PL3508483T3 - Związek dihydropirymidynowy oraz sposób jego wytwarzania i jego zastosowanie - Google Patents

Związek dihydropirymidynowy oraz sposób jego wytwarzania i jego zastosowanie

Info

Publication number
PL3508483T3
PL3508483T3 PL17870982T PL17870982T PL3508483T3 PL 3508483 T3 PL3508483 T3 PL 3508483T3 PL 17870982 T PL17870982 T PL 17870982T PL 17870982 T PL17870982 T PL 17870982T PL 3508483 T3 PL3508483 T3 PL 3508483T3
Authority
PL
Poland
Prior art keywords
preparation
dihydropyrimidine compound
dihydropyrimidine
compound
Prior art date
Application number
PL17870982T
Other languages
English (en)
Inventor
Shuai SONG
Jiaqiang Cai
Qiang Tian
Hong Zeng
Hongmei SONG
Hanwen DENG
Zujian TANG
Xiaofan DUAN
Rongrong LONG
Yao Liu
Lichun WANG
Jingyi Wang
Original Assignee
Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. filed Critical Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.
Publication of PL3508483T3 publication Critical patent/PL3508483T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355Non-condensed oxazines and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL17870982T 2016-11-18 2017-11-09 Związek dihydropirymidynowy oraz sposób jego wytwarzania i jego zastosowanie PL3508483T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN201611015150 2016-11-18
CN201710328659 2017-05-11
PCT/CN2017/110123 WO2018090862A1 (zh) 2016-11-18 2017-11-09 二氢嘧啶类化合物及其制备方法和用途
EP17870982.0A EP3508483B1 (en) 2016-11-18 2017-11-09 Dihydropyrimidine compound and preparation method and use thereof

Publications (1)

Publication Number Publication Date
PL3508483T3 true PL3508483T3 (pl) 2022-02-07

Family

ID=62145967

Family Applications (1)

Application Number Title Priority Date Filing Date
PL17870982T PL3508483T3 (pl) 2016-11-18 2017-11-09 Związek dihydropirymidynowy oraz sposób jego wytwarzania i jego zastosowanie

Country Status (16)

Country Link
US (1) US10696669B2 (pl)
EP (1) EP3508483B1 (pl)
JP (1) JP7139568B2 (pl)
KR (1) KR102496508B1 (pl)
CN (1) CN109790145B (pl)
AU (1) AU2017359773B2 (pl)
BR (1) BR112019005205A2 (pl)
CA (1) CA3037218A1 (pl)
ES (1) ES2901401T3 (pl)
IL (1) IL266345A (pl)
MX (1) MX2019005119A (pl)
MY (1) MY194471A (pl)
PH (1) PH12019550039A1 (pl)
PL (1) PL3508483T3 (pl)
SG (1) SG10202010180YA (pl)
WO (1) WO2018090862A1 (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108329308B (zh) 2018-05-16 2022-11-01 四川科伦博泰生物医药股份有限公司 一种二氢嘧啶类化合物的固体形式及其制备方法
US20220249647A1 (en) 2019-06-18 2022-08-11 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators
CN112575389B (zh) * 2019-09-30 2023-09-19 成都先导药物开发股份有限公司 一种dna编码化合物库的液相色谱纯化方法
EP4289842A4 (en) 2021-02-05 2025-01-08 Hepagene Therapeutics (HK) Limited Phenyldihydropyrimidine compound and use thereof
CN114853761A (zh) * 2021-02-05 2022-08-05 刘沛 一种含有二氢嘧啶的双功能衍生物及其用途
CN113512035B (zh) * 2021-04-26 2023-11-24 山东大学 二氢嘧啶-泊马度胺缀合物及其制备方法与应用
CN120157666A (zh) * 2025-05-19 2025-06-17 中国医学科学院医药生物技术研究所 一种二氢嘧啶类化合物及其制备方法和应用、二氢嘧啶衍生物及其应用、药物组合物及其应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
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DE10013126A1 (de) * 2000-03-17 2001-09-20 Bayer Ag Arzneimittel gegen virale Erkrankungen
CN101225084A (zh) 2007-01-16 2008-07-23 北京摩力克科技有限公司 二氢嘧啶类化合物及其用于制备治疗和预防病毒性疾病的药物的用途
WO2010069147A1 (zh) * 2008-12-17 2010-06-24 张中能 二氢嘧啶类化合物、其组合物及其应用
CN101575318B (zh) * 2009-06-25 2012-02-08 中国人民解放军军事医学科学院毒物药物研究所 二氢嘧啶类化合物及其用于制备治疗和/或预防病毒性疾病的药物的用途
ES2575398T3 (es) * 2012-03-31 2016-06-28 F. Hoffmann-La Roche Ag 4-Metil-dihidropirimidinas novedosas para el tratamiento y la profilaxis de la infección por el virus de la hepatitis B
WO2014003748A1 (en) 2012-06-28 2014-01-03 Nuance Communications, Inc. Meta-data inputs to front end processing for automatic speech recognition
CN104926808B (zh) 2012-08-24 2018-09-14 广东东阳光药业有限公司 二氢嘧啶类化合物及其在药物中的应用
CN103664925B (zh) * 2012-09-07 2018-01-23 广东东阳光药业有限公司 杂芳基取代的二氢嘧啶类化合物及其在药物中的应用
CA2881322A1 (en) 2012-09-10 2014-03-13 F. Hoffmann-La Roche Ag 6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
CN103664899B (zh) * 2012-09-11 2017-06-16 广东东阳光药业有限公司 杂芳基取代的二氢嘧啶类化合物及其在药物中的应用
US8993771B2 (en) 2013-03-12 2015-03-31 Novira Therapeutics, Inc. Hepatitis B antiviral agents
SG11201507698QA (en) * 2013-03-20 2015-10-29 Univ Indiana Res & Tech Corp Fluorescent-hap: a diagnostic stain for hbv cores in cells
MX353412B (es) 2013-04-03 2018-01-10 Janssen Sciences Ireland Uc Derivados de n-fenil-carboxamida y su uso como medicamentos para el tratamiento de la hepatitis b.
BR112015028873A2 (pt) * 2013-05-17 2017-07-25 Hoffmann La Roche heteroaril-diidro-pirimidinas interligados na posição 6, para o tratamento e profilaxia de infecção pelo vírus da hepatite b
CN104650069B (zh) * 2013-11-19 2019-04-19 广东东阳光药业有限公司 4-甲基二氢嘧啶类化合物及其在药物中的应用
WO2015074546A1 (en) * 2013-11-19 2015-05-28 Sunshine Lake Pharma Co., Ltd. Dihydropyrimidine compounds and their application in pharmaceuticals
CN104650070B (zh) * 2013-11-25 2018-09-14 广东东阳光药业有限公司 二氢嘧啶类化合物及其在药物中的应用
KR102284938B1 (ko) 2013-11-27 2021-08-02 선샤인 레이크 파르마 컴퍼니 리미티드 다이하이드로피리미딘 유도체 및 이의 중간산물의 제조 방법
AU2015226206B2 (en) * 2014-03-07 2017-03-16 F. Hoffmann-La Roche Ag Novel 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of Hepatitis B virus infection
CN104945395B (zh) 2014-03-28 2018-01-23 广东东阳光药业有限公司 二氢嘧啶类化合物及其在药物中的应用
CN108329308B (zh) * 2018-05-16 2022-11-01 四川科伦博泰生物医药股份有限公司 一种二氢嘧啶类化合物的固体形式及其制备方法

Also Published As

Publication number Publication date
CN109790145A (zh) 2019-05-21
MY194471A (en) 2022-11-30
CA3037218A1 (en) 2018-05-24
US20190225603A1 (en) 2019-07-25
JP7139568B2 (ja) 2022-09-21
WO2018090862A1 (zh) 2018-05-24
KR20190077312A (ko) 2019-07-03
KR102496508B1 (ko) 2023-02-03
EP3508483A1 (en) 2019-07-10
IL266345A (en) 2019-06-30
US10696669B2 (en) 2020-06-30
ES2901401T3 (es) 2022-03-22
MX2019005119A (es) 2019-06-20
BR112019005205A2 (pt) 2019-06-11
SG10202010180YA (en) 2020-11-27
AU2017359773A1 (en) 2019-04-11
CN109790145B (zh) 2020-09-22
JP2019535644A (ja) 2019-12-12
EP3508483B1 (en) 2021-10-06
AU2017359773B2 (en) 2021-05-20
EP3508483A4 (en) 2020-04-15
PH12019550039A1 (en) 2019-11-25

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