PL3519416T3 - Pochodne chromanu, izochromanu i dihydroizobenzofuranu jako ujemne allosteryczne modulatory mglur2, ich kompozycje i zastosowanie - Google Patents

Pochodne chromanu, izochromanu i dihydroizobenzofuranu jako ujemne allosteryczne modulatory mglur2, ich kompozycje i zastosowanie

Info

Publication number: PL3519416T3
Authority: PL; Poland
Prior art keywords: isochromane; mglur2; chromane; compositions; allosteric modulators
Prior art date: 2016-09-27

Application number

PL17781253T

Other languages

English (en)

Inventor

Iyassu K. Sebhat

Ashok Arasappan

Scott B. Hoyt

Robert R. Wilkening

Duane Demong

Original Assignee

Merck Sharp & Dohme Corp.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2016-09-27

Filing date

2017-09-25

Publication date

2021-09-06

2017-09-25 Application filed by Merck Sharp & Dohme Corp. filed Critical Merck Sharp & Dohme Corp.

2021-09-06 Publication of PL3519416T3 publication Critical patent/PL3519416T3/pl

Links

VZWXIQHBIQLMPN-UHFFFAOYSA-N chromane Chemical compound C1=CC=C2CCCOC2=C1 VZWXIQHBIQLMPN-UHFFFAOYSA-N 0.000 title 1
HEBMCVBCEDMUOF-UHFFFAOYSA-N isochromane Chemical compound C1=CC=C2COCCC2=C1 HEBMCVBCEDMUOF-UHFFFAOYSA-N 0.000 title 1
239000000203 mixture Substances 0.000 title 1
229940126662 negative allosteric modulator Drugs 0.000 title 1
SFLGSKRGOWRGBR-UHFFFAOYSA-N phthalane Chemical class C1=CC=C2COCC2=C1 SFLGSKRGOWRGBR-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/18—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/02—Halogenated hydrocarbons
- A61K31/025—Halogenated hydrocarbons carbocyclic
- A61K31/03—Halogenated hydrocarbons carbocyclic aromatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/24—Camphidines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Plant Substances (AREA)

PL17781253T 2016-09-27 2017-09-25 Pochodne chromanu, izochromanu i dihydroizobenzofuranu jako ujemne allosteryczne modulatory mglur2, ich kompozycje i zastosowanie PL3519416T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201662400150P	2016-09-27	2016-09-27
EP17781253.4A EP3519416B1 (en)	2016-09-27	2017-09-25	Chromane, isochromane and dihydroisobenzofuran derivatives as mglur2-negative allosteric modulators, compositions, and their use
PCT/US2017/053155 WO2018063955A1 (en)	2016-09-27	2017-09-25	CHROMANE, ISOCHROMANE AND DIHYDROISOBENZOFURAN DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE

Publications (1)

Publication Number	Publication Date
PL3519416T3 true PL3519416T3 (pl)	2021-09-06

Family

ID=60043302

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL17781253T PL3519416T3 (pl)	2016-09-27	2017-09-25	Pochodne chromanu, izochromanu i dihydroizobenzofuranu jako ujemne allosteryczne modulatory mglur2, ich kompozycje i zastosowanie

Country Status (39)

Country	Link
US (4)	US10335399B2 (pl)
EP (1)	EP3519416B1 (pl)
JP (3)	JP6681517B2 (pl)
KR (1)	KR102296043B1 (pl)
CN (1)	CN109983022B (pl)
AR (1)	AR109714A1 (pl)
AU (2)	AU2017334870C1 (pl)
CA (1)	CA3037537C (pl)
CL (1)	CL2019000778A1 (pl)
CO (1)	CO2019002673A2 (pl)
CR (1)	CR20190147A (pl)
CY (1)	CY1124346T1 (pl)
DK (1)	DK3519416T3 (pl)
DO (1)	DOP2019000076A (pl)
EA (1)	EA038627B1 (pl)
EC (1)	ECSP19020742A (pl)
ES (1)	ES2868973T3 (pl)
GE (4)	GEP20217266B (pl)
HR (1)	HRP20210793T1 (pl)
HU (1)	HUE054898T2 (pl)
IL (1)	IL265366B (pl)
JO (1)	JOP20190058B1 (pl)
LT (1)	LT3519416T (pl)
MA (1)	MA46342B1 (pl)
MD (1)	MD3519416T2 (pl)
MX (1)	MX392132B (pl)
MY (1)	MY196807A (pl)
NI (1)	NI201900025A (pl)
PE (1)	PE20190609A1 (pl)
PH (1)	PH12019500597B1 (pl)
PL (1)	PL3519416T3 (pl)
PT (1)	PT3519416T (pl)
RS (1)	RS61890B1 (pl)
SI (1)	SI3519416T1 (pl)
TN (2)	TN2020000160A1 (pl)
TW (1)	TWI764934B (pl)
UA (1)	UA123687C2 (pl)
WO (1)	WO2018063955A1 (pl)
ZA (1)	ZA201901701B (pl)

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EP3519416B1 (en) *	2016-09-27	2021-03-31	Merck Sharp & Dohme Corp.	Chromane, isochromane and dihydroisobenzofuran derivatives as mglur2-negative allosteric modulators, compositions, and their use
BR112020014428A2 (pt)	2018-01-19	2020-12-01	Cytokinetics, Inc.	composto, composição farmacêutica, e, métodos para o tratamento de uma doença cardíaca em um indivíduo, para o tratamento de uma doença ou condição que está associada com cavidade ventricular esquerda pequena e obliteração da cavidade, contração hiperdinâmica do ventrículo esquerdo, isquemia do miocárdio ou fibrose cardíaca, para o tratamento de uma doença ou condição selecionada dentre distrofias musculares e doenças de armazenamento do glicogênio e para inibição do sarcômero cardíaco
JP7610985B2 (ja)	2018-06-26	2025-01-09	サイトキネティックス，インコーポレイテッド	心臓サルコメア阻害剤
EP3814342B1 (en)	2018-06-26	2022-07-27	Cytokinetics, Inc.	Cardiac sarcomere inhibitors
MY205394A (en) *	2019-03-01	2024-10-19	Novo Nordisk As	Process for preparing a fused tricyclic compound, and intermediate thereof
MX2023010125A (es)	2021-03-04	2023-09-11	Cytokinetics Inc	Inhibidores del sarcomero cardiaco.
WO2023278729A1 (en) *	2021-06-30	2023-01-05	The General Hospital Corporation	Chromane imaging ligands

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US5576338A (en)	1995-02-15	1996-11-19	Merck Frosst Canada, Inc.	Bis (biaryl) compounds as inhibitors of leukotriene biosynthesis
WO2005014543A1 (ja)	2003-08-06	2005-02-17	Japan Tobacco Inc.	縮合環化合物及びそのｈｃｖポリメラーゼ阻害剤としての利用
WO2007038865A1 (en)	2005-10-05	2007-04-12	Merck Frosst Canada Ltd.	Substituted quinolines as inhibitors of leukotriene biosynthesis
AR065093A1 (es)	2007-02-05	2009-05-13	Merck Frosst Canada Ltd	Compuestos farmacéuticos inhibidores de la biosintesis de leucotrienos
PE20110368A1 (es)	2008-08-18	2011-06-13	Univ Yale	Moduladores de mif
CN102439008B (zh) *	2009-05-12	2015-04-29	杨森制药有限公司	1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途
CA2784830C (en)	2009-12-18	2018-03-27	Sunovion Pharmaceuticals Inc.	Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof
CN104010504B (zh) *	2011-11-03	2016-04-06	默沙东公司	作为mGluR2负变构调节剂的喹啉甲酰胺和喹啉甲腈的衍生物、组合物、及其用途
JO3368B1 (ar)	2013-06-04	2019-03-13	Janssen Pharmaceutica Nv	مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
WO2016029454A1 (en)	2014-08-29	2016-03-03	Merck Sharp & Dohme Corp.	TETRAHYDRONAPHTHYRIDINE DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE
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JP6471614B2 (ja)	2015-05-29	2019-02-20	株式会社リコー	通信端末、通信システム、通信制御方法、及びプログラム
JP2018154554A (ja)	2015-07-29	2018-10-04	大日本住友製薬株式会社	新規リンカー部位を持つ縮合ピラゾール誘導体およびその医薬用途
EP3519416B1 (en) *	2016-09-27	2021-03-31	Merck Sharp & Dohme Corp.	Chromane, isochromane and dihydroisobenzofuran derivatives as mglur2-negative allosteric modulators, compositions, and their use

2017
- 2017-09-25 EP EP17781253.4A patent/EP3519416B1/en active Active
- 2017-09-25 MY MYPI2019001659A patent/MY196807A/en unknown
- 2017-09-25 PT PT177812534T patent/PT3519416T/pt unknown
- 2017-09-25 GE GEAP201715056A patent/GEP20217266B/en unknown
- 2017-09-25 US US15/713,769 patent/US10335399B2/en active Active
- 2017-09-25 HR HRP20210793TT patent/HRP20210793T1/hr unknown
- 2017-09-25 DK DK17781253.4T patent/DK3519416T3/da active
- 2017-09-25 ES ES17781253T patent/ES2868973T3/es active Active
- 2017-09-25 MA MA46342A patent/MA46342B1/fr unknown
- 2017-09-25 TN TNP/2020/000160A patent/TN2020000160A1/en unknown
- 2017-09-25 KR KR1020197011789A patent/KR102296043B1/ko not_active Expired - Fee Related
- 2017-09-25 MD MDE20190867T patent/MD3519416T2/ro unknown
- 2017-09-25 WO PCT/US2017/053155 patent/WO2018063955A1/en not_active Ceased
- 2017-09-25 AU AU2017334870A patent/AU2017334870C1/en not_active Ceased
- 2017-09-25 UA UAA201904545A patent/UA123687C2/uk unknown
- 2017-09-25 RS RS20210649A patent/RS61890B1/sr unknown
- 2017-09-25 JO JOP/2019/0058A patent/JOP20190058B1/ar active
- 2017-09-25 GE GEAP202115056A patent/GEAP202115056A/en unknown
- 2017-09-25 CR CR20190147A patent/CR20190147A/es unknown
- 2017-09-25 CN CN201780071759.0A patent/CN109983022B/zh not_active Expired - Fee Related
- 2017-09-25 LT LTEP17781253.4T patent/LT3519416T/lt unknown
- 2017-09-25 SI SI201730727T patent/SI3519416T1/sl unknown
- 2017-09-25 AR ARP170102642A patent/AR109714A1/es active IP Right Grant
- 2017-09-25 TN TNP/2020/000161A patent/TN2020000161A1/en unknown
- 2017-09-25 EA EA201990818A patent/EA038627B1/ru unknown
- 2017-09-25 TW TW106132824A patent/TWI764934B/zh not_active IP Right Cessation
- 2017-09-25 CA CA3037537A patent/CA3037537C/en active Active
- 2017-09-25 HU HUE17781253A patent/HUE054898T2/hu unknown
- 2017-09-25 PH PH1/2019/500597A patent/PH12019500597B1/en unknown
- 2017-09-25 JP JP2019516203A patent/JP6681517B2/ja not_active Expired - Fee Related
- 2017-09-25 PE PE2019000706A patent/PE20190609A1/es unknown
- 2017-09-25 GE GEAP202115310A patent/GEAP202115310A/en unknown
- 2017-09-25 MX MX2019003492A patent/MX392132B/es unknown
- 2017-09-25 GE GEAP201715310A patent/GEP20217279B/en unknown
- 2017-09-25 PL PL17781253T patent/PL3519416T3/pl unknown
2019
- 2019-03-13 IL IL265366A patent/IL265366B/en unknown
- 2019-03-19 ZA ZA2019/01701A patent/ZA201901701B/en unknown
- 2019-03-20 NI NI201900025A patent/NI201900025A/es unknown
- 2019-03-22 CO CONC2019/0002673A patent/CO2019002673A2/es unknown
- 2019-03-25 CL CL2019000778A patent/CL2019000778A1/es unknown
- 2019-03-26 DO DO2019000076A patent/DOP2019000076A/es unknown
- 2019-03-28 EC ECSENADI201920742A patent/ECSP19020742A/es unknown
- 2019-04-23 US US16/392,131 patent/US10806724B2/en active Active
- 2019-09-30 JP JP2019178232A patent/JP6945605B2/ja not_active Expired - Fee Related
2020
- 2020-03-23 JP JP2020051049A patent/JP6992109B2/ja not_active Expired - Fee Related
- 2020-09-25 US US17/032,626 patent/US20210015800A1/en not_active Abandoned
- 2020-11-16 AU AU2020270468A patent/AU2020270468B2/en not_active Ceased
2021
- 2021-05-31 CY CY20211100468T patent/CY1124346T1/el unknown
2022
- 2022-03-15 US US17/695,262 patent/US20220218676A1/en active Pending

Also Published As

Publication number	Publication date
JP2020011989A (ja)	2020-01-23
JP6681517B2 (ja)	2020-04-15
AR109714A1 (es)	2019-01-16
SI3519416T1 (sl)	2021-08-31
ES2868973T3 (es)	2021-10-22
GEP20217266B (en)	2021-06-25
US20180085358A1 (en)	2018-03-29
HRP20210793T1 (hr)	2021-09-03
US10335399B2 (en)	2019-07-02
AU2020270468A1 (en)	2020-12-10
CL2019000778A1 (es)	2019-05-31
GEAP202115310A (en)	2021-04-12
MX392132B (es)	2025-03-12
PH12019500597A1 (en)	2019-07-24
AU2017334870B2 (en)	2020-08-20
IL265366B (en)	2021-12-01
RS61890B1 (sr)	2021-06-30
CR20190147A (es)	2019-05-17
MX2019003492A (es)	2019-09-19
US20190247374A1 (en)	2019-08-15
US10806724B2 (en)	2020-10-20
JP6945605B2 (ja)	2021-10-06
JP6992109B2 (ja)	2022-02-15
BR112019005869A2 (pt)	2019-06-11
TN2020000161A1 (en)	2022-04-04
MY196807A (en)	2023-05-03
AU2017334870A1 (en)	2019-03-28
CA3037537C (en)	2021-06-15
BR112019005869A8 (pt)	2023-05-02
EP3519416A1 (en)	2019-08-07
MD3519416T2 (ro)	2021-09-30
DOP2019000076A (es)	2019-07-15
EA201990818A1 (ru)	2019-08-30
CA3037537A1 (en)	2018-04-05
UA123687C2 (uk)	2021-05-12
KR20190056418A (ko)	2019-05-24
US20210015800A1 (en)	2021-01-21
WO2018063955A1 (en)	2018-04-05
KR102296043B1 (ko)	2021-08-30
TWI764934B (zh)	2022-05-21
MA46342A (fr)	2019-08-07
EA038627B1 (ru)	2021-09-24
CY1124346T1 (el)	2022-07-22
JP2020111596A (ja)	2020-07-27
JOP20190058B1 (ar)	2023-09-17
JOP20190058A1 (ar)	2019-03-24
LT3519416T (lt)	2021-06-10
DK3519416T3 (da)	2021-05-25
CN109983022B (zh)	2022-06-07
CN109983022A (zh)	2019-07-05
ZA201901701B (en)	2023-03-29
GEAP202115056A (en)	2021-01-25
TW201815794A (zh)	2018-05-01
PT3519416T (pt)	2021-05-13
EP3519416B1 (en)	2021-03-31
MA46342B1 (fr)	2021-05-31
US20220218676A1 (en)	2022-07-14
JP2019529468A (ja)	2019-10-17
AU2017334870C1 (en)	2020-12-17
CO2019002673A2 (es)	2019-03-29
PE20190609A1 (es)	2019-04-23
HUE054898T2 (hu)	2021-10-28
TN2020000160A1 (en)	2022-04-04
NI201900025A (es)	2019-05-27
GEP20217279B (en)	2021-08-10
PH12019500597B1 (en)	2023-05-10
AU2020270468B2 (en)	2022-02-17
IL265366A (en)	2019-05-30
ECSP19020742A (es)	2019-04-30

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