PL355149A1 - Sposób otrzymywania chlorowodorku N-(4,5-bis-metanosulfonylo-2-metylobenzoilo)-guanidyny - Google Patents

Sposób otrzymywania chlorowodorku N-(4,5-bis-metanosulfonylo-2-metylobenzoilo)-guanidyny

Info

Publication number
PL355149A1
PL355149A1 PL00355149A PL35514900A PL355149A1 PL 355149 A1 PL355149 A1 PL 355149A1 PL 00355149 A PL00355149 A PL 00355149A PL 35514900 A PL35514900 A PL 35514900A PL 355149 A1 PL355149 A1 PL 355149A1
Authority
PL
Poland
Prior art keywords
hydrochloride
guanidine
methanesulfonyl
benzoyl
bis
Prior art date
Application number
PL00355149A
Other languages
English (en)
Other versions
PL199010B1 (pl
Inventor
Rolf Gericke
Manfred Baumgarth
Hans Markus Bender
Bernhard Ladstetter
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of PL355149A1 publication Critical patent/PL355149A1/pl
Publication of PL199010B1 publication Critical patent/PL199010B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL355149A 1999-10-26 2000-10-11 Sposób otrzymywania chlorowodorku N-(4,5-bis-metanosulfonylo-2-metylobenzoilo) - guanidyny PL199010B1 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19951418A DE19951418A1 (de) 1999-10-26 1999-10-26 Verfahren zur Herstellung von N-(4,5-Bismethansulfonyl-2-methyl-benzoyl) -guanidin, Hydrochlorid
PCT/EP2000/009977 WO2001030750A1 (de) 1999-10-26 2000-10-11 Verfahren zur herstellung von n-(4,5-bis-methansulfonyl-2-methyl-benzoyl)-guanidin, hydrochlorid

Publications (2)

Publication Number Publication Date
PL355149A1 true PL355149A1 (pl) 2004-04-05
PL199010B1 PL199010B1 (pl) 2008-08-29

Family

ID=7926842

Family Applications (1)

Application Number Title Priority Date Filing Date
PL355149A PL199010B1 (pl) 1999-10-26 2000-10-11 Sposób otrzymywania chlorowodorku N-(4,5-bis-metanosulfonylo-2-metylobenzoilo) - guanidyny

Country Status (25)

Country Link
US (1) US6673968B1 (pl)
EP (1) EP1224166B1 (pl)
JP (1) JP4969750B2 (pl)
KR (1) KR100699571B1 (pl)
CN (1) CN1202078C (pl)
AT (1) ATE250026T1 (pl)
AU (1) AU782471B2 (pl)
BR (1) BR0015022A (pl)
CA (1) CA2388915C (pl)
CZ (1) CZ299201B6 (pl)
DE (2) DE19951418A1 (pl)
DK (1) DK1224166T3 (pl)
ES (1) ES2204712T3 (pl)
HU (1) HU228634B1 (pl)
MX (1) MXPA02004144A (pl)
MY (1) MY122651A (pl)
NO (1) NO328250B1 (pl)
PL (1) PL199010B1 (pl)
PT (1) PT1224166E (pl)
RU (1) RU2276134C2 (pl)
SI (1) SI1224166T1 (pl)
SK (1) SK286603B6 (pl)
UA (1) UA73329C2 (pl)
WO (1) WO2001030750A1 (pl)
ZA (1) ZA200204119B (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10023405A1 (de) * 2000-05-12 2001-11-15 Merck Patent Gmbh Verfahren zur Herstellung von Sulfonyl-benzoylguanidinum-Salzen
EP1620394B1 (de) * 2003-05-06 2008-08-13 MERCK PATENT GmbH Verfahren zur kristallisation von guanidinium-salzen
AU2009243749B2 (en) * 2008-05-09 2013-11-21 Merck Patent Gmbh Pharmaceutical composition comprising rimeporide for treating diseases associated with insulin resistance and beta-cell dysfunction
MA53572A1 (fr) * 2013-06-10 2021-10-29 Amgen Inc Procédés de production et formes cristallines d'un inhibiteur mdm2
JP6562221B2 (ja) * 2014-06-23 2019-08-21 日産化学株式会社 スルホニル結合を有するシラン化合物の製造方法
MX391727B (es) * 2016-02-08 2025-03-21 Merck Patent Gmbh Modificaciones cristalinas de clorhidrato de n-(4,5-bismetansulfonil-2-metilbenzoil)guanidina y sales de n-(4,5-bismetansulfonil-2-metilbenzoil)guanidina.
EP3960165A1 (en) * 2020-08-25 2022-03-02 Fondation EspeRare Nhe-1 inhibitors for the treatment of coronavirus infections

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59216865A (ja) * 1983-05-26 1984-12-06 Mitsui Toatsu Chem Inc システイン塩酸塩水和物の乾燥方法
DE3929582A1 (de) * 1989-09-06 1991-03-07 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
EP0589336B1 (de) * 1992-09-22 1997-01-08 Hoechst Aktiengesellschaft Benzoylguanidine, Verfahren zu ihrer Herstellung, sowie ihre Verwendung als Antiarrhythmika
EP0604852A1 (de) * 1992-12-28 1994-07-06 Hoechst Aktiengesellschaft 2,4-Substituierte 5-(N-substituierte-Sulfamoyl)-Benzoylguanidine, als Antiarrythmika, Inhibitoren der Proliferationen von Zellen, und Inhibitoren des Natrium-Protonen-Antiporters
JPH07206857A (ja) * 1993-12-28 1995-08-08 Synthelabo Sa アルフゾシン塩酸塩の二水和物
JP3755908B2 (ja) * 1994-08-17 2006-03-15 塩野義製薬株式会社 セファロスポリン化合物の晶析法
DK0723956T3 (da) * 1995-01-30 2000-04-17 Hoechst Ag Basisk substituerede benzoylguanidiner, fremgangsmåde til fremstilling deraf, anvendelse deraf som lægemiddel eller diagnos
DE19502895A1 (de) * 1995-01-31 1996-08-01 Merck Patent Gmbh 4-Mercapto-benzoylguanidin-Derivate
DE19526381A1 (de) * 1995-07-19 1997-01-23 Hoechst Ag 4-Fluoralkyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19529612A1 (de) * 1995-08-11 1997-02-13 Merck Patent Gmbh Sulfonyl- oder Sulfinyl-benzoylguanidin-Derivate

Also Published As

Publication number Publication date
NO20021950L (no) 2002-04-25
DE50003759D1 (de) 2003-10-23
RU2276134C2 (ru) 2006-05-10
NO20021950D0 (no) 2002-04-25
MXPA02004144A (es) 2006-01-12
CN1202078C (zh) 2005-05-18
CZ20021354A3 (cs) 2002-09-11
SK286603B6 (sk) 2009-02-05
DK1224166T3 (da) 2004-01-05
CN1382120A (zh) 2002-11-27
SK5462002A3 (en) 2002-10-08
WO2001030750A1 (de) 2001-05-03
PT1224166E (pt) 2004-02-27
PL199010B1 (pl) 2008-08-29
HU228634B1 (en) 2013-04-29
BR0015022A (pt) 2002-06-18
CA2388915A1 (en) 2001-05-03
HUP0203132A2 (hu) 2003-01-28
EP1224166B1 (de) 2003-09-17
UA73329C2 (uk) 2005-07-15
ES2204712T3 (es) 2004-05-01
JP4969750B2 (ja) 2012-07-04
NO328250B1 (no) 2010-01-18
CZ299201B6 (cs) 2008-05-14
KR100699571B1 (ko) 2007-03-23
DE19951418A1 (de) 2001-05-03
HUP0203132A3 (en) 2004-12-28
HK1051358A1 (en) 2003-08-01
AU1136101A (en) 2001-05-08
US6673968B1 (en) 2004-01-06
KR20020044572A (ko) 2002-06-15
JP2003512451A (ja) 2003-04-02
ZA200204119B (en) 2003-10-29
MY122651A (en) 2006-04-29
ATE250026T1 (de) 2003-10-15
CA2388915C (en) 2009-12-15
EP1224166A1 (de) 2002-07-24
AU782471B2 (en) 2005-08-04
SI1224166T1 (en) 2004-04-30

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