PL345998A1 - New carboxylic acid derivatives carrying keto side-chains, their production and their use as endothelin-receptor antagonists - Google Patents

New carboxylic acid derivatives carrying keto side-chains, their production and their use as endothelin-receptor antagonists

Info

Publication number
PL345998A1
PL345998A1 PL99345998A PL34599899A PL345998A1 PL 345998 A1 PL345998 A1 PL 345998A1 PL 99345998 A PL99345998 A PL 99345998A PL 34599899 A PL34599899 A PL 34599899A PL 345998 A1 PL345998 A1 PL 345998A1
Authority
PL
Poland
Prior art keywords
endothelin
chains
production
carboxylic acid
acid derivatives
Prior art date
Application number
PL99345998A
Other languages
English (en)
Inventor
Wilhelm Amberg
Rolf Jansen
Georg Kettschau
Stefan Hergenroeder
Manfred Raschack
Liliane Unger
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of PL345998A1 publication Critical patent/PL345998A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL99345998A 1998-08-10 1999-08-07 New carboxylic acid derivatives carrying keto side-chains, their production and their use as endothelin-receptor antagonists PL345998A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19836044A DE19836044A1 (de) 1998-08-10 1998-08-10 Neue Carbonsäurederivate, die Ketoseitenketten tragen, ihre Herstellung und Verwendung als Endothelin-Rezeptorantagonisten
PCT/EP1999/005728 WO2000009489A1 (de) 1998-08-10 1999-08-07 Neue carbonsäurederivate, die ketoseitenketten tragen, ihre herstellung und verwendung als endothelin-rezeptorantagonisten

Publications (1)

Publication Number Publication Date
PL345998A1 true PL345998A1 (en) 2002-01-14

Family

ID=7876981

Family Applications (1)

Application Number Title Priority Date Filing Date
PL99345998A PL345998A1 (en) 1998-08-10 1999-08-07 New carboxylic acid derivatives carrying keto side-chains, their production and their use as endothelin-receptor antagonists

Country Status (22)

Country Link
EP (1) EP1104410A1 (id)
JP (1) JP2002522531A (id)
KR (1) KR20010072378A (id)
CN (1) CN1323298A (id)
AR (1) AR020147A1 (id)
AU (1) AU5374199A (id)
BG (1) BG105236A (id)
BR (1) BR9912889A (id)
CA (1) CA2340167A1 (id)
CO (1) CO5261504A1 (id)
DE (1) DE19836044A1 (id)
HK (1) HK1042086A1 (id)
HR (1) HRP20010164A2 (id)
HU (1) HUP0104007A3 (id)
ID (1) ID27965A (id)
IL (1) IL140915A0 (id)
NO (1) NO20010622L (id)
PL (1) PL345998A1 (id)
SK (1) SK832001A3 (id)
TR (1) TR200100427T2 (id)
WO (1) WO2000009489A1 (id)
ZA (1) ZA200101975B (id)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19924892A1 (de) * 1999-06-01 2000-12-07 Basf Ag Neue Carbonsäurederivate mit arylsubstituierten Stickstoffheterocyclen, ihre Herstellung und Verwendung als Endothelin Rezeptorantagonisten

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19636046A1 (de) * 1996-09-05 1998-03-12 Basf Ag Neue Carbonsäurederivate, ihre Herstellung und Verwendung als gemischte ET¶A¶/ET¶B¶-Rezeptorantagonisten

Also Published As

Publication number Publication date
AU5374199A (en) 2000-03-06
DE19836044A1 (de) 2000-02-17
NO20010622D0 (no) 2001-02-06
ID27965A (id) 2001-05-03
CO5261504A1 (es) 2003-03-31
CA2340167A1 (en) 2000-02-24
BG105236A (en) 2001-12-29
AR020147A1 (es) 2002-04-10
HUP0104007A2 (hu) 2002-05-29
JP2002522531A (ja) 2002-07-23
CN1323298A (zh) 2001-11-21
SK832001A3 (en) 2001-11-06
NO20010622L (no) 2001-02-06
KR20010072378A (ko) 2001-07-31
WO2000009489A1 (de) 2000-02-24
HK1042086A1 (zh) 2002-08-02
EP1104410A1 (de) 2001-06-06
BR9912889A (pt) 2001-05-08
TR200100427T2 (tr) 2001-07-23
HUP0104007A3 (en) 2002-12-28
IL140915A0 (en) 2002-02-10
ZA200101975B (en) 2002-03-11
HRP20010164A2 (en) 2002-04-30

Similar Documents

Publication Publication Date Title
SI1492771T1 (sl) Kinolinski in izokinolinski derivati, postopek za njihovo pripravo in njihova uporaba kot protivnetna sredstva
AU3301800A (en) 1,4-diazabicyclo(3.2.2)nonane-4-carboxylate and carboxamide derivatives, production and use thereof in therapeutics
HUP0203425A3 (en) Quinazoline derivatives, process for their preparation and their use
IL147744A0 (en) Novel hydantoin, thiohydantoin, pyrimidinedione and thioxopyrimidinone derivatives, preparation method and use as medicines
IL144370A0 (en) Epothilon derivatives, method for the production and the use thereof as pharmaceuticals
IL155624A0 (en) Novel imidazole derivatives, production method thereof and use thereof
AU2001226794A1 (en) Substituted 1,2,3,4- tetrahydroquinoline-2-carboxylic acid derivatives
HRP970199A2 (en) New carboxylic acid derivatives, their production and use
IL135347A0 (en) New carboxylic acid derivatives, carrying amido side-chains; production and use as endothelin receptor antagonists
HRP970200A2 (en) Novel carboxylic acid derivatives, their production and use
IL130251A0 (en) Heterocyclic carboxylic acid derivatives the production and use thereof as endothelin receptor antagonists
IL140915A0 (en) New carboxylic acid derivatives carrying keto side-chains, their production and their use as endothelin-receptor antagonists
IL133104A0 (en) New - beta-amino and beta-azidocarboxylic acid derivatives the production thereof and the use thereof as endothelin receptor antagonists
IL134276A0 (en) Novel carboxylic acid derivatives, their production and their use as mixed eta/etb endothelin-receptor antagonists
IL137038A0 (en) 5-substituted pyrimidine-2-yloxy carboxylic acid derivatives, the production of the same and their utilization as endothelin antagonists
AU2001252254A1 (en) 2,6-diamino-6-methyl-heptanoic acid and derivatives, process for the preparationthereof and use thereof
HU0001397D0 (en) 3-amino-3-arylpropan-1-ol derivatives, production and use thereof
AU3036400A (en) New beta-amide and beta-sulfonamide carboxylic acid derivatives, their preparation and their use as endothelin receptor antagonists
PL355112A1 (en) Carboxylic acid derivatives comprising aryl-substituted nitrogen heterocycles, their production and their use as endothelin receptor antagonists
AU2001268490A1 (en) Dihydrostilbene alkanoic acid derivatives useful as vitronectin antagonists
HUP0004341A3 (en) Novel heterocyclically substituted alpha-hydroxycarboxilic acid derivatives, method for producing the same and their use as endothelin receptor antagonists
AU2795202A (en) Klainetin and derivatives thereof, method for their production and the use of the same
IL147666A0 (en) Novel carboxylic acid derivatives with 5, 6 substituted pyrimidine ring, the production and utilization thereof as endothelin receptor antagonists
AU2002227952A1 (en) Klainetin and derivatives thereof, method for their production and the use of the same
AU2624799A (en) Novel unsymmetrically substituted carboxylic acid derivatives, method for producing them, and their use as mixed etA/etB-receptor antagonists

Legal Events

Date Code Title Description
REFS Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)