PL359826A1 - A pyridine-1-oxide derivative, and process for its transformation into pharmaceutically effective compounds - Google Patents

A pyridine-1-oxide derivative, and process for its transformation into pharmaceutically effective compounds

Info

Publication number: PL359826A1
Authority: PL; Poland
Prior art keywords: pyridine; transformation; pharmaceutically effective; oxide; oxide derivative
Prior art date: 2000-04-18

Application number

PL35982601A

Other languages

English (en)

Polish (pl)

Inventor

Laszlo Urogdi

Csakai Zita Jegesne

Lajos Gruber

Laszlo Otvos

József Toth

Istvan Tomoskozi

Schmidt Aniko Szakacsne

Ferencne Reider

Barlay Maria Schneiderne

Original Assignee

Biorex Kutato Es Fejleszto Rt.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-04-18

Filing date

2001-04-17

Publication date

2004-09-06

2001-04-17 Application filed by Biorex Kutato Es Fejleszto Rt. filed Critical Biorex Kutato Es Fejleszto Rt.

2004-09-06 Publication of PL359826A1 publication Critical patent/PL359826A1/xx

Links

150000001875 compounds Chemical class 0.000 title abstract 3
ILVXOBCQQYKLDS-UHFFFAOYSA-N pyridine N-oxide Chemical class [O-][N+]1=CC=CC=C1 ILVXOBCQQYKLDS-UHFFFAOYSA-N 0.000 title 1
230000009466 transformation Effects 0.000 title 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 2
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
QPANXJTVLHTKCV-UHFFFAOYSA-N n'-(2-hydroxy-3-piperidin-1-ylpropoxy)-1-oxidopyridin-1-ium-3-carboximidamide Chemical compound C=1C=C[N+]([O-])=CC=1C(N)=NOCC(O)CN1CCCCC1 QPANXJTVLHTKCV-UHFFFAOYSA-N 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PL35982601A 2000-04-18 2001-04-17 A pyridine-1-oxide derivative, and process for its transformation into pharmaceutically effective compounds PL359826A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU0001583A HUP0001583A2 (hu)	2000-04-18	2000-04-18	Egy piridin-1-oxid-származék és eljárás annak átalakítására gyógyászati hatású vegyületekké
PCT/HU2001/000046 WO2001079174A1 (en)	2000-04-18	2001-04-17	A pyridine-1-oxide derivative, and process for its transformation into pharmaceutically effective compounds

Publications (1)

Publication Number	Publication Date
PL359826A1 true PL359826A1 (en)	2004-09-06

Family

ID=90001563

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL35982601A PL359826A1 (en)	2000-04-18	2001-04-17	A pyridine-1-oxide derivative, and process for its transformation into pharmaceutically effective compounds

Country Status (31)

Country	Link
US (1)	US7126002B2 (de)
EP (1)	EP1274685B1 (de)
JP (1)	JP5066638B2 (de)
KR (1)	KR100742482B1 (de)
CN (1)	CN1216868C (de)
AT (1)	ATE332894T1 (de)
AU (2)	AU5499701A (de)
BG (1)	BG65889B1 (de)
BR (1)	BRPI0110184B8 (de)
CA (1)	CA2406266C (de)
CY (1)	CY1107473T1 (de)
CZ (1)	CZ301576B6 (de)
DE (1)	DE60121431T2 (de)
DK (1)	DK1274685T3 (de)
EE (1)	EE05085B1 (de)
ES (1)	ES2267758T3 (de)
HR (1)	HRP20020825A2 (de)
HU (1)	HUP0001583A2 (de)
IL (2)	IL152337A0 (de)
MX (1)	MXPA02010320A (de)
NO (1)	NO323535B1 (de)
NZ (1)	NZ522017A (de)
PL (1)	PL359826A1 (de)
PT (1)	PT1274685E (de)
RS (1)	RS51003B (de)
RU (1)	RU2281282C2 (de)
SI (1)	SI1274685T1 (de)
SK (1)	SK287606B6 (de)
UA (1)	UA75353C2 (de)
WO (1)	WO2001079174A1 (de)
ZA (1)	ZA200208460B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUP9900475D0 (en) *	1999-02-26	1999-04-28	Biorex Kutato Fejlesztoe Kft	O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component
HU0103939D0 (en) *	2001-09-27	2001-11-28	Biorex Kutato Fejlesztoe Kft	Pharmaceutical composition containing methformin and n-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboximidoyl chloride
WO2003057664A1 (en) *	2002-01-11	2003-07-17	Biorex Kutató És Fejlesztö Rt.	Carboxamidine derivatives and their use in the treatment of vascular diseases
HUP0303584A3 (en)	2003-10-30	2009-12-28	Cytrx Corp	Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases
TW200831479A (en) *	2006-09-26	2008-08-01	Cytrx Corp	Pharmaceutical compositions and methods for treating diseases
JP5616336B2 (ja)	2008-06-26	2014-10-29	オルファザイムエーピーエスＯｒｐｈａｚｙｍｅＡｐｓ	酵素活性の調節因子としてのＨｓｐ７０の使用
US9662375B2 (en)	2010-11-30	2017-05-30	Orphazyme Aps	Methods for increasing intracellular activity of Hsp70
HUP1100534A2 (en)	2011-09-26	2013-04-29	Balazs Dr Hazay	Pharmaceutical composition for the treatment of muscle atrophy
HUP1100535A2 (en)	2011-09-26	2013-04-29	Bracelia Invest Ltd	Pharmaceutical composition for enhancement of stem cell treatment
US10709700B2 (en)	2014-09-15	2020-07-14	Orphazyme A/S	Arimoclomol formulation
WO2017178029A1 (en)	2016-04-13	2017-10-19	Orphazyme Aps	Heat shock proteins and cholesterol homeostasis
ES2831764T3 (es)	2016-04-29	2021-06-09	Orphazyme As	Arimoclomol para el tratamiento de trastornos asociados a glucocerebrosidasa
US20210145815A1 (en)	2017-09-22	2021-05-20	The University Of Adelaide	Methods and products for improving sperm quality
HUP1800298A1 (hu)	2018-08-30	2020-05-28	N Gene Res Laboratories Inc	Gyógyszerkombináció béta-receptor blokkolók hatásának módosítására és a mellékhatások csökkentésére
KR20230035586A (ko)	2020-06-24	2023-03-14	켐팜 덴마크 에이/에스	고셔병을 치료하기 위한 아리모클로몰
CN116783164A (zh) *	2020-11-19	2023-09-19	泽维拉丹麦股份有限公司	制备柠檬酸阿瑞洛莫及其中间体的方法
EP4247792A1 (de) *	2020-11-19	2023-09-27	Zevra Denmark A/S	Verfahren zur herstellung von arimoclomolcitrat und zwischenprodukten davon
WO2022136640A1 (en)	2020-12-24	2022-06-30	Orphazyme A/S	Arimoclomol for the treatment of niemann pick disease, type c, in patients with er type missense mutations
EP4743072A1 (de)	2023-07-10	2026-05-20	N-Gene Research Laboratories Inc.	Erhöhung der telomerlänge und/oder unterdrückung der telomerverkürzung

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU207988B (en) *	1988-10-20	1993-07-28	Biorex Kutato Fejlesztoe Kft	Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components
HU9502843D0 (en)	1995-09-29	1995-11-28	Livigene Ltd	Pharmaceutical composition
HU222994B1 (hu) *	1995-11-02	2004-01-28	BIOREX Kutató és Fejlesztő Rt.	Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására
HUP9900475D0 (en) *	1999-02-26	1999-04-28	Biorex Kutato Fejlesztoe Kft	O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component

2000
- 2000-04-18 HU HU0001583A patent/HUP0001583A2/hu unknown
2001
- 2001-04-17 AT AT01928133T patent/ATE332894T1/de not_active IP Right Cessation
- 2001-04-17 AU AU5499701A patent/AU5499701A/xx active Pending
- 2001-04-17 JP JP2001576775A patent/JP5066638B2/ja not_active Expired - Lifetime
- 2001-04-17 PL PL35982601A patent/PL359826A1/xx not_active IP Right Cessation
- 2001-04-17 MX MXPA02010320A patent/MXPA02010320A/es active IP Right Grant
- 2001-04-17 ES ES01928133T patent/ES2267758T3/es not_active Expired - Lifetime
- 2001-04-17 DE DE60121431T patent/DE60121431T2/de not_active Expired - Lifetime
- 2001-04-17 CZ CZ20023445A patent/CZ301576B6/cs not_active IP Right Cessation
- 2001-04-17 CA CA2406266A patent/CA2406266C/en not_active Expired - Lifetime
- 2001-04-17 EP EP01928133A patent/EP1274685B1/de not_active Expired - Lifetime
- 2001-04-17 HR HRP20020825 patent/HRP20020825A2/hr not_active Application Discontinuation
- 2001-04-17 UA UA2002108255A patent/UA75353C2/uk unknown
- 2001-04-17 NZ NZ522017A patent/NZ522017A/en unknown
- 2001-04-17 RS YUP-783/02A patent/RS51003B/sr unknown
- 2001-04-17 WO PCT/HU2001/000046 patent/WO2001079174A1/en not_active Ceased
- 2001-04-17 CN CN018108318A patent/CN1216868C/zh not_active Expired - Lifetime
- 2001-04-17 PT PT01928133T patent/PT1274685E/pt unknown
- 2001-04-17 DK DK01928133T patent/DK1274685T3/da active
- 2001-04-17 BR BRPI0110184A patent/BRPI0110184B8/pt not_active IP Right Cessation
- 2001-04-17 IL IL15233701A patent/IL152337A0/xx active IP Right Grant
- 2001-04-17 SK SK1508-2002A patent/SK287606B6/sk not_active IP Right Cessation
- 2001-04-17 SI SI200130607T patent/SI1274685T1/sl unknown
- 2001-04-17 EE EEP200200591A patent/EE05085B1/xx not_active IP Right Cessation
- 2001-04-17 US US10/257,755 patent/US7126002B2/en not_active Expired - Lifetime
- 2001-04-17 RU RU2002130710/04A patent/RU2281282C2/ru not_active IP Right Cessation
- 2001-04-17 AU AU2001254997A patent/AU2001254997B2/en not_active Expired
- 2001-04-17 KR KR1020027014047A patent/KR100742482B1/ko not_active Expired - Fee Related
2002
- 2002-10-16 BG BG107199A patent/BG65889B1/bg unknown
- 2002-10-17 IL IL152337A patent/IL152337A/en unknown
- 2002-10-18 ZA ZA200208460A patent/ZA200208460B/en unknown
- 2002-10-18 NO NO20025015A patent/NO323535B1/no not_active IP Right Cessation
2006
- 2006-07-21 CY CY20061101020T patent/CY1107473T1/el unknown

Also Published As

Publication number	Publication date
EP1274685B1 (de)	2006-07-12
US20040006232A1 (en)	2004-01-08
CZ20023445A3 (cs)	2003-03-12
CA2406266C (en)	2010-07-20
IL152337A0 (en)	2003-05-29
HK1055741A1 (en)	2004-01-21
DE60121431T2 (de)	2007-01-18
EE05085B1 (et)	2008-10-15
RU2002130710A (ru)	2004-03-20
HUP0001583A2 (hu)	2002-11-28
CZ301576B6 (cs)	2010-04-21
HUP0001583D0 (en)	2000-06-28
JP5066638B2 (ja)	2012-11-07
NO323535B1 (no)	2007-06-04
NZ522017A (en)	2004-06-25
RS51003B (sr)	2010-10-31
ZA200208460B (en)	2003-10-20
MXPA02010320A (es)	2004-09-06
IL152337A (en)	2007-10-31
US7126002B2 (en)	2006-10-24
BG65889B1 (bg)	2010-04-30
AU2001254997B2 (en)	2006-11-23
JP2004501080A (ja)	2004-01-15
CA2406266A1 (en)	2001-10-25
BG107199A (bg)	2003-07-31
CY1107473T1 (el)	2012-12-19
NO20025015D0 (no)	2002-10-18
YU78302A (sh)	2005-09-19
NO20025015L (no)	2002-12-16
SI1274685T1 (sl)	2006-10-31
UA75353C2 (en)	2006-04-17
AU5499701A (en)	2001-10-30
SK15082002A3 (sk)	2003-05-02
RU2281282C2 (ru)	2006-08-10
EP1274685A1 (de)	2003-01-15
WO2001079174A8 (en)	2002-12-27
KR100742482B1 (ko)	2007-07-25
HRP20020825A2 (en)	2004-12-31
PT1274685E (pt)	2006-09-29
KR20030011309A (ko)	2003-02-07
BRPI0110184B8 (pt)	2021-05-25
SK287606B6 (sk)	2011-03-04
DK1274685T3 (da)	2006-11-06
BR0110184A (pt)	2003-06-17
EE200200591A (et)	2004-04-15
DE60121431D1 (de)	2006-08-24
BRPI0110184B1 (pt)	2015-12-29
ES2267758T3 (es)	2007-03-16
WO2001079174A1 (en)	2001-10-25
CN1216868C (zh)	2005-08-31
ATE332894T1 (de)	2006-08-15
CN1434800A (zh)	2003-08-06

Legal Events

Date	Code	Title	Description
2011-10-31	VOID	Decisions declaring the decisions on the grant of the patent lapsed

Publication	Publication Date	Title
AU5499701A (en)	2001-10-30	A pyridine-1-oxide derivative, and process for its transformation into pharmaceutically effective compounds
WO2004055006A8 (en)	2005-06-30	Novel compounds having selective inhibiting effect at gsk3
MY127718A (en)	2006-12-29	Dolastatin 10 derivatives.
GB9914486D0 (en)	1999-08-18	Medicaments
PT1263730E (pt)	2008-02-11	Derivados amina para o tratamento de apoptose
SI1417206T1 (sl)	2010-09-30	Novi H piridazin onski derivati farmacevtski sestavki ki jih vsebujejo in postopek za pripravo aktivne sestavine
GB0109122D0 (en)	2001-05-30	Novel compounds
WO2001081316A3 (en)	2002-05-23	Substituted phenyl farnesyltransferase inhibitors
IL157540A (en)	2010-11-30	Pharmaceutical compositions comprising n-(aryl)-2-arylethenesulfonamides, some such novel compounds and process for their preparation
SE0102440D0 (sv)	2001-07-05	New compound
HRP20010969B1 (en)	2005-04-30	Novel piperazinylalkylthiopyrimidine derivatives,
AU2001246999A1 (en)	2001-10-23	New neurokinin antagonists for use as medicaments
BR9502079A (pt)	1996-03-05	Composto,formulação farmaceutica e processo para preparar um composto
WO2004048381A3 (en)	2004-08-05	Pyrazoloazepine compounds as pharmaceutical agents
MY133438A (en)	2007-11-30	Morpholinobenzamide salts
AU2001244999A1 (en)	2001-10-23	Naphthamide neurokinin antagonists for use as medicaments
MXPA03009723A (es)	2004-03-16	Procedimientos e intermediarios para preparar epoxidos substituidos de bencilo.
MXPA05009763A (es)	2006-01-27	2-(butil-1-sulfonilamino)-n-[1 (r)-(6-metoxipiridin-3-il) propil] benzamida, su uso en forma de un farmaco y preparaciones farmaceuticas que contienen a dicho compuesto.
WO2002046163A3 (de)	2003-02-13	Chinolin-derivative und ihre verwendung als antiepileptika
NO20014889D0 (no)	2001-10-08	Fremgangsmåte for fremstilling av medisinske midler
DE69824410D1 (en)	2004-07-15	Antithrombosemittel
HUP9801086A3 (en)	2000-09-28	Benzofurane derivatives, pharmaceutical compositions containing them as active ingredient process for producing the active ingredient and intermediates of them
WO2000046193A3 (en)	2000-12-21	Ether derivatives having neuronal activity
SE9901338D0 (sv)	1999-04-15	Novel process
WO2002036554A3 (en)	2003-03-13	Amidino-urea serotonin receptor ligands and compositions, their pharmaceutical uses, and methods for their snythesis