PL361230A1 - Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same - Google Patents

Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same

Info

Publication number: PL361230A1
Authority: PL; Poland
Prior art keywords: pravastatin; epi; substantially free; compositions containing; lactone
Prior art date: 2000-10-05

Application number

PL01361230A

Other languages

Polish (pl)

Inventor

Vilmos Keri

Lajos Deak

Ilona Forgacs

Csaba Szabo

Arvai Edit Nagyne

Original Assignee

Biogal Gyogyszergyar Rt.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-05

Filing date

2001-10-05

Publication date

2004-10-04

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22897222&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL361230(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-10-05 Application filed by Biogal Gyogyszergyar Rt. filed Critical Biogal Gyogyszergyar Rt.

2004-10-04 Publication of PL361230A1 publication Critical patent/PL361230A1/en

Links

239000000203 mixture Substances 0.000 title 1
229960002965 pravastatin Drugs 0.000 title 1
TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 title 1
OQARDMYXSOFTLN-PZAWKZKUSA-N pravastatin lactone Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@@H](O)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 OQARDMYXSOFTLN-PZAWKZKUSA-N 0.000 title 1
229960001495 pravastatin sodium Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
- C07F1/04—Sodium compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/225—Polycarboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Crystallography & Structural Chemistry (AREA)
Hematology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pyrane Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PL01361230A 2000-10-05 2001-10-05 Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same PL361230A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US23827800P	2000-10-05	2000-10-05
PCT/US2001/031230 WO2002030415A1 (en)	2000-10-05	2001-10-05	Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same

Publications (1)

Publication Number	Publication Date
PL361230A1 true PL361230A1 (en)	2004-10-04

Family

ID=22897222

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL01361230A PL361230A1 (en)	2000-10-05	2001-10-05	Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same

Country Status (18)

Country	Link
EP (1)	EP1330245A4 (en)
JP (6)	JP3737801B2 (en)
KR (1)	KR20030059173A (en)
CN (1)	CN1468098A (en)
AU (1)	AU2002211462A1 (en)
CA (1)	CA2422744A1 (en)
CZ (1)	CZ20031166A3 (en)
HR (1)	HRP20030347A2 (en)
HU (1)	HUP0400913A2 (en)
IL (1)	IL155194A0 (en)
IS (1)	IS6766A (en)
MX (1)	MXPA03002963A (en)
NO (1)	NO20031532L (en)
NZ (1)	NZ525631A (en)
PL (1)	PL361230A1 (en)
SK (1)	SK5232003A3 (en)
WO (1)	WO2002030415A1 (en)
ZA (1)	ZA200302313B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI1265604T1 (en) *	1999-11-30	2007-04-30	Sag Teva Gyogyszergyar Zartkoe	Process for recovering statin compounds from a fermentation broth
EP1798214A3 (en) *	1999-11-30	2007-08-01	Teva Gyogyszergyár Zártköruen Muködo Részvenytarsaság	Process for recovering statin compounds from a fermentation broth
US6444452B1 (en) *	1999-11-30	2002-09-03	Biogal Gyogyszergyar Rt.	Process for recovering statin compounds from a fermentation broth
CZ20021998A3 (en)	1999-12-14	2003-02-12	Biogal Gyogyszergyar Rt.	Novel forms of pravastatin sodium salt
JP3737801B2 (en) *	2000-10-05	2006-01-25	テバジョジセルジャールレースベニュタールシャシャーグ	Pravastatin sodium substantially free of pravastatin lactone and epipravastatin, and a composition comprising the same
JP3236282B1 (en) *	2000-10-16	2001-12-10	三共株式会社	How to purify pravastatin
GB0218781D0 (en)	2002-08-13	2002-09-18	Astrazeneca Ab	Chemical process
EP1452519A1 (en) *	2003-02-25	2004-09-01	Balkanpharma-Razgrad AD	Method for the isolation and purification of pravastatin sodium
GB0312896D0 (en)	2003-06-05	2003-07-09	Astrazeneca Ab	Chemical process
UY28501A1 (en)	2003-09-10	2005-04-29	Astrazeneca Uk Ltd	CHEMICAL COMPOUNDS
GB0324791D0 (en)	2003-10-24	2003-11-26	Astrazeneca Ab	Chemical process
EP1641447B1 (en) *	2003-11-24	2008-10-29	TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság	Method of purifying pravastatin
EP1786414A4 (en)	2004-08-06	2008-04-09	Transform Pharmaceuticals Inc	Novel statin pharmaceutical compositions and related methods of treatment
ES2254028B1 (en) *	2004-11-29	2007-03-01	Ercros Industrial, S.A.	PROCEDURE FOR OBTAINING PRAVASTATIN SODIUM PURIFIED.
WO2006091980A1 (en) *	2005-02-25	2006-08-31	Teva Pharmaceutical Industries Ltd.	Process of purifying tadalafil
JP4813841B2 (en) *	2005-07-25	2011-11-09	キユーピー株式会社	Method for producing pravastatin sodium
HU229260B1 (en) *	2010-11-29	2013-10-28	Egis Gyogyszergyar Nyrt	Process for preparation of rosuvastatin salts
CN114031496B (en) *	2021-11-30	2024-09-27	广东蓝宝制药有限公司	A method for preparing high-purity pravastatin 1,1,3,3-tetramethylbutylamine

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US3378441A (en) *	1963-10-17	1968-04-16	S B Penick & Company	Tetraene antibiotic purification
JPS5221594B2 (en) *	1973-09-29	1977-06-11
YU40452B (en) *	1975-02-07	1986-02-28	Beecham Group Plc	Process for the elimination of contaminating impurities from clavulinic acid
US4231938A (en) *	1979-06-15	1980-11-04	Merck & Co., Inc.	Hypocholesteremic fermentation products and process of preparation
MX7065E (en) *	1980-06-06	1987-04-10	Sankyo Co	A MICROBIOLOGICAL PROCEDURE FOR PREPARING DERIVATIVES OF ML-236B
JPS572240A (en) *	1980-06-06	1982-01-07	Sankyo Co Ltd	Ml-236b derivative
JPS5889191A (en) *	1981-11-20	1983-05-27	Sankyo Co Ltd	Preparation of 3-hydroxy-ml-236b derivative
JPS5890509A (en) *	1981-11-25	1983-05-30	Sankyo Co Ltd	Composition for remedy of hypercholesterolemia
JPH01190661A (en) *	1988-01-22	1989-07-31	Konishi Kagaku Kogyo Kk	Purification of 4,4'-dihydroxydiphenylsulfone
JP2739328B2 (en) *	1988-09-14	1998-04-15	日本ケミファ株式会社	Purification method of benzimidazole compound
US5202029A (en) *	1991-03-13	1993-04-13	Caron Kabushiki Kaisha	Process for purification of hmg-coa reductase inhibitors
NZ250609A (en) *	1992-12-28	1995-07-26	Sankyo Co	Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments
JPH06256278A (en) *	1993-03-03	1994-09-13	Nissan Chem Ind Ltd	Optically active alpha-carbamoylalkanoic acid derivative and its production
CA2126365C (en) *	1993-07-06	1999-08-24	Steven W. Felman	Recovery of citric acid from impure process streams by addition of strong acids and salts thereof
ES2112042T3 (en) *	1994-03-31	1998-03-16	Cultor Oy	PROCEDURE FOR THE RECOVERY OF NATAMYCIN.
WO1997006128A1 (en) *	1995-08-03	1997-02-20	Gist-Brocades B.V.	Selective process for the deacylation of acylated compounds
JPH09124655A (en) *	1995-11-01	1997-05-13	Sankyo Co Ltd	Novel squalene synthase inhibitory compounds
EP0877089A1 (en) *	1997-05-07	1998-11-11	Gist-Brocades B.V.	HMG-CoA reductase inhibitor preparation process
SI20072A (en) *	1998-09-18	2000-04-30	LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d.	PROCEDURE OF PREPARATION OF INHIBITORS OF HMG-CoA REDUCTASE
SI20070A (en) *	1998-09-18	2000-04-30	LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d.	NOVEL SALTS OF INHIBITORS OF HMG-CoA REDUCTASE
JP2000229855A (en) *	1998-12-07	2000-08-22	Satoshi Takebe	Pravastatin sodium tablet
DE60019898T2 (en) *	1999-02-03	2006-08-10	Institute For Drug Research Ltd.	MICROBIAL METHOD FOR PREPARING PRAVASTATIN
HUP9902352A1 (en) *	1999-07-12	2000-09-28	Gyógyszerkutató Intézet Kft.	Process for producing pravastatin by microbiological way
US6444452B1 (en) *	1999-11-30	2002-09-03	Biogal Gyogyszergyar Rt.	Process for recovering statin compounds from a fermentation broth
JP3737801B2 (en) *	2000-10-05	2006-01-25	テバジョジセルジャールレースベニュタールシャシャーグ	Pravastatin sodium substantially free of pravastatin lactone and epipravastatin, and a composition comprising the same

2001
- 2001-10-05 JP JP2002533858A patent/JP3737801B2/en not_active Expired - Fee Related
- 2001-10-05 CN CNA018168604A patent/CN1468098A/en active Pending
- 2001-10-05 SK SK523-2003A patent/SK5232003A3/en unknown
- 2001-10-05 NZ NZ525631A patent/NZ525631A/en unknown
- 2001-10-05 KR KR10-2003-7004764A patent/KR20030059173A/en not_active Abandoned
- 2001-10-05 WO PCT/US2001/031230 patent/WO2002030415A1/en not_active Ceased
- 2001-10-05 CA CA002422744A patent/CA2422744A1/en not_active Abandoned
- 2001-10-05 AU AU2002211462A patent/AU2002211462A1/en not_active Abandoned
- 2001-10-05 IL IL15519401A patent/IL155194A0/en unknown
- 2001-10-05 EP EP01979511A patent/EP1330245A4/en not_active Withdrawn
- 2001-10-05 HU HU0400913A patent/HUP0400913A2/en not_active IP Right Cessation
- 2001-10-05 PL PL01361230A patent/PL361230A1/en unknown
- 2001-10-05 CZ CZ20031166A patent/CZ20031166A3/en unknown
- 2001-10-05 MX MXPA03002963A patent/MXPA03002963A/en not_active Application Discontinuation
- 2001-10-05 HR HR20030347A patent/HRP20030347A2/en not_active Application Discontinuation
2003
- 2003-03-25 ZA ZA200302313A patent/ZA200302313B/en unknown
- 2003-04-01 IS IS6766A patent/IS6766A/en unknown
- 2003-04-04 NO NO20031532A patent/NO20031532L/en not_active Application Discontinuation
2004
- 2004-09-24 JP JP2004278522A patent/JP2005013238A/en not_active Withdrawn
2005
- 2005-08-18 JP JP2005237299A patent/JP2006036781A/en active Pending
2009
- 2009-08-21 JP JP2009191951A patent/JP2009268479A/en not_active Withdrawn
2013
- 2013-01-25 JP JP2013011711A patent/JP2013128486A/en not_active Withdrawn
2015
- 2015-07-31 JP JP2015152088A patent/JP2015212300A/en active Pending

Also Published As

Publication number	Publication date
EP1330245A4 (en)	2004-10-20
HUP0400913A2 (en)	2006-11-28
NO20031532D0 (en)	2003-04-04
CA2422744A1 (en)	2002-04-18
IL155194A0 (en)	2003-11-23
JP2013128486A (en)	2013-07-04
WO2002030415A1 (en)	2002-04-18
JP2006036781A (en)	2006-02-09
JP2004510817A (en)	2004-04-08
WO2002030415A9 (en)	2002-10-31
JP3737801B2 (en)	2006-01-25
ZA200302313B (en)	2004-03-25
AU2002211462A1 (en)	2002-04-22
EP1330245A1 (en)	2003-07-30
HRP20030347A2 (en)	2005-04-30
SK5232003A3 (en)	2004-06-08
JP2015212300A (en)	2015-11-26
NZ525631A (en)	2005-05-27
NO20031532L (en)	2003-04-04
CZ20031166A3 (en)	2004-04-14
IS6766A (en)	2003-04-01
CN1468098A (en)	2004-01-14
KR20030059173A (en)	2003-07-07
JP2009268479A (en)	2009-11-19
JP2005013238A (en)	2005-01-20
MXPA03002963A (en)	2005-01-25

Publication	Publication Date	Title
HRP20030347A2 (en)	2005-04-30	Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same
AU3459702A (en)	2002-07-01	Branched primary alcohol compositions and derivatives thereof
HUP0400691A3 (en)	2010-03-29	Pyrimidineamines as angiogenesis modulators and pharmaceutical compositions containing them
HUP0302297A3 (en)	2007-05-02	Substituted thioacetamides and pharmaceutical compositions containing them
AU2001281140A1 (en)	2002-02-18	Anti-plasmodium compositions and methods of use
ZA200106648B (en)	2002-02-13	Synthesis of low silocon sodium X zeolite.
IL137363A0 (en)	2001-07-24	Pharmaceutical compositions containing mupirocin
HUP0303184A3 (en)	2008-03-28	Substituted c-cyclohexylmethylamine derivatives and pharmaceutical compositions containing them
GB0118579D0 (en)	2001-09-19	Pharmaceutical composition containing citalopram
IL154068A0 (en)	2003-07-31	Highly purified simvastatin compositions
HUP0303204A3 (en)	2010-04-28	1-methylcarbapenem derivatives and pharmaceutical compositions containing them
IL150187A0 (en)	2002-12-01	Novel forms of pravastatin sodium
GB0029847D0 (en)	2001-01-24	Preparation of spheroids
AU4834101A (en)	2001-09-24	N-deacetylthiocolchicine derivatives and pharmaceutical compositions containing them
AU9482601A (en)	2002-04-08	Tocol-based compositions containing amiodarone
IL159614A0 (en)	2004-06-01	Benzofuran derivatives and pharmaceutical compositions containing the same
HUP0302531A3 (en)	2007-06-28	Pharmaceutical compositions containing citalopram
HK1055685A (en)	2004-01-21	Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same
AU2001272490A1 (en)	2002-01-14	Use of galiella lactone
AU2001264324A1 (en)	2002-01-02	Method of stabilizing medicinal compositions containing pravastatin
AU2001294374A1 (en)	2002-03-13	2-acylindenes and these containing perfume compositions
AU7057701A (en)	2001-12-24	New use as antihelmintics of albofungin and analogs
GB0018502D0 (en)	2000-09-13	New compositions of matter
ZA200204500B (en)	2003-08-27	Forms of pravastatin sodium.
AU2002216388A1 (en)	2002-07-16	Benzofuran derivatives and pharmaceutical compositions containing the same