PL339176A1 - Derivatives of pyrrolopyrrolone as inhibitors of neutrophilic elastase - Google Patents

Derivatives of pyrrolopyrrolone as inhibitors of neutrophilic elastase

Info

Publication number
PL339176A1
PL339176A1 PL98339176A PL33917698A PL339176A1 PL 339176 A1 PL339176 A1 PL 339176A1 PL 98339176 A PL98339176 A PL 98339176A PL 33917698 A PL33917698 A PL 33917698A PL 339176 A1 PL339176 A1 PL 339176A1
Authority
PL
Poland
Prior art keywords
pyrrolopyrrolone
inhibitors
derivatives
neutrophilic elastase
neutrophilic
Prior art date
Application number
PL98339176A
Other languages
English (en)
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9719189.4A external-priority patent/GB9719189D0/en
Priority claimed from GBGB9719183.7A external-priority patent/GB9719183D0/en
Priority claimed from GBGB9719290.0A external-priority patent/GB9719290D0/en
Priority claimed from GBGB9803611.4A external-priority patent/GB9803611D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PL339176A1 publication Critical patent/PL339176A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
PL98339176A 1997-09-09 1998-09-07 Derivatives of pyrrolopyrrolone as inhibitors of neutrophilic elastase PL339176A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9719189.4A GB9719189D0 (en) 1997-09-09 1997-09-09 New therapeutic method
GBGB9719183.7A GB9719183D0 (en) 1997-09-09 1997-09-09 Compounds
GBGB9719290.0A GB9719290D0 (en) 1997-09-10 1997-09-10 Compounds
GBGB9803611.4A GB9803611D0 (en) 1998-02-21 1998-02-21 Compounds
PCT/EP1998/005609 WO1999012933A2 (en) 1997-09-09 1998-09-07 Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase

Publications (1)

Publication Number Publication Date
PL339176A1 true PL339176A1 (en) 2000-12-04

Family

ID=27451698

Family Applications (1)

Application Number Title Priority Date Filing Date
PL98339176A PL339176A1 (en) 1997-09-09 1998-09-07 Derivatives of pyrrolopyrrolone as inhibitors of neutrophilic elastase

Country Status (24)

Country Link
EP (1) EP1003748A2 (tr)
JP (1) JP2001515904A (tr)
KR (1) KR20010023766A (tr)
CN (1) CN1278820A (tr)
AP (1) AP2000001761A0 (tr)
AR (1) AR017072A1 (tr)
AU (1) AU9741298A (tr)
BR (1) BR9812062A (tr)
CA (1) CA2303176A1 (tr)
CO (1) CO4970719A1 (tr)
EA (1) EA200000204A1 (tr)
EE (1) EE200000138A (tr)
HU (1) HUP0004644A3 (tr)
ID (1) ID24452A (tr)
IL (1) IL134791A0 (tr)
IS (1) IS5391A (tr)
MA (1) MA26543A1 (tr)
NO (1) NO20001198L (tr)
NZ (1) NZ503130A (tr)
PE (1) PE107899A1 (tr)
PL (1) PL339176A1 (tr)
SK (1) SK3192000A3 (tr)
TR (1) TR200000907T2 (tr)
WO (1) WO1999012933A2 (tr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9905418D0 (en) * 1999-03-09 1999-05-05 Glaxo Group Ltd Process
ATE490959T1 (de) 2004-03-31 2010-12-15 Janssen Pharmaceutica Nv Heterocyclische nichtimidazolverbindungen als modulatoren des histamin-h3-rezeptors
DE102004024772A1 (de) * 2004-05-17 2005-12-22 Grünenthal GmbH Substituierte 5-Aminomethyl-1H-pyrrol-2-carbonsäureamide
TWI355380B (en) 2004-05-27 2012-01-01 Nihon Nohyaku Co Ltd Substituted pyrazinecarboxanilide derivatives or s
JP4853759B2 (ja) * 2004-05-27 2012-01-11 日本農薬株式会社 置換ピラジンカルボン酸アニリド誘導体又はその塩類、その中間体及び農園芸用薬剤並びにその使用方法
GB2418427A (en) 2004-09-02 2006-03-29 Univ Cambridge Tech Ligands for G-protein coupled receptors
AP2007003979A0 (en) 2004-11-23 2007-06-30 Warner Lambert Co 7-(2h-pyrazol-3-yl)-3,5-dihyroxy-heptanoic acid derivatives as hmg co-a reductase inhibitors for thetreatment of lipidemia
US8198288B2 (en) 2006-05-04 2012-06-12 Pulmagen Therapeutics (Inflammation) Limited Tetrahydropyrrolopyrimidinediones and their use in therapy
DE602007009095D1 (de) 2006-05-04 2010-10-21 Pulmagen Therapeutics Inflamma Tetrahydropyrrolopyrimidindione und ihre verwendung als inhibitoren der humanen neutrophilen elastase
GB2452696B (en) 2007-08-02 2009-09-23 Cambridge Entpr Ltd 3-(2',2'-dimethylpropanoylamino)-tetrahydropyridin-2-one and its use in pharmaceutical compositions
US7662967B2 (en) 2007-08-02 2010-02-16 Cambridge Enterprise Limited Anti-inflammatory compounds and compositions
WO2009060206A1 (en) * 2007-11-07 2009-05-14 Argenta Discovery Limited 3,4,6,7-tetrahydro-1h-pyrrolo[3,4-d]pyrimidine-2,5-diones and their therapeutic use
US20110212181A1 (en) * 2010-02-26 2011-09-01 The University Of Hong Kong Compositions and methods for treating chronic respiratory inflammation
JP7672641B2 (ja) 2019-09-17 2025-05-08 メレオ バイオファーマ ４ リミテッド 移植片拒絶反応、閉塞性細気管支炎症候群、及び移植片対宿主病の治療に使用するためのアルベレスタット
IL297211B2 (en) 2020-04-16 2025-12-01 Mereo Biopharma 4 Ltd Methods involving neutrophil elastase inhibitor alvelestat for treating respiratory disease mediated by alpha-1 antitrypsin deficiency
KR20240090272A (ko) 2021-10-20 2024-06-21 메레오 바이오파마 4 리미티드 섬유화 치료에 사용하기 위한 호중구 엘라스테이스 억제제

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9211783D0 (en) * 1992-06-04 1992-07-15 Ici Plc Amide derivatives
GB9402680D0 (en) * 1994-02-11 1994-04-06 Zeneca Ltd Pyrrolidine derivatives
CA2250209A1 (en) * 1996-03-28 1997-10-09 Glaxo Group Limited Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase

Also Published As

Publication number Publication date
TR200000907T2 (tr) 2000-11-21
PE107899A1 (es) 1999-11-17
CO4970719A1 (es) 2000-11-07
AU9741298A (en) 1999-03-29
ID24452A (id) 2000-07-20
EE200000138A (et) 2001-02-15
MA26543A1 (fr) 2004-12-20
CA2303176A1 (en) 1999-03-18
WO1999012933A2 (en) 1999-03-18
AP2000001761A0 (en) 2000-03-31
IL134791A0 (en) 2001-04-30
SK3192000A3 (en) 2001-03-12
WO1999012933A3 (en) 1999-05-27
JP2001515904A (ja) 2001-09-25
AR017072A1 (es) 2001-08-22
NZ503130A (en) 2001-08-31
IS5391A (is) 2000-02-29
BR9812062A (pt) 2000-09-26
HUP0004644A3 (en) 2002-01-28
NO20001198L (no) 2000-05-08
CN1278820A (zh) 2001-01-03
HUP0004644A2 (hu) 2001-09-28
EP1003748A2 (en) 2000-05-31
KR20010023766A (ko) 2001-03-26
EA200000204A1 (ru) 2000-10-30
NO20001198D0 (no) 2000-03-08

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Legal Events

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