PL356127A1 - Pochodne kwasu 15-hydroksyeikozatetraenowego ze zmodyfikowanym łańcuchem omega oraz sposoby ich zastosowania do leczenia zespołu suchego oka - Google Patents

Pochodne kwasu 15-hydroksyeikozatetraenowego ze zmodyfikowanym łańcuchem omega oraz sposoby ich zastosowania do leczenia zespołu suchego oka

Info

Publication number
PL356127A1
PL356127A1 PL00356127A PL35612700A PL356127A1 PL 356127 A1 PL356127 A1 PL 356127A1 PL 00356127 A PL00356127 A PL 00356127A PL 35612700 A PL35612700 A PL 35612700A PL 356127 A1 PL356127 A1 PL 356127A1
Authority
PL
Poland
Prior art keywords
treatment
methods
acid derivatives
dry eye
chain modified
Prior art date
Application number
PL00356127A
Other languages
English (en)
Inventor
David B. Belanger
Original Assignee
Alcon Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc. filed Critical Alcon Inc.
Publication of PL356127A1 publication Critical patent/PL356127A1/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/46—Unsaturated compounds containing hydroxy or O-metal groups containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL00356127A 1999-11-09 2000-10-23 Pochodne kwasu 15-hydroksyeikozatetraenowego ze zmodyfikowanym łańcuchem omega oraz sposoby ich zastosowania do leczenia zespołu suchego oka PL356127A1 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16437599P 1999-11-09 1999-11-09
US21158700P 2000-06-15 2000-06-15
PCT/US2000/029255 WO2001034546A2 (en) 1999-11-09 2000-10-23 Omega chain modified 15-hydroxyeicosatetraenoic acid derivatives and methods of their use for the treatment of dry eye

Publications (1)

Publication Number Publication Date
PL356127A1 true PL356127A1 (pl) 2004-06-14

Family

ID=26860505

Family Applications (1)

Application Number Title Priority Date Filing Date
PL00356127A PL356127A1 (pl) 1999-11-09 2000-10-23 Pochodne kwasu 15-hydroksyeikozatetraenowego ze zmodyfikowanym łańcuchem omega oraz sposoby ich zastosowania do leczenia zespołu suchego oka

Country Status (20)

Country Link
US (2) US6326499B1 (pl)
EP (1) EP1228031B1 (pl)
JP (1) JP2003513946A (pl)
KR (1) KR20020050237A (pl)
CN (1) CN1387504A (pl)
AR (1) AR030262A1 (pl)
AT (1) ATE257144T1 (pl)
AU (1) AU775290B2 (pl)
BR (1) BR0015402A (pl)
CA (1) CA2386632A1 (pl)
DE (1) DE60007548T2 (pl)
DK (1) DK1228031T3 (pl)
ES (1) ES2208440T3 (pl)
HK (1) HK1045984B (pl)
MX (1) MXPA02004699A (pl)
PL (1) PL356127A1 (pl)
PT (1) PT1228031E (pl)
TR (1) TR200201251T2 (pl)
TW (1) TWI241290B (pl)
WO (1) WO2001034546A2 (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0119583D0 (en) * 2001-08-10 2001-10-03 Unilever Plc Cosmetic composition and method of treating skin
WO2003030892A1 (en) * 2001-10-11 2003-04-17 Alcon, Inc. Methods for treating dry eye
MXPA04003299A (es) * 2001-10-11 2004-07-23 Alcon Inc Metodos para tratar la resequedad ocular mediante una combinacion de un esteroide antiinflamatorio y un secretagogo muc-1.
US20030109508A1 (en) * 2001-10-11 2003-06-12 Alcon, Inc. Methods for treating dry eye
WO2003105824A1 (en) * 2002-06-14 2003-12-24 Alcon, Inc. Topical use of hydroxyeicosatetraenoic acid compounds to treat psoriasis
US6825232B2 (en) * 2002-06-14 2004-11-30 Alcon, Inc. Use of hydroxyeicosatetraenoic acid compounds to treat ophthalmic inflammatory disorders
BR0314603A (pt) * 2002-09-20 2005-07-26 Alcon Inc Uso de inibidores da sìntese de citoquina para o tratamento de distúrbios de olhos secos

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3991759A (en) 1975-10-28 1976-11-16 Alza Corporation Method and therapeutic system for treating aqueous deficient dry eye
US4131651A (en) 1977-10-25 1978-12-26 Barnes-Hind Pharmaceuticals, Inc. Treatment of dry eye
US4409205A (en) 1979-03-05 1983-10-11 Cooper Laboratories, Inc. Ophthalmic solution
US4370325A (en) 1979-03-30 1983-01-25 Dermik Laboratories Pharmaceutical compositions and method of treatment
AU546872B2 (en) 1982-06-16 1985-09-26 Unilever Plc Skin treatment compositions containing a fatty acid or ester
US4421748A (en) 1982-07-13 1983-12-20 Trager Seymour F Artificial tear aid
GB8319073D0 (en) 1983-07-14 1983-08-17 Efamol Ltd Fatty acid compositions
US4868154A (en) 1986-02-19 1989-09-19 Eye Research Institute Of Retina Foundation Stimulation of tear secretion with melanocyte stimulating hormones
US4753945A (en) 1986-02-19 1988-06-28 Eye Research Institute Of Retina Foundation Stimulation of tear secretion with phosphodiesterase inhibitors
US4744980A (en) 1986-04-28 1988-05-17 Holly Frank J Ophthalmic solution for treatment of dry eye syndrome
US4883658A (en) 1986-04-28 1989-11-28 Holly Frank J Ophthalmic solution for treatment of dry-eye syndrome
US4804539A (en) 1986-07-28 1989-02-14 Liposome Technology, Inc. Ophthalmic liposomes
US4818537A (en) 1986-10-21 1989-04-04 Liposome Technology, Inc. Liposome composition for treating dry eye
US4966773A (en) 1986-11-25 1990-10-30 Alcon Laboratories, Inc. Topical ophthalmic compositions containing microfine retinoid particles
US5278151A (en) 1987-04-02 1994-01-11 Ocular Research Of Boston, Inc. Dry eye treatment solution
US4914088A (en) 1987-04-02 1990-04-03 Thomas Glonek Dry eye treatment solution and method
US4921644A (en) 1988-02-29 1990-05-01 Technology Unlimited, Inc. Mucin directed lipsome
US4906467A (en) 1988-03-24 1990-03-06 New York Medical College Novel, long-duration treatment for glaucoma
US4923700A (en) 1988-06-03 1990-05-08 Kaufman Herbert E Artificial tear suspension
US5064655A (en) 1989-02-24 1991-11-12 Liposome Technology, Inc. Liposome gel composition and method
US5075104A (en) 1989-03-31 1991-12-24 Alcon Laboratories, Inc. Ophthalmic carboxy vinyl polymer gel for dry eye syndrome
US5174988A (en) 1989-07-27 1992-12-29 Scientific Development & Research, Inc. Phospholipid delivery system
WO1991012808A1 (en) 1990-02-22 1991-09-05 Macnaught Pty Limited Artificial tears
US5041434A (en) 1991-08-17 1991-08-20 Virginia Lubkin Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application
EP0459148B1 (en) 1990-05-29 1996-01-03 Ocular Research Of Boston Inc. Dry eye treatment composition
ZA912797B (en) 1990-05-29 1992-12-30 Boston Ocular Res Dry eye treatment process and solution
US5102670A (en) 1990-09-14 1992-04-07 Abraham Nader G Method for treating eye disorders by reducing 12(r)-hydroxyeicosatetraenoic acid and 12(r)-dihydroxyeicosatrienoic acid levels
DK0495421T3 (da) 1991-01-15 1996-12-09 Alcon Lab Inc Anvendelse af carragenaner i topiske ophthalmiske sammensætninger
ZA927277B (en) 1991-10-02 1993-05-19 Boston Ocular Res Dry eye treatment process and solution.
EP0546728A3 (en) 1991-12-13 1993-09-08 Alcon Laboratories Inc Physiological tear compositions and methods for their preparation
EP0643581B1 (en) 1992-04-21 1999-10-20 The Schepens Eye Research Institute, Inc. Ocular androgen therapy in sjögren's syndrome
US5290572A (en) 1992-08-06 1994-03-01 Deo Corporation Opthalmic composition for treating dry eye
US5358706A (en) 1992-09-30 1994-10-25 Union Carbide Chemicals & Plastics Technology Corporation Muco-adhesive polymers
US5455265A (en) 1993-02-11 1995-10-03 Allergan, Inc. Method of treatment with compounds having selective agonist-like activity on RXR retinoid receptors
US5389383A (en) 1993-06-18 1995-02-14 Allergan, Inc. Method for treating hypoxia-associated ocular complications
US5696166A (en) 1995-10-31 1997-12-09 Yanni; John M. Compositions containing hydroxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders
EP0964690B1 (en) 1996-10-15 2003-07-09 The Liposome Company, Inc. Peptide-lipid conjugates, liposomes and liposomal drug delivery
US5800807A (en) 1997-01-29 1998-09-01 Bausch & Lomb Incorporated Ophthalmic compositions including glycerin and propylene glycol
JP2002538124A (ja) 1999-03-01 2002-11-12 ヴィスタ サイエンティフィック エルエルシー ムチンを含む眼科用調合物

Also Published As

Publication number Publication date
KR20020050237A (ko) 2002-06-26
ES2208440T3 (es) 2004-06-16
TWI241290B (en) 2005-10-11
CA2386632A1 (en) 2001-05-17
HK1045984B (en) 2004-04-23
PT1228031E (pt) 2004-04-30
MXPA02004699A (es) 2004-09-10
WO2001034546A2 (en) 2001-05-17
EP1228031A2 (en) 2002-08-07
JP2003513946A (ja) 2003-04-15
EP1228031B1 (en) 2004-01-02
WO2001034546A3 (en) 2001-10-25
AU775290B2 (en) 2004-07-29
DE60007548D1 (de) 2004-02-05
US6326499B1 (en) 2001-12-04
TR200201251T2 (tr) 2002-11-21
AR030262A1 (es) 2003-08-20
HK1045984A1 (en) 2002-12-20
BR0015402A (pt) 2002-06-25
US20020037881A1 (en) 2002-03-28
AU1913101A (en) 2001-06-06
ATE257144T1 (de) 2004-01-15
US6462061B1 (en) 2002-10-08
DK1228031T3 (da) 2004-04-13
CN1387504A (zh) 2002-12-25
DE60007548T2 (de) 2004-06-17

Similar Documents

Publication Publication Date Title
NO20014046D0 (no) Gabapentinderivater for forhindring og behandling av visceral smerte
ATE455106T1 (de) Acyl derivate zur behandlung von krankheiten die in zusammenhang mit vla-4 stehen
DE69940131D1 (de) Mittel zur Behandlung von Erkrankungen der Speiseröhre
NO20001754D0 (no) Prostaglandinagonister og anvendelse derav for behandling av benforstyrrelser
EE200000366A (et) Seade ja meetod keha kudede ravimiseks elektri või ravimitega
DE60019556D1 (de) 2-amino-benzoxazinonderivate zur behandlung von fettleibigkeit
DE60019555D1 (de) 2-oxy-benzoxazinonderivate zur behandlung von fettleibigkeit
PT1228032E (pt) Composicoes contendo derivados do acido hidroxieicosatetraenoico e metodos de utilizacao para o tratamento de desordens do olho seco
NO20005387L (no) 3-(amino- eller aminoalkyl-)pyridinonderivater og deres anvendelse for behandling av HIV-relaterte sykdommer
NO985484L (no) FremgangsmÕte og preparat for behandling og forhindring av hyperurikemi
WO2001028494A3 (en) Nordihydroguaiaretic derivatives for use in treatment of tumors
NO20015542D0 (no) Fremgangsmåte for fremstilling og anvendelse av N- desmetylzopikloner
EE200100416A (et) Hargneva ahelaga aminohappe-sõltuvad aminotransferaasinhibiitorid ja nende kasutamine diabeetilise retinopaatia ravis
EE200200305A (et) Südame arütmiate ravis kasutatavad uued asabitsüklooktaani derivaadid
NO20003229L (no) Kombinasjon av benzosykloheptapyridinforbindelser og antineoplastiske midler for behandling av proliferaktive sykdommer
WO2001034129A3 (en) Heteroatom-interrupted analogs of 15-hydroxyeicosatetraenoic acid and methods of use
WO2001034546A3 (en) Omega chain modified 15-hydroxyeicosatetraenoic acid derivatives and methods of their use for the treatment of dry eye
WO2001034550A3 (en) 15-hydroxyeicosatetraenoic acid analogs with enhanced metabolic stability and methods of their use in treating dry eye disorders
WO2001034553A3 (en) 2,2-difluoro 15-hydroxyeicosatetraenoic acid analogs and methods of use
ATE261965T1 (de) Bispidin-derivate zur behandlung von herzarrhythmien
NO20022990L (no) Fremgangsmåte og sammensetning for behandling av smerte
HUP0105203A3 (en) S-nitrosothiols as agents for the treatment of circulatory dysfunctions and their use
NO20013464D0 (no) Anvendelse av 3-isoksazolidinoner og hydroksylaminsyrer for behandling av infeksjoner
PL356105A1 (pl) Analogi kwasu hydroksyeikozatetraenowego oraz sposoby ich zastosowania do leczenia zespołu suchego oka
ATE259809T1 (de) Bispidin-derivate zur behandlung von herzarrhythmien

Legal Events

Date Code Title Description
REFS Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)