PL3339323T3 - Przeciwciała przeciwko peptydowi N3pGlu amyloidu beta i ich zastosowania - Google Patents

Przeciwciała przeciwko peptydowi N3pGlu amyloidu beta i ich zastosowania

Info

Publication number: PL3339323T3
Authority: PL; Poland
Prior art keywords: amyloid beta; beta peptide; peptide antibodies; n3pglu amyloid; n3pglu
Prior art date: 2010-08-12

Application number

PL18150424T

Other languages

English (en)

Inventor

Ronald Bradley Demattos

Jirong Lu

Ying Tang

Original Assignee

Eli Lilly And Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-08-12

Filing date

2011-08-09

Publication date

2020-05-18

2011-08-09 Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company

2020-05-18 Publication of PL3339323T3 publication Critical patent/PL3339323T3/pl

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Neurology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Microbiology (AREA)
Mycology (AREA)
Epidemiology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

PL18150424T 2010-08-12 2011-08-09 Przeciwciała przeciwko peptydowi N3pGlu amyloidu beta i ich zastosowania PL3339323T3 (pl)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US37302610P	2010-08-12	2010-08-12
EP15196358.4A EP3042917B1 (en)	2010-08-12	2011-08-09	Anti-n3pglu amyloid beta peptide antibodies and uses thereof
EP18150424.2A EP3339323B1 (en)	2010-08-12	2011-08-09	Anti-n3pglu amyloid beta peptide antibodies and uses thereof
EP11745672.3A EP2603523B1 (en)	2010-08-12	2011-08-09	ANTI-N3pGlu AMYLOID BETA PEPTIDE ANTIBODIES AND USES THEREOF
PCT/US2011/046994 WO2012021469A1 (en)	2010-08-12	2011-08-09	ANTI-N3pGlu AMYLOID BETA PEPTIDE ANTIBODIES AND USES THEREOF

Publications (1)

Publication Number	Publication Date
PL3339323T3 true PL3339323T3 (pl)	2020-05-18

Family

ID=44543826

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
PL15196358T PL3042917T3 (pl)	2010-08-12	2011-08-09	Przeciwciała przeciwko peptydowi beta amyloidu N3pGlu i ich zastosowanie
PL18150424T PL3339323T3 (pl)	2010-08-12	2011-08-09	Przeciwciała przeciwko peptydowi N3pGlu amyloidu beta i ich zastosowania
PL11745672T PL2603523T3 (pl)	2010-08-12	2011-08-09	Przeciwciała przeciwko peptydowi amyloidu beta N3pGlu i ich zastosowania

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
PL15196358T PL3042917T3 (pl)	2010-08-12	2011-08-09	Przeciwciała przeciwko peptydowi beta amyloidu N3pGlu i ich zastosowanie

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
PL11745672T PL2603523T3 (pl)	2010-08-12	2011-08-09	Przeciwciała przeciwko peptydowi amyloidu beta N3pGlu i ich zastosowania

Country Status (41)

Country	Link
US (2)	US8679498B2 (pl)
EP (3)	EP2603523B1 (pl)
JP (2)	JP5980207B2 (pl)
KR (1)	KR101498833B1 (pl)
CN (2)	CN103068848B (pl)
AU (1)	AU2011289629B2 (pl)
BR (1)	BR112013004056B8 (pl)
CA (1)	CA2805114C (pl)
CL (1)	CL2013000390A1 (pl)
CO (1)	CO6670526A2 (pl)
CR (1)	CR20130016A (pl)
CY (2)	CY1120144T1 (pl)
DK (3)	DK2603523T3 (pl)
DO (1)	DOP2013000029A (pl)
EA (1)	EA023021B1 (pl)
EC (1)	ECSP13012436A (pl)
ES (3)	ES2564252T3 (pl)
FI (1)	FIC20250038I1 (pl)
FR (1)	FR25C1055I1 (pl)
GT (1)	GT201300036A (pl)
HR (3)	HRP20160151T1 (pl)
HU (2)	HUE037524T2 (pl)
IL (2)	IL285226B2 (pl)
LT (3)	LT3042917T (pl)
MA (1)	MA34461B1 (pl)
ME (3)	ME03032B (pl)
MX (2)	MX342782B (pl)
MY (2)	MY181969A (pl)
NL (1)	NL301359I2 (pl)
NO (2)	NO3042917T3 (pl)
NZ (2)	NZ626665A (pl)
PE (1)	PE20130817A1 (pl)
PH (1)	PH12013500277A1 (pl)
PL (3)	PL3042917T3 (pl)
PT (2)	PT3042917T (pl)
RS (3)	RS59652B1 (pl)
SG (2)	SG187586A1 (pl)
SI (3)	SI3042917T1 (pl)
UA (1)	UA107600C2 (pl)
WO (1)	WO2012021469A1 (pl)
ZA (1)	ZA201300437B (pl)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HRP20140049T1 (hr)	2007-01-05	2014-02-28	University Of Zürich	Anti beta-amiloid antitijela i njihova upotreba
PL3042917T3 (pl) *	2010-08-12	2018-07-31	Eli Lilly And Company	Przeciwciała przeciwko peptydowi beta amyloidu N3pGlu i ich zastosowanie
US9499610B2 (en)	2011-04-08	2016-11-22	H. Lundbeck A/S	Antibodies specific to pyroglutamated Aβ
US20170008955A1 (en) *	2014-02-03	2017-01-12	Cnj Holdings, Inc.	Humanized beta-amyloid binding molecules and uses thereof
WO2015175769A1 (en)	2014-05-15	2015-11-19	Biogen Ma Inc.	Methods for the detection of amyloid beta oligomers in biological samples
DK3166973T3 (da) *	2014-07-10	2020-04-06	Univ Zuerich	Immunstimulerende monoklonale antistoffer mod human interleukin-2
TWI599358B (zh) *	2014-09-16	2017-09-21	美國禮來大藥廠	組合療法
MA41115A (fr)	2014-12-02	2017-10-10	Biogen Int Neuroscience Gmbh	Procédé de traitement de la maladie d'alzheimer
JP2018501482A (ja)	2014-12-19	2018-01-18	プロビオドルグエージー	ｐＧｌｕ−Ａｂｅｔａペプチドの検出のための新規の方法
JO3627B1 (ar)	2015-04-30	2020-08-27	H Lundbeck As	إيميدازو بيرازينونات على هيئة مثبطات pde1
CN106699888B (zh) *	2015-07-28	2020-11-06	上海昀怡健康科技发展有限公司	一种pd-1抗体及其制备方法和应用
AU2016325630B2 (en) *	2015-09-23	2022-11-17	Regeneron Pharmaceuticals, Inc.	Optimized anti-CD3 bispecific antibodies and uses thereof
WO2017122130A1 (en)	2016-01-11	2017-07-20	Novartis Ag	Immune-stimulating humanized monoclonal antibodies against human interleukin-2, and fusion proteins thereof
JOP20170004B1 (ar)	2016-01-15	2022-09-15	Lilly Co Eli	الأجسام المضادة لببتيد بيتا النشوي مضاد N3pGlu واستخداماته
AR107783A1 (es) *	2016-03-15	2018-06-06	Lilly Co Eli	Terapia de combinación
AR107774A1 (es)	2016-03-16	2018-05-30	Lilly Co Eli	Terapia de combinación, método para el tratamiento de la enfermedad de alzheimer
TWI798751B (zh) *	2016-07-01	2023-04-11	美商美國禮來大藥廠	抗－N3pGlu類澱粉β肽抗體及其用途
US10034861B2 (en)	2016-07-04	2018-07-31	H. Lundbeck A/S	1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
CA3032692A1 (en) *	2016-08-09	2018-02-15	Eli Lilly And Company	Combination antibody therapy for the treatment of neurodegenerative diseases
CN109641052A (zh) *	2016-08-18	2019-04-16	伊莱利利公司	BACE-1抑制剂和抗-N3pGlu Aβ抗体的组合疗法
AR110470A1 (es) *	2016-10-21	2019-04-03	Lilly Co Eli	Terapia de combinación para tratar la enfermedad de alzheimer
AU2017350473A1 (en)	2016-10-28	2019-04-18	H. Lundbeck A/S	Combination treatments comprising imidazopyrazinones for the treatment of psychiatric and/or cognitive disorders
WO2018078042A1 (en)	2016-10-28	2018-05-03	H. Lundbeck A/S	Combination treatments comprising administration of imidazopyrazinones
TW201827467A (zh) *	2016-11-03	2018-08-01	比利時商健生藥品公司	焦穀胺酸類澱粉蛋白－β之抗體及其用途
TWI789644B (zh)	2017-04-20	2023-01-11	美商美國禮來大藥廠	抗－N3pGlu類澱粉β肽抗體及其用途
CN111201030B (zh)	2017-07-25	2024-11-01	真和制药有限公司	通过阻断tim-3和其配体的相互作用治疗癌症
CN118370815A (zh)	2017-08-22	2024-07-23	渤健马萨诸塞州股份有限公司	含有抗β淀粉样蛋白抗体的药物组合物
EP3723807B1 (en)	2017-12-14	2021-10-20	H. Lundbeck A/S	Combination treatments comprising administration of 1h-pyrazolo[4,3-b]pyridines
AR113926A1 (es)	2017-12-14	2020-07-01	H Lundbeck As	Derivados de 1h-pirazolo[4,3-b]piridinas
WO2019121840A1 (en)	2017-12-20	2019-06-27	H. Lundbeck A/S	Pyrazolo[3,4-b]pyridines and imidazo[1,5-b]pyridazines as pde1 inhibitors
CN116693686A (zh) *	2018-02-11	2023-09-05	江苏豪森药业集团有限公司	抗b7-h4抗体、其抗原结合片段及其医药用途
JP2021516682A (ja) *	2018-03-13	2021-07-08	スミヴェットビー．ブイ．ＳｍｉｖｅｔＢ．Ｖ．	破傷風神経毒素に結合する単一ドメイン抗体
WO2020160156A2 (en)	2019-01-30	2020-08-06	Immutics, Inc.	Anti-gal3 antibodies and uses thereof
JOP20210265A1 (ar) *	2019-03-26	2023-01-30	Janssen Pharmaceutica Nv	الأجسام المضادة لبيروغلوتامات أميلويد بيتا واستخداماتها
CN114555792A (zh)	2019-10-15	2022-05-27	伊莱利利公司	重组改造的、脂肪酶/酯酶缺陷型哺乳动物细胞系
EP4157338A4 (en)	2020-05-26	2024-11-13	TrueBinding, Inc.	METHOD FOR TREATING INFLAMMATORY DISEASES BY GALECTIN-3 BLOCKING
US20230250193A1 (en) *	2020-06-17	2023-08-10	Proviva Therapeutics (Hong Kong) Limited	Antibodies to fibroblast activation protein and b7h3
KR20230039734A (ko)	2020-07-23	2023-03-21	오타이르 프로테나 리미티드	항-Aβ 항체
KR20230078748A (ko) *	2020-10-02	2023-06-02	일라이 릴리 앤드 캄파니	항체 정제 공정에서의 숙주 세포 단백질 함량을 감소시키는 방법 및 감소된 숙주 세포 단백질 함량을 가지는 항체 조성물
TWI843040B (zh)	2021-01-11	2024-05-21	美商美國禮來大藥廠	抗N3pGlu類澱粉β抗體及其用途
TW202300517A (zh)	2021-03-12	2023-01-01	美商美國禮來大藥廠	抗類澱粉β抗體及其用途
TW202300518A (zh)	2021-03-12	2023-01-01	美商美國禮來大藥廠	抗N3pGlu類澱粉β抗體及其用途
AU2022371475A1 (en)	2021-10-22	2024-05-09	Eli Lilly And Company	O-glcnacase (oga) inhibitor combination therapy
EP4422751A1 (en)	2021-10-29	2024-09-04	Eli Lilly and Company	Compounds and methods targeting interleukin-34
KR20240105403A (ko)	2021-10-29	2024-07-05	일라이 릴리 앤드 캄파니	인터류킨-34를 표적화하는 화합물 및 방법
CN118475610A (zh)	2021-10-29	2024-08-09	伊莱利利公司	靶向白细胞介素-34的化合物和方法
MX2024005146A (es)	2021-10-29	2024-05-13	Lilly Co Eli	Compuestos y metodos dirigidos a interleucina-34.
CA3243602A1 (en)	2022-02-03	2023-08-10	Eli Lilly And Company	Regional Tau Imaging for the Diagnosis and Treatment of Alzheimer's Disease
EP4558166A1 (en) *	2022-07-21	2025-05-28	Eli Lilly and Company	Pharmaceutical solutions of anti-n3 pglu a beta antibodies and uses thereof
PE20252307A1 (es)	2022-12-22	2025-09-22	Bioarctic Ab	Anticuerpo que se une a abetape3
WO2025106313A1 (en)	2023-11-14	2025-05-22	Eli Lilly And Company	Fc RECEPTOR BASED ASSAYS FOR ANALYZING IgG ANTIBODIES
WO2025228315A1 (en) *	2024-04-28	2025-11-06	Jacobio Pharmaceuticals Co., Ltd.	Anti-n3pglu amyloid beta antibodies and uses thereof
WO2025237397A1 (zh) *	2024-05-16	2025-11-20	江苏恒瑞医药股份有限公司	抗N3pGlu Aβ抗体及其医药用途
WO2025245381A1 (en)	2024-05-23	2025-11-27	The Trustrees Of Dartmouth College	Methods and compositions for enhancing the persistence of car expressing tregs in the cns and other tissues
WO2025262228A1 (en)	2024-06-20	2025-12-26	Bioarctic Ab	Bispecific binding molecule
WO2026012421A1 (zh) *	2024-07-11	2026-01-15	齐鲁制药有限公司	抗N3pGlu淀粉样蛋白β抗体及其用途
WO2026055601A1 (en)	2024-09-09	2026-03-12	Eli Lilly And Company	METHOD OF TREATING ALZHEIMER'S DISEASE USING ANTI-N3pGlu AMYLOID BETA ANTIBODIES

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8308235D0 (en)	1983-03-25	1983-05-05	Celltech Ltd	Polypeptides
US5225539A (en)	1986-03-27	1993-07-06	Medical Research Council	Recombinant altered antibodies and methods of making altered antibodies
US5530101A (en)	1988-12-28	1996-06-25	Protein Design Labs, Inc.	Humanized immunoglobulins
US7122374B1 (en)	2002-04-09	2006-10-17	Takaomi Saido	Amyloid beta-protein 3(pE)-42 antibodies and uses thereof
WO2004013172A2 (en)	2002-07-24	2004-02-12	Innogenetics N.V.	Fragments of beta-amyloid as targets for vaccination against alzheimer disease
WO2005018424A2 (en) *	2003-08-18	2005-03-03	Research Foundation For Mental Hygiene, Inc.	Antibodies specific for fibrillar amyloid and a procedure to detect fibrillar amyloid deposits
EP1666061A1 (en)	2003-09-09	2006-06-07	Takeda Pharmaceutical Company Limited	Use of antibody
SI1720909T1 (sl) *	2004-02-23	2012-01-31	Lilly Co Eli	Anti-abeta protitelo
MX2007000998A (es) *	2004-07-30	2007-07-11	Rinat Neuroscience Corp	Anticuerpos dirigidos peptido beta-amiloide y procedimientos que usan los mismos.
EP2046833B9 (en)	2006-07-14	2014-02-19	AC Immune S.A.	Humanized antibody against amyloid beta
US20080292625A1 (en) *	2007-04-18	2008-11-27	Sally Schroeter	Prevention and treatment of cerebral amyloid angiopathy
CN102123726A (zh)	2008-06-12	2011-07-13	阿费里斯股份公司	用于治疗与帕金森氏病有关的症状的化合物
EP2321348A2 (en)	2008-07-09	2011-05-18	University of Zürich	Method of promoting neurogenesis
WO2010009987A2 (en)	2008-07-21	2010-01-28	Probiodrug Ag	Diagnostic antibody assay
WO2011151076A2 (en)	2010-06-04	2011-12-08	Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin	MONOCLONAL ANTIBODIES TARGETING Αβ OLIGOMERS
PL3042917T3 (pl) *	2010-08-12	2018-07-31	Eli Lilly And Company	Przeciwciała przeciwko peptydowi beta amyloidu N3pGlu i ich zastosowanie

2011
- 2011-08-09 PL PL15196358T patent/PL3042917T3/pl unknown
- 2011-08-09 KR KR1020137003412A patent/KR101498833B1/ko active Active
- 2011-08-09 NZ NZ626665A patent/NZ626665A/en unknown
- 2011-08-09 MY MYPI2016001651A patent/MY181969A/en unknown
- 2011-08-09 HU HUE15196358A patent/HUE037524T2/hu unknown
- 2011-08-09 HR HRP20160151TT patent/HRP20160151T1/hr unknown
- 2011-08-09 MA MA35653A patent/MA34461B1/fr unknown
- 2011-08-09 HU HUE11745672A patent/HUE028678T2/en unknown
- 2011-08-09 SI SI201131449T patent/SI3042917T1/en unknown
- 2011-08-09 MY MYPI2013700226A patent/MY163521A/en unknown
- 2011-08-09 EP EP11745672.3A patent/EP2603523B1/en active Active
- 2011-08-09 EP EP15196358.4A patent/EP3042917B1/en active Active
- 2011-08-09 NO NO15196358A patent/NO3042917T3/no unknown
- 2011-08-09 SG SG2013005210A patent/SG187586A1/en unknown
- 2011-08-09 RS RS20191581A patent/RS59652B1/sr unknown
- 2011-08-09 IL IL285226A patent/IL285226B2/en unknown
- 2011-08-09 CN CN201180039876.1A patent/CN103068848B/zh active Active
- 2011-08-09 US US13/810,895 patent/US8679498B2/en active Active
- 2011-08-09 CN CN201510613319.6A patent/CN105111308B/zh active Active
- 2011-08-09 SG SG10201509330XA patent/SG10201509330XA/en unknown
- 2011-08-09 ES ES11745672.3T patent/ES2564252T3/es active Active
- 2011-08-09 PH PH1/2013/500277A patent/PH12013500277A1/en unknown
- 2011-08-09 LT LTEP15196358.4T patent/LT3042917T/lt unknown
- 2011-08-09 NZ NZ606095A patent/NZ606095A/en unknown
- 2011-08-09 ME MEP-2018-79A patent/ME03032B/me unknown
- 2011-08-09 PE PE2013000253A patent/PE20130817A1/es active IP Right Grant
- 2011-08-09 BR BR112013004056A patent/BR112013004056B8/pt active IP Right Grant
- 2011-08-09 RS RS20160129A patent/RS54685B1/sr unknown
- 2011-08-09 SI SI201131817T patent/SI3339323T1/sl unknown
- 2011-08-09 ME MEP-2019-356A patent/ME03661B/me unknown
- 2011-08-09 CA CA2805114A patent/CA2805114C/en active Active
- 2011-08-09 WO PCT/US2011/046994 patent/WO2012021469A1/en not_active Ceased
- 2011-08-09 LT LTEP18150424.2T patent/LT3339323T/lt unknown
- 2011-08-09 PT PT151963584T patent/PT3042917T/pt unknown
- 2011-08-09 DK DK11745672.3T patent/DK2603523T3/en active
- 2011-08-09 ES ES18150424T patent/ES2764728T3/es active Active
- 2011-08-09 AU AU2011289629A patent/AU2011289629B2/en active Active
- 2011-08-09 PL PL18150424T patent/PL3339323T3/pl unknown
- 2011-08-09 ME MEP-2016-28A patent/ME02352B/me unknown
- 2011-08-09 ES ES15196358.4T patent/ES2664128T3/es active Active
- 2011-08-09 RS RS20180323A patent/RS57026B1/sr unknown
- 2011-08-09 DK DK15196358.4T patent/DK3042917T3/en active
- 2011-08-09 JP JP2013524156A patent/JP5980207B2/ja active Active
- 2011-08-09 EA EA201270813A patent/EA023021B1/ru not_active IP Right Cessation
- 2011-08-09 PL PL11745672T patent/PL2603523T3/pl unknown
- 2011-08-09 DK DK18150424.2T patent/DK3339323T3/da active
- 2011-08-09 MX MX2013001716A patent/MX342782B/es active IP Right Grant
- 2011-08-09 EP EP18150424.2A patent/EP3339323B1/en active Active
- 2011-08-09 SI SI201130740T patent/SI2603523T1/sl unknown
- 2011-08-09 PT PT181504242T patent/PT3339323T/pt unknown
- 2011-09-08 UA UAA201301508A patent/UA107600C2/ru unknown
2012
- 2012-12-31 IL IL224030A patent/IL224030B/en unknown
2013
- 2013-01-16 ZA ZA2013/00437A patent/ZA201300437B/en unknown
- 2013-01-16 CR CR20130016A patent/CR20130016A/es unknown
- 2013-02-05 DO DO2013000029A patent/DOP2013000029A/es unknown
- 2013-02-08 GT GT201300036A patent/GT201300036A/es unknown
- 2013-02-08 CL CL2013000390A patent/CL2013000390A1/es unknown
- 2013-02-08 EC ECSP13012436 patent/ECSP13012436A/es unknown
- 2013-02-12 MX MX2016005533A patent/MX355268B/es unknown
- 2013-02-12 CO CO13028596A patent/CO6670526A2/es unknown
- 2013-09-27 US US14/039,113 patent/US8961972B2/en active Active
2016
- 2016-04-22 JP JP2016086317A patent/JP6395755B2/ja active Active
2018
- 2018-04-18 HR HRP20180616TT patent/HRP20180616T1/hr unknown
- 2018-04-20 CY CY20181100420T patent/CY1120144T1/el unknown
2019
- 2019-12-12 HR HRP20192233TT patent/HRP20192233T1/hr unknown
2020
- 2020-01-07 CY CY20201100005T patent/CY1122458T1/el unknown
2025
- 2025-12-11 NO NO2025056C patent/NO2025056I1/no unknown
- 2025-12-18 FI FIC20250038C patent/FIC20250038I1/fi unknown
- 2025-12-29 FR FR25C1055C patent/FR25C1055I1/fr active Active
2026
- 2026-01-07 NL NL301359C patent/NL301359I2/nl unknown
- 2026-01-20 LT LTPA2026504C patent/LTPA2026504I1/lt unknown

Also Published As

Publication number	Publication date
RS59652B1 (sr)	2020-01-31
BR112013004056A2 (pt)	2020-08-04
HRP20192233T1 (hr)	2020-03-06
LT3339323T (lt)	2020-02-10
LT3042917T (lt)	2018-05-10
PT3042917T (pt)	2018-05-02
IL224030B (en)	2022-04-01
JP2013536191A (ja)	2013-09-19
PE20130817A1 (es)	2013-07-18
ME02352B (me)	2016-06-20
SI3339323T1 (sl)	2019-12-31
FR25C1055I1 (fr)	2026-03-06
FIC20250038I1 (fi)	2025-12-18
EA201270813A1 (ru)	2013-05-30
EP3042917A1 (en)	2016-07-13
CA2805114A1 (en)	2012-02-16
JP6395755B2 (ja)	2018-09-26
MY163521A (en)	2017-09-15
LTPA2026504I1 (pl)	2026-02-10
PL3042917T3 (pl)	2018-07-31
ES2664128T3 (es)	2018-04-18
HRP20180616T1 (hr)	2018-07-13
NZ606095A (en)	2014-11-28
EP3042917B1 (en)	2018-02-21
CL2013000390A1 (es)	2014-03-21
CN103068848A (zh)	2013-04-24
HK1180703A1 (zh)	2013-10-25
IL285226A (en)	2021-09-30
MX2013001716A (es)	2013-10-28
BR112013004056B8 (pt)	2022-10-18
ME03661B (me)	2020-07-20
CY1120144T1 (el)	2018-12-12
IL285226B2 (en)	2023-02-01
SI2603523T1 (sl)	2016-04-29
EP3339323A1 (en)	2018-06-27
CN105111308A (zh)	2015-12-02
EP3339323B1 (en)	2019-11-13
SG10201509330XA (en)	2015-12-30
AU2011289629A1 (en)	2013-02-14
KR20130051989A (ko)	2013-05-21
HRP20160151T1 (hr)	2016-03-11
JP2016179985A (ja)	2016-10-13
KR101498833B1 (ko)	2015-03-04
SG187586A1 (en)	2013-03-28
ES2564252T3 (es)	2016-03-21
HUE037524T2 (hu)	2018-09-28
HUE028678T2 (en)	2016-12-28
RS54685B1 (sr)	2016-08-31
ECSP13012436A (es)	2013-03-28
NO3042917T3 (pl)	2018-07-21
NZ626665A (en)	2016-04-29
GT201300036A (es)	2014-07-16
US20130142806A1 (en)	2013-06-06
SI3042917T1 (en)	2018-04-30
ZA201300437B (en)	2014-06-25
UA107600C2 (uk)	2015-01-26
CA2805114C (en)	2017-12-05
ME03032B (me)	2018-10-20
CO6670526A2 (es)	2013-05-15
DOP2013000029A (es)	2013-03-15
BR112013004056B1 (pt)	2022-05-17
WO2012021469A1 (en)	2012-02-16
NL301359I2 (nl)	2026-02-10
MX355268B (es)	2018-04-11
DK2603523T3 (en)	2016-03-21
ES2764728T3 (es)	2020-06-04
AU2011289629B2 (en)	2014-07-03
PL2603523T3 (pl)	2016-07-29
MX342782B (es)	2016-10-12
NO2025056I1 (no)	2025-12-11
CR20130016A (es)	2013-03-21
EP2603523A1 (en)	2013-06-19
US8961972B2 (en)	2015-02-24
CY1122458T1 (el)	2021-01-27
MY181969A (en)	2021-01-15
DK3042917T3 (en)	2018-04-23
US20140065138A1 (en)	2014-03-06
DK3339323T3 (da)	2020-01-20
CN105111308B (zh)	2019-03-12
IL285226B (en)	2022-10-01
US8679498B2 (en)	2014-03-25
EA023021B1 (ru)	2016-04-29
MA34461B1 (fr)	2013-08-01
JP5980207B2 (ja)	2016-08-31
RS57026B1 (sr)	2018-05-31
PH12013500277A1 (en)	2017-04-21
EP2603523B1 (en)	2016-01-27
CN103068848B (zh)	2015-11-25
PT3339323T (pt)	2020-01-14

Publication	Publication Date	Title
HRP20180616T1 (hr)	2018-07-13	Protutijela protiv amiloidnog beta peptida n3pglu i njihova upotreba
IL272831B (en)	2021-12-01	Meditops and Meditop binding antibodies and their use
IL259436A (en)	2018-07-31	Antibodies against 3angptl and their uses
IL230918A0 (en)	2014-03-31	Modified proteins and peptides
LT2946791T (lt)	2022-01-10	Anti-cd277 antikūnai ir jų panaudojimas
IL232399A0 (en)	2014-06-30	Anti-2fgfr antibodies and their use
ZA201208541B (en)	2015-06-24	Antibody preparations
ZA201206916B (en)	2014-03-26	Oligomer-specific amyloid beta epitope and antibodies
HUE044549T2 (hu)	2019-11-28	Peptidek és azok felhasználása
PL2621955T3 (pl)	2018-07-31	Przeciwciała anty-CEACAM6 i ich zastosowania
GB201121236D0 (en)	2012-01-18	Proteins and peptides
GB201121226D0 (en)	2012-01-18	Modified proteins and peptides
GB201121233D0 (en)	2012-01-18	Modified proteins and peptides