PL3618811T3 - Proces wytwarzania porowatych cząsteczek krzemionki załadowanych co najmniej jednym związkiem bioaktywnym dostosowanych do dostarczania dopłucnego, donosowego, podjęzykowego i/lub dogardłowego - Google Patents

Proces wytwarzania porowatych cząsteczek krzemionki załadowanych co najmniej jednym związkiem bioaktywnym dostosowanych do dostarczania dopłucnego, donosowego, podjęzykowego i/lub dogardłowego

Info

Publication number
PL3618811T3
PL3618811T3 PL18723453T PL18723453T PL3618811T3 PL 3618811 T3 PL3618811 T3 PL 3618811T3 PL 18723453 T PL18723453 T PL 18723453T PL 18723453 T PL18723453 T PL 18723453T PL 3618811 T3 PL3618811 T3 PL 3618811T3
Authority
PL
Poland
Prior art keywords
sublingual
nasal
lung
silica particles
porous silica
Prior art date
Application number
PL18723453T
Other languages
English (en)
Inventor
Adam Feiler
Chunfang Zhou
Paulina PASZKIEWICZ
Xin XIA
Original Assignee
Nanologica Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanologica Ab filed Critical Nanologica Ab
Publication of PL3618811T3 publication Critical patent/PL3618811T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B33/00—Silicon; Compounds thereof
    • C01B33/113—Silicon oxides; Hydrates thereof
    • C01B33/12—Silica; Hydrates thereof, e.g. lepidoic silicic acid
    • C01B33/124—Preparation of adsorbing porous silica not in gel form and not finely divided, i.e. silicon skeletons, by acidic treatment of siliceous materials
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2006/00—Physical properties of inorganic compounds
    • C01P2006/14—Pore volume
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2006/00—Physical properties of inorganic compounds
    • C01P2006/16—Pore diameter

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Inorganic Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL18723453T 2017-05-04 2018-05-03 Proces wytwarzania porowatych cząsteczek krzemionki załadowanych co najmniej jednym związkiem bioaktywnym dostosowanych do dostarczania dopłucnego, donosowego, podjęzykowego i/lub dogardłowego PL3618811T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE1750544 2017-05-04
EP18723453.9A EP3618811B1 (en) 2017-05-04 2018-05-03 A process for manufacturing porous silica particles loaded with at least one bioactive compound adapted for lung, nasal, sublingual and/or pharyngeal delivery
PCT/EP2018/061436 WO2018202818A1 (en) 2017-05-04 2018-05-03 A process for manufacturing porous silica particles loaded with at least one bioactive compound adapted for lung, nasal, sublingual and/or pharyngeal delivery

Publications (1)

Publication Number Publication Date
PL3618811T3 true PL3618811T3 (pl) 2021-04-06

Family

ID=62143135

Family Applications (1)

Application Number Title Priority Date Filing Date
PL18723453T PL3618811T3 (pl) 2017-05-04 2018-05-03 Proces wytwarzania porowatych cząsteczek krzemionki załadowanych co najmniej jednym związkiem bioaktywnym dostosowanych do dostarczania dopłucnego, donosowego, podjęzykowego i/lub dogardłowego

Country Status (11)

Country Link
US (1) US11285107B2 (pl)
EP (1) EP3618811B1 (pl)
JP (1) JP7048642B2 (pl)
KR (1) KR102579524B1 (pl)
CN (1) CN110603034A (pl)
AU (1) AU2018262708B2 (pl)
CA (1) CA3059099C (pl)
DK (1) DK3618811T3 (pl)
ES (1) ES2837675T3 (pl)
PL (1) PL3618811T3 (pl)
WO (1) WO2018202818A1 (pl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3618811T3 (da) 2017-05-04 2020-12-21 Nanologica Ab Fremgangsmåde til fremstilling af porøse siliciumdioxidpartikler ladet med mindst én biologisk aktiv forbindelse, der er tilpasset til pulmonal, nasal, sublingual og/eller pharyngeal tilførsel
GB201818164D0 (en) 2018-11-07 2018-12-19 Vicore Pharma Ab New composition
IL286273B2 (en) * 2019-03-24 2025-11-01 Buzzelet Development And Technologies Ltd Cannabis inhalation products and methods of production thereof
JP7394493B2 (ja) * 2019-07-31 2023-12-13 レモネックス インコーポレイテッド 抗癌剤および多孔性シリカ粒子の製造方法
GB201916121D0 (en) 2019-11-06 2019-12-18 Vicore Pharma Ab New compositions
GB201916117D0 (en) 2019-11-06 2019-12-18 Vicore Pharma Ab New compositions
GB201916130D0 (en) 2019-11-06 2019-12-18 Vicore Pharma Ab New compositions
GB201916122D0 (en) 2019-11-06 2019-12-18 Nanologica Ab New compositions
WO2021211738A1 (en) * 2020-04-15 2021-10-21 Sanford Burnham Prebys Medical Discovery Institute Methods and compositions for antiviral treatment
US11793808B2 (en) 2021-02-22 2023-10-24 Mannkind Corp. Compositions of clofazimine, combinations comprising them, processes for their preparation, uses and methods comprising them

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6254854B1 (en) 1996-05-24 2001-07-03 The Penn Research Foundation Porous particles for deep lung delivery
GB2355711B (en) 1999-10-27 2003-12-24 Agilent Technologies Inc Porous silica microsphere scavengers
US6485707B2 (en) 2001-02-15 2002-11-26 Aeropharm Technology Incorporated Modulated release particles for aerosol delivery
US6544497B2 (en) 2001-02-15 2003-04-08 Aeropharm Technology Incorporated Modulated release particles for aerosol delivery
US6596262B2 (en) 2001-02-15 2003-07-22 Aeropharm Technology Incorporated Modulated release particles for aerosol delivery
GB0118689D0 (en) 2001-08-01 2001-09-19 Psimedica Ltd Pharmaceutical formulation
US20040242729A1 (en) 2003-05-30 2004-12-02 3M Innovative Properties Company Stabilized particle dispersions containing surface-modified inorganic nanoparticles
FI20060428L (fi) 2006-05-03 2007-11-04 Esko Kauppinen Pintamodifioidut aerosolihiukkaset, menetelmä ja laite niiden tuottamiseksi sekä jauheet ja dispersiot jotka sisältävät kyseisiä hiukkasia
US20100116743A1 (en) 2007-06-04 2010-05-13 James Neil Pryor Silica particles and methods of making and using the same
GB0714134D0 (en) 2007-07-19 2007-08-29 Norton Healthcare Ltd Dry-powder medicament
CA2698683A1 (en) 2007-09-07 2009-03-12 Epigenesis Pharmaceuticals, Llc Dheas inhalation compositions
WO2009101110A2 (en) 2008-02-11 2009-08-20 Alfonso Garcia-Bennet Method for manufacturing mesoporous materials, materials so produced and use of mesoporous materials.
JP5437232B2 (ja) 2008-03-11 2014-03-12 あすか製薬株式会社 固体分散体とその医薬組成物、並びにそれらの製造方法
JP6073788B2 (ja) 2010-09-14 2017-02-01 ナノロジカ アクティエボラーグ 難水溶性医薬及び化粧品有効成分のための過飽和送達媒体
GB201212866D0 (en) * 2012-07-20 2012-09-05 Formac Pharmaceuticals Nv Dry granulates of mesoporous silica powders
PL3104853T3 (pl) 2014-02-10 2020-05-18 Respivant Sciences Gmbh Leczenie stabilizatorami komórek tucznych zaburzeń ogólnoustrojowych
WO2016013751A1 (ko) * 2014-07-22 2016-01-28 주식회사 레모넥스 생리활성 물질 또는 단백질 전달용 조성물 및 이의 용도
US20160090603A1 (en) * 2014-09-30 2016-03-31 Sandia Corporation Delivery platforms for the domestication of algae and plants
WO2017023407A2 (en) * 2015-06-01 2017-02-09 Stc. Unm Nanobiocomposite compositions and methods
ES2965015T3 (es) * 2016-02-29 2024-04-10 Emplicure Ab Dispositivos de evaporación e inhalación de principios activos
DK3618811T3 (da) 2017-05-04 2020-12-21 Nanologica Ab Fremgangsmåde til fremstilling af porøse siliciumdioxidpartikler ladet med mindst én biologisk aktiv forbindelse, der er tilpasset til pulmonal, nasal, sublingual og/eller pharyngeal tilførsel

Also Published As

Publication number Publication date
KR102579524B1 (ko) 2023-09-18
CA3059099A1 (en) 2018-11-08
US11285107B2 (en) 2022-03-29
DK3618811T3 (da) 2020-12-21
JP7048642B2 (ja) 2022-04-05
EP3618811A1 (en) 2020-03-11
CA3059099C (en) 2023-06-27
AU2018262708A1 (en) 2019-11-28
WO2018202818A1 (en) 2018-11-08
ES2837675T3 (es) 2021-07-01
US20200069588A1 (en) 2020-03-05
CN110603034A (zh) 2019-12-20
EP3618811B1 (en) 2020-09-30
KR20190142386A (ko) 2019-12-26
AU2018262708B2 (en) 2021-06-03
JP2020518620A (ja) 2020-06-25

Similar Documents

Publication Publication Date Title
AU201712950S (en) Respiratory mask with air delivery aadapter
IL292251A (en) Use of anti-static materials in air passages in the process of thermal condensation of an aerosol
PL3892127T3 (pl) Papieros elektroniczny z masowym czujnikiem przepływu powietrza
IL263339A (en) Nicotine inhaler system
PL3093567T3 (pl) Zasobnik filtra, walec i nawilżacz powietrza
PL3298911T3 (pl) Papieros elektroniczny ze zintegrowaną dyszą do zasysania
PT3288401T (pt) Artigo gerador de aerossol compreendendo um elemento de aplicação de aerossol destacavel com ventilação elevada
GB201508412D0 (en) Electronic cigarette with woven fiber tube atomizer
PL3558037T3 (pl) Układ napełniania inhalatora aerozolu
PT3508078T (pt) Conjunto de cigarro para inalação nasal do tipo pressão com função de aquecimento
PL3283551T3 (pl) Kompozycja aktywowanej ligniny, sposób jej wytwarzania oraz jej zastosowanie
AU201812272S (en) Nicotine Inhaler
IL263326A (en) Delivery of consumable nicotine particles
DK3522962T3 (en) A nasal delivery system
AU201715847S (en) Air delivery adapter for respiratory mask
ZA201706165B (en) Tiotropium inhalation solution for nebulization
EP3383565C0 (de) Verfahren zur herstellung von feuerfesten kompositpartikeln und von speiserelementen für die giessereiindustrie, entsprechende speiserelemente und verwendungen
CA189046S (en) Mist inhaler
PL3310731T3 (pl) Wyrób powlekany sekwencyjnie aktywowaną powłoką niskoemisyjną i/lub sposób jego wytwarzania
EP3337944A4 (en) Evacuation head with ceramic heater for vig unit manufacture
GB2569145B (en) Nasal breathing control apparatus
IL229771B (en) Peptide preparations for the treatment of lung damage, asthma, anaphylaxis, angioedema, systemic syndromes of vascular permeability and nasal congestion
GB2563362B (en) Airway valve for irregular shaped airway
PL3173390T3 (pl) Powierzchniowy substrat tekstylny z występującą przynajmniej częściowo powłoką ogniochronną, sposób jego wytwarzania i jego zastosowanie
AU201812268S (en) Nicotine Inhaler