PL344745A1 - Pharmaceutical formulation containing a microbial enzyme which digests hyaluronic acid - Google Patents

Pharmaceutical formulation containing a microbial enzyme which digests hyaluronic acid

Info

Publication number: PL344745A1
Authority: PL; Poland
Prior art keywords: hyaluronic acid; pharmaceutical formulation; formulation containing; microbial enzyme; digests
Prior art date: 1998-12-23

Application number

PL99344745A

Inventor

Norbert Presselt

Peter-Juergen Mueller

Joerg-Hermann Ozegowski

Albert Haertl

Gundela Peschel

Original Assignee

Id Pharma Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-12-23

Filing date

1999-12-22

Publication date

2001-11-19

1998-12-23 Priority claimed from DE1998160542 external-priority patent/DE19860542A1/en

1998-12-23 Priority claimed from DE1998160541 external-priority patent/DE19860541A1/en

1999-12-22 Application filed by Id Pharma Gmbh filed Critical Id Pharma Gmbh

2001-11-19 Publication of PL344745A1 publication Critical patent/PL344745A1/en

Links

KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title 1
102000004190 Enzymes Human genes 0.000 title 1
108090000790 Enzymes Proteins 0.000 title 1
229920002674 hyaluronan Polymers 0.000 title 1
229960003160 hyaluronic acid Drugs 0.000 title 1
230000000813 microbial effect Effects 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/51—Lyases (4)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/02—Carbon-oxygen lyases (4.2) acting on polysaccharides (4.2.2)
- C12Y402/02001—Hyaluronate lyase (4.2.2.1)

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Microbiology (AREA)
Cardiology (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Diabetes (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

PL99344745A 1998-12-23 1999-12-22 Pharmaceutical formulation containing a microbial enzyme which digests hyaluronic acid PL344745A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE1998160542 DE19860542A1 (en)	1998-12-23	1998-12-23	An enzyme fragment with hyaluronate lyase activity is derived from streptococci and used for medical applications
DE1998160541 DE19860541A1 (en)	1998-12-23	1998-12-23	Composition for the treatment of vascular disease comprises holozyme with hyaluronate lyase activity from microbial origin
PCT/DE1999/004108 WO2000039290A2 (en)	1998-12-23	1999-12-22	Pharmaceutical formulation containing a microbial enzyme which digests hyaluronic acid

Publications (1)

Publication Number	Publication Date
PL344745A1 true PL344745A1 (en)	2001-11-19

Family

ID=26051101

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL99344745A PL344745A1 (en)	1998-12-23	1999-12-22	Pharmaceutical formulation containing a microbial enzyme which digests hyaluronic acid

Country Status (10)

Country	Link
EP (1)	EP1056839A1 (en)
JP (1)	JP2002533473A (en)
KR (1)	KR20010041235A (en)
AU (1)	AU3032400A (en)
CA (1)	CA2318356A1 (en)
DE (1)	DE19982882D2 (en)
HU (1)	HUP0103660A2 (en)
IL (1)	IL138051A0 (en)
PL (1)	PL344745A1 (en)
WO (1)	WO2000039290A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19963538A1 (en) *	1999-12-22	2001-07-05	Univ Schiller Jena	Use of an enzyme to improve tissue absorption of drugs
DE10103271A1 (en) *	2001-01-23	2002-07-25	Knoell Hans Forschung Ev	Pharmaceutical formulation containing hyaluronatlyase, useful for softening of connective tissue in medical and cosmetic treatment, especially in shape correction
US7871607B2 (en)	2003-03-05	2011-01-18	Halozyme, Inc.	Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
US20060104968A1 (en) *	2003-03-05	2006-05-18	Halozyme, Inc.	Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
EP2330213A1 (en)	2003-03-05	2011-06-08	Halozyme, Inc.	Soluble hyaluronidase glycoprotein (sHASEGP), process for preparing the same, uses and pharmaceutical compositions comprising thereof
WO2004110479A1 (en) *	2003-05-27	2004-12-23	Hans-Knöll-Institut für Naturstoff-Forschung e.V.	Hyaluronate lyase-containing agent for treating acute myocardial infarction or symptoms thereof and for the treatment of postinfarction myocarditis and myocardial ischaemia
DE102007031417A1 (en)	2007-07-04	2009-01-08	Friedrich-Schiller-Universität Jena	Hyaluronate lyase with a histidine tag e.g. useful in pharmaceutical formulations and medical products
RU2501811C2 (en)	2007-11-13	2013-12-20	Био-Текнолоджи Дженерал (Изрейел) Лтд.	Method for sterilisation by filtration of diluted viscoelastic biopolymers (versions)
CN102307993B (en)	2008-12-09	2014-06-25	哈洛齐梅公司	Extended soluble ph20 polypeptides and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1120298A (en) *	1966-07-11	1968-07-17	Biorex Laboratories Ltd	Stabilised enzymes
US3708575A (en) *	1970-05-13	1973-01-02	Biorex Laboratories Ltd	Method for the treatment of atherosclerosis employing glucuronoglycos-aminoglycan-hyaluronate-lyase
US3728223A (en) *	1971-10-08	1973-04-17	Amano Pharma Co Ltd	Production of hyaluronidase from a strain of streptomyces
DE59906392D1 (en) *	1998-12-23	2003-08-28	Esparma Gmbh	HYALURONATE LASE AS A PENETRATION CONVEYOR IN TOPICAL AGENTS

1999
- 1999-12-22 AU AU30324/00A patent/AU3032400A/en not_active Abandoned
- 1999-12-22 IL IL13805199A patent/IL138051A0/en unknown
- 1999-12-22 EP EP99964464A patent/EP1056839A1/en not_active Withdrawn
- 1999-12-22 CA CA002318356A patent/CA2318356A1/en not_active Abandoned
- 1999-12-22 JP JP2000591182A patent/JP2002533473A/en active Pending
- 1999-12-22 PL PL99344745A patent/PL344745A1/en not_active Application Discontinuation
- 1999-12-22 WO PCT/DE1999/004108 patent/WO2000039290A2/en not_active Ceased
- 1999-12-22 DE DE19982882T patent/DE19982882D2/en not_active Expired - Lifetime
- 1999-12-22 KR KR1020007009327A patent/KR20010041235A/en not_active Ceased
- 1999-12-22 HU HU0103660A patent/HUP0103660A2/en unknown

Also Published As

Publication number	Publication date
AU3032400A (en)	2000-07-31
IL138051A0 (en)	2001-10-31
KR20010041235A (en)	2001-05-15
WO2000039290A8 (en)	2000-10-19
WO2000039290A3 (en)	2001-03-08
JP2002533473A (en)	2002-10-08
CA2318356A1 (en)	2000-07-06
HUP0103660A2 (en)	2002-01-28
WO2000039290A2 (en)	2000-07-06
EP1056839A1 (en)	2000-12-06
DE19982882D2 (en)	2001-10-04

Legal Events

Date	Code	Title	Description
2008-03-31	REFS	Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)

Publication	Publication Date	Title
AU4823800A (en)	2000-11-17	Modular display system
AU6740298A (en)	1998-10-20	Pharmaceutical composition
AU1878601A (en)	2001-06-18	Enzyme
AU1574900A (en)	2000-06-26	Pharmaceutical compositions containing insulin
AU3556400A (en)	2000-10-04	Pharmaceutical compositions
AU2005300A (en)	2000-08-07	Medicinal compositions
AU4328800A (en)	2000-11-10	Pharmaceutical formulation
AU1887401A (en)	2001-06-25	Medicinal composition
AU8107998A (en)	1998-12-11	Pharmaceutical compositions
AU6715600A (en)	2001-03-19	Pharmaceutical formulations
AU1564501A (en)	2001-06-04	Display system
AU6949200A (en)	2001-03-26	Human hydrolytic enzymes
AU3677100A (en)	2000-11-14	Alpha-glycated amino acid releasing enzyme
AU3032400A (en)	2000-07-31	Pharmaceutical formulation containing a microbial enzyme which digests hyaluronic acid
AU6460400A (en)	2001-03-13	Pharmaceutical compositions
AU9343098A (en)	1999-03-08	Pharmaceutical composition
AU4977300A (en)	2000-11-17	Pharmaceutical formulations
AU1385801A (en)	2001-04-30	Pharmaceutical formulations
AU6460200A (en)	2001-03-13	Pharmaceutical compositions
AUPP332898A0 (en)	1998-05-28	Pharmaceutical composition
AU3041500A (en)	2000-07-31	Dermatological compositions containing tannic acid and a microbial proliferationinhibitor
AU3839900A (en)	2000-11-10	Pharmaceutical formulation
AU6460100A (en)	2001-03-13	Pharmaceutical compositions
AU6460300A (en)	2001-03-13	Pharmaceutical compositions
AU5182099A (en)	2000-03-06	Pharmaceutical formulation