PL3408276T3 - 5’-tiofosforanowe analogi końca 5’ mRNA (kapu), mRNA je zawierające, sposób ich otrzymywania i zastosowania - Google Patents
5’-tiofosforanowe analogi końca 5’ mRNA (kapu), mRNA je zawierające, sposób ich otrzymywania i zastosowaniaInfo
- Publication number
- PL3408276T3 PL3408276T3 PL17712541T PL17712541T PL3408276T3 PL 3408276 T3 PL3408276 T3 PL 3408276T3 PL 17712541 T PL17712541 T PL 17712541T PL 17712541 T PL17712541 T PL 17712541T PL 3408276 T3 PL3408276 T3 PL 3408276T3
- Authority
- PL
- Poland
- Prior art keywords
- mrna
- phosphorothiolate
- analogs
- cap
- obtaining
- Prior art date
Links
- 108020004999 messenger RNA Proteins 0.000 title 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/02—Phosphorylation
- C07H1/04—Introducing polyphosphoric acid radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL415967A PL415967A1 (pl) | 2016-01-29 | 2016-01-29 | 5'-tiofosforanowe analogi końca 5' mRNA (kapu), sposób ich otrzymywania i zastosowanie |
| EP17712541.6A EP3408276B1 (en) | 2016-01-29 | 2017-01-27 | 5'-phosphorothiolate mrna 5'-end (cap) analogs, mrna comprising the same, method of obtaining and uses thereof |
| PCT/IB2017/050447 WO2017130151A1 (en) | 2016-01-29 | 2017-01-27 | 5'-phosphorothiolate mrna 5'-end (cap) analogs, mrna comprising the same, method of obtaining and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3408276T3 true PL3408276T3 (pl) | 2021-10-25 |
Family
ID=58387852
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL415967A PL415967A1 (pl) | 2016-01-29 | 2016-01-29 | 5'-tiofosforanowe analogi końca 5' mRNA (kapu), sposób ich otrzymywania i zastosowanie |
| PL17712541T PL3408276T3 (pl) | 2016-01-29 | 2017-01-27 | 5’-tiofosforanowe analogi końca 5’ mRNA (kapu), mRNA je zawierające, sposób ich otrzymywania i zastosowania |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL415967A PL415967A1 (pl) | 2016-01-29 | 2016-01-29 | 5'-tiofosforanowe analogi końca 5' mRNA (kapu), sposób ich otrzymywania i zastosowanie |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11066436B2 (pl) |
| EP (1) | EP3408276B1 (pl) |
| JP (1) | JP7144050B2 (pl) |
| KR (1) | KR102742219B1 (pl) |
| CN (1) | CN109071589A (pl) |
| AU (1) | AU2017211693B2 (pl) |
| CA (1) | CA3011663C (pl) |
| EA (1) | EA038834B1 (pl) |
| ES (1) | ES2879802T3 (pl) |
| PL (2) | PL415967A1 (pl) |
| WO (1) | WO2017130151A1 (pl) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020231697A1 (en) * | 2019-05-10 | 2020-11-19 | New England Biolabs, Inc. | Chemical capping for template switching |
| CN110907358B (zh) * | 2019-12-09 | 2022-08-30 | 福建师范大学 | 一种光微流微泡腔铅离子传感器的实现装置及方法 |
| PL432884A1 (pl) * | 2020-02-12 | 2021-08-16 | Uniwersytet Warszawski | Nowe analogi kapu końca 5' mRNA, cząsteczka RNA je zawierająca, ich zastosowania i sposób syntezy cząsteczki RNA i peptydu |
| CN113337558A (zh) * | 2020-08-20 | 2021-09-03 | 深圳市瑞吉生物科技有限公司 | 一种Cap2结构5`帽子类似物及其制备方法和应用 |
| EP4208549A4 (en) | 2020-09-04 | 2025-04-16 | Verve Therapeutics, Inc. | Compositions and methods for capping RNAs |
| WO2023167880A2 (en) * | 2022-03-01 | 2023-09-07 | Verve Therapeutics, Inc. | Compositions and methods for capping rnas |
| CN114685588B (zh) * | 2022-05-05 | 2024-03-29 | 江苏申基生物科技有限公司 | 一种含开环核苷结构的起始加帽寡核苷酸引物 |
| CN116143855B (zh) * | 2022-11-08 | 2023-11-28 | 江苏申基生物科技有限公司 | 一种乙烯基膦酸修饰的mRNA帽类似物及其制备方法和应用 |
| EP4464713A1 (en) | 2023-05-18 | 2024-11-20 | Siec Badawcza Lukasiewicz - PORT Polski Osrodek Rozwoju Technologii | Circular rna analogs, preparation and application thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008546424A (ja) | 2005-06-28 | 2008-12-25 | アジェンコート パーソナル ジェノミクス コーポレイション | 修飾ポリヌクレオチドを作製する方法および配列決定する方法 |
| EP2167523B1 (en) * | 2007-06-19 | 2014-07-23 | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College | Synthesis and use of anti-reverse phosphorothioate analogs of the messenger rna cap |
| PL215513B1 (pl) | 2008-06-06 | 2013-12-31 | Univ Warszawski | Nowe boranofosforanowe analogi dinukleotydów, ich zastosowanie, czasteczka RNA, sposób otrzymywania RNA oraz sposób otrzymywania peptydów lub bialka |
| EP2281579A1 (en) * | 2009-08-05 | 2011-02-09 | BioNTech AG | Vaccine composition comprising 5'-Cap modified RNA |
| ES2647832T3 (es) * | 2013-03-14 | 2017-12-26 | Translate Bio, Inc. | Ácidos ribonucleicos con nucleótidos modificados con 4-tio y procedimientos relacionados |
| RS59991B1 (sr) * | 2013-08-08 | 2020-04-30 | Scripps Research Inst | Metoda enzimskog in vitro obeležavanja specifičnog za položaj nukleinskih kiselina uvođenjem neprirodnih nukleotida |
-
2016
- 2016-01-29 PL PL415967A patent/PL415967A1/pl unknown
-
2017
- 2017-01-27 EA EA201891429A patent/EA038834B1/ru unknown
- 2017-01-27 US US16/073,499 patent/US11066436B2/en active Active
- 2017-01-27 CA CA3011663A patent/CA3011663C/en active Active
- 2017-01-27 AU AU2017211693A patent/AU2017211693B2/en active Active
- 2017-01-27 KR KR1020187021714A patent/KR102742219B1/ko active Active
- 2017-01-27 PL PL17712541T patent/PL3408276T3/pl unknown
- 2017-01-27 ES ES17712541T patent/ES2879802T3/es active Active
- 2017-01-27 EP EP17712541.6A patent/EP3408276B1/en active Active
- 2017-01-27 JP JP2018537845A patent/JP7144050B2/ja active Active
- 2017-01-27 CN CN201780013350.3A patent/CN109071589A/zh active Pending
- 2017-01-27 WO PCT/IB2017/050447 patent/WO2017130151A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| KR20180100595A (ko) | 2018-09-11 |
| ES2879802T3 (es) | 2021-11-23 |
| PL415967A1 (pl) | 2017-07-31 |
| US20190300563A1 (en) | 2019-10-03 |
| AU2017211693A1 (en) | 2018-08-09 |
| EA201891429A1 (ru) | 2019-02-28 |
| EA038834B1 (ru) | 2021-10-26 |
| KR102742219B1 (ko) | 2024-12-13 |
| CA3011663A1 (en) | 2017-08-03 |
| US11066436B2 (en) | 2021-07-20 |
| CN109071589A (zh) | 2018-12-21 |
| AU2017211693B2 (en) | 2021-09-09 |
| CA3011663C (en) | 2023-10-31 |
| JP2019504837A (ja) | 2019-02-21 |
| WO2017130151A1 (en) | 2017-08-03 |
| EP3408276A1 (en) | 2018-12-05 |
| EP3408276B1 (en) | 2021-04-07 |
| JP7144050B2 (ja) | 2022-09-29 |
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