ATE432936T1 - Imidazotriazin verbindungen zur behandlung von krebserkrankungen - Google Patents

Imidazotriazin verbindungen zur behandlung von krebserkrankungen

Info

Publication number
ATE432936T1
ATE432936T1 AT04749497T AT04749497T ATE432936T1 AT E432936 T1 ATE432936 T1 AT E432936T1 AT 04749497 T AT04749497 T AT 04749497T AT 04749497 T AT04749497 T AT 04749497T AT E432936 T1 ATE432936 T1 AT E432936T1
Authority
AT
Austria
Prior art keywords
compounds used
treat cancer
cancer diseases
imidazotriazine compounds
imidazotriazine
Prior art date
Application number
AT04749497T
Other languages
English (en)
Inventor
Mui Cheung
Nigel Paul King
Kevin Wayne Kuntz
Robert Anthony Mook Jr
Mark Pobanz
James Michael Salovich
Brian John Wilson
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Application granted granted Critical
Publication of ATE432936T1 publication Critical patent/ATE432936T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT04749497T 2003-04-01 2004-03-29 Imidazotriazin verbindungen zur behandlung von krebserkrankungen ATE432936T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45929303P 2003-04-01 2003-04-01
PCT/US2004/009553 WO2004087652A2 (en) 2003-04-01 2004-03-29 Imidazotriazine compounds

Publications (1)

Publication Number Publication Date
ATE432936T1 true ATE432936T1 (de) 2009-06-15

Family

ID=33131876

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04749497T ATE432936T1 (de) 2003-04-01 2004-03-29 Imidazotriazin verbindungen zur behandlung von krebserkrankungen

Country Status (7)

Country Link
US (1) US7462614B2 (de)
EP (1) EP1608656B1 (de)
JP (1) JP2006522127A (de)
AT (1) ATE432936T1 (de)
DE (1) DE602004021363D1 (de)
ES (1) ES2326808T3 (de)
WO (1) WO2004087652A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006258842B2 (en) * 2005-06-13 2011-09-15 Merck Sharp & Dohme Limited Therapeutic agents
JP5498703B2 (ja) * 2006-01-23 2014-05-21 バーテックス ファーマシューティカルズ インコーポレイテッド プロテインキナーゼのインヒビターとして有用なチオフェン−カルボキサミド
US7504513B2 (en) 2006-02-27 2009-03-17 Hoffman-La Roche Inc. Thiazolyl-benzimidazoles
EP2418210A1 (de) 2006-04-13 2012-02-15 Vertex Pharmceuticals Incorporated Als Protein-Kinase-Inhibitoren nutzbare Thiophen-Carboxamide
WO2007139795A1 (en) 2006-05-23 2007-12-06 Vertex Pharmaceuticals Incorporated Thiophene-carboxamides useful as inhibitors of protein kinases
JP2009538309A (ja) 2006-05-23 2009-11-05 バーテックス ファーマシューティカルズ インコーポレイテッド プロテインキナーゼのインヒビターとして有用なチオフェンカルボキサミド
EP2100894A1 (de) 2008-03-12 2009-09-16 4Sc Ag Pyridopyrimidinone verwendbar als Plk1 (polo-like kinase) Hemmen
JP2012512223A (ja) 2008-12-18 2012-05-31 エフ．ホフマン−ラ ロシュ アーゲー チアゾリル−ベンズイミダゾール類
CN102552274B (zh) * 2010-11-12 2013-10-23 姚雪彪 动点马达蛋白小分子抑制剂在抑制肿瘤细胞增殖中的应用
CN102827022A (zh) * 2012-09-21 2012-12-19 西华大学 2-乙酰氧基-n-(4-甲氧基苯基)苯甲酰胺及其制备方法和用途
IL296025A (en) * 2020-03-02 2022-10-01 Sironax Ltd Proptosis inhibitors - diarylamine para-acetamides
GB202018412D0 (en) * 2020-11-23 2021-01-06 Exscientia Ltd Malt-1 modulators ii
WO2025024726A1 (en) * 2023-07-26 2025-01-30 Kinnate Biopharma Inc. Inhibitors of cyclin-dependent kinase

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE791025A (fr) * 1971-11-19 1973-05-07 Allen & Hanburys Ltd Composes heterocycliques
GB1457873A (en) * 1973-01-04 1976-12-08 Allen & Hanburys Ltd Imidazotriazines
DK109578A (da) * 1977-03-25 1978-09-26 Allen & Hanburys Ltd Fremgangsmaade til fremstilling af heterocycliske forbindelser
US4308384A (en) * 1978-09-18 1981-12-29 Glaxo Group Limited Production of triazinones
JPS59164553A (ja) * 1983-03-08 1984-09-17 Fuji Photo Film Co Ltd カラ−写真感光材料
US4838925A (en) * 1986-04-25 1989-06-13 E. I. Du Pont De Nemours And Company Heterocyclic acyl sulfonamides
NZ504436A (en) * 1997-11-12 2001-08-31 Bayer Ag 2-Phenyl substituted imidazotriazinones as phosphodiesterase inhibitors
DE10011530A1 (de) * 2000-03-13 2001-09-27 Robert Elez Hochwirksame Antisense-Oligodesoxynucleotide gegen Polio-like Kinasel
DE10230604A1 (de) 2002-07-08 2004-01-29 Bayer Ag Heterocyclisch substituierte Imidazotriazine

Also Published As

Publication number Publication date
US7462614B2 (en) 2008-12-09
DE602004021363D1 (de) 2009-07-16
WO2004087652A2 (en) 2004-10-14
US20060217382A1 (en) 2006-09-28
ES2326808T3 (es) 2009-10-20
EP1608656B1 (de) 2009-06-03
JP2006522127A (ja) 2006-09-28
EP1608656A2 (de) 2005-12-28
WO2004087652A3 (en) 2005-02-10

Similar Documents

Publication Publication Date Title
ATE433447T1 (de) Pyrimiidinverbindungen
DE60214179D1 (de) IMIDAZOi1,2-AöPYRIDIN-DERIVATE ZUR PROPHYLAXE UND BEHANDLUNG VON HERPES-INFEKTIONEN
EA200601212A1 (ru) Ингибиторы фосфодиэстеразы, получение и их терапевтическое применение
ATE364043T1 (de) Pyrazolo-pyridine für die behandlung von herpes- ansteckungen
DE602004019198D1 (de) Chinolin-2-on-derivate zur behandlung von erkankungen der atemwege
ATE396973T1 (de) Benzylether- und benzylamino-beta-sekretase- hemmer zur behandlung von alzheimer-krankheit
ATE402180T1 (de) Verbindungen zur behandlung von dyslipidemie
ATE538651T1 (de) Spiropiperidininhibitoren von beta-secretase zur behandlung von alzheimer-krankheit
ATE506951T1 (de) Als inhibitoren von beta-secretase aktive tertiäre carbinamine mit substituierten heterocyclen zur behandlung der alzheimer- krankheit
ATE517861T1 (de) Benzylether und benzylaminoverbindungen als inhibitoren von beta-secretase zur behandlung von alzheimer-krankheit
DE60225556D1 (de) Dpp-iv-inhibierende purin-derivative zur behandlung von diabetes
MXPA03011484A (es) Heteroarilos multiciclicos sustituidos con quinuclidinas para el tratamiento de enfermedades.
GB0305152D0 (en) Organic compounds
TW200510317A (en) Caspase inhibitors and uses thereof
DE60211539D1 (de) Imidazopyridinderivate zur verwendung bei der behandlung von herpes-vireninfektion
ES2243579T3 (es) Derivados de pirazolopirideno.
ATE389395T1 (de) Substituierte 2-aminotetraline zur vorbeugenden behandlung von morbus parkinson
TW200738659A (en) Novel compounds
DE502005008058D1 (de) Gesättigte und ungesättigte 3-pyridyl-benzocycloalkylmethyl-amine zur behandlung von schmerzen, depressionen und angstzuständen
ATE432936T1 (de) Imidazotriazin verbindungen zur behandlung von krebserkrankungen
ATE302203T1 (de) Pyrazolopyrimidin- und pyrazolotriazinderivate und diese enthaltende pharmazeutische zubereitungen
ATE457027T1 (de) Substituierte 1,4,8-triazaspiroä4.5 decan-2-on- verbindungen zur behandlung von fettsucht
ATE512147T1 (de) Makrozyklische aminiopyridyl-beta-sekretase- hemmer zur behandlung von morbus alzheimer
ATE538796T1 (de) Piperidin- und pyrrolidin-beta-secretase-hemmer zur behandlung von alzheimer-krankheit
EA200600992A1 (ru) Амиды тиазолидинона, амиды тиазолидинкарбоновой кислоты, способы их получения и их применение

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties