PL361355A1 - Pochodne fenyloglicyny - Google Patents

Pochodne fenyloglicyny

Info

Publication number: PL361355A1
Authority: PL; Poland
Prior art keywords: phenylglycine derivatives; physiologically acceptable; derivatives; phenylglycine; carbamimidoyl
Prior art date: 2000-05-23

Application number

PL36135501A

Other languages

English (en)

Inventor

Leo Alig

Zbinden Katrin Groebke

Kurt Hilpert

Holger Kuehne

Ulrike Obst

Hans Peter Wessel

Original Assignee

F.Hoffmann-La Roche Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-23

Filing date

2001-05-17

Publication date

2004-10-04

2001-05-17 Application filed by F.Hoffmann-La Roche Ag filed Critical F.Hoffmann-La Roche Ag

2004-10-04 Publication of PL361355A1 publication Critical patent/PL361355A1/pl

Links

150000005331 phenylglycines Chemical class 0.000 title 1
LXUXHIBNHAQIJI-UHFFFAOYSA-N 2-(4-carbamimidoylanilino)acetic acid Chemical class NC(=N)C1=CC=C(NCC(O)=O)C=C1 LXUXHIBNHAQIJI-UHFFFAOYSA-N 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
- C07D317/36—Alkylene carbonates; Substituted alkylene carbonates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
- C07C259/18—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Furan Compounds (AREA)
Indole Compounds (AREA)

PL36135501A 2000-05-23 2001-05-17 Pochodne fenyloglicyny PL361355A1 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP00110881		2000-05-23
PCT/EP2001/005633 WO2001090051A1 (en)	2000-05-23	2001-05-17	Phenylglycine derivatives

Publications (1)

Publication Number	Publication Date
PL361355A1 true PL361355A1 (pl)	2004-10-04

Family

ID=8168800

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL36135501A PL361355A1 (pl)	2000-05-23	2001-05-17	Pochodne fenyloglicyny

Country Status (23)

Country	Link
US (1)	US6548694B2 (pl)
EP (1)	EP1289939A1 (pl)
JP (1)	JP3842132B2 (pl)
KR (1)	KR100569517B1 (pl)
CN (1)	CN1305839C (pl)
AR (1)	AR028596A1 (pl)
AU (2)	AU8177401A (pl)
BR (1)	BR0110998A (pl)
CA (1)	CA2408602C (pl)
EC (1)	ECSP024360A (pl)
HU (1)	HUP0302073A2 (pl)
IL (1)	IL152581A0 (pl)
MA (1)	MA26905A1 (pl)
MX (1)	MXPA02011466A (pl)
NO (1)	NO20025590L (pl)
NZ (1)	NZ522412A (pl)
PE (1)	PE20011314A1 (pl)
PL (1)	PL361355A1 (pl)
RU (1)	RU2268257C2 (pl)
UY (1)	UY26721A1 (pl)
WO (1)	WO2001090051A1 (pl)
YU (1)	YU83602A (pl)
ZA (1)	ZA200208899B (pl)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
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KR100473966B1 (ko) *	1998-12-14	2005-03-08	에프. 호프만-라 로슈 아게	페닐글리신 유도체
DE10300049A1 (de) *	2003-01-03	2004-07-15	Morphochem AG Aktiengesellschaft für kombinatorische Chemie	Neue Verbindungen, die Faktor VIIa inhibieren
US6642386B2 (en) *	2002-02-06	2003-11-04	Hoffmann-La Roche Inc.	N-(4-carbamimidoyl-phenyl)-glycine derivatives
GB0211931D0 (en) *	2002-05-23	2002-07-03	Univ Liverpool	Methods & device utilizing adsorption of molecules at a surface or interface
TW200410921A (en) *	2002-11-25	2004-07-01	Hoffmann La Roche	Mandelic acid derivatives
EP1594505A4 (en)	2003-02-11	2008-08-13	Bristol Myers Squibb Co	PHENYLGLYCIN DERIVATIVES USEFUL AS SERINE PROTEASE INHIBITORS
US7144895B2 (en)	2003-02-11	2006-12-05	Bristol-Myers Squibb Co.	Benzene acetamide compounds useful as serine protease inhibitors
DE10306202A1 (de)	2003-02-13	2004-08-26	Grünenthal GmbH	Arzneimittel enthaltend substituierte 2-Aryl-Aminoessigsäure-Verbindungen und/oder substituierte 2-Heteroaryl-Aminoessigsäure-Verbindungen
US7917130B1 (en)	2003-03-21	2011-03-29	Stratosaudio, Inc.	Broadcast response method and system
US7776804B2 (en) *	2005-03-16	2010-08-17	The Lubrizol Corporation	Viscosity improver compositions providing improved low temperature characteristics to lubricating oil
US7056932B2 (en) *	2003-12-19	2006-06-06	Hoffman-La Roche Inc.	Heterocyclyl substituted 1-alkoxy acetic acid amides
WO2006041119A1 (ja) *	2004-10-13	2006-04-20	Eisai R & D Management Co., Ltd.	ヒドラジド誘導体
WO2006045010A2 (en) *	2004-10-20	2006-04-27	Resverlogix Corp.	Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
DE602006016566D1 (de)	2005-01-10	2010-10-14	Bristol Myers Squibb Co	Als antikoagulanzien verwendbare phenylglycinamid-derivate
US7456195B2 (en) *	2005-06-24	2008-11-25	Bristol-Myers Squibb Company	Phenylglycinamide and pyridylglycinamide derivatives useful as anticoagulants
US8044242B2 (en)	2006-03-09	2011-10-25	Bristol-Myers Squibb Company	2-(aryloxy) acetamide factor VIIa inhibitors useful as anticoagulants
NZ571441A (en) *	2006-03-24	2010-08-27	Eisai R&D Man Co Ltd	Triazolone derivative
US7855194B2 (en)	2006-03-27	2010-12-21	Hoffmann-La Roche Inc.	Pyrimidine, quinazoline, pteridine and triazine derivatives
PT2118074E (pt)	2007-02-01	2014-03-20	Resverlogix Corp	Compostos para a prevenção e tratamento de doenças cardiovasculares
EP1967522A1 (en) *	2007-03-07	2008-09-10	Novo Nordisk A/S	New blood coagulation factor inhibitors
JPWO2009038157A1 (ja) *	2007-09-21	2011-01-06	エーザイ・アール・アンド・ディー・マネジメント株式会社	２，３−ジヒドロ−イミノイソインドール誘導体
WO2009079417A1 (en)	2007-12-14	2009-06-25	Stratosaudio, Inc.	Systems and methods for scheduling interactive media and events
SI2346837T1 (sl) *	2008-06-26	2015-05-29	Resverlogix Corporation	Postopki pripravljanja kinazolinonskih derivatov
US8952021B2 (en)	2009-01-08	2015-02-10	Resverlogix Corp.	Compounds for the prevention and treatment of cardiovascular disease
KR101913109B1 (ko)	2009-03-18	2018-10-31	리스버로직스 코퍼레이션	신규한 소염제
US9757368B2 (en)	2009-04-22	2017-09-12	Resverlogix Corp.	Anti-inflammatory agents
CN102887836B (zh) *	2011-07-18	2014-03-26	西南大学	L-苯甘氨酸衍生物及其应用
GB201118876D0 (en) *	2011-11-01	2011-12-14	Astex Therapeutics Ltd	Pharmaceutical compounds
CA2851996C (en)	2011-11-01	2020-01-07	Resverlogix Corp.	Pharmaceutical compositions for substituted quinazolinones
US9073878B2 (en)	2012-11-21	2015-07-07	Zenith Epigenetics Corp.	Cyclic amines as bromodomain inhibitors
US9765039B2 (en)	2012-11-21	2017-09-19	Zenith Epigenetics Ltd.	Biaryl derivatives as bromodomain inhibitors
JP2016507496A (ja)	2012-12-21	2016-03-10	ゼニス・エピジェネティクス・コーポレイションＺｅｎｉｔｈＥｐｉｇｅｎｅｔｉｃｓＣｏｒｐ．	ブロモドメイン阻害剤としての新規複素環式化合物
US10111885B2 (en)	2015-03-13	2018-10-30	Resverlogix Corp.	Compositions and therapeutic methods for the treatment of complement-associated diseases
CN111072562B (zh) *	2019-11-07	2021-12-07	中山大学	一种四氢异喹啉衍生物及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2008116C (en) *	1989-02-23	2001-11-20	Thomas Weller	Glycine derivatives
DE4421052A1 (de) *	1994-06-17	1995-12-21	Basf Ag	Neue Thrombininhibitoren, ihre Herstellung und Verwendung
DK0921116T3 (da)	1997-12-04	2003-10-06	Hoffmann La Roche	N-(4-carbamimido-phenyl)-glycinamidderivater
KR20010082515A (ko)	1998-02-17	2001-08-30	우에노 도시오	아미디노 유도체 및 그 유도체를 유효 성분으로서함유하는 약제
KR100473966B1 (ko) *	1998-12-14	2005-03-08	에프. 호프만-라 로슈 아게	페닐글리신 유도체

2001
- 2001-05-16 US US09/858,535 patent/US6548694B2/en not_active Expired - Fee Related
- 2001-05-17 IL IL15258101A patent/IL152581A0/xx unknown
- 2001-05-17 WO PCT/EP2001/005633 patent/WO2001090051A1/en not_active Ceased
- 2001-05-17 AU AU8177401A patent/AU8177401A/xx active Pending
- 2001-05-17 HU HU0302073A patent/HUP0302073A2/hu unknown
- 2001-05-17 CN CNB018099297A patent/CN1305839C/zh not_active Expired - Fee Related
- 2001-05-17 MX MXPA02011466A patent/MXPA02011466A/es active IP Right Grant
- 2001-05-17 EP EP01960221A patent/EP1289939A1/en not_active Withdrawn
- 2001-05-17 NZ NZ522412A patent/NZ522412A/en unknown
- 2001-05-17 AU AU2001281774A patent/AU2001281774B2/en not_active Ceased
- 2001-05-17 JP JP2001586241A patent/JP3842132B2/ja not_active Expired - Fee Related
- 2001-05-17 BR BR0110998-7A patent/BR0110998A/pt not_active IP Right Cessation
- 2001-05-17 PL PL36135501A patent/PL361355A1/pl not_active Application Discontinuation
- 2001-05-17 PE PE2001000442A patent/PE20011314A1/es not_active Application Discontinuation
- 2001-05-17 CA CA002408602A patent/CA2408602C/en not_active Expired - Fee Related
- 2001-05-17 KR KR1020027015798A patent/KR100569517B1/ko not_active Expired - Fee Related
- 2001-05-17 RU RU2002133215/04A patent/RU2268257C2/ru active
- 2001-05-17 YU YU83602A patent/YU83602A/sh unknown
- 2001-05-21 AR ARP010102385A patent/AR028596A1/es not_active Application Discontinuation
- 2001-05-22 UY UY26721A patent/UY26721A1/es not_active Application Discontinuation
2002
- 2002-11-01 ZA ZA200208899A patent/ZA200208899B/en unknown
- 2002-11-21 NO NO20025590A patent/NO20025590L/no not_active Application Discontinuation
- 2002-11-22 EC EC2002004360A patent/ECSP024360A/es unknown
- 2002-11-22 MA MA26921A patent/MA26905A1/fr unknown

Also Published As

Publication number	Publication date
YU83602A (sh)	2006-05-25
PE20011314A1 (es)	2002-01-04
US20020004608A1 (en)	2002-01-10
HUP0302073A2 (hu)	2003-09-29
US6548694B2 (en)	2003-04-15
CA2408602C (en)	2008-01-08
KR100569517B1 (ko)	2006-04-07
AR028596A1 (es)	2003-05-14
JP3842132B2 (ja)	2006-11-08
KR20030007678A (ko)	2003-01-23
BR0110998A (pt)	2003-04-08
ECSP024360A (es)	2003-03-31
NO20025590D0 (no)	2002-11-21
AU8177401A (en)	2001-12-03
RU2268257C2 (ru)	2006-01-20
WO2001090051A1 (en)	2001-11-29
CA2408602A1 (en)	2001-11-29
NO20025590L (no)	2002-11-21
NZ522412A (en)	2004-05-28
EP1289939A1 (en)	2003-03-12
UY26721A1 (es)	2001-12-28
MXPA02011466A (es)	2003-04-25
CN1430599A (zh)	2003-07-16
MA26905A1 (fr)	2004-12-20
IL152581A0 (en)	2003-05-29
AU2001281774B2 (en)	2005-03-10
CN1305839C (zh)	2007-03-21
ZA200208899B (en)	2004-02-19
JP2003534311A (ja)	2003-11-18

Legal Events

Date	Code	Title	Description
2009-11-30	REFS	Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)

Publication	Publication Date	Title
PL361355A1 (pl)	2004-10-04	Pochodne fenyloglicyny
DE60112974D1 (en)	2005-09-29	Carbolinderivate
AP2002002637A0 (en)	2002-09-30	Novel piperazine
PT1193270E (pt)	2003-10-31	Pirrolobenzodiazepinas
DE60236102D1 (en)	2010-06-02	1h-indolderivate als hochselektive cyclooxygenase-2-inhibitoren
MXPA02000973A (es)	2002-07-30	Benzofurilpiperazinas y benzofurilhomopiperazinas: agonistas de serotonina.
MXPA03004794A (es)	2003-09-10	Derivados de acido mandelico y su uso como inhibidores de trombina.
MX9700885A (es)	1998-04-30	Nuevas heteroariloxazolidinonas.
DE60216233D1 (en)	2007-01-04	Carbolinderivate
MXPA05010000A (es)	2005-11-17	Derivados de p-diaminobenceno substituidos.
MY133969A (en)	2007-11-30	Indoloquinazolinones
MY138826A (en)	2009-07-31	2,7-substituted indoles
AP2001002306A0 (en)	2001-12-31	Bridged piperazine derivatives.
MXPA05009282A (es)	2005-10-05	Derivados de anilina sustituidos.
AP2002002466A0 (en)	2002-06-30	3-heterocycliylpropanohydroxamic acid PCP INHIBITORS.
AU2001263278A1 (en)	2002-01-08	Cyclic gmp-specific phosphodiesterase inhibitors
GB0229081D0 (en)	2003-01-15	Multifunctional cationic photoinitiators, their preparation and use
ATE259813T1 (de)	2004-03-15	Triazolopyrimidinderivate
MXPA03003971A (es)	2004-02-12	Derivados de indol como inhibidores de pde5.
PT1204659E (pt)	2004-04-30	Benzofuranos serotoninergicos
MY136938A (en)	2008-11-28	New process for the synthesis of perindopril and its pharmaceutically acceptable salts
IL152614A0 (en)	2003-06-24	Derivatives of uridine as antibiotics
MY136288A (en)	2008-09-30	New process for the synthesis of perindopril and its pharmaceutically acceptable salts
MY135359A (en)	2008-03-31	New process for the synthesis of perindopril and pharmaceutically acceptable salts thereof
MY136638A (en)	2008-11-28	New process for the synthesis of perindopril and its pharmaceutically acceptable salts