PL3247791T3 - Uniwersalne komórki nkt - Google Patents

Uniwersalne komórki nkt

Info

Publication number: PL3247791T3
Authority: PL; Poland
Prior art keywords: universal; nkt cells; nkt; cells; universal nkt
Prior art date: 2015-01-23

Application number

PL16701339.0T

Other languages

English (en)

Inventor

Sébastien WÄLCHLI

Else Marit INDERBERG

Gustav Gaudernack

Gunnar Kvalheim

Original Assignee

Oslo Universitetssykehus Hf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-01-23

Filing date

2016-01-22

Publication date

2022-09-05

2016-01-22 Application filed by Oslo Universitetssykehus Hf filed Critical Oslo Universitetssykehus Hf

2022-09-05 Publication of PL3247791T3 publication Critical patent/PL3247791T3/pl

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/32—T-cell receptors [TCR]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4225—Growth factors
- A61K40/4229—Transforming growth factor [TGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4244—Enzymes
- A61K40/4246—Telomerase or [telomerase reverse transcriptase [TERT]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4271—Melanoma antigens
- A61K40/4272—Melan-A/MART
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/27—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by targeting or presenting multiple antigens
- A61K2239/28—Expressing multiple CARs, TCRs or antigens
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/99—Coculture with; Conditioned medium produced by genetically modified cells

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Cell Biology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
Hematology (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Toxicology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Virology (AREA)
Developmental Biology & Embryology (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

PL16701339.0T 2015-01-23 2016-01-22 Uniwersalne komórki nkt PL3247791T3 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB1501175.2A GB201501175D0 (en)	2015-01-23	2015-01-23	A universal T-cell for personalised medicine
PCT/EP2016/051344 WO2016116601A1 (en)	2015-01-23	2016-01-22	Universal killer t-cell

Publications (1)

Publication Number	Publication Date
PL3247791T3 true PL3247791T3 (pl)	2022-09-05

Family

ID=52673865

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL16701339.0T PL3247791T3 (pl)	2015-01-23	2016-01-22	Uniwersalne komórki nkt

Country Status (17)

Country	Link
US (2)	US11155786B2 (pl)
EP (3)	EP4095239A1 (pl)
JP (1)	JP6899333B2 (pl)
KR (1)	KR102479118B1 (pl)
CN (1)	CN107250351A (pl)
AU (2)	AU2016208475B2 (pl)
CA (1)	CA2973924C (pl)
DK (1)	DK3247791T3 (pl)
EA (1)	EA201791381A1 (pl)
ES (1)	ES2922231T3 (pl)
GB (1)	GB201501175D0 (pl)
IL (1)	IL253464B (pl)
MX (1)	MX390756B (pl)
PL (1)	PL3247791T3 (pl)
PT (1)	PT3247791T (pl)
SG (1)	SG11201705693XA (pl)
WO (1)	WO2016116601A1 (pl)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB201501175D0 (en) *	2015-01-23	2015-03-11	Univ Oslo Hf	A universal T-cell for personalised medicine
MX2017014822A (es)	2015-05-18	2018-04-30	Tcr2 Therapeutics Inc	Composiciones y métodos para la reprogramación del tcr con proteínas de fusión.
WO2017192440A1 (en) *	2016-05-02	2017-11-09	Cerus Corporation	Compositions and methods for improved nk cell therapies
CA3032498A1 (en)	2016-08-02	2018-02-08	TCR2 Therapeutics Inc.	Compositions and methods for tcr reprogramming using fusion proteins
MX2019003899A (es)	2016-10-07	2019-08-14	Tcr2 Therapeutics Inc	Composiciones y metodos para reprogramacion de receptores de linfocitos t mediante el uso de proteinas de fusion.
EP3544996A2 (en)	2016-11-22	2019-10-02	TCR2 Therapeutics Inc.	Compositions and methods for tcr reprogramming using fusion proteins
US20190358263A1 (en)	2016-12-07	2019-11-28	Oslo Universitetssykehus Hf	Compositions and Methods for Cell Therapy
US11752172B2 (en) *	2017-01-04	2023-09-12	Nova Southeastern University	Natural killer (NK) cells expressing an antigen-specific functional T cell receptor (TCR) complex, methods for production thereof, and methods for therapeutic use thereof
GB201803178D0 (en)	2018-02-27	2018-04-11	Univ Oslo Hf	Specific binding molecules for htert
WO2020043903A1 (en) *	2018-08-31	2020-03-05	Invectys	Method to assess car functionality
US20220362304A1 (en) *	2019-03-20	2022-11-17	2Seventy Bio, Inc.	Adoptive cell therapy
JP6977969B2 (ja) *	2019-03-22	2021-12-08	株式会社ガイアバイオメディシン	免疫細胞提供システム
EP3750547A1 (en) *	2019-06-13	2020-12-16	Universitätsmedizin der Johannes Gutenberg-Universität Mainz	Modified nk-92 cells, and therapeutic and diagnostic uses thereof
EP4004181A1 (en)	2019-07-29	2022-06-01	Massachusetts Institute Of Technology	Synthetic hydrogels for organogenesis
CN111662871A (zh) *	2020-06-11	2020-09-15	福建医科大学孟超肝胆医院(福州市传染病医院)	一种核酸适体功能化nk细胞及其制备与应用
CN116615445A (zh)	2020-09-24	2023-08-18	基因医疗免疫疗法有限责任公司	Prame特异性t细胞受体及其用途
TW202233831A (zh) *	2020-11-03	2022-09-01	中國大陸商杭州啟函生物科技有限公司	增強免疫療法的系統和方法
GB202017873D0 (en)	2020-11-12	2020-12-30	Olso Unversitetssykehus Hf	Method of determining DLBCL prognosis
KR20220160479A (ko) *	2021-05-27	2022-12-06	(주)에스엠티바이오	신경내분비종양의 치료용 자연살해세포
JP2024534537A (ja)	2021-09-21	2024-09-20	オスロユニヴェルジテットサイケフスホーエフ	末端デオキシヌクレオチジルトランスフェラーゼ（ＴｄＴ）の結合タンパク質
WO2023078287A1 (en) *	2021-11-03	2023-05-11	Hangzhou Qihan Biotechnology Co., Ltd.	Systems and methods for enhanced immunotherapies
CN119744173A (zh) *	2022-07-22	2025-04-01	得克萨斯大学体系董事会	用于过继免疫疗法的具有增强功能的表达cd3的自然杀伤细胞
CN121358493A (zh)	2023-06-20	2026-01-16	泽卢纳免疫疗法公司	增强或修饰nk细胞的方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5124251A (en)	1990-01-31	1992-06-23	Becton, Dickinson And Company	CD3 ζ co-associated complex on CD16- NK cells
DE69834257T2 (de)	1997-04-30	2007-01-04	Klingemann, Hans	Natürliche killerzelllinien und verfahren zu ihrer verwendung
IL127142A0 (en)	1998-11-19	1999-09-22	Yeda Res & Dev	Immune cells having predefined biological specificity
EP1470159B1 (en)	2001-12-04	2013-08-07	Dana-Farber Cancer Institute, Inc.	Antibody to latent membrane proteins and uses thereof
EP2801583B1 (en)	2004-07-10	2018-04-25	Fox Chase Cancer Center	Genetically modified human natural killer cell lines
US20090104170A1 (en) *	2004-11-02	2009-04-23	Richard William Wyatt Childs	Compositions and methods for treating hyperproliferative disorders
US8518697B2 (en)	2006-04-04	2013-08-27	Washington University	Single chain trimers and uses therefor
CN101631138A (zh)	2008-07-18	2010-01-20	深圳富泰宏精密工业有限公司	个人信息代理系统及方法
US8785601B2 (en) *	2009-01-28	2014-07-22	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	T cell receptors and related materials and methods of use
DK2817620T3 (en) *	2012-02-22	2016-09-05	Verik Bio Inc	IMMUNTERY TREATMENT SYSTEM FOR TUMOR FORMATION AND PROGRESSION
US11471486B2 (en)	2012-09-04	2022-10-18	Inven2 As	Selective and controlled expansion of educated NK cells
WO2014117121A1 (en)	2013-01-28	2014-07-31	St. Jude Children's Research Hospital, Inc.	A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease
CA2900380A1 (en)	2013-02-04	2014-08-07	Roger Williams Medical Center	Methods and compositions for treating gastrointestinal stromal tumor(gist)
JP6425301B2 (ja) *	2014-05-29	2018-11-21	国立大学法人富山大学	Ｔｃｒの細胞傷害活性誘導能を評価するためのｎｋ細胞株、およびその作製方法
EP3157958B1 (en)	2014-06-18	2020-05-06	Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus	Car-expressing nk-92 cells as cell therapeutic agents
US20170274014A1 (en) *	2014-07-21	2017-09-28	Jennifer Brogdon	Combinations of low, immune enhancing, doses of mtor inhibitors and cars
GB201501175D0 (en) *	2015-01-23	2015-03-11	Univ Oslo Hf	A universal T-cell for personalised medicine

2015
- 2015-01-23 GB GBGB1501175.2A patent/GB201501175D0/en not_active Ceased
2016
- 2016-01-22 US US15/545,021 patent/US11155786B2/en active Active
- 2016-01-22 ES ES16701339T patent/ES2922231T3/es active Active
- 2016-01-22 PL PL16701339.0T patent/PL3247791T3/pl unknown
- 2016-01-22 WO PCT/EP2016/051344 patent/WO2016116601A1/en not_active Ceased
- 2016-01-22 EP EP22170488.5A patent/EP4095239A1/en not_active Withdrawn
- 2016-01-22 MX MX2017009459A patent/MX390756B/es unknown
- 2016-01-22 AU AU2016208475A patent/AU2016208475B2/en active Active
- 2016-01-22 PT PT167013390T patent/PT3247791T/pt unknown
- 2016-01-22 JP JP2017557481A patent/JP6899333B2/ja active Active
- 2016-01-22 KR KR1020177023284A patent/KR102479118B1/ko active Active
- 2016-01-22 EP EP25201972.4A patent/EP4681735A3/en active Pending
- 2016-01-22 CA CA2973924A patent/CA2973924C/en active Active
- 2016-01-22 SG SG11201705693XA patent/SG11201705693XA/en unknown
- 2016-01-22 DK DK16701339.0T patent/DK3247791T3/da active
- 2016-01-22 CN CN201680006587.4A patent/CN107250351A/zh active Pending
- 2016-01-22 EP EP16701339.0A patent/EP3247791B1/en active Active
- 2016-01-22 EA EA201791381A patent/EA201791381A1/ru unknown
2017
- 2017-07-13 IL IL253464A patent/IL253464B/en unknown
2021
- 2021-09-23 US US17/483,484 patent/US20220127574A1/en not_active Abandoned
2022
- 2022-01-11 AU AU2022200126A patent/AU2022200126A1/en not_active Abandoned

Also Published As

Publication number	Publication date
AU2016208475A1 (en)	2017-08-03
CA2973924A1 (en)	2016-07-28
US20220127574A1 (en)	2022-04-28
EP3247791B1 (en)	2022-05-04
NZ733855A (en)	2023-10-27
US11155786B2 (en)	2021-10-26
GB201501175D0 (en)	2015-03-11
CA2973924C (en)	2024-06-04
ES2922231T3 (es)	2022-09-12
KR20170121178A (ko)	2017-11-01
BR112017015631A2 (pt)	2018-03-13
IL253464A0 (en)	2017-09-28
PT3247791T (pt)	2022-07-20
JP6899333B2 (ja)	2021-07-07
IL253464B (en)	2022-04-01
MX2017009459A (es)	2018-04-11
EP4681735A3 (en)	2026-03-25
EP3247791A1 (en)	2017-11-29
KR102479118B1 (ko)	2022-12-16
WO2016116601A1 (en)	2016-07-28
SG11201705693XA (en)	2017-08-30
JP2018512047A (ja)	2018-05-10
AU2016208475B2 (en)	2021-10-14
DK3247791T3 (da)	2022-07-11
EP4681735A2 (en)	2026-01-21
MX390756B (es)	2025-03-04
EA201791381A1 (ru)	2018-02-28
AU2022200126A1 (en)	2022-02-10
CN107250351A (zh)	2017-10-13
EP4095239A1 (en)	2022-11-30
US20180010097A1 (en)	2018-01-11

Publication	Publication Date	Title
PL3247791T3 (pl)	2022-09-05	Uniwersalne komórki nkt
KR102034727B9 (ko)	2021-07-29	배터리 모듈
PL3560953T3 (pl)	2024-05-13	Komórka
EP3858365C0 (en)	2024-01-31	T CAR CELLS OPTIMIZED WITH GOLD
PL3288830T3 (pl)	2025-07-14	Jednostka nadzoru
DK3356188T3 (da)	2020-11-16	Batterisystem
PL3118311T3 (pl)	2019-09-30	Antysensowny kwas nukleinowy
PL3151327T3 (pl)	2019-11-29	Roztwór elektrolitu
PL3547392T3 (pl)	2025-07-07	Akumulator
DK3174483T3 (da)	2022-01-03	Hyporørkonstruktion
DK3341303T3 (da)	2020-02-17	Blisterpakning
DK3526827T3 (da)	2022-09-19	Batterienhed
DK3365107T3 (da)	2020-10-26	Cellekultur
EP3370324A4 (en)	2019-06-05	CHARGER
EP3341117C0 (en)	2024-11-13	Reactor
DE112015003671A5 (de)	2017-05-04	Befeuchter
EP3309797A4 (en)	2019-03-06	SOLID ELECTROLYTE
UA30460S (uk)	2015-09-25	Акумуляторна батарея
ES1141181Y (es)	2015-09-30	Envase con abrefacil incorporado
UA34266S (uk)	2017-04-10	Акумуляторна батарея
TH1601003330A (th)	2017-06-29	เซลล์หุ่นยนต์
FI20155407A7 (fi)	2016-11-30	Akkujärjestelmä
UA35580S (uk)	2017-10-25	Акумуляторна батарея
UA35581S (uk)	2017-10-25	Акумуляторна батарея
UA35362S (uk)	2017-09-25	Акумуляторна батарея