PL3233832T3 - Podstawione aminotriazole przydatne jako inhibitory kwaśnej chitynazy ssaków - Google Patents

Podstawione aminotriazole przydatne jako inhibitory kwaśnej chitynazy ssaków

Info

Publication number
PL3233832T3
PL3233832T3 PL15825641T PL15825641T PL3233832T3 PL 3233832 T3 PL3233832 T3 PL 3233832T3 PL 15825641 T PL15825641 T PL 15825641T PL 15825641 T PL15825641 T PL 15825641T PL 3233832 T3 PL3233832 T3 PL 3233832T3
Authority
PL
Poland
Prior art keywords
substituted amino
mammalian chitinase
acidic mammalian
triazoles useful
amino triazoles
Prior art date
Application number
PL15825641T
Other languages
English (en)
Inventor
Adam A. GOŁĘBIOWSKI
Robert KORALEWSKI
Wojciech CZESTKOWSKI
Krzysztof MATYSZEWSKI
Sylwia OLEJNICZAK
Jacek OLCZAK
Paul R. BECKETT
Original Assignee
Oncoarendi Therapeutics S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncoarendi Therapeutics S.A. filed Critical Oncoarendi Therapeutics S.A.
Publication of PL3233832T3 publication Critical patent/PL3233832T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/924Hydrolases (3) acting on glycosyl compounds (3.2)
    • G01N2333/942Hydrolases (3) acting on glycosyl compounds (3.2) acting on beta-1, 4-glucosidic bonds, e.g. cellulase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/04Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/12Pulmonary diseases
    • G01N2800/122Chronic or obstructive airway disorders, e.g. asthma COPD
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL15825641T 2014-12-19 2015-12-18 Podstawione aminotriazole przydatne jako inhibitory kwaśnej chitynazy ssaków PL3233832T3 (pl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462094446P 2014-12-19 2014-12-19
US14/959,369 US9440953B2 (en) 2014-12-19 2015-12-04 Substituted amino triazoles useful as acidic mammalian chitinase inhibitors
PL415073A PL415073A1 (pl) 2014-12-19 2015-12-04 Podstawione aminotriazole przydatne jako inhibitory kwaśnej chitynazy ssaków
EP15825641.2A EP3233832B1 (en) 2014-12-19 2015-12-18 Substituted amino triazoles useful as acidic mammalian chitinase inhibitors
PCT/PL2015/050071 WO2016099311A1 (en) 2014-12-19 2015-12-18 Substituted amino triazoles useful as acidic mammalian chitinase inhibitors

Publications (1)

Publication Number Publication Date
PL3233832T3 true PL3233832T3 (pl) 2020-06-29

Family

ID=56120793

Family Applications (2)

Application Number Title Priority Date Filing Date
PL415073A PL415073A1 (pl) 2014-12-19 2015-12-04 Podstawione aminotriazole przydatne jako inhibitory kwaśnej chitynazy ssaków
PL15825641T PL3233832T3 (pl) 2014-12-19 2015-12-18 Podstawione aminotriazole przydatne jako inhibitory kwaśnej chitynazy ssaków

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL415073A PL415073A1 (pl) 2014-12-19 2015-12-04 Podstawione aminotriazole przydatne jako inhibitory kwaśnej chitynazy ssaków

Country Status (8)

Country Link
US (2) US9440953B2 (pl)
EP (1) EP3233832B1 (pl)
CN (1) CN107428720B (pl)
AU (1) AU2015363761B2 (pl)
CA (1) CA2971395A1 (pl)
PL (2) PL415073A1 (pl)
WO (1) WO2016099311A1 (pl)
ZA (1) ZA201704879B (pl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL415078A1 (pl) * 2015-09-04 2017-03-13 Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością Podstawione aminotriazole przydatne jako inhibitory kwaśnej chitynazy ssaków
MX2022000306A (es) 2019-07-15 2022-03-11 Oncoarendi Therapeutics Sa Amino triazoles sustituidos utiles como inhibidores de quitinasa.
MX2022002881A (es) 2019-09-25 2022-06-08 Oncoarendi Therapeutics Sa Proceso para la produccion de 5-(4-((2s,5s)-5-(4-clorobencil)-2-me tilmorfolino)piperidin-1-il)-1h-1,2,4-triazol-3-amina.
US11912647B2 (en) 2020-05-22 2024-02-27 University Of Georgia Research Foundation, Inc. Diversity-oriented synthesis of N,N,O-trisubstituted hydroxylamines from alcohols and amines by N—O bond formation
CN111732571B (zh) * 2020-07-24 2021-06-29 广西壮族自治区农业科学院 一种用于防治香蕉枯萎病的杀植物真菌剂

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4276297A (en) * 1979-06-18 1981-06-30 Pfizer Inc. Pyridylaminotriazole therapeutic agents
US4421753A (en) * 1982-01-15 1983-12-20 American Cyanamid Company 1-(5-Amino-4H-1,2,4-triazol-3-yl)-4-substituted-piperazines
JP3507486B2 (ja) 1991-03-15 2004-03-15 アムジエン・インコーポレーテツド 顆粒球コロニー刺激因子の肺内投与
US5451569A (en) 1994-04-19 1995-09-19 Hong Kong University Of Science And Technology R & D Corporation Limited Pulmonary drug delivery system
EP3082805B1 (en) 2013-12-20 2020-02-05 Institute for Drug Discovery, LLC Substituted amino triazoles, and methods using same

Also Published As

Publication number Publication date
EP3233832A1 (en) 2017-10-25
EP3233832B1 (en) 2019-11-20
CA2971395A1 (en) 2016-06-23
US20160176843A1 (en) 2016-06-23
PL415073A1 (pl) 2016-06-20
AU2015363761B2 (en) 2020-07-09
ZA201704879B (en) 2020-01-29
US9440953B2 (en) 2016-09-13
CN107428720B (zh) 2020-06-30
US20160368894A1 (en) 2016-12-22
CN107428720A (zh) 2017-12-01
WO2016099311A1 (en) 2016-06-23
WO2016099311A4 (en) 2016-09-09
AU2015363761A1 (en) 2017-07-20

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