PL355887A1 - Inhibitory transferazy farnezylowej - Google Patents

Inhibitory transferazy farnezylowej

Info

Publication number
PL355887A1
PL355887A1 PL00355887A PL35588700A PL355887A1 PL 355887 A1 PL355887 A1 PL 355887A1 PL 00355887 A PL00355887 A PL 00355887A PL 35588700 A PL35588700 A PL 35588700A PL 355887 A1 PL355887 A1 PL 355887A1
Authority
PL
Poland
Prior art keywords
transferase inhibitors
farnesyl transferase
farnesyl
inhibitors
transferase
Prior art date
Application number
PL00355887A
Other languages
English (en)
Inventor
Francis Thomas Boyle
James Michael Wardleworth
Zbigniew Matusiak
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PL355887A1 publication Critical patent/PL355887A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PL00355887A 1999-12-22 2000-12-18 Inhibitory transferazy farnezylowej PL355887A1 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9930318.2A GB9930318D0 (en) 1999-12-22 1999-12-22 Novel compounds
PCT/GB2000/004856 WO2001046137A1 (en) 1999-12-22 2000-12-18 Farnesyl transferase inhibitors

Publications (1)

Publication Number Publication Date
PL355887A1 true PL355887A1 (pl) 2004-05-31

Family

ID=10866834

Family Applications (1)

Application Number Title Priority Date Filing Date
PL00355887A PL355887A1 (pl) 1999-12-22 2000-12-18 Inhibitory transferazy farnezylowej

Country Status (27)

Country Link
US (1) US7101897B2 (pl)
EP (1) EP1255733B1 (pl)
JP (1) JP3742593B2 (pl)
KR (1) KR20020063251A (pl)
CN (2) CN1680313A (pl)
AR (1) AR029460A1 (pl)
AT (1) ATE316074T1 (pl)
AU (1) AU776003B2 (pl)
BR (1) BR0016669A (pl)
CA (1) CA2387579A1 (pl)
CO (1) CO5360641A1 (pl)
CZ (1) CZ20022125A3 (pl)
DE (1) DE60025650D1 (pl)
EE (1) EE200200206A (pl)
GB (1) GB9930318D0 (pl)
HU (1) HUP0204135A3 (pl)
IL (1) IL149871A0 (pl)
IS (1) IS6358A (pl)
MX (1) MXPA02005981A (pl)
MY (1) MY133606A (pl)
NO (1) NO20022924D0 (pl)
NZ (1) NZ518341A (pl)
PL (1) PL355887A1 (pl)
RU (1) RU2259997C2 (pl)
SK (1) SK8642002A3 (pl)
WO (1) WO2001046137A1 (pl)
ZA (1) ZA200202694B (pl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005117864A1 (en) * 2004-05-28 2005-12-15 Astrazeneca Ab Combination product comprising anastrozole and a dual prenyl transferase inhibitor
EP1813620A4 (en) * 2004-10-08 2009-12-30 Kotobuki Pharmaceutical Co Ltd PHOSPHONIC ACID DERIVATIVE AND THERAPEUTIC AGENT AGAINST DISEASES ASSOCIATED WITH HIGH PHOSPHAT MIRRORS IN THE BLOOD
US20110136867A1 (en) * 2006-02-02 2011-06-09 Justman Craig J Treatment of Synucleinopathies
US8232402B2 (en) 2008-03-12 2012-07-31 Link Medicine Corporation Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
MX2011005096A (es) 2008-11-13 2011-11-18 Link Medicine Corp Derivados de azaquinolinona y usos de los mismos.
US8975247B2 (en) 2009-03-18 2015-03-10 The Board Of Trustees Of The Leland Stanford Junion University Methods and compositions of treating a flaviviridae family viral infection
WO2011088126A2 (en) * 2010-01-13 2011-07-21 Eiger Biopharmaceuticals, Inc. Treatment of viral infection with prenyltransferase inhibitors
WO2018132791A1 (en) 2017-01-16 2018-07-19 The Regents Of The University Of California Treatment of neurodegenerative conditions by disruption of rhes

Family Cites Families (45)

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SU422723A1 (ru) * 1972-03-29 1974-04-05 Б. В. Салов, Т. А. Губенкова , И. В. Быховска Способ получения 5-нитро-2-аминобензойнойкислоты
CA1283906C (en) 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
JPS60233076A (ja) 1984-05-03 1985-11-19 Sumitomo Chem Co Ltd 新規なβ−ラクタム化合物およびその製造法
CA1281720C (en) 1984-11-08 1991-03-19 Makoto Sunagawa Carbapenem compounds and production thereof
KR880006244A (ko) 1986-11-24 1988-07-22 후지사와 도모 기찌 로 3-피롤리디닐티오-1-아자바이스클로[3.2.0]햅트2-엔-2-카르복실산 화합물 및 이의 제조방법
GB8921635D0 (en) 1989-09-25 1989-11-08 Fujisawa Pharmaceutical Co 3-pyrrolidinylthio-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives
CA2036163C (en) 1990-02-14 2001-06-19 Makoto Sunagawa Novel beta-lactam compounds and their production
CA2036941A1 (en) 1990-02-23 1991-08-24 Isao Kawamoto Carbapenem derivatives having antibiotic activity, their preparation and their use
GB9107363D0 (en) 1991-04-08 1991-05-22 Ici Plc Antibiotic compounds
US6083917A (en) 1990-04-18 2000-07-04 Board Of Regents, The University Of Texas System Methods and compositions for the identification, characterization and inhibition of farnesyltransferase
US5185248A (en) 1990-05-08 1993-02-09 E. R. Squibb & Sons, Inc. Farnesyl-protein transferase assay for identifying compounds that block neoplastic transformation
JPH0578360A (ja) 1991-01-31 1993-03-30 Banyu Pharmaceut Co Ltd ２−［２−（スルフアモイルアルキル）ピロリジニルチオカルバペネム誘導体
GB9107341D0 (en) 1991-04-08 1991-05-22 Ici Plc Antibiotic compounds
GB9107342D0 (en) 1991-04-08 1991-05-22 Ici Plc Antibiotic compounds
CA2070305A1 (en) 1991-06-04 1992-12-05 Isao Kawamoto 1-methylcarbapenem derivatives, their preparation and their use as antibiotics
JPH04368386A (ja) 1991-06-18 1992-12-21 Sankyo Co Ltd １−メチルカルバペネム−３−カルボン酸の製造法
US5360798A (en) 1991-07-04 1994-11-01 Shionogi Seiyaku Kabushiki Kaisha Aminooxypyrrolidinylthiocarbapenem compounds
EP0537007B1 (en) 1991-10-11 1995-08-09 E.R. SQUIBB & SONS, INC. Use of formesyl-protein transferase inhibitors for the manufacture of a medicament for blocking neoplastic transformation of cells induced by ras oncogenes
JPH05239058A (ja) 1991-12-17 1993-09-17 Fujisawa Pharmaceut Co Ltd ３−ピロリジニルチオ−１−アザビシクロ［３．２．０ヘプト−２−エン−２−カルボン酸化合物
GB9202298D0 (en) 1992-02-04 1992-03-18 Ici Plc Antibiotic compounds
HU218676B (hu) 1992-03-11 2000-10-28 Sankyo Co. Ltd. Antimikrobiális karbapenemszármazékok, ilyen vegyületeket tartalmazó gyógyászati készítmények és eljárás ezek előállítására
CA2091309A1 (en) 1992-03-26 1993-09-27 Frederic H. Jung Antibiotic compounds
GB9304156D0 (en) 1992-03-26 1993-04-21 Zeneca Ltd Antibiotic compounds
IL105348A0 (en) 1992-04-13 1993-08-18 Fujisawa Pharmaceutical Co Azabicyclo derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
EP0581502B1 (en) 1992-07-21 1998-10-21 Zeneca Limited Antibiotic carbapenem compounds
EP0581501B1 (en) 1992-07-21 1998-09-09 Zeneca Limited Antibiotic carbapenem compounds
CA2099818A1 (en) 1992-07-21 1994-01-22 Frederic H. Jung Antibiotic compounds
EP0590885B1 (en) 1992-09-28 2000-03-15 Zeneca Limited Antibiotic carbapenem compounds
CA2106330A1 (en) 1992-10-07 1994-04-08 Patrice J. Siret Antibiotic compounds
CA2118985A1 (en) 1993-04-02 1994-10-03 Dinesh V. Patel Heterocyclic inhibitors of farnesyl protein transferase
WO1995000497A1 (en) 1993-06-18 1995-01-05 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
JP2534823B2 (ja) 1993-07-07 1996-09-18 日本電気株式会社 印刷装置
JPH09504277A (ja) 1993-09-30 1997-04-28 メルク エンド カンパニー インコーポレーテッド ファルネシル−タンパク質トランスフェラーゼの阻害剤
US5468733A (en) 1993-09-30 1995-11-21 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
CA2155448A1 (en) 1994-08-11 1996-02-12 Katerina Leftheris Inhibitors of farnesyl protein transferase
US5571835A (en) 1994-09-29 1996-11-05 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
CA2216564A1 (en) 1995-03-29 1996-10-03 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
BR9609744A (pt) 1995-07-31 1999-03-02 Shionogi & Co Derivados de pirrolidina tendo atividade inibitória de fosfolipase a2
GB9515975D0 (en) * 1995-08-04 1995-10-04 Zeneca Ltd Chemical compounds
NO307879B1 (no) * 1995-09-18 2000-06-13 Sankyo Co Nye ureaderivater med ACAT-inhiberende aktivitet og farmasøytisk preparat inneholdende disse
JPH1050029A (ja) 1996-05-28 1998-02-20 Nobuyuki Higuchi 情報記憶装置
AU4020897A (en) 1996-08-17 1998-03-06 Zeneca Limited 3-mercaptopyrrolidines as farnesyl protein transferase inhibitors
EP0975603A1 (en) 1997-01-29 2000-02-02 Zeneca Limited Inhibitors of farnesyl protein transferase
AU7371998A (en) 1997-05-07 1998-11-27 University Of Pittsburgh Inhibitors of protein isoprenyl transferases
EP1054865A1 (en) 1998-02-10 2000-11-29 AstraZeneca UK Limited Farnesyl transferase inhibitors

Also Published As

Publication number Publication date
RU2259997C2 (ru) 2005-09-10
CN1229344C (zh) 2005-11-30
ATE316074T1 (de) 2006-02-15
GB9930318D0 (en) 2000-02-09
JP3742593B2 (ja) 2006-02-08
EP1255733A1 (en) 2002-11-13
ZA200202694B (en) 2003-12-31
CO5360641A1 (es) 2004-01-30
NO20022924L (no) 2002-06-18
EP1255733B1 (en) 2006-01-18
US20030083348A1 (en) 2003-05-01
DE60025650D1 (de) 2006-04-06
NZ518341A (en) 2004-01-30
WO2001046137A1 (en) 2001-06-28
AU2201301A (en) 2001-07-03
CZ20022125A3 (cs) 2002-09-11
SK8642002A3 (en) 2002-12-03
CN1411442A (zh) 2003-04-16
HUP0204135A2 (hu) 2003-03-28
AR029460A1 (es) 2003-07-02
AU776003B2 (en) 2004-08-19
NO20022924D0 (no) 2002-06-18
CN1680313A (zh) 2005-10-12
KR20020063251A (ko) 2002-08-01
IL149871A0 (en) 2002-11-10
RU2002119405A (ru) 2004-01-10
EE200200206A (et) 2003-04-15
US7101897B2 (en) 2006-09-05
IS6358A (is) 2002-04-23
MY133606A (en) 2007-11-30
HUP0204135A3 (en) 2005-03-29
JP2003518091A (ja) 2003-06-03
MXPA02005981A (es) 2005-07-01
CA2387579A1 (en) 2001-06-28
BR0016669A (pt) 2002-10-08

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Legal Events

Date Code Title Description
REFS Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)