PL3325631T3 - Rekombinowany wektor wirusa orf - Google Patents

Rekombinowany wektor wirusa orf

Info

Publication number: PL3325631T3
Authority: PL; Poland
Prior art keywords: virus vector; recombinant orf; orf; recombinant; virus
Prior art date: 2015-07-20

Application number

PL16741595.9T

Other languages

English (en)

Inventor

Hans-Joachim Rziha

Ralf Amann

Original Assignee

Prime Vector Technologies Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-07-20

Filing date

2016-07-15

Publication date

2026-02-02

2016-07-15 Application filed by Prime Vector Technologies Gmbh filed Critical Prime Vector Technologies Gmbh

2026-02-02 Publication of PL3325631T3 publication Critical patent/PL3325631T3/pl

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- C12N2015/8527—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic for producing animal models, e.g. for tests or diseases
- C12N2015/8572—Animal models for proliferative diseases, e.g. comprising an oncogene
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- C12N2015/8527—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic for producing animal models, e.g. for tests or diseases
- C12N2015/8581—Animal models for infectious diseases, e.g. AIDS
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24031—Uses of virus other than therapeutic or vaccine, e.g. disinfectant
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24041—Use of virus, viral particle or viral elements as a vector
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24211—Parapoxvirus, e.g. Orf virus
- C12N2710/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24211—Parapoxvirus, e.g. Orf virus
- C12N2710/24241—Use of virus, viral particle or viral elements as a vector
- C12N2710/24243—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/106—Plasmid DNA for vertebrates
- C12N2800/107—Plasmid DNA for vertebrates for mammalian
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/34—Vector systems having a special element relevant for transcription being a transcription initiation element
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/60—Vector systems having a special element relevant for transcription from viruses
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/10—Vectors comprising a special translation-regulating system regulates levels of translation
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Zoology (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
Microbiology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Virology (AREA)
Molecular Biology (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Mycology (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

PL16741595.9T 2015-07-20 2016-07-15 Rekombinowany wektor wirusa orf PL3325631T3 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE102015111756.8A DE102015111756A1 (de)	2015-07-20	2015-07-20	Rekombinanter Orf-Virus-Vektor
PCT/EP2016/066926 WO2017013023A1 (de)	2015-07-20	2016-07-15	Rekombinanter orf-virus-vektor

Publications (1)

Publication Number	Publication Date
PL3325631T3 true PL3325631T3 (pl)	2026-02-02

Family

ID=56507584

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL16741595.9T PL3325631T3 (pl)	2015-07-20	2016-07-15	Rekombinowany wektor wirusa orf

Country Status (20)

Country	Link
US (2)	US11286500B2 (pl)
EP (2)	EP3325631B1 (pl)
JP (2)	JP7092663B2 (pl)
KR (2)	KR102433709B1 (pl)
CN (2)	CN116445547A (pl)
AU (2)	AU2016294855B2 (pl)
CA (1)	CA2993263A1 (pl)
CL (1)	CL2018000164A1 (pl)
DE (1)	DE102015111756A1 (pl)
DK (1)	DK3325631T3 (pl)
EA (1)	EA201890351A1 (pl)
ES (1)	ES3054068T3 (pl)
IL (1)	IL257025B2 (pl)
MX (1)	MX2018000845A (pl)
NZ (1)	NZ739286A (pl)
PH (1)	PH12018500155A1 (pl)
PL (1)	PL3325631T3 (pl)
PT (1)	PT3325631T (pl)
WO (1)	WO2017013023A1 (pl)
ZA (1)	ZA201801091B (pl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
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DE102015111756A1 (de) *	2015-07-20	2017-01-26	Eberhard Karls Universität Tübingen Medizinische Fakultät	Rekombinanter Orf-Virus-Vektor
CA3093093A1 (en) *	2018-03-07	2019-09-12	Transgene	Parapoxvirus vectors
CN112522215B (zh) *	2019-09-18	2023-06-02	重庆市畜牧科学院	一种缺失008基因的重组羊口疮病毒及其构建方法
EP3871690A1 (en)	2020-02-27	2021-09-01	Technische Hochschule Mittelhessen	Method for virus production
CN116744952A (zh) *	2020-08-13	2023-09-12	苏州般若生物科技有限公司	一种突变型羊传染性脓疱皮炎病毒及其用途
EP3957322A1 (en) *	2020-08-19	2022-02-23	Eberhard Karls Universität Tübingen Medizinische Fakultät	Recombinant poxviridae vector expressing co-stimulatory molecules
EP4014991A1 (en) *	2020-12-21	2022-06-22	Eberhard Karls Universität Tübingen Medizinische Fakultät	Modified parapoxvirus having increased immunogenicity
EP4014990A1 (en) *	2020-12-21	2022-06-22	Eberhard Karls Universität Tübingen Medizinische Fakultät	Modified parapoxvirus having increased immunogenicity
EP4014992A1 (en) *	2020-12-21	2022-06-22	Eberhard Karls Universität Tübingen Medizinische Fakultät	Modified parapoxvirus having increased immunogenicity

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AU718141B2 (en) *	1996-02-28	2000-04-06	Bayer Healthcare Ag	Parapoxviruses which contain foreign DNA, their preparation and their use in vaccines
AU2182697A (en) *	1996-03-29	1997-10-22	University Of Otago	Parapoxvirus vectors
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NZ701949A (en) *	2012-05-18	2016-07-29	Otago Innovation Ltd	Combination treatments and compositions for wound healing
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DE102015111756A1 (de) *	2015-07-20	2017-01-26	Eberhard Karls Universität Tübingen Medizinische Fakultät	Rekombinanter Orf-Virus-Vektor

2015
- 2015-07-20 DE DE102015111756.8A patent/DE102015111756A1/de active Pending
2016
- 2016-07-15 EP EP16741595.9A patent/EP3325631B1/de active Active
- 2016-07-15 MX MX2018000845A patent/MX2018000845A/es unknown
- 2016-07-15 EP EP25156960.4A patent/EP4545094A3/de active Pending
- 2016-07-15 JP JP2018522854A patent/JP7092663B2/ja active Active
- 2016-07-15 AU AU2016294855A patent/AU2016294855B2/en active Active
- 2016-07-15 EA EA201890351A patent/EA201890351A1/ru unknown
- 2016-07-15 ES ES16741595T patent/ES3054068T3/es active Active
- 2016-07-15 NZ NZ73928616A patent/NZ739286A/en unknown
- 2016-07-15 IL IL257025A patent/IL257025B2/en unknown
- 2016-07-15 CN CN202211462316.3A patent/CN116445547A/zh active Pending
- 2016-07-15 CA CA2993263A patent/CA2993263A1/en active Pending
- 2016-07-15 WO PCT/EP2016/066926 patent/WO2017013023A1/de not_active Ceased
- 2016-07-15 KR KR1020217015985A patent/KR102433709B1/ko active Active
- 2016-07-15 DK DK16741595.9T patent/DK3325631T3/da active
- 2016-07-15 CN CN201680053548.XA patent/CN108026542B/zh active Active
- 2016-07-15 PL PL16741595.9T patent/PL3325631T3/pl unknown
- 2016-07-15 KR KR1020187004903A patent/KR102259277B1/ko active Active
- 2016-07-15 PT PT167415959T patent/PT3325631T/pt unknown
2018
- 2018-01-19 CL CL2018000164A patent/CL2018000164A1/es unknown
- 2018-01-19 PH PH12018500155A patent/PH12018500155A1/en unknown
- 2018-01-19 US US15/875,389 patent/US11286500B2/en active Active
- 2018-02-16 ZA ZA2018/01091A patent/ZA201801091B/en unknown
2020
- 2020-06-03 JP JP2020097200A patent/JP2020188776A/ja active Pending
- 2020-11-04 AU AU2020264302A patent/AU2020264302B2/en active Active
2022
- 2022-03-17 US US17/655,316 patent/US20220204992A1/en active Pending

Also Published As

Publication number	Publication date
DE102015111756A1 (de)	2017-01-26
PH12018500155A1 (en)	2018-07-23
KR20210064427A (ko)	2021-06-02
DK3325631T3 (da)	2025-12-01
US11286500B2 (en)	2022-03-29
ES3054068T3 (en)	2026-01-29
CN108026542A (zh)	2018-05-11
MX2018000845A (es)	2018-08-16
EP4545094A3 (de)	2025-11-19
KR102259277B1 (ko)	2021-06-01
KR20180058705A (ko)	2018-06-01
US20180148739A1 (en)	2018-05-31
CN116445547A (zh)	2023-07-18
EP3325631B1 (de)	2025-09-03
WO2017013023A1 (de)	2017-01-26
AU2016294855B2 (en)	2020-08-06
JP2020188776A (ja)	2020-11-26
JP2018523491A (ja)	2018-08-23
IL257025A (en)	2018-03-29
EA201890351A1 (ru)	2018-06-29
CL2018000164A1 (es)	2018-08-24
EP3325631A1 (de)	2018-05-30
US20220204992A1 (en)	2022-06-30
AU2020264302A1 (en)	2020-11-26
IL257025B1 (en)	2024-02-01
AU2020264302B2 (en)	2023-06-08
CN108026542B (zh)	2022-12-09
EP4545094A2 (de)	2025-04-30
AU2016294855A1 (en)	2018-02-15
CA2993263A1 (en)	2017-01-26
PT3325631T (pt)	2025-12-05
IL257025B2 (en)	2024-06-01
ZA201801091B (en)	2022-07-27
NZ739286A (en)	2019-10-25
JP7092663B2 (ja)	2022-06-28
BR112018001121A2 (pt)	2018-09-11
KR102433709B1 (ko)	2022-08-18

Publication	Publication Date	Title
IL290258A (en)	2022-04-01	Transgenic Isfahan Viral Vector
GB201509578D0 (en)	2015-07-15	Vectors
GB201520559D0 (en)	2016-01-06	Peptides
GB201520539D0 (en)	2016-01-06	Peptides
GB201520543D0 (en)	2016-01-06	Peptides
GB201520546D0 (en)	2016-01-06	Peptides
GB201520536D0 (en)	2016-01-06	Peptides
GB201520544D0 (en)	2016-01-06	Peptides
GB201520563D0 (en)	2016-01-06	Peptides
GB201520562D0 (en)	2016-01-06	Peptides
GB201520545D0 (en)	2016-01-06	Peptides
GB201520567D0 (en)	2016-01-06	Peptides
GB201520550D0 (en)	2016-01-06	Peptides
GB201520568D0 (en)	2016-01-06	Peptides
GB201520564D0 (en)	2016-01-06	Peptides
GB201520541D0 (en)	2016-01-06	Peptides
GB201520603D0 (en)	2016-01-06	Peptides
GB201520566D0 (en)	2016-01-06	Peptides
GB201520542D0 (en)	2016-01-06	Peptides
GB201520570D0 (en)	2016-01-06	Peptides
GB201520558D0 (en)	2016-01-06	Peptides
GB201520548D0 (en)	2016-01-06	Peptides
GB201520557D0 (en)	2016-01-06	Peptides
GB201518700D0 (en)	2015-12-02	Peptides
GB201520537D0 (en)	2016-01-06	Peptides