link
US (2)	US11198721B2 (pl)
EP (2)	EP3226888B1 (pl)
JP (1)	JP6775513B2 (pl)
KR (2)	KR20170135819A (pl)
CN (1)	CN107223132A (pl)
CA (1)	CA2969301A1 (pl)
DK (1)	DK3226888T3 (pl)
ES (1)	ES2875351T3 (pl)
HR (1)	HRP20210737T1 (pl)
HU (1)	HUE054742T2 (pl)
LT (1)	LT3226888T (pl)
MA (2)	MA41114B1 (pl)
MD (1)	MD3226888T2 (pl)
MX (1)	MX2017007067A (pl)
PL (1)	PL3226888T3 (pl)
PT (1)	PT3226888T (pl)
RS (1)	RS61947B1 (pl)
SI (1)	SI3226888T1 (pl)
WO (1)	WO2016087941A1 (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RS65665B1 (sr)	2014-12-01	2024-07-31	Ferring Bv	Selektivne kompozicije inhibitora il-6-trans-signalizacije
JP7432506B2 (ja)	2017-10-30	2024-02-16	武田薬品工業株式会社	脂質エンベロープウイルスを不活化するための環境適合性の界面活性剤
JP7287611B2 (ja) *	2018-02-07	2023-06-06	学校法人日本医科大学	改良型アデノ随伴ウイルスベクター
JP7781786B2 (ja) *	2020-06-10	2025-12-08	フェリング・ベー・フェー	アテローム性動脈硬化性心血管疾患を治療するための医薬化合物
WO2022139580A1 (en)	2020-12-22	2022-06-30	Ferring B.V.	Blood gene expression biomarkers to predict response in patients with inflammatory bowel diseases
CN114681592A (zh) *	2020-12-31	2022-07-01	天境生物科技(杭州)有限公司	包含可溶性gp130二聚体的制剂和使用方法
WO2024011946A1 (en) *	2022-07-12	2024-01-18	I-Mab Biopharma (Hangzhou) Co., Ltd	Polypeptide dimers for the treatment of systemic sclerosis

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US4751180A (en)	1985-03-28	1988-06-14	Chiron Corporation	Expression using fused genes providing for protein product
JPH04218000A (ja)	1990-02-13	1992-08-07	Kirin Amgen Inc	修飾ポリペプチド
AU5670194A (en)	1992-11-20	1994-06-22	Enzon, Inc.	Linker for linked fusion polypeptides
US5457035A (en)	1993-07-23	1995-10-10	Immunex Corporation	Cytokine which is a ligand for OX40
US5783672A (en)	1994-05-26	1998-07-21	Immunex Corporation	Receptor for oncostatin M
US6472179B2 (en)	1998-09-25	2002-10-29	Regeneron Pharmaceuticals, Inc.	Receptor based antagonists and methods of making and using
DE19941897B4 (de)	1999-09-02	2006-06-14	GSF - Forschungszentrum für Umwelt und Gesundheit GmbH	IL-6 Rezeptor-Protein, Beta-Kette (gp130) des IL-6 Rezeptor-Proteins, für diese Proteine kodierende DNA, davon abgeleitete RNA, Peptid mit den Aminosäuren 771-811 dieser Beta-Kette oder Teilen davon und deren Verwendungen
JP5179689B2 (ja)	2000-02-11	2013-04-10	メルクパテントゲゼルシャフトミットベシュレンクテルハフツング	抗体ベース融合タンパク質の循環系内半減期の増強
ES2298106T3 (es)	2000-04-21	2008-05-16	Conaris Research Institute Ag	Proteinas de fusion que comprenden dos moleculas gp130 solubles.
CA2447236A1 (en)	2001-05-21	2002-11-28	Nektar Therapeutics	Pulmonary administration of chemically modified insulin
WO2003008454A2 (en)	2001-07-18	2003-01-30	Merck Patent Gmbh	Glycoprotein vi fusion proteins
US6887687B2 (en)	2001-07-30	2005-05-03	Immunex Corporation	Nucleic acids encoding human ataxin-1-like polypeptide IMX97018
JP2004182638A (ja)	2002-12-03	2004-07-02	Yakult Honsha Co Ltd	炎症性疾患又は悪性腫瘍の予防治療剤
EP1491554A1 (en)	2003-06-23	2004-12-29	CONARIS research institute AG	PEGylated soluble gp130-dimers useful as a medicament
EP1630232B1 (en)	2004-08-27	2008-07-02	CONARIS research institute AG	Optimized nucleotide sequences encoding sgp130
EP1801121A1 (en)	2005-12-23	2007-06-27	CONARIS research institute AG	Soluble gp130 molecule variants useful as a medicament
EA200870130A1 (ru) *	2005-12-30	2009-02-27	Мерк Патент Гмбх	Антитела против ил-6, предотвращающие связывание с gp130 комплекса ил-6 и альфа-рецептора ил-6
ES2352561T3 (es) *	2006-06-30	2011-02-21	Conaris Research Institute Ag	Dímeros de sgp 130fc mejorados.
EP2050759A1 (en)	2007-10-19	2009-04-22	CONARIS research institute AG	Soluble gp 130 muteins with improved binding activity
DK2661492T3 (en)	2011-01-06	2018-01-15	Univ Johns Hopkins	Method for Preparing Recombinant Glycoproteins with Increased Circuit Half Life in Mammalian Cells
RS65665B1 (sr)	2014-12-01	2024-07-31	Ferring Bv	Selektivne kompozicije inhibitora il-6-trans-signalizacije

2015
- 2015-12-01 EP EP15832692.6A patent/EP3226888B1/en active Active
- 2015-12-01 JP JP2017547084A patent/JP6775513B2/ja active Active
- 2015-12-01 KR KR1020177018155A patent/KR20170135819A/ko not_active Ceased
- 2015-12-01 MA MA41114A patent/MA41114B1/fr unknown
- 2015-12-01 CA CA2969301A patent/CA2969301A1/en active Pending
- 2015-12-01 MD MDE20170156T patent/MD3226888T2/ro unknown
- 2015-12-01 KR KR1020247038063A patent/KR20240166606A/ko active Pending
- 2015-12-01 MX MX2017007067A patent/MX2017007067A/es unknown
- 2015-12-01 ES ES15832692T patent/ES2875351T3/es active Active
- 2015-12-01 LT LTEP15832692.6T patent/LT3226888T/lt unknown
- 2015-12-01 WO PCT/IB2015/002459 patent/WO2016087941A1/en not_active Ceased
- 2015-12-01 HR HRP20210737TT patent/HRP20210737T1/hr unknown
- 2015-12-01 SI SI201531602T patent/SI3226888T1/sl unknown
- 2015-12-01 PT PT158326926T patent/PT3226888T/pt unknown
- 2015-12-01 EP EP21162245.1A patent/EP3912636B1/en active Active
- 2015-12-01 RS RS20210709A patent/RS61947B1/sr unknown
- 2015-12-01 DK DK15832692.6T patent/DK3226888T3/da active
- 2015-12-01 MA MA054761A patent/MA54761A/fr unknown
- 2015-12-01 HU HUE15832692A patent/HUE054742T2/hu unknown
- 2015-12-01 PL PL15832692T patent/PL3226888T3/pl unknown
- 2015-12-01 CN CN201580075096.0A patent/CN107223132A/zh active Pending
- 2015-12-01 US US15/532,092 patent/US11198721B2/en active Active
2021
- 2021-11-09 US US17/522,320 patent/US20220135652A1/en active Pending

Also Published As

Publication number	Publication date
KR20240166606A (ko)	2024-11-26
US11198721B2 (en)	2021-12-14
EP3226888B1 (en)	2021-04-21
JP6775513B2 (ja)	2020-10-28
DK3226888T3 (da)	2021-07-12
CA2969301A1 (en)	2016-06-09
CN107223132A (zh)	2017-09-29
US20170320932A1 (en)	2017-11-09
PT3226888T (pt)	2021-06-02
KR20170135819A (ko)	2017-12-08
HUE054742T2 (hu)	2021-09-28
EP3226888A1 (en)	2017-10-11
EP3912636B1 (en)	2026-02-11
HRP20210737T1 (hr)	2021-06-11
ES2875351T3 (es)	2021-11-10
MA41114B1 (fr)	2021-06-30
MA54761A (fr)	2021-11-24
SI3226888T1 (sl)	2021-08-31
MX2017007067A (es)	2018-04-30
RS61947B1 (sr)	2021-07-30
EP3912636A1 (en)	2021-11-24
WO2016087941A1 (en)	2016-06-09
US20220135652A1 (en)	2022-05-05
JP2017537155A (ja)	2017-12-14
MD3226888T2 (ro)	2021-08-31
LT3226888T (lt)	2021-05-25

Publication	Publication Date	Title
FIC20230006I1 (fi)	2023-02-06	Vutrisiraani
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LT3303334T (lt)	2021-07-12	Tirozinkinazės inhibitoriai
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PL3417725T3 (pl)	2021-10-18	Fajka wodna
DK3442972T3 (da)	2020-04-27	Bromdomænehæmmere
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KR102494289B9 (ko)	2024-08-22	활성 혼합물
BR112017000042A2 (pt)	2018-07-17	inibidores de desmetilase-1 lisina-específica
DK3341379T3 (da)	2019-12-02	EZH2-hæmmere
DK3186242T3 (da)	2021-12-20	Alfa-amino-beta-carboxymuconsyre-semialdehyd-decarboxylasehæmmere
DK3283210T3 (da)	2021-11-22	Fremgangsmåde
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PL3227325T3 (pl)	2024-10-07	Selektywne kompozycje inhibitorów trans-sygnałowania il-6
LT3212237T (lt)	2022-02-25	Metotreksato vaistinė forma
HUE054742T2 (hu)	2021-09-28	Szelektív IL-6-transz-szignalizációs inhibitor beadása
IL254502A0 (en)	2017-11-30	Solid forms of menaquinols
DE112016003293A5 (de)	2018-04-26	Feuerlöscher
DK3298133T3 (da)	2019-12-09	Acetatforbrugende gærcelle
DK3481826T3 (da)	2022-01-10	Tyrosinkinaseinhibitorer