PL357881A1 - Sposób wytwarzania półproduktów użytecznych w syntezie paklitakselu - Google Patents

Sposób wytwarzania półproduktów użytecznych w syntezie paklitakselu

Info

Publication number: PL357881A1
Authority: PL; Poland
Prior art keywords: semi; finished products; products useful; manufacture; paclitaxel
Prior art date: 2002-12-19

Application number

PL02357881A

Other languages

English (en)

Other versions

PL194032B1 (pl

Inventor

Beata Kolesińska

Zbigniew J. Kamiński

Janina E. Kamińska

Original Assignee

Agropharm S.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-12-19

Filing date

2002-12-19

Publication date

2004-06-28

2002-12-19 Application filed by Agropharm S.A. filed Critical Agropharm S.A.

2002-12-19 Priority to PL357881A priority Critical patent/PL194032B1/pl

2003-12-11 Priority to AU2003294189A priority patent/AU2003294189A1/en

2003-12-11 Priority to EP03789656A priority patent/EP1575929B1/en

2003-12-11 Priority to PCT/PL2003/000139 priority patent/WO2004056790A1/en

2003-12-11 Priority to AT03789656T priority patent/ATE357436T1/de

2003-12-11 Priority to DE60312734T priority patent/DE60312734D1/de

2004-06-28 Publication of PL357881A1 publication Critical patent/PL357881A1/pl

2007-04-30 Publication of PL194032B1 publication Critical patent/PL194032B1/pl

Links

229930012538 Paclitaxel Natural products 0.000 title abstract 2
230000015572 biosynthetic process Effects 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title abstract 2
229960001592 paclitaxel Drugs 0.000 title abstract 2
239000011265 semifinished product Substances 0.000 title abstract 2
238000003786 synthesis reaction Methods 0.000 title abstract 2
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title abstract 2
238000000034 method Methods 0.000 title 1
OVMSOCFBDVBLFW-VHLOTGQHSA-N 5beta,20-epoxy-1,7beta,13alpha-trihydroxy-9-oxotax-11-ene-2alpha,4alpha,10beta-triyl 4,10-diacetate 2-benzoate Chemical compound O([C@@H]1[C@@]2(C[C@H](O)C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)O)C(=O)C1=CC=CC=C1 OVMSOCFBDVBLFW-VHLOTGQHSA-N 0.000 abstract 2
239000003960 organic solvent Substances 0.000 abstract 2
JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical compound C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 abstract 1
HOJZAHQWDXAPDJ-UHFFFAOYSA-N 3-anilino-2-hydroxypropanoic acid Chemical class OC(=O)C(O)CNC1=CC=CC=C1 HOJZAHQWDXAPDJ-UHFFFAOYSA-N 0.000 abstract 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
229930014667 baccatin III Natural products 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
150000003512 tertiary amines Chemical class 0.000 abstract 1
150000003918 triazines Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D305/04—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

PL357881A 2002-12-19 2002-12-19 Sposób wytwarzania półproduktów użytecznych w syntezie paklitakselu PL194032B1 (pl)

Priority Applications (6)

Application Number	Priority Date	Filing Date	Title
PL357881A PL194032B1 (pl)	2002-12-19	2002-12-19	Sposób wytwarzania półproduktów użytecznych w syntezie paklitakselu
AU2003294189A AU2003294189A1 (en)	2002-12-19	2003-12-11	The method for production of semi-finished products useful in synthesis of paclitaxel
EP03789656A EP1575929B1 (en)	2002-12-19	2003-12-11	The method for production of semi-finished products useful in synthesis of paclitaxel
PCT/PL2003/000139 WO2004056790A1 (en)	2002-12-19	2003-12-11	The method for production of semi-finished products useful in synthesis of paclitaxel
AT03789656T ATE357436T1 (de)	2002-12-19	2003-12-11	Verfahren zur herstellung von halbfertigen produkten verwendbar für die synthese des paclitaxels
DE60312734T DE60312734D1 (de)	2002-12-19	2003-12-11	Verfahren zur herstellung von halbfertigen produkten verwendbar für die synthese des paclitaxels

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PL357881A PL194032B1 (pl)	2002-12-19	2002-12-19	Sposób wytwarzania półproduktów użytecznych w syntezie paklitakselu

Publications (2)

Publication Number	Publication Date
PL357881A1 true PL357881A1 (pl)	2004-06-28
PL194032B1 PL194032B1 (pl)	2007-04-30

Family

ID=32678124

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL357881A PL194032B1 (pl)	2002-12-19	2002-12-19	Sposób wytwarzania półproduktów użytecznych w syntezie paklitakselu

Country Status (6)

Country	Link
EP (1)	EP1575929B1 (pl)
AT (1)	ATE357436T1 (pl)
AU (1)	AU2003294189A1 (pl)
DE (1)	DE60312734D1 (pl)
PL (1)	PL194032B1 (pl)
WO (1)	WO2004056790A1 (pl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN101020672B (zh) *	2006-12-28	2010-08-25	上海百灵医药科技有限公司	多烯紫杉醇的合成方法
KR101096282B1 (ko)	2009-04-24	2011-12-20	주식회사 삼양제넥스	탁산 유도체를 제조하는 방법

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1993006079A1 (en) *	1991-09-23	1993-04-01	Florida State University	PREPARATION OF SUBSTITUTED ISOSERINE ESTERS USING METAL ALKOXIDES AND β-LACTAMS
GB9512471D0 (en) *	1995-06-20	1995-08-23	Pharmacia Spa	Method for the preparation of taxol and its derivatives
US6150537A (en) *	1997-12-12	2000-11-21	Emory University	Methods for the esterification of alcohols and compounds useful therefor as potential anticancer agents

2002
- 2002-12-19 PL PL357881A patent/PL194032B1/pl not_active IP Right Cessation
2003
- 2003-12-11 AU AU2003294189A patent/AU2003294189A1/en not_active Abandoned
- 2003-12-11 WO PCT/PL2003/000139 patent/WO2004056790A1/en not_active Ceased
- 2003-12-11 AT AT03789656T patent/ATE357436T1/de not_active IP Right Cessation
- 2003-12-11 EP EP03789656A patent/EP1575929B1/en not_active Expired - Lifetime
- 2003-12-11 DE DE60312734T patent/DE60312734D1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE60312734D1 (de)	2007-05-03
WO2004056790A1 (en)	2004-07-08
AU2003294189A1 (en)	2004-07-14
EP1575929B1 (en)	2007-03-21
PL194032B1 (pl)	2007-04-30
EP1575929A1 (en)	2005-09-21
ATE357436T1 (de)	2007-04-15

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Legal Events

Date	Code	Title	Description
2015-02-27	LAPS	Decisions on the lapse of the protection rights	Effective date: 20131219