PL3279195T3 - Synteza i nowe postacie soli (R)-5-((E)-2-pirolidyn-3-ylowinylo)pirymidyny - Google Patents

Synteza i nowe postacie soli (R)-5-((E)-2-pirolidyn-3-ylowinylo)pirymidyny

Info

Publication number: PL3279195T3
Authority: PL; Poland
Prior art keywords: ylvinyl; pyrrolidin; pyrimidine; synthesis; salt forms
Prior art date: 2008-12-01

Application number

PL17179369T

Other languages

English (en)

Inventor

Srinivisa Rao Akireddy

Balwinder Singh Bhatti

Timothy J. Cuthbertson

Gary Maurice Dull

Craig Harrison Miller

Jr. Joseph Pike Mitchener

Julio A. Munoz

Pieter Albert Otten

Original Assignee

Oyster Point Pharma, Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-12-01

Filing date

2009-11-30

Publication date

2020-12-14

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41650077&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL3279195(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2009-11-30 Application filed by Oyster Point Pharma, Inc. filed Critical Oyster Point Pharma, Inc.

2020-12-14 Publication of PL3279195T3 publication Critical patent/PL3279195T3/pl

Links

FNEHSHNEXMPCLJ-VWCDRPFISA-N 5-[(e)-2-[(3r)-pyrrolidin-3-yl]ethenyl]pyrimidine Chemical compound C1NCC[C@@H]1\C=C\C1=CN=CN=C1 FNEHSHNEXMPCLJ-VWCDRPFISA-N 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
150000003839 salts Chemical group 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PL17179369T 2008-12-01 2009-11-30 Synteza i nowe postacie soli (R)-5-((E)-2-pirolidyn-3-ylowinylo)pirymidyny PL3279195T3 (pl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US11879608P	2008-12-01	2008-12-01
EP09775408.9A EP2364307B1 (en)	2008-12-01	2009-11-30	Synthesis and novel salt forms of (r)-5-((e)-2-(pyrrolidin-3-ylvinyl)pyrimidine
PCT/US2009/066078 WO2010065443A1 (en)	2008-12-01	2009-11-30	Synthesis and novel salt forms of (r)-5-((e)-2-(pyrrolidin-3-ylvinyl)pyrimidine
EP17179369.8A EP3279195B1 (en)	2008-12-01	2009-11-30	Synthesis and novel salt forms of (r)-5-((e)-2-pyrrolidin-3-ylvinyl)pyrimidine

Publications (1)

Publication Number	Publication Date
PL3279195T3 true PL3279195T3 (pl)	2020-12-14

Family

ID=41650077

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL17179369T PL3279195T3 (pl)	2008-12-01	2009-11-30	Synteza i nowe postacie soli (R)-5-((E)-2-pirolidyn-3-ylowinylo)pirymidyny

Country Status (25)

Country	Link
US (1)	US8604191B2 (pl)
EP (2)	EP2364307B1 (pl)
JP (1)	JP5710490B2 (pl)
KR (1)	KR20110098763A (pl)
CN (1)	CN102232070A (pl)
AU (1)	AU2009322624B2 (pl)
BR (1)	BRPI0922759A2 (pl)
CA (2)	CA3090738C (pl)
CL (1)	CL2011001258A1 (pl)
CO (1)	CO6390106A2 (pl)
DK (1)	DK3279195T3 (pl)
EC (1)	ECSP11011167A (pl)
ES (2)	ES2641762T3 (pl)
HU (1)	HUE050540T2 (pl)
IL (2)	IL266097B (pl)
MX (1)	MX2011005611A (pl)
NZ (3)	NZ703381A (pl)
PE (1)	PE20110589A1 (pl)
PL (1)	PL3279195T3 (pl)
PT (1)	PT3279195T (pl)
RU (2)	RU2533819C2 (pl)
SG (2)	SG10201902903RA (pl)
UA (1)	UA107336C2 (pl)
WO (1)	WO2010065443A1 (pl)
ZA (1)	ZA201103737B (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9145396B2 (en) *	2008-12-01	2015-09-29	Targacept, Inc.	Synthesis and novel salt forms of (R)-5-((E)-2-pyrrolidin-3ylvinyl)pyrimidine
US20130237550A1 (en) *	2010-03-11	2013-09-12	Targacept, Inc.	Arylvinylazacycloalkane compounds for constipation
CN107106542B (zh)	2014-10-20	2020-05-08	奥伊斯特普安生物制药公司	治疗眼部病状的方法
NZ746468A (en)	2016-04-07	2023-06-30	Oyster Point Pharma Inc	Methods of treating ocular conditions
WO2020014217A1 (en)	2018-07-10	2020-01-16	Oyster Point Pharma, Inc.	Methods of treating ocular conditions
EP3820443A1 (en)	2018-07-10	2021-05-19	Oyster Point Pharma, Inc.	Combinations of positive allosteric modulators and nicotinic acetylcholine receptor agonists for treating ocular conditions
EP4142734B1 (en)	2020-04-28	2025-08-20	Oyster Point Pharma, Inc.	Local administration of nicotinic acetylcholine receptor agonists for the inhibition of coronavirus infections

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4649041A (en) *	1983-07-20	1987-03-10	Warner-Lambert Company	Magnesium trisilicate suitable for preparation of medicament adsorbates of antinauseants
SU1605922A3 (ru) *	1987-05-01	1990-11-07	Фудзисава Фармасьютикал Ко., Лтд (Фирма)	Способ получени производных пирролидина или их солей
US5202128A (en) *	1989-01-06	1993-04-13	F. H. Faulding & Co. Limited	Sustained release pharmaceutical composition
IL107184A (en)	1992-10-09	1997-08-14	Abbott Lab	Heterocyclic ether compounds that enhance cognitive function
US5852041A (en)	1993-04-07	1998-12-22	Sibia Neurosciences, Inc.	Substituted pyridines useful as modulators of acethylcholine receptors
US5493026A (en)	1993-10-25	1996-02-20	Organix, Inc.	Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl) nortropanes and their use as imaging for agents for neurodegenerative disorders
US5597919A (en)	1995-01-06	1997-01-28	Dull; Gary M.	Pyrimidinyl or Pyridinyl alkenyl amine compounds
US5604231A (en)	1995-01-06	1997-02-18	Smith; Carr J.	Pharmaceutical compositions for prevention and treatment of ulcerative colitis
US5585388A (en)	1995-04-07	1996-12-17	Sibia Neurosciences, Inc.	Substituted pyridines useful as modulators of acetylcholine receptors
ES2097703B1 (es) *	1995-04-12	1997-12-01	Decox S L	Una nueva composicion estimulante de la actividad cerebral basada en alcaloides de nucleo de eburnamenina, y sus metodos de preparacion.
US5583140A (en)	1995-05-17	1996-12-10	Bencherif; Merouane	Pharmaceutical compositions for the treatment of central nervous system disorders
IL118279A (en)	1995-06-07	2006-10-05	Abbott Lab	Compounds 3 - Pyridyloxy (or Thio) Alkyl Heterocyclic Pharmaceutical Compositions Containing Them and Their Uses for Preparing Drugs to Control Synaptic Chemical Transmission
US5726189A (en)	1996-05-03	1998-03-10	The United States Of America, Represented By The Secretary, Department Of Health And Human Services	Method for imaging nicotinic acetylcholinergic receptors in the brain using radiolabeled pyridyl-7-azabicyclo 2.2.1!heptanes
US5795909A (en) *	1996-05-22	1998-08-18	Neuromedica, Inc.	DHA-pharmaceutical agent conjugates of taxanes
ZA9711092B (en)	1996-12-11	1999-07-22	Smithkline Beecham Corp	Novel compounds.
US5952339A (en)	1998-04-02	1999-09-14	Bencherif; Merouane	Pharmaceutical compositions and methods of using nicotinic antagonists for treating a condition or disorder characterized by alteration in normal neurotransmitter release
US6310043B1 (en)	1998-08-07	2001-10-30	Governors Of The University Of Alberta	Treatment of bacterial infections
US6761903B2 (en) *	1999-06-30	2004-07-13	Lipocine, Inc.	Clear oil-containing pharmaceutical compositions containing a therapeutic agent
JP2003513054A (ja) *	1999-11-01	2003-04-08	ターガセプト，インコーポレイテッド	アリールオレフィンアザ環式化合物及びアリールアセチレンアザ環式化合物、それらを含有する薬剤組成物、及び、ニコチンコリン作動性受容体の阻害薬としてのそれらの使用
EP1302458A4 (en) *	2000-07-11	2005-10-19	Banyu Pharma Co Ltd	ESTERDERIVATE
WO2003013526A1 (en) *	2001-08-08	2003-02-20	Merck & Co. Inc.	Anticoagulant compounds
US6872827B2 (en) *	2002-04-26	2005-03-29	Chembridge Research Laboratories, Inc.	Somatostatin analogue compounds
US7098331B2 (en) *	2003-03-05	2006-08-29	Targacept, Inc.	Arylvinylazacycloalkane compounds and methods of preparation and use thereof
JP5162236B2 (ja) *	2004-03-25	2013-03-13	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	イミダゾール化合物
AR053364A1 (es) *	2005-04-20	2007-05-02	Smithkline Beecham	Compuesto de 1h-imidazo 84,5-c) piridin -2- ilo, composicion farmaceutica que lo comprende, proceso para prepararla y su uso para preparar un medicamento para tratamiento de cancer o artritis
US7598255B2 (en) *	2005-08-04	2009-10-06	Janssen Pharmaceutica Nv	Pyrimidine compounds as serotonin receptor modulators
US20060223820A1 (en) *	2006-03-21	2006-10-05	Chemagis Ltd.	Crystalline aripiprazole salts and processes for preparation and purification thereof
WO2008157365A2 (en) *	2007-06-15	2008-12-24	Targacept, Inc.	Vinylazacycloalkanes for treating neuropathic pain
TW201024283A (en) *	2008-12-01	2010-07-01	Targacept Inc	Synthesis and novel salt forms of (R)-3-((E)-2-(pyrrolidin-3-yl)vinyl)-5-(tetrahydropyran-4-yloxy)pyridine

2009
- 2009-11-30 IL IL266097A patent/IL266097B/en unknown
- 2009-11-30 JP JP2011538710A patent/JP5710490B2/ja not_active Expired - Fee Related
- 2009-11-30 SG SG10201902903RA patent/SG10201902903RA/en unknown
- 2009-11-30 PL PL17179369T patent/PL3279195T3/pl unknown
- 2009-11-30 NZ NZ703381A patent/NZ703381A/en not_active IP Right Cessation
- 2009-11-30 CA CA3090738A patent/CA3090738C/en active Active
- 2009-11-30 PE PE2011001110A patent/PE20110589A1/es active IP Right Grant
- 2009-11-30 HU HUE17179369A patent/HUE050540T2/hu unknown
- 2009-11-30 WO PCT/US2009/066078 patent/WO2010065443A1/en not_active Ceased
- 2009-11-30 UA UAA201108206A patent/UA107336C2/ru unknown
- 2009-11-30 AU AU2009322624A patent/AU2009322624B2/en not_active Ceased
- 2009-11-30 CN CN2009801480732A patent/CN102232070A/zh active Pending
- 2009-11-30 RU RU2011127010/04A patent/RU2533819C2/ru active IP Right Revival
- 2009-11-30 US US13/129,898 patent/US8604191B2/en not_active Expired - Fee Related
- 2009-11-30 MX MX2011005611A patent/MX2011005611A/es active IP Right Grant
- 2009-11-30 DK DK17179369.8T patent/DK3279195T3/da active
- 2009-11-30 NZ NZ611965A patent/NZ611965A/en not_active IP Right Cessation
- 2009-11-30 ES ES09775408.9T patent/ES2641762T3/es active Active
- 2009-11-30 EP EP09775408.9A patent/EP2364307B1/en active Active
- 2009-11-30 ES ES17179369T patent/ES2820857T3/es active Active
- 2009-11-30 KR KR1020117014867A patent/KR20110098763A/ko not_active Ceased
- 2009-11-30 PT PT171793698T patent/PT3279195T/pt unknown
- 2009-11-30 SG SG10201406410UA patent/SG10201406410UA/en unknown
- 2009-11-30 NZ NZ592554A patent/NZ592554A/xx not_active IP Right Cessation
- 2009-11-30 BR BRPI0922759A patent/BRPI0922759A2/pt not_active IP Right Cessation
- 2009-11-30 EP EP17179369.8A patent/EP3279195B1/en active Active
- 2009-11-30 CA CA2742366A patent/CA2742366C/en active Active
2011
- 2011-05-09 IL IL212798A patent/IL212798B/en active IP Right Grant
- 2011-05-20 ZA ZA2011/03737A patent/ZA201103737B/en unknown
- 2011-05-30 CL CL2011001258A patent/CL2011001258A1/es unknown
- 2011-06-29 CO CO11081403A patent/CO6390106A2/es not_active Application Discontinuation
- 2011-06-29 EC EC2011011167A patent/ECSP11011167A/es unknown
2014
- 2014-09-11 RU RU2014136983A patent/RU2700796C2/ru active

Also Published As

Publication number	Publication date
ZA201103737B (en)	2012-01-25
IL212798B (en)	2019-05-30
RU2014136983A (ru)	2016-04-10
UA107336C2 (ru)	2014-12-25
RU2700796C2 (ru)	2019-09-23
CN102232070A (zh)	2011-11-02
SG10201902903RA (en)	2019-05-30
HUE050540T2 (hu)	2020-12-28
EP3279195A1 (en)	2018-02-07
ES2641762T3 (es)	2017-11-13
ES2820857T3 (es)	2021-04-22
EP2364307A1 (en)	2011-09-14
CA3090738C (en)	2023-06-13
IL266097B (en)	2022-07-01
AU2009322624A1 (en)	2010-06-10
AU2009322624B2 (en)	2015-06-11
WO2010065443A1 (en)	2010-06-10
MX2011005611A (es)	2011-09-15
CA2742366C (en)	2020-09-22
IL212798A0 (en)	2011-07-31
SG10201406410UA (en)	2014-11-27
NZ592554A (en)	2013-08-30
PE20110589A1 (es)	2011-09-07
CO6390106A2 (es)	2012-02-29
JP2012510471A (ja)	2012-05-10
BRPI0922759A2 (pt)	2016-01-05
CL2011001258A1 (es)	2011-09-02
CA3090738A1 (en)	2010-06-10
ECSP11011167A (es)	2011-10-31
NZ703381A (en)	2016-03-31
RU2533819C2 (ru)	2014-11-20
EP3279195B1 (en)	2020-07-01
DK3279195T3 (en)	2020-08-17
KR20110098763A (ko)	2011-09-01
US8604191B2 (en)	2013-12-10
NZ611965A (en)	2015-01-30
RU2011127010A (ru)	2013-01-10
IL266097A (en)	2019-06-30
PT3279195T (pt)	2020-09-29
EP2364307B1 (en)	2017-07-05
US20110281895A1 (en)	2011-11-17
CA2742366A1 (en)	2010-06-10
HK1250572A1 (en)	2018-12-28
JP5710490B2 (ja)	2015-04-30

Publication	Publication Date	Title
AP2651A (en)	2013-04-25	Crystal form of phenylamino pyrimidine derivatives
IL210462A0 (en)	2011-03-31	Pyrimidine compounds, compositions and methods of use
IL184036A0 (en)	2007-10-31	Preparation of rosuvastatin
EP2297174A4 (en)	2013-04-03	EXCLUSIVE SYNTHESIS OF GALACTOSIDE INHIBITORS
IL213701A0 (en)	2011-07-31	Synthesis of purine nucleosides
GB0711523D0 (en)	2007-07-25	Mode of transport determination
EP2185570A4 (en)	2011-02-09	NOVEL GLUCCOKINASE ACTIVATORS
ZA201102892B (en)	2012-02-29	Pyrazolylaminopyridines as inhibitors of fak
ZA200902393B (en)	2010-03-31	Preparation of azoxystrobin
GB0822149D0 (en)	2009-01-14	Provision of image data
EP2249650A4 (en)	2012-01-11	ANILINOPYRIDINE AS A FAK HEMMER
PL2328545T3 (pl)	2016-04-29	Zastosowanie glukozyloglicerolu
HUE050540T2 (hu)	2020-12-28	(R)-5-((E)-2-pirrolidin-3-ilvinil)pirimidin elõállítása és új sóformái
ZA201100123B (en)	2011-09-28	Bromine-facilitated synthesis of fluoro-sulfur compounds
PL2117372T3 (pl)	2016-09-30	Opakowanie na bagaż
EP2332112A4 (en)	2013-10-09	PORTFOLIO PART REFERENCE
IL200087A0 (en)	2010-04-15	Novel crystal of piperacillin sodium
IL195061A0 (en)	2009-08-03	Crystalline forms of atorvastatin
PL2237782T3 (pl)	2018-12-31	Zastosowanie tetrahydropirymidyn
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