PL361886A1 - Sposób otrzymywania gabapentyny i gabapentyna - Google Patents

Sposób otrzymywania gabapentyny i gabapentyna

Info

Publication number: PL361886A1
Authority: PL; Poland
Prior art keywords: gabapentin; hydrochloride; aminomethyl; preparation; cyclohexaneacetic acid
Prior art date: 2000-12-01

Application number

PL36188601A

Other languages

English (en)

Inventor

Massimo Ferrari

Marcello Ghezzi

Paolo Belotti

Original Assignee

Erregierre S.P.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-01

Filing date

2001-11-29

Publication date

2004-10-04

2001-11-29 Application filed by Erregierre S.P.A. filed Critical Erregierre S.P.A.

2004-10-04 Publication of PL361886A1 publication Critical patent/PL361886A1/pl

Links

UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 title abstract 8
238000000034 method Methods 0.000 title abstract 2
XBUDZAQEMFGLEU-UHFFFAOYSA-N 2-[1-(aminomethyl)cyclohexyl]acetic acid;hydron;chloride Chemical compound Cl.OC(=O)CC1(CN)CCCCC1 XBUDZAQEMFGLEU-UHFFFAOYSA-N 0.000 abstract 4
229960002870 gabapentin Drugs 0.000 abstract 3
150000001412 amines Chemical class 0.000 abstract 2
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
125000003275 alpha amino acid group Chemical group 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
238000004090 dissolution Methods 0.000 abstract 1
238000001556 precipitation Methods 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
- C07C227/42—Crystallisation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Crystallography & Structural Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PL36188601A 2000-12-01 2001-11-29 Sposób otrzymywania gabapentyny i gabapentyna PL361886A1 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT2000MI002608A IT1319674B1 (it)	2000-12-01	2000-12-01	Processo per la preparazione dell'acido1-(aminometil)cicloesanacetico.
PCT/EP2001/013953 WO2002044123A1 (en)	2000-12-01	2001-11-29	A process for the preparation of 1-(aminomethyl) cyclohexaneacetic acid

Publications (1)

Publication Number	Publication Date
PL361886A1 true PL361886A1 (pl)	2004-10-04

Family

ID=11446165

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL36188601A PL361886A1 (pl)	2000-12-01	2001-11-29	Sposób otrzymywania gabapentyny i gabapentyna

Country Status (19)

Country	Link
US (1)	US7393974B2 (pl)
EP (1)	EP1347951B1 (pl)
JP (1)	JP2004521875A (pl)
AT (1)	ATE339400T1 (pl)
AU (2)	AU2957502A (pl)
BR (1)	BR0115755A (pl)
CA (1)	CA2436908A1 (pl)
DE (1)	DE60123125T2 (pl)
ES (1)	ES2271102T3 (pl)
HR (1)	HRP20030438A2 (pl)
HU (1)	HU228047B1 (pl)
IL (2)	IL156185A0 (pl)
IT (1)	IT1319674B1 (pl)
MX (1)	MXPA03004775A (pl)
NZ (1)	NZ526370A (pl)
PL (1)	PL361886A1 (pl)
RU (1)	RU2289572C2 (pl)
WO (1)	WO2002044123A1 (pl)
ZA (1)	ZA200304484B (pl)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2002356424A1 (en)	2002-11-18	2004-06-15	Nicholas Piramal India Limited	Improved process for preparation of gabapentin
PT1603863E (pt) *	2002-11-20	2010-02-05	Hikal Ltd	Processo para a preparação de ácidos amino-metil-cicloalcano-acéticos
WO2004093780A2 (en)	2003-04-21	2004-11-04	Matrix Laboratories Ltd	Process for the preparation of gabapentin form-ii
WO2004101489A1 (en) *	2003-05-19	2004-11-25	Shasun Chemicals And Drugs Limited	Process for the preparation of gabapentin
ITMI20042418A1 (it) *	2004-12-17	2005-03-17	Zambon Spa	Processo per la purificazione della gabapentina
US7071356B1 (en)	2005-12-01	2006-07-04	Isp Investments Inc.	Process for the preparation of 1-(aminomethyl) cyclohexaneacetic acid
WO2009015685A1 (en)	2007-07-27	2009-02-05	Medichem, S.A.	Method for preparing polymorph form ii of gabapentin
EP2368872A1 (en)	2010-03-25	2011-09-28	Serichim S.r.l.	Process for the preparation of Gabapentin
ITMI20131757A1 (it)	2013-10-22	2015-04-23	Zach System Spa	Processo di preparazione di gabapentina
EP3018131A1 (en) *	2014-11-07	2016-05-11	Bayer Pharma Aktiengesellschaft	Synthesis of copanlisib and its dihydrochloride salt
EP3018127A1 (en) *	2014-11-07	2016-05-11	Bayer Pharma Aktiengesellschaft	Synthesis of copanlisib and its dihydrochloride salt

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2460891C2 (de) *	1974-12-21	1982-09-23	Gödecke AG, 1000 Berlin	1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US4960931A (en)	1988-05-02	1990-10-02	Warner-Lambert Company	Gabapentin mohohydrate and a process for producing the same
DE3928184A1 (de)	1989-08-25	1991-02-28	Goedecke Ag	Verfahren zur herstellung von cyclischen aminosaeurederivaten sowie zwischenprodukte
FI905584A7 (fi) *	1989-11-16	1991-05-17	Lonza Ag	Menetelmä 1-(aminometyyli)sykloheksaanietikkahapon valmistamiseksi
IL119890A (en) *	1996-12-24	2002-03-10	Teva Pharma	Gabapentin form iii and preparation of gabapentin form ii
US6255526B1 (en) *	1996-12-24	2001-07-03	Teva Pharmaceutical Industries Ltd.	Preparation of gabapentin

2000
- 2000-12-01 IT IT2000MI002608A patent/IT1319674B1/it active
2001
- 2001-11-28 HU HU0302642A patent/HU228047B1/hu unknown
- 2001-11-29 AU AU2957502A patent/AU2957502A/xx active Pending
- 2001-11-29 CA CA002436908A patent/CA2436908A1/en not_active Abandoned
- 2001-11-29 IL IL15618501A patent/IL156185A0/xx active IP Right Grant
- 2001-11-29 NZ NZ526370A patent/NZ526370A/en unknown
- 2001-11-29 PL PL36188601A patent/PL361886A1/pl not_active Application Discontinuation
- 2001-11-29 AT AT01990454T patent/ATE339400T1/de not_active IP Right Cessation
- 2001-11-29 BR BR0115755-8A patent/BR0115755A/pt not_active IP Right Cessation
- 2001-11-29 AU AU2002229575A patent/AU2002229575B2/en not_active Ceased
- 2001-11-29 HR HR20030438A patent/HRP20030438A2/hr not_active Application Discontinuation
- 2001-11-29 MX MXPA03004775A patent/MXPA03004775A/es active IP Right Grant
- 2001-11-29 US US10/433,241 patent/US7393974B2/en not_active Expired - Fee Related
- 2001-11-29 WO PCT/EP2001/013953 patent/WO2002044123A1/en not_active Ceased
- 2001-11-29 ES ES01990454T patent/ES2271102T3/es not_active Expired - Lifetime
- 2001-11-29 DE DE60123125T patent/DE60123125T2/de not_active Expired - Fee Related
- 2001-11-29 RU RU2003119451/04A patent/RU2289572C2/ru not_active IP Right Cessation
- 2001-11-29 JP JP2002546493A patent/JP2004521875A/ja active Pending
- 2001-11-29 EP EP01990454A patent/EP1347951B1/en not_active Expired - Lifetime
2003
- 2003-05-28 IL IL156185A patent/IL156185A/en not_active IP Right Cessation
- 2003-06-09 ZA ZA200304484A patent/ZA200304484B/en unknown

Also Published As

Publication number	Publication date
DE60123125T2 (de)	2007-03-01
ES2271102T3 (es)	2007-04-16
IL156185A0 (en)	2003-12-23
HU228047B1 (en)	2012-09-28
AU2957502A (en)	2002-06-11
WO2002044123A1 (en)	2002-06-06
HUP0302642A3 (en)	2010-01-28
US7393974B2 (en)	2008-07-01
CA2436908A1 (en)	2002-06-06
ITMI20002608A1 (it)	2002-06-01
HUP0302642A2 (hu)	2003-11-28
RU2289572C2 (ru)	2006-12-20
BR0115755A (pt)	2003-12-30
HRP20030438A2 (en)	2004-08-31
US20050049432A1 (en)	2005-03-03
JP2004521875A (ja)	2004-07-22
ZA200304484B (en)	2004-09-09
DE60123125D1 (de)	2006-10-26
IL156185A (en)	2008-08-07
IT1319674B1 (it)	2003-10-23
ATE339400T1 (de)	2006-10-15
NZ526370A (en)	2003-08-29
MXPA03004775A (es)	2004-12-03
AU2002229575B2 (en)	2006-12-07
EP1347951A1 (en)	2003-10-01
EP1347951B1 (en)	2006-09-13

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Legal Events

Date	Code	Title	Description
2010-04-30	REFS	Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)