PL359862A1 - Benzofenony jako inhibitory IL-1beta i TNF-alfa - Google Patents

Benzofenony jako inhibitory IL-1beta i TNF-alfa

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Publication number
PL359862A1
PL359862A1 PL35986201A PL35986201A PL359862A1 PL 359862 A1 PL359862 A1 PL 359862A1 PL 35986201 A PL35986201 A PL 35986201A PL 35986201 A PL35986201 A PL 35986201A PL 359862 A1 PL359862 A1 PL 359862A1
Authority
PL
Poland
Prior art keywords
1beta
benzophenones
tnf
inhibitors
alpha
Prior art date
Application number
PL35986201A
Other languages
English (en)
Inventor
Anne Marie Horneman
Original Assignee
Leo Pharma A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharma A/S filed Critical Leo Pharma A/S
Publication of PL359862A1 publication Critical patent/PL359862A1/pl

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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RU2270194C2 (ru) 2006-02-20
AU6008101A (en) 2001-12-03
CA2408727A1 (en) 2001-11-29
US6432962B2 (en) 2002-08-13
EP1289958A2 (en) 2003-03-12
US20020016347A1 (en) 2002-02-07
KR20030001551A (ko) 2003-01-06
HK1055949A1 (en) 2004-01-30
MXPA02011376A (es) 2004-02-26
CN1239485C (zh) 2006-02-01
CN1430607A (zh) 2003-07-16
HUP0301932A3 (en) 2007-09-28
WO2001090074A3 (en) 2002-05-02
AU2001260081B2 (en) 2005-07-28

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