PL3277682T3 - Pochodne 6-morfolinylo-2-pirazolylo-9h-puryny i ich zastosowanie jako inhibitory pi3k - Google Patents
Pochodne 6-morfolinylo-2-pirazolylo-9h-puryny i ich zastosowanie jako inhibitory pi3kInfo
- Publication number
- PL3277682T3 PL3277682T3 PL16718910T PL16718910T PL3277682T3 PL 3277682 T3 PL3277682 T3 PL 3277682T3 PL 16718910 T PL16718910 T PL 16718910T PL 16718910 T PL16718910 T PL 16718910T PL 3277682 T3 PL3277682 T3 PL 3277682T3
- Authority
- PL
- Poland
- Prior art keywords
- morpholinyl
- pyrazolyl
- purine derivatives
- pi3k inhibitors
- pi3k
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN878DE2015 | 2015-03-30 | ||
| EP16718910.9A EP3277682B1 (en) | 2015-03-30 | 2016-03-29 | 6-morpholinyl-2-pyrazolyl-9h-purine derivatives and their use as pi3k inhibitors |
| PCT/IB2016/051762 WO2016157074A1 (en) | 2015-03-30 | 2016-03-29 | 6-morpholinyl-2-pyrazolyl-9h-purine derivatives and their use as pi3k inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3277682T3 true PL3277682T3 (pl) | 2019-09-30 |
Family
ID=55854760
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL16718910T PL3277682T3 (pl) | 2015-03-30 | 2016-03-29 | Pochodne 6-morfolinylo-2-pirazolylo-9h-puryny i ich zastosowanie jako inhibitory pi3k |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US10174035B2 (pl) |
| EP (1) | EP3277682B1 (pl) |
| JP (1) | JP6669417B2 (pl) |
| KR (1) | KR20170131444A (pl) |
| CN (1) | CN107428756B (pl) |
| AU (1) | AU2016242080B2 (pl) |
| BR (1) | BR112017020818A2 (pl) |
| CA (1) | CA2980517C (pl) |
| CO (1) | CO2017011020A2 (pl) |
| CY (1) | CY1122018T1 (pl) |
| DK (1) | DK3277682T3 (pl) |
| ES (1) | ES2733505T3 (pl) |
| HK (1) | HK1250161B (pl) |
| HR (1) | HRP20190998T1 (pl) |
| HU (1) | HUE045192T2 (pl) |
| IL (1) | IL254688B (pl) |
| LT (1) | LT3277682T (pl) |
| MX (1) | MX2017012390A (pl) |
| MY (1) | MY185268A (pl) |
| PH (1) | PH12017501750A1 (pl) |
| PL (1) | PL3277682T3 (pl) |
| PT (1) | PT3277682T (pl) |
| RS (1) | RS59213B1 (pl) |
| RU (1) | RU2710549C2 (pl) |
| SG (1) | SG11201706509QA (pl) |
| SI (1) | SI3277682T1 (pl) |
| SM (1) | SMT201900405T1 (pl) |
| TR (1) | TR201910941T4 (pl) |
| TW (1) | TWI689508B (pl) |
| WO (1) | WO2016157074A1 (pl) |
| ZA (1) | ZA201705530B (pl) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10822336B2 (en) * | 2016-09-29 | 2020-11-03 | Daiichi Sankyo Company, Limited | Crystals of [2-(1-methyl-1H-pyrazol-4-yl)-6(morpholin-4-yl)-9H-purin-8-yl][4-(morpholin-4-yl)piperidin-1-yl]methanone and pharmaceutically acceptable salt thereof |
| CN107163061A (zh) * | 2017-04-14 | 2017-09-15 | 江西科技师范大学 | 含吡唑啉结构的噻吩并嘧啶类化合物的制备及应用 |
| CN110963955A (zh) * | 2018-09-30 | 2020-04-07 | 南京富润凯德生物医药有限公司 | 一种单氟代螺环化合物的合成方法及其中间体 |
| CN111087336A (zh) * | 2018-10-24 | 2020-05-01 | 南京富润凯德生物医药有限公司 | 一种双氟代螺环化合物的合成方法及其中间体 |
| CN110577515B (zh) * | 2019-09-02 | 2022-05-17 | 南通大学 | 一种4-(氮杂环丁烷-3-基)-1-甲基哌嗪-2-酮二盐酸盐的合成方法 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003284142A1 (en) | 2002-10-15 | 2004-05-04 | Synta Pharmaceuticals Corp | Aromatic bicyclic heterocyles to modulate 1L-12 production |
| WO2005000404A2 (en) | 2003-05-29 | 2005-01-06 | Synta Pharmaceuticals, Corp. | Heterocyclic compounds for preventing and treating disorders associated with excessive bone loss |
| GB2431156A (en) | 2005-10-11 | 2007-04-18 | Piramed Ltd | 1-cyclyl-3-substituted- -benzenes and -azines as inhibitors of phosphatidylinositol 3-kinase |
| PL2041139T3 (pl) * | 2006-04-26 | 2012-05-31 | Hoffmann La Roche | Związki farmaceutyczne |
| AU2007243466B2 (en) * | 2006-04-26 | 2012-01-19 | F. Hoffmann-La Roche Ag | Phosphoinositide 3-kinase inhibitor compounds and pharmaceutical compositions containing them |
| US20080233127A1 (en) | 2007-03-21 | 2008-09-25 | Wyeth | Imidazolopyrimidine analogs and their use as pi3 kinase and mtor inhibitors |
| WO2009034386A1 (en) | 2007-09-13 | 2009-03-19 | Astrazeneca Ab | Derivatives of adenine and 8-aza-adenine and uses thereof-796 |
| ES2406129T3 (es) | 2007-10-05 | 2013-06-05 | Verastem, Inc. | Derivados de purina sustituidos con pirimidina |
| EP2209785A1 (en) | 2007-10-05 | 2010-07-28 | S*BIO Pte Ltd | 2-morpholinylpurines as inhibitors of pi3k |
| JP5638955B2 (ja) | 2007-10-26 | 2014-12-10 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Pi3キナーゼ阻害剤として有用なプリン誘導体 |
| US20110098267A1 (en) | 2008-02-07 | 2011-04-28 | Synta Pharmaceuticals Corporation | Topical formulations for the treatment of psoriasis |
| ES2533788T3 (es) | 2008-05-30 | 2015-04-14 | Genentech, Inc. | Compuestos inhibidores de PI3K de tipo purina y métodos de uso |
| AU2009269087A1 (en) | 2008-07-07 | 2010-01-14 | Xcovery Holding Company Llc | PI3K isoform selective inhibitors |
| TWI378933B (en) | 2008-10-14 | 2012-12-11 | Daiichi Sankyo Co Ltd | Morpholinopurine derivatives |
| WO2010114494A1 (en) | 2009-04-03 | 2010-10-07 | S*Bio Pte Ltd | 8-substituted-2-morpholino purines for use as pi3k and/or mtor inhibitors in the treatment of proliferative disorders |
| SG182247A1 (en) | 2009-05-27 | 2012-08-30 | Hoffmann La Roche | Bicyclic indole-pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use |
| MX2011012520A (es) * | 2009-05-27 | 2011-12-12 | Hoffmann La Roche | Compuestos inhibidores de pi3k de pirimidina biciclicos selectivos para p110 delta y metodos de uso de los mismos. |
| WO2011058027A2 (en) | 2009-11-12 | 2011-05-19 | F. Hoffmann-La Roche Ag | N-9-substituted purine compounds, compositions and methods of use |
| MX2013000389A (es) | 2010-07-14 | 2013-03-08 | Hoffmann La Roche | Compuestos de purina selectivos para fosfatidilinositol 3-cinasa p110 delta, y metodods de uso. |
| EP2616469B1 (en) | 2010-09-14 | 2016-10-26 | Exelixis, Inc. | 9h-purine compounds as pi3k-delta inhibitors and methods for their manufacture |
| EA026134B1 (ru) | 2010-12-16 | 2017-03-31 | Ф. Хоффманн-Ля Рош Аг | Трициклические ингибиторы pi3k и способы их применения |
| WO2012104776A1 (en) | 2011-01-31 | 2012-08-09 | Novartis Ag | Novel heterocyclic derivatives |
| US8653089B2 (en) | 2011-02-09 | 2014-02-18 | F. Hoffmann-La Roche Ag | Heterocyclic compounds and methods of use |
-
2016
- 2016-03-29 TR TR2019/10941T patent/TR201910941T4/tr unknown
- 2016-03-29 TW TW105109845A patent/TWI689508B/zh not_active IP Right Cessation
- 2016-03-29 HR HRP20190998TT patent/HRP20190998T1/hr unknown
- 2016-03-29 HU HUE16718910A patent/HUE045192T2/hu unknown
- 2016-03-29 DK DK16718910.9T patent/DK3277682T3/da active
- 2016-03-29 SG SG11201706509QA patent/SG11201706509QA/en unknown
- 2016-03-29 JP JP2017545934A patent/JP6669417B2/ja not_active Expired - Fee Related
- 2016-03-29 KR KR1020177026959A patent/KR20170131444A/ko not_active Withdrawn
- 2016-03-29 CA CA2980517A patent/CA2980517C/en not_active Expired - Fee Related
- 2016-03-29 ES ES16718910T patent/ES2733505T3/es active Active
- 2016-03-29 MX MX2017012390A patent/MX2017012390A/es active IP Right Grant
- 2016-03-29 RS RSP20190941 patent/RS59213B1/sr unknown
- 2016-03-29 SI SI201630267T patent/SI3277682T1/sl unknown
- 2016-03-29 MY MYPI2017001151A patent/MY185268A/en unknown
- 2016-03-29 AU AU2016242080A patent/AU2016242080B2/en not_active Ceased
- 2016-03-29 SM SM20190405T patent/SMT201900405T1/it unknown
- 2016-03-29 LT LTEP16718910.9T patent/LT3277682T/lt unknown
- 2016-03-29 RU RU2017134110A patent/RU2710549C2/ru active
- 2016-03-29 BR BR112017020818-0A patent/BR112017020818A2/pt not_active IP Right Cessation
- 2016-03-29 WO PCT/IB2016/051762 patent/WO2016157074A1/en not_active Ceased
- 2016-03-29 US US15/560,466 patent/US10174035B2/en active Active
- 2016-03-29 EP EP16718910.9A patent/EP3277682B1/en active Active
- 2016-03-29 PT PT16718910T patent/PT3277682T/pt unknown
- 2016-03-29 CN CN201680019892.7A patent/CN107428756B/zh not_active Expired - Fee Related
- 2016-03-29 HK HK18109578.1A patent/HK1250161B/en not_active IP Right Cessation
- 2016-03-29 PL PL16718910T patent/PL3277682T3/pl unknown
-
2017
- 2017-08-15 ZA ZA2017/05530A patent/ZA201705530B/en unknown
- 2017-09-25 IL IL254688A patent/IL254688B/en active IP Right Grant
- 2017-09-25 PH PH12017501750A patent/PH12017501750A1/en unknown
- 2017-10-27 CO CONC2017/0011020A patent/CO2017011020A2/es unknown
-
2019
- 2019-07-19 CY CY20191100773T patent/CY1122018T1/el unknown
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