PL3536807T3 - Nieinwazyjne określanie metylomu guza z wykorzystaniem osocza - Google Patents
Nieinwazyjne określanie metylomu guza z wykorzystaniem osoczaInfo
- Publication number
- PL3536807T3 PL3536807T3 PL19171630.7T PL19171630T PL3536807T3 PL 3536807 T3 PL3536807 T3 PL 3536807T3 PL 19171630 T PL19171630 T PL 19171630T PL 3536807 T3 PL3536807 T3 PL 3536807T3
- Authority
- PL
- Poland
- Prior art keywords
- methylome
- tumor
- plasma
- invasive determination
- invasive
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2523/00—Reactions characterised by treatment of reaction samples
- C12Q2523/10—Characterised by chemical treatment
- C12Q2523/125—Bisulfite(s)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
- C12Q2535/122—Massive parallel sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Medical Informatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261703512P | 2012-09-20 | 2012-09-20 | |
| US13/842,209 US9732390B2 (en) | 2012-09-20 | 2013-03-15 | Non-invasive determination of methylome of fetus or tumor from plasma |
| US201361830571P | 2013-06-03 | 2013-06-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3536807T3 true PL3536807T3 (pl) | 2024-05-06 |
Family
ID=50340462
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL13838770.9T PL2898100T5 (pl) | 2012-09-20 | 2013-09-20 | Nieinwazyjny sposób określania metylomu płodu lub guza z wykorzystaniem osocza |
| PL19171630.7T PL3536807T3 (pl) | 2012-09-20 | 2013-09-20 | Nieinwazyjne określanie metylomu guza z wykorzystaniem osocza |
| PL17202149T PL3354747T3 (pl) | 2012-09-20 | 2013-09-20 | Nieinwazyjne określanie metylomu guza z wykorzystaniem osocza |
| PL22171427.2T PL4056712T3 (pl) | 2012-09-20 | 2013-09-20 | Nieinwazyjne określanie metylomu guza w osoczu |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL13838770.9T PL2898100T5 (pl) | 2012-09-20 | 2013-09-20 | Nieinwazyjny sposób określania metylomu płodu lub guza z wykorzystaniem osocza |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL17202149T PL3354747T3 (pl) | 2012-09-20 | 2013-09-20 | Nieinwazyjne określanie metylomu guza z wykorzystaniem osocza |
| PL22171427.2T PL4056712T3 (pl) | 2012-09-20 | 2013-09-20 | Nieinwazyjne określanie metylomu guza w osoczu |
Country Status (28)
| Country | Link |
|---|---|
| EP (6) | EP3839065A1 (pl) |
| JP (6) | JP6317354B2 (pl) |
| KR (5) | KR102587176B1 (pl) |
| CN (2) | CN117757932A (pl) |
| AU (5) | AU2013317708C1 (pl) |
| BR (3) | BR112015006183B1 (pl) |
| CA (2) | CA2884066C (pl) |
| CY (1) | CY1124139T1 (pl) |
| DK (4) | DK4056712T3 (pl) |
| EA (1) | EA201500327A1 (pl) |
| ES (4) | ES2969567T3 (pl) |
| FI (2) | FI4056712T3 (pl) |
| HR (3) | HRP20241142T1 (pl) |
| HU (3) | HUE053822T2 (pl) |
| IL (4) | IL313451A (pl) |
| LT (2) | LT3354747T (pl) |
| MX (1) | MX360034B (pl) |
| MY (2) | MY187444A (pl) |
| NZ (2) | NZ706269A (pl) |
| PH (2) | PH12022552061A1 (pl) |
| PL (4) | PL2898100T5 (pl) |
| PT (4) | PT3536807T (pl) |
| SG (2) | SG11201501927VA (pl) |
| SI (1) | SI4056712T1 (pl) |
| SM (1) | SMT202100256T1 (pl) |
| TW (5) | TWI707953B (pl) |
| WO (1) | WO2014043763A1 (pl) |
| ZA (1) | ZA201501772B (pl) |
Families Citing this family (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI335354B (en) | 2006-09-27 | 2011-01-01 | Univ Hong Kong Chinese | Methods for the detection of the degree of the methylation of a target dna and kits |
| US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| US9732390B2 (en) | 2012-09-20 | 2017-08-15 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
| BR112015006183B1 (pt) * | 2012-09-20 | 2022-04-26 | The Chinese University Of Hong Kong | Métodos para analisar uma amostra biológica de um organismo, para determinar um primeiro perfil de metilação de uma amostra biológica de um organismo, para detecção de uma anormalidade cromossômica de uma amostra biológica de um organismo e para estimar um nível de metilação do dna em uma amostra biológica de um organismo, produto de computador, e, kit para análise de dna fetal |
| US10706957B2 (en) | 2012-09-20 | 2020-07-07 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of tumor from plasma |
| US20130309666A1 (en) | 2013-01-25 | 2013-11-21 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| EP3029148B1 (en) * | 2013-07-30 | 2018-06-27 | BGI Genomics Co., Limited | Method for determining nucleic acid composition of nucleic acid mixture |
| US10174375B2 (en) * | 2013-09-20 | 2019-01-08 | The Chinese University Of Hong Kong | Sequencing analysis of circulating DNA to detect and monitor autoimmune diseases |
| WO2015126840A1 (en) * | 2014-02-18 | 2015-08-27 | Bionano Genomics, Inc. | Improved methods of determining nucleic acid structural information |
| CA2945962C (en) * | 2014-04-21 | 2023-08-29 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| US12492429B2 (en) | 2014-04-21 | 2025-12-09 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| EP2942400A1 (en) | 2014-05-09 | 2015-11-11 | Lifecodexx AG | Multiplex detection of DNA that originates from a specific cell-type |
| MA39951A (fr) | 2014-05-09 | 2017-03-15 | Lifecodexx Ag | Détection de l'adn provenant d'un type spécifique de cellule et méthodes associées |
| WO2016010401A1 (ko) * | 2014-07-18 | 2016-01-21 | 에스케이텔레콘 주식회사 | 산모의 혈청 dna를 이용한 태아의 단일유전자 유전변이의 예측방법 |
| EP3543356B1 (en) * | 2014-07-18 | 2021-06-30 | The Chinese University of Hong Kong | Methylation pattern analysis of tissues in dna mixture |
| KR102696857B1 (ko) | 2014-07-25 | 2024-08-19 | 유니버시티 오브 워싱톤 | 무세포 dna를 생성하는 조직 및/또는 세포 유형을 결정하는 방법 및 이를 사용하여 질환 또는 장애를 확인하는 방법 |
| EP4574996B1 (en) | 2014-12-31 | 2025-11-05 | Guardant Health, Inc. | Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results |
| US10364467B2 (en) * | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
| PT3256605T (pt) | 2015-02-10 | 2022-03-17 | Univ Hong Kong Chinese | Deteção de mutações para rastreio de cancro e análise fetal |
| EP3325663B1 (en) * | 2015-07-20 | 2020-08-19 | The Chinese University Of Hong Kong | Methylation pattern analysis of haplotypes in tissues in dna mixture |
| TWI730973B (zh) | 2015-07-23 | 2021-06-21 | 香港中文大學 | 游離dna(cell-free dna)之片段化模式分析 |
| CN115433769A (zh) | 2015-08-12 | 2022-12-06 | 香港中文大学 | 血浆dna的单分子测序 |
| TWI767888B (zh) | 2015-09-22 | 2022-06-21 | 香港中文大學 | 藉由母體血漿dna之淺深度測序以準確定量胎兒dna含量 |
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| WO2017083366A1 (en) * | 2015-11-09 | 2017-05-18 | Progenity, Inc. | Methods for determining the origin of dna molecules |
| DK3168309T3 (da) | 2015-11-10 | 2020-06-22 | Eurofins Lifecodexx Gmbh | Detektion af føtale kromosomale aneuploidier under anvendelse af dna-regioner med forskellig metylering mellem fosteret og det gravide hunkøn |
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| JP6979554B2 (ja) | 2016-05-03 | 2021-12-15 | ユニバーシティー ヘルス ネットワーク | 無細胞メチル化dnaを捕捉する方法及びその使用 |
| US12300356B2 (en) | 2016-05-04 | 2025-05-13 | Queen's University At Kingston | Cell-free detection of methylated tumour DNA |
| EP4324937B1 (en) * | 2016-05-30 | 2026-01-21 | The Chinese University Of Hong Kong | Detecting hematological disorders using cell-free dna in blood |
| ES2897550T3 (es) * | 2016-06-16 | 2022-03-01 | Univ Johns Hopkins | Métodos y sistema de análisis epigenético |
| US11999998B2 (en) | 2016-08-24 | 2024-06-04 | Center For Excellence In Molecular Cell Science, Chinese Academy Of Sciences | Modification of 5-methylcytosine catalyzed by Cmd1 enzyme and application thereof |
| EP3529377B1 (en) * | 2016-10-19 | 2023-04-05 | The Chinese University Of Hong Kong | Gestational age assessment by methylation and size profiling of maternal plasma dna |
| WO2018081130A1 (en) | 2016-10-24 | 2018-05-03 | The Chinese University Of Hong Kong | Methods and systems for tumor detection |
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| US12227737B2 (en) | 2017-07-12 | 2025-02-18 | University Health Network | Cancer detection and classification using methylome analysis |
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