PL362289A1 - Sposób wyodrębniania i oczyszczania (1RS,2RS)-2-[(dimetyloamino)metylo]-1-(3-metoksyfenylo) cykloheksanolu - Google Patents

Sposób wyodrębniania i oczyszczania (1RS,2RS)-2-[(dimetyloamino)metylo]-1-(3-metoksyfenylo) cykloheksanolu

Info

Publication number: PL362289A1
Authority: PL; Poland
Prior art keywords: cyclohexanol; methoxyphenyl; dimethylamino; methyl; purifying
Prior art date: 2001-02-21

Application number

PL36228902A

Other languages

English (en)

Other versions

PL207042B1 (pl

Inventor

Wolfgang Hell

Original Assignee

Grünenthal GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-02-21

Filing date

2002-02-20

Publication date

2004-10-18

2002-02-20 Application filed by Grünenthal GmbH filed Critical Grünenthal GmbH

2004-10-18 Publication of PL362289A1 publication Critical patent/PL362289A1/pl

2010-10-29 Publication of PL207042B1 publication Critical patent/PL207042B1/pl

Links

TVYLLZQTGLZFBW-UHFFFAOYSA-N 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol Chemical compound COC1=CC=CC(C2(O)C(CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-UHFFFAOYSA-N 0.000 title abstract 3
CVHZOJJKTDOEJC-UHFFFAOYSA-M 1,1-dioxo-1,2-benzothiazol-3-olate Chemical compound C1=CC=C2C([O-])=NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-M 0.000 abstract 1
239000012535 impurity Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Thiazole And Isothizaole Compounds (AREA)

PL362289A 2001-02-21 2002-02-20 Sposób wyodrębniania i oczyszczania (1RS,2RS) -2-[(dimetyloamino)metylo] -1-(3-metoksyfenylo)cykloheksanolu PL207042B1 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10108308A DE10108308A1 (de)	2001-02-21	2001-02-21	Verfahren zur Isolierung und Reinigung von (1RS,2RS)-2[(Dimethylamino)methyl]-1-(3-methoxyphenyl)-cyclohexanol
PCT/EP2002/001764 WO2002066414A1 (de)	2001-02-21	2002-02-20	Verfahren zur isolierung und reinigung von (1rs,2rs)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)-cyclohexanol

Publications (2)

Publication Number	Publication Date
PL362289A1 true PL362289A1 (pl)	2004-10-18
PL207042B1 PL207042B1 (pl)	2010-10-29

Family

ID=7674966

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL362289A PL207042B1 (pl)	2001-02-21	2002-02-20	Sposób wyodrębniania i oczyszczania (1RS,2RS) -2-[(dimetyloamino)metylo] -1-(3-metoksyfenylo)cykloheksanolu

Country Status (13)

Country	Link
US (1)	US6909017B2 (pl)
EP (1)	EP1363872B1 (pl)
JP (1)	JP4190288B2 (pl)
AT (1)	ATE405541T1 (pl)
AU (1)	AU2002253040B2 (pl)
CA (1)	CA2437117C (pl)
DE (2)	DE10108308A1 (pl)
ES (1)	ES2312562T3 (pl)
HU (1)	HUP0303302A3 (pl)
MX (1)	MXPA03007478A (pl)
NZ (1)	NZ528135A (pl)
PL (1)	PL207042B1 (pl)
WO (1)	WO2002066414A1 (pl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE102005033732B4 (de) *	2005-05-27	2014-02-13	Grünenthal GmbH	Trennung stereoisomerer N,N-Dialkylamino-2-alkyl-3-hydroxy-3-phenyl-alkane
EP1785412A1 (en)	2005-11-14	2007-05-16	IPCA Laboratories Limited	Tramadol recovery process
CN105884630B (zh) *	2016-04-18	2018-06-01	镇江高海生物药业有限公司	一种盐酸文拉法辛的有关物质及其分析检测方法
FR3074497B1 (fr)	2017-12-06	2020-09-11	Total Marketing Services	Composition d’additifs pour carburant
KR102789259B1 (ko) *	2021-11-30	2025-04-02	주식회사 브이에스팜텍	고순도의 1-(1-(2-벤질페녹시)프로판-2-일)-2-메틸피페리딘 단일 이성질체의 제조방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3652589A (en)	1967-07-27	1972-03-28	Gruenenthal Chemie	1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
IL116281A (en) *	1995-12-07	1999-06-20	Chemagis Ltd	Process for the purification of (rr,ss)-2-dimethylaminomethyl-1-(3-methoxyphenyl) cyclohexanol and its salts
US5877351A (en) *	1997-12-24	1999-03-02	Wyckoff Chemical Company, Inc.	Preparation and purification process for 2- (dimethylamino) methyl!-1-(3-methoxphenyl)-cyclohexanol and its salts
CA2330142A1 (en)	1998-05-22	1999-12-02	Mallinckrodt, Inc.	An improved synthesis and purification of (r,r)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol hydrochloride
CA2375234A1 (en) *	1999-06-22	2000-12-28	Grunenthal Gmbh	Process for the separation of the diastereomeric bases of 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol
DE19940740A1 (de) *	1999-08-31	2001-03-01	Gruenenthal Gmbh	Pharmazeutische Salze

2001
- 2001-02-21 DE DE10108308A patent/DE10108308A1/de not_active Ceased
2002
- 2002-02-20 ES ES02722103T patent/ES2312562T3/es not_active Expired - Lifetime
- 2002-02-20 AT AT02722103T patent/ATE405541T1/de active
- 2002-02-20 EP EP02722103A patent/EP1363872B1/de not_active Expired - Lifetime
- 2002-02-20 NZ NZ528135A patent/NZ528135A/en not_active IP Right Cessation
- 2002-02-20 WO PCT/EP2002/001764 patent/WO2002066414A1/de not_active Ceased
- 2002-02-20 PL PL362289A patent/PL207042B1/pl not_active IP Right Cessation
- 2002-02-20 MX MXPA03007478A patent/MXPA03007478A/es active IP Right Grant
- 2002-02-20 DE DE50212672T patent/DE50212672D1/de not_active Expired - Lifetime
- 2002-02-20 HU HU0303302A patent/HUP0303302A3/hu unknown
- 2002-02-20 AU AU2002253040A patent/AU2002253040B2/en not_active Ceased
- 2002-02-20 CA CA2437117A patent/CA2437117C/en not_active Expired - Fee Related
- 2002-02-20 JP JP2002565932A patent/JP4190288B2/ja not_active Expired - Fee Related
2003
- 2003-08-11 US US10/638,703 patent/US6909017B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PL207042B1 (pl)	2010-10-29
US6909017B2 (en)	2005-06-21
US20040225154A1 (en)	2004-11-11
ES2312562T3 (es)	2009-03-01
MXPA03007478A (es)	2003-12-04
HUP0303302A2 (hu)	2004-01-28
EP1363872A1 (de)	2003-11-26
WO2002066414A1 (de)	2002-08-29
ATE405541T1 (de)	2008-09-15
DE10108308A1 (de)	2002-08-29
CA2437117A1 (en)	2002-08-29
NZ528135A (en)	2005-03-24
CA2437117C (en)	2010-11-30
AU2002253040B2 (en)	2006-09-28
JP2004524306A (ja)	2004-08-12
DE50212672D1 (de)	2008-10-02
JP4190288B2 (ja)	2008-12-03
EP1363872B1 (de)	2008-08-20
HUP0303302A3 (en)	2007-03-28

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Legal Events

Date	Code	Title	Description
2015-04-30	LAPS	Decisions on the lapse of the protection rights	Effective date: 20140220