PL338954A1 - Novel derivatives of carboxylic acids, their production and application as mixed antagonists of endothelin et a/et b receptors - Google Patents

Novel derivatives of carboxylic acids, their production and application as mixed antagonists of endothelin et a/et b receptors

Info

Publication number: PL338954A1
Authority: PL; Poland
Prior art keywords: endothelin; receptors; production; application; carboxylic acids
Prior art date: 1997-09-04

Application number

PL98338954A

Other languages

English (en)

Original Assignee

Basf Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-04

Filing date

1998-08-24

Publication date

2000-12-04

1997-09-04 Priority claimed from DE19738578A external-priority patent/DE19738578A1/de

1998-03-18 Priority claimed from DE1998111915 external-priority patent/DE19811915A1/de

1998-08-24 Application filed by Basf Ag filed Critical Basf Ag

2000-12-04 Publication of PL338954A1 publication Critical patent/PL338954A1/xx

Links

102000002045 Endothelin Human genes 0.000 title 1
108050009340 Endothelin Proteins 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
150000001735 carboxylic acids Chemical class 0.000 title 1
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/36—One oxygen atom
- C07D263/38—One oxygen atom attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/44—Two oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)
Thiazole And Isothizaole Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PL98338954A 1997-09-04 1998-08-24 Novel derivatives of carboxylic acids, their production and application as mixed antagonists of endothelin et a/et b receptors PL338954A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19738578A DE19738578A1 (de)	1997-09-04	1997-09-04	Neue Carbonsäurederivate, ihre Herstellung und Verwendung als gemischte ET¶A¶/ET¶B¶-Rezeptorantagonisten
DE1998111915 DE19811915A1 (de)	1998-03-18	1998-03-18	Neue Carbonsäurederivate, ihre Herstellung und Verwendung als gemischte ET¶A¶/ET¶B¶-Rezeptorantagonisten

Publications (1)

Publication Number	Publication Date
PL338954A1 true PL338954A1 (en)	2000-12-04

Family

ID=26039663

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL98338954A PL338954A1 (en)	1997-09-04	1998-08-24	Novel derivatives of carboxylic acids, their production and application as mixed antagonists of endothelin et a/et b receptors

Country Status (21)

Country	Link
EP (1)	EP1009741A1 (id)
JP (1)	JP2001514254A (id)
KR (1)	KR20010023615A (id)
CN (1)	CN1269792A (id)
AR (1)	AR017052A1 (id)
AU (1)	AU748610B2 (id)
BG (1)	BG104222A (id)
BR (1)	BR9811631A (id)
CA (1)	CA2302350A1 (id)
CO (1)	CO4970738A1 (id)
HR (1)	HRP980484A2 (id)
HU (1)	HUP0004935A3 (id)
ID (1)	ID25620A (id)
IL (1)	IL134276A0 (id)
NO (1)	NO20001077D0 (id)
NZ (1)	NZ502660A (id)
PL (1)	PL338954A1 (id)
SK (1)	SK1522000A3 (id)
TR (1)	TR200000602T2 (id)
TW (1)	TW546295B (id)
WO (1)	WO1999011629A1 (id)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19924892A1 (de) *	1999-06-01	2000-12-07	Basf Ag	Neue Carbonsäurederivate mit arylsubstituierten Stickstoffheterocyclen, ihre Herstellung und Verwendung als Endothelin Rezeptorantagonisten
AU2007267209A1 (en) *	2006-05-29	2007-12-06	Nicox S.A.	Nitrated heterocyclic compounds as endothelin receptor antagonist
AU2009221179A1 (en)	2008-03-05	2009-09-11	Boehringer Ingelheim International Gmbh	Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation
ES2462065T3 (es) *	2009-07-10	2014-05-22	Cadila Healthcare Limited	Proceso mejorado para la preparación de Ambrisentán e intermedios novedosos de este
AU2011217206A1 (en)	2010-02-19	2012-08-02	Boehringer Ingelheim International Gmbh	Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation
EP2760868B1 (en)	2011-08-17	2018-04-25	Boehringer Ingelheim International GmbH	Furo[3,4-c]quinoline derivatives, medicaments containing such compounds, their use and process for their preparation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4411225A1 (de) *	1994-03-31	1995-10-05	Basf Ag	Verwendung von Carbonsäurederivaten als Arzneimittel
DE19533023B4 (de) *	1994-10-14	2007-05-16	Basf Ag	Neue Carbonsäurederivate, ihre Herstellung und Verwendung
WO1997028160A1 (en) *	1996-02-01	1997-08-07	Smithkline Beecham Corporation	Endothelin receptor antagonists
DE19614542A1 (de) *	1996-04-12	1997-10-16	Basf Ag	Neue Carbonsäurederivate, ihre Herstellung und Verwendung
DE19636046A1 (de) *	1996-09-05	1998-03-12	Basf Ag	Neue Carbonsäurederivate, ihre Herstellung und Verwendung als gemischte ET¶A¶/ET¶B¶-Rezeptorantagonisten

1998
- 1998-08-24 CA CA002302350A patent/CA2302350A1/en not_active Abandoned
- 1998-08-24 KR KR1020007002264A patent/KR20010023615A/ko not_active Withdrawn
- 1998-08-24 EP EP98948859A patent/EP1009741A1/de not_active Withdrawn
- 1998-08-24 PL PL98338954A patent/PL338954A1/xx unknown
- 1998-08-24 AU AU95333/98A patent/AU748610B2/en not_active Ceased
- 1998-08-24 HU HU0004935A patent/HUP0004935A3/hu unknown
- 1998-08-24 NZ NZ502660A patent/NZ502660A/en unknown
- 1998-08-24 WO PCT/EP1998/005354 patent/WO1999011629A1/de not_active Ceased
- 1998-08-24 CN CN98808862A patent/CN1269792A/zh active Pending
- 1998-08-24 BR BR9811631-2A patent/BR9811631A/pt not_active IP Right Cessation
- 1998-08-24 IL IL13427698A patent/IL134276A0/xx unknown
- 1998-08-24 SK SK152-2000A patent/SK1522000A3/sk unknown
- 1998-08-24 ID IDW20000386D patent/ID25620A/id unknown
- 1998-08-24 JP JP2000508669A patent/JP2001514254A/ja active Pending
- 1998-08-24 TR TR2000/00602T patent/TR200000602T2/xx unknown
- 1998-09-02 HR HR19811915.1A patent/HRP980484A2/hr not_active Application Discontinuation
- 1998-09-03 CO CO98050561A patent/CO4970738A1/es unknown
- 1998-09-03 TW TW087114595A patent/TW546295B/zh active
- 1998-09-03 AR ARP980104402A patent/AR017052A1/es not_active Application Discontinuation
2000
- 2000-03-02 NO NO20001077A patent/NO20001077D0/no not_active Application Discontinuation
- 2000-03-06 BG BG104222A patent/BG104222A/xx unknown

Also Published As

Publication number	Publication date
WO1999011629A1 (de)	1999-03-11
NO20001077L (no)	2000-03-02
CA2302350A1 (en)	1999-03-11
JP2001514254A (ja)	2001-09-11
AU748610B2 (en)	2002-06-06
AR017052A1 (es)	2001-08-22
HUP0004935A3 (en)	2001-12-28
NZ502660A (en)	2002-02-01
CO4970738A1 (es)	2000-11-07
IL134276A0 (en)	2001-04-30
CN1269792A (zh)	2000-10-11
HUP0004935A2 (hu)	2001-10-28
TR200000602T2 (tr)	2000-12-21
TW546295B (en)	2003-08-11
SK1522000A3 (en)	2000-08-14
NO20001077D0 (no)	2000-03-02
HRP980484A2 (en)	1999-06-30
BG104222A (en)	2001-02-28
EP1009741A1 (de)	2000-06-21
KR20010023615A (ko)	2001-03-26
ID25620A (id)	2000-10-19
AU9533398A (en)	1999-03-22
BR9811631A (pt)	2000-09-26

Publication	Publication Date	Title
PL331998A1 (en)	1999-08-16	Derivatives of azinyloxy-a nd phenyloxy-diaryl carboxylic acids, their production and application as mixed antagonists of endothelin et/et receptors
PL337809A1 (en)	2000-09-11	Derivatives of 1-aminoalkyl cyclohexane as antagonists of nmda receptor
AU6267198A (en)	1998-09-08	Amides as npy5 receptor antagonists
IL122464A0 (en)	1998-09-15	N-heteroaryl-pyridinesulonamide derivatives and their use as endothelin antagonists
AU2001269876A1 (en)	2001-12-24	Heteroarylalkanoic acids as integrin receptor antagonists
AU2001269821A1 (en)	2001-12-24	Cycloalkyl alkanoic acids as integrin receptor antagonists
PL342500A1 (en)	2001-06-04	Derivatives of pyrolydin-3-carboxylic acid and their application as endothelin antagonists
AU2001231730A1 (en)	2001-08-20	Piperidyl carboxylic acids as integrin antagonists
PL329241A1 (en)	1999-03-15	Novel derivatives of alpha-hydroxycarboxylic acids, their production and application
IL113050A0 (en)	1995-06-29	Antagonists of endothelin receptors
IL135347A0 (en)	2001-05-20	New carboxylic acid derivatives, carrying amido side-chains; production and use as endothelin receptor antagonists
HRP970199A2 (en)	1998-06-30	New carboxylic acid derivatives, their production and use
PL334014A1 (en)	2000-01-31	Heterocyclic derivatives of carboxylic acids, their preduction and application as antagonists of endothelin receptors
PL329240A1 (en)	1999-03-15	Novel derivatives of carboxylic acid, their production and application
PL337507A1 (en)	2000-08-28	Novel derivatives of beta-amino and beta-azidocarboxylic acids, their production and application as antagonists of endothelin receptors
IL129660A0 (en)	2000-02-29	Piperazino derivatives as neurokinin antagonists
PL320638A1 (en)	1997-10-13	Antagonists of endothein receptors
HUP0004935A3 (en)	2001-12-28	Novel carboxylic acid derivatives, their production and their use as mixed eta/etb endothelin-receptor antagonists
PL325398A1 (en)	1998-07-20	Novel derivatives of carboxylic acids, their production and application
IL132615A0 (en)	2001-03-19	Pyrrolidine carboxylic acid derivatives as endothelin antagonists
PL342806A1 (en)	2001-07-02	Novel dissymmetrical substitute derivatives of carboxylic acids, their production and application as mixed antagonists of eta/etb receptors
AU3027199A (en)	1999-09-06	5-substituted pyrimidine-2-yloxy carboxylic acid derivatives, the production of the same and their utilization as endothelin antagonists
IL135461A0 (en)	2001-05-20	NOVEL HETEROCYCLICALLY SUBSTITUTED α- HYDROXYCARBOXLIC ACID DERIVATIVES, METHOD FOR PRODUCING THE SAME AND THEIR USE AS ENDOTHELIN RECEPTOR ANTAGONISTS
AU3036400A (en)	2000-07-12	New beta-amide and beta-sulfonamide carboxylic acid derivatives, their preparation and their use as endothelin receptor antagonists
IL147666A0 (en)	2002-08-14	Novel carboxylic acid derivatives with 5, 6 substituted pyrimidine ring, the production and utilization thereof as endothelin receptor antagonists