PL354030A1 - Związki przeciwpikornawirusowe i zawierające je koZwiązki przeciwpikornawirusowe i zawierające je kompozycje, ich zastosowanie farmaceutyczne i materimpozycje, ich zastosowanie farmaceutyczne i materiały do ich syntezyały do ich syntezy - Google Patents

Związki przeciwpikornawirusowe i zawierające je koZwiązki przeciwpikornawirusowe i zawierające je kompozycje, ich zastosowanie farmaceutyczne i materimpozycje, ich zastosowanie farmaceutyczne i materiały do ich syntezyały do ich syntezy

Info

Publication number
PL354030A1
PL354030A1 PL00354030A PL35403000A PL354030A1 PL 354030 A1 PL354030 A1 PL 354030A1 PL 00354030 A PL00354030 A PL 00354030A PL 35403000 A PL35403000 A PL 35403000A PL 354030 A1 PL354030 A1 PL 354030A1
Authority
PL
Poland
Prior art keywords
compounds
synthesis
compositions
materials
pharmaceutical uses
Prior art date
Application number
PL00354030A
Other languages
English (en)
Inventor
Peter ScottDragovich Peter Scott Dragovich
RuZhou Ru Zhou
Stephen EvanWebber Stephen Evan Webber
Thomas J.Prins Thomas J. Prins
Siegfried HeinzReich Siegfried Heinz Reich
Susan E.Kephart Susan E. Kephart
YuanjinRui Yuanjin Rui
Original Assignee
Agouron Pharmaceuticals, Inc.Agouron Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharmaceuticals, Inc.Agouron Pharmaceuticals, Inc. filed Critical Agouron Pharmaceuticals, Inc.Agouron Pharmaceuticals, Inc.
Publication of PL354030A1 publication Critical patent/PL354030A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Peptides Or Proteins (AREA)
PL00354030A 1999-08-04 2000-08-03 Związki przeciwpikornawirusowe i zawierające je koZwiązki przeciwpikornawirusowe i zawierające je kompozycje, ich zastosowanie farmaceutyczne i materimpozycje, ich zastosowanie farmaceutyczne i materiały do ich syntezyały do ich syntezy PL354030A1 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14737399P 1999-08-04 1999-08-04
PCT/US2000/021061 WO2001010894A2 (en) 1999-08-04 2000-08-03 Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis

Publications (1)

Publication Number Publication Date
PL354030A1 true PL354030A1 (pl) 2003-12-15

Family

ID=22521323

Family Applications (1)

Application Number Title Priority Date Filing Date
PL00354030A PL354030A1 (pl) 1999-08-04 2000-08-03 Związki przeciwpikornawirusowe i zawierające je koZwiązki przeciwpikornawirusowe i zawierające je kompozycje, ich zastosowanie farmaceutyczne i materimpozycje, ich zastosowanie farmaceutyczne i materiały do ich syntezyały do ich syntezy

Country Status (18)

Country Link
US (1) US6534530B1 (pl)
EP (1) EP1206484B1 (pl)
JP (1) JP2003506457A (pl)
KR (1) KR20020025964A (pl)
CN (1) CN1372566A (pl)
AT (1) ATE278707T1 (pl)
AU (1) AU779321B2 (pl)
BR (1) BR0012970A (pl)
CA (1) CA2380647A1 (pl)
DE (1) DE60014670T2 (pl)
DK (1) DK1206484T3 (pl)
ES (1) ES2230135T3 (pl)
HU (1) HUP0203108A3 (pl)
MX (1) MXPA02001179A (pl)
PL (1) PL354030A1 (pl)
PT (1) PT1206484E (pl)
WO (1) WO2001010894A2 (pl)
ZA (1) ZA200200881B (pl)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010043004A (ko) 1998-04-30 2001-05-25 개리 이. 프라이드만 피코르나 바이러스 억제 화합물, 그의 제조 방법 및 용도
PA8507801A1 (es) 1999-12-03 2002-08-26 Agouron Pharma Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y los materiales para su sintesis
PE20011277A1 (es) * 2000-04-14 2002-01-07 Agouron Pharma Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y los materiales para su sintesis
NZ523134A (en) 2000-06-14 2004-08-27 Agouron Pharma Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
WO2002006280A2 (en) * 2000-07-13 2002-01-24 Millennium Pharamaceuticals, Inc. INHIBITORS OF FACTOR Xa
WO2004094647A2 (en) * 2003-04-18 2004-11-04 Cytovia, Inc. Methods of treating diseases responsive to induction of apoptosis and screening assays
WO2004093860A1 (en) * 2003-04-21 2004-11-04 Pfizer Inc. Inhibitors of sars related coronavirus proteinase
US20040235952A1 (en) * 2003-05-05 2004-11-25 Agouron Pharmaceuticals, Inc. Inhibitors of severe acute respiratory syndrome (SARS) 3C-like proteinase
US7504382B2 (en) * 2003-05-06 2009-03-17 Cytovia, Inc. Protease inhibitors for coronaviruses and SARS-CoV and the use thereof
AU2004312547A1 (en) * 2003-12-31 2005-07-21 Taigen Biotechnology Protease inhibitors
US7462594B2 (en) * 2003-12-31 2008-12-09 Taigen Biotechnology Co., Ltd. Peptide-like compounds that inhibit coronaviral 3CL and flaviviridae viral proteases
WO2005113580A1 (en) * 2004-05-21 2005-12-01 Pfizer Inc. Anticoronviral compounds and compositions, their pharmaceutical uses and materials for their synthesis
ES2676412T3 (es) 2011-06-02 2018-07-19 Socpra Sciences Santé Et Humaines S.E.C. Inhibidores de matriptasa y usos de los mismos contra infecciones por ortomixovirus
CN102838523A (zh) * 2011-06-23 2012-12-26 南开大学 抗肠病毒71(ev71)戊内酰胺类化合物及其制备方法和用途
US9474759B2 (en) 2011-09-27 2016-10-25 Kansas State University Research Foundation Broad-spectrum antivirals against 3C or 3C-like proteases of picornavirus-like supercluster: picornaviruses, caliciviruses and coronaviruses
CN103130710B (zh) * 2011-11-29 2015-12-16 南开大学 抗肠病毒71(ev71)己内酰胺醛类化合物及其制备方法和用途
CN103145608B (zh) * 2011-12-07 2015-09-02 南开大学 抗肠病毒71(ev71)己内酰胺类化合物及其制备方法和用途
CA2872147A1 (en) 2012-05-02 2013-11-07 Kansas State University Research Foundation Macrocyclic and peptidomimetic compounds as broad-spectrum antivirals against 3c or 3c-like proteases of picornaviruses, caliciviruses and coronaviruses
CA2920220A1 (en) * 2013-09-06 2015-03-12 Sandoz Ag Synthesis of peptide epoxy ketones
JP2019533007A (ja) 2016-09-13 2019-11-14 ハプロゲン・ゲーエムベーハー 抗ウイルス化合物
US11124497B1 (en) 2020-04-17 2021-09-21 Pardes Biosciences, Inc. Inhibitors of cysteine proteases and methods of use thereof
US11174231B1 (en) 2020-06-09 2021-11-16 Pardes Biosciences, Inc. Inhibitors of cysteine proteases and methods of use thereof
WO2022013684A1 (en) 2020-07-11 2022-01-20 Pfizer Inc. Antiviral heteroaryl ketone derivatives
US11351149B2 (en) 2020-09-03 2022-06-07 Pfizer Inc. Nitrile-containing antiviral compounds
EP4216961A4 (en) * 2020-09-23 2024-10-30 Lighthouse Pharmaceuticals, Inc. COMPOSITIONS AND METHODS FOR TREATING CORONAVIRUS INFECTIONS
US20250099392A1 (en) * 2022-01-20 2025-03-27 Ohio State Innovation Foundation Compositions comprising lipid compounds and methods of making and use thereof

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4652676A (en) 1985-05-06 1987-03-24 General Foods Corporation L-aminodicarboxylic acid alkenes
EP0668870A1 (en) 1991-06-14 1995-08-30 Chiron Corporation Inhibitors of picornavirus proteases
US5374623A (en) 1992-08-20 1994-12-20 Prototek, Inc. Cysteine protease inhibitors effective for in vivo use
US5486623A (en) 1993-12-08 1996-01-23 Prototek, Inc. Cysteine protease inhibitors containing heterocyclic leaving groups
US5498616A (en) 1994-11-04 1996-03-12 Cephalon, Inc. Cysteine protease and serine protease inhibitors
IT1281031B1 (it) 1995-11-17 1998-02-11 Carlo Chiaves Struttura prefabbricata per la realizzazione di opere costruite a cielo aperto, particolarmente per cavalcavia autostradali,
IL120310A (en) * 1996-03-01 2002-02-10 Akzo Nobel Nv Serine protease inhibitors and pharmaceuticals containing them
WO1997043305A1 (en) 1996-05-14 1997-11-20 Agouron Pharmaceuticals, Inc. Inhibitors of picornavirus 3c proteases and methods for their use and preparation
US5856530A (en) 1996-05-14 1999-01-05 Agouron Pharmaceuticals, Inc. Antipicornaviral compounds and methods for their use and preparation
WO1997049668A1 (en) 1996-06-13 1997-12-31 Smithkline Beecham Corporation Inhibitiors of cysteine protease
US6020371A (en) 1997-03-28 2000-02-01 Agouron Pharmaceuticals, Inc. Antipicornaviral compounds compositions containing them and methods for their use
DE69817798T2 (de) 1997-03-28 2004-08-05 Agouron Pharmaceuticals, Inc., La Jolla Gegen picorna-viren gerichtete verbindungen, zusammensetzungen die diese verbindungen enthalten und methoden zu ihrer anwendung
US6331554B1 (en) 1997-03-28 2001-12-18 Agouron Pharmaceuticals, Inc. Antipicornaviral compounds, compositions containing them, and methods for their use
US5962487A (en) * 1997-12-16 1999-10-05 Agouron Pharmaceuticals, Inc. Antipicornaviral compounds and methods for their use and preparation
PE20010517A1 (es) 1999-08-24 2001-05-16 Agouron Pharma Las rutas sinteticas eficientes para la preparacion de los inhibidores de la proteasa del rinovirus y los intermedios claves
BR0013323A (pt) 1999-08-24 2002-04-02 Agouron Pharma Processos úteis para a preparação de agentes antipicornavirais, processos úteis para a preparação de um composto, compostos, processos para preparação de um composto e processos para a execução de uma reação catalisada por um grande catalisador

Also Published As

Publication number Publication date
US6534530B1 (en) 2003-03-18
WO2001010894A2 (en) 2001-02-15
WO2001010894A3 (en) 2001-06-07
DE60014670D1 (de) 2004-11-11
CN1372566A (zh) 2002-10-02
HUP0203108A2 (hu) 2002-12-28
KR20020025964A (ko) 2002-04-04
JP2003506457A (ja) 2003-02-18
AU6511200A (en) 2001-03-05
HUP0203108A3 (en) 2004-07-28
BR0012970A (pt) 2002-04-30
ES2230135T3 (es) 2005-05-01
ZA200200881B (en) 2003-04-30
PT1206484E (pt) 2005-01-31
DE60014670T2 (de) 2006-03-09
DK1206484T3 (da) 2005-01-24
CA2380647A1 (en) 2001-02-15
AU779321B2 (en) 2005-01-20
MXPA02001179A (es) 2002-07-30
EP1206484A2 (en) 2002-05-22
EP1206484B1 (en) 2004-10-06
ATE278707T1 (de) 2004-10-15

Similar Documents

Publication Publication Date Title
WO2001010894A3 (en) Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
YU66000A (sh) Antipikovirusna jedinjenja, njihovo dobijanje i upotreba
AP2003002915A0 (en) HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis.
YU40002A (sh) Antipikornavirusna jedinjenja i kompozicije, njihove farmaceutske upotrebe, i materijali za njihove sinteze
PL371414A1 (pl) Dipodstawione tiazolilokarboksyanilidy oraz ich zastosowanie jako środków mikrobójczych
SE9901875D0 (sv) Novel compounds
DE60021381D1 (de) Chinonverbindungen zur behandlung von krankheiten
DE60112330D1 (en) Pyrazolopyridinderivate
IL160171A0 (en) Depsipeptide derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
WO2001079167A3 (en) Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
DE602004031410D1 (de) Inden derivate als pharmazeutika
SE9804212D0 (sv) Compounds
EA200600778A1 (ru) 1,3-диметилбутилкарбоксанилиды для борьбы с нежелательными микроорганизмами
DE60116106D1 (de) Benzofuran derivate und ihre verwendung als antibakterielle wirkstoffe
ATE432936T1 (de) Imidazotriazin verbindungen zur behandlung von krebserkrankungen
DK0975588T3 (da) Antipicornavirale forbindelser, sammensætninger indeholdende dem og fremgangsmåder til deres anvendelse
MXPA02012426A (es) Compuestos nuevos.
EA200600777A1 (ru) N-замещённые пиразолилкарбоксанилиды
WO2001014576A8 (en) Process and intermediates for the preparation of isoxazolecaroxamides and analogues
WO2001096297A3 (en) Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
EP1329457A3 (en) Antipicornaviral compounds, their preparation and use
SE0002330D0 (sv) Novel compounds
IL140919A0 (en) N-substituted azabicycloheptane derivatives, production and use thereof

Legal Events

Date Code Title Description
REFS Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)