PL363237A1 - Podstawione cukrem 2-azetydynony użyteczne jako środki hipocholesterolemiczne - Google Patents

Podstawione cukrem 2-azetydynony użyteczne jako środki hipocholesterolemiczne

Info

Publication number
PL363237A1
PL363237A1 PL01363237A PL36323701A PL363237A1 PL 363237 A1 PL363237 A1 PL 363237A1 PL 01363237 A PL01363237 A PL 01363237A PL 36323701 A PL36323701 A PL 36323701A PL 363237 A1 PL363237 A1 PL 363237A1
Authority
PL
Poland
Prior art keywords
sugar
substituted
cholesterol
hypocholesterolemic agents
azetidinones useful
Prior art date
Application number
PL01363237A
Other languages
English (en)
Other versions
PL208242B1 (pl
Inventor
Anima Ghosal
Shumel Zbaida
Swapan K. Chowdhury
Robert M. Jannucci
Wenqing Feng
Kevin B. Alton
James E. Patrick
Harry R. Davis
Original Assignee
Schering Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22973953&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL363237(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corporation filed Critical Schering Corporation
Publication of PL363237A1 publication Critical patent/PL363237A1/pl
Publication of PL208242B1 publication Critical patent/PL208242B1/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PL363237A 2000-12-20 2001-12-17 Pochodna 2-azetydynonu, zawierająca ją farmaceutyczna kompozycja i zastosowanie tej pochodnej, oraz farmaceutyczna kompozycja zawierająca kombinację tej pochodnej i zastosowanie takiej kombinacji PL208242B1 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25687500P 2000-12-20 2000-12-20
PCT/US2001/049127 WO2002050090A1 (en) 2000-12-20 2001-12-17 Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents

Publications (2)

Publication Number Publication Date
PL363237A1 true PL363237A1 (pl) 2004-11-15
PL208242B1 PL208242B1 (pl) 2011-04-29

Family

ID=22973953

Family Applications (1)

Application Number Title Priority Date Filing Date
PL363237A PL208242B1 (pl) 2000-12-20 2001-12-17 Pochodna 2-azetydynonu, zawierająca ją farmaceutyczna kompozycja i zastosowanie tej pochodnej, oraz farmaceutyczna kompozycja zawierająca kombinację tej pochodnej i zastosowanie takiej kombinacji

Country Status (34)

Country Link
US (1) US20020137690A1 (pl)
EP (1) EP1347987B1 (pl)
JP (2) JP4351842B2 (pl)
KR (1) KR100883461B1 (pl)
CN (1) CN100475829C (pl)
AR (1) AR035611A1 (pl)
AT (2) ATE369334T1 (pl)
AU (2) AU3104902A (pl)
BR (1) BR0116212A (pl)
CA (1) CA2432798C (pl)
CY (1) CY1106912T1 (pl)
CZ (1) CZ302193B6 (pl)
DE (2) DE60106489T2 (pl)
DK (2) DK1593670T3 (pl)
EC (1) ECSP034659A (pl)
ES (2) ES2230385T3 (pl)
GE (1) GEP20053548B (pl)
HU (1) HUP0302269A3 (pl)
IL (1) IL155771A0 (pl)
MA (1) MA26975A1 (pl)
MX (1) MXPA03005671A (pl)
MY (1) MY129148A (pl)
NO (2) NO326981B1 (pl)
NZ (1) NZ525722A (pl)
PE (1) PE20020718A1 (pl)
PL (1) PL208242B1 (pl)
PT (2) PT1593670E (pl)
RU (1) RU2297422C2 (pl)
SI (2) SI1347987T1 (pl)
SK (1) SK286703B6 (pl)
TR (1) TR200402758T4 (pl)
TW (1) TWI316942B (pl)
WO (1) WO2002050090A1 (pl)
ZA (1) ZA200303694B (pl)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6982251B2 (en) 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
US7071181B2 (en) 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
PT1355644E (pt) 2001-01-26 2006-11-30 Schering Corp Utilização de compostos azetidinona substituídos para o tratamento de sitosterolemia
RS20100015A (sr) 2001-01-26 2010-12-31 Schering Corporation Kombinacija aktivatora receptora aktiviranog peroksizom- proliferatorom (ppar) fenofibrata sa inhibitorom apsorpcije sterola ezetimibom za vaskularne indikacije
IL157552A0 (en) 2001-03-28 2004-03-28 Schering Corp Enantioselective synthesis of azetidinone intermediate compounds
EP1429756B1 (en) 2001-09-21 2006-11-22 Schering Corporation Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors
US7056906B2 (en) 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
US7053080B2 (en) 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
GB0215579D0 (en) * 2002-07-05 2002-08-14 Astrazeneca Ab Chemical compounds
AR040588A1 (es) 2002-07-26 2005-04-13 Schering Corp Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa
JP2006508188A (ja) 2002-11-06 2006-03-09 シェーリング コーポレイション 脱髄の処置のためのコレステロール吸収インヒビター
DE602004016123D1 (de) 2003-03-07 2008-10-09 Schering Corp Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia
CN1756755A (zh) 2003-03-07 2006-04-05 先灵公司 取代的2-吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途
US7459442B2 (en) 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
CN1756756A (zh) 2003-03-07 2006-04-05 先灵公司 取代的2-吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途
JP2005015434A (ja) * 2003-06-27 2005-01-20 Kotobuki Seiyaku Kk 血清コレステロール低下剤或はアテローム性硬化症の予防又は治療剤
EP1522541A1 (en) * 2003-10-07 2005-04-13 Lipideon Biotechnology AG Novel hypocholesterolemic compounds
EP1918000A2 (en) 2003-11-05 2008-05-07 Schering Corporation Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions
CA2550215A1 (en) * 2003-12-23 2005-07-07 Astrazeneca Ab Diphenylazetidinone derivates possessing cholesterol absorption inhibitory activity
GB0329778D0 (en) * 2003-12-23 2004-01-28 Astrazeneca Ab Chemical compounds
WO2005062824A2 (en) 2003-12-23 2005-07-14 Merck & Co., Inc. Anti-hypercholesterolemic compounds
JP2008514718A (ja) * 2004-09-29 2008-05-08 シェーリング コーポレイション 置換アゼチドノンおよびcb1アンタゴニストの組み合わせ
US7737155B2 (en) 2005-05-17 2010-06-15 Schering Corporation Nitrogen-containing heterocyclic compounds and methods of use thereof
AR054482A1 (es) * 2005-06-22 2007-06-27 Astrazeneca Ab Derivados de azetidinona para el tratamiento de hiperlipidemias
SA06270191B1 (ar) 2005-06-22 2010-03-29 استرازينيكا ايه بي مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
BRPI0708556A2 (pt) * 2006-03-06 2011-05-31 Teva Pharma composição de ezetimiba
AR060623A1 (es) 2006-04-27 2008-07-02 Astrazeneca Ab Compuestos derivados de 2-azetidinona y un metodo de preparacion
CN104803957A (zh) * 2007-04-02 2015-07-29 泰拉科斯有限公司 苄基化糖苷衍生物及其用法
US20110245209A1 (en) 2008-12-16 2011-10-06 Schering Corporation Pyridopyrimidine derivatives and methods of use thereof
US20110243940A1 (en) 2008-12-16 2011-10-06 Schering Corporation Bicyclic pyranone derivatives and methods of use thereof
CN102388059B (zh) * 2009-02-11 2015-03-04 陶氏益农公司 杀虫组合物
WO2010100255A1 (en) 2009-03-06 2010-09-10 Lipideon Biotechnology Ag Pharmaceutical hypocholesterolemic compositions
EP2414529A2 (en) 2009-04-01 2012-02-08 Matrix Laboratories Ltd Enzymatic process for the preparation of (s)-5-(4-fluoro-phenyl)-5-hydroxy- 1morpholin-4-yl-pentan-1-one, an intermediate of ezetimibe and further conversion to ezetimibe
CN101993403B (zh) 2009-08-11 2012-07-11 浙江海正药业股份有限公司 氮杂环丁酮类化合物及医药应用
KR101102749B1 (ko) * 2009-11-30 2012-01-05 최길용 곱셈 학습기
KR20150079373A (ko) 2013-12-30 2015-07-08 한미약품 주식회사 에제티미브 및 로수바스타틴을 포함하는 경구용 복합제제
CN105055404B (zh) * 2015-08-19 2017-07-18 四川大学 Hmgcs2抑制剂在制备治疗可卡因成瘾的药物中的用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3595B (en) * 1993-01-21 1995-12-27 Schering Corp Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents
US5631365A (en) * 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
US5627176A (en) * 1994-03-25 1997-05-06 Schering Corporation Substituted azetidinone compounds useful as hypocholesterolemic agents
US5633246A (en) * 1994-11-18 1997-05-27 Schering Corporation Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
DE69621952T2 (de) * 1995-10-31 2003-01-16 Schering Corp., Kenilworth Zuckersubstituierte 2-azetidinone, verwendbar als hypocholesterdenische arzneimittel
US5756470A (en) * 1996-10-29 1998-05-26 Schering Corporation Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
AUPQ342599A0 (en) * 1999-10-14 1999-11-04 University Of Melbourne, The Conjugates and uses thereof

Also Published As

Publication number Publication date
CN1483039A (zh) 2004-03-17
KR20030063414A (ko) 2003-07-28
AU3104902A (en) 2002-07-01
HUP0302269A3 (en) 2009-08-28
EP1347987A1 (en) 2003-10-01
TWI316942B (en) 2009-11-11
SI1347987T1 (en) 2005-02-28
MA26975A1 (fr) 2004-12-20
JP2004516299A (ja) 2004-06-03
NO20083737L (no) 2003-08-19
PE20020718A1 (es) 2002-08-09
JP4351842B2 (ja) 2009-10-28
SK286703B6 (sk) 2009-03-05
GEP20053548B (en) 2005-06-27
CZ20031674A3 (cs) 2003-10-15
RU2297422C2 (ru) 2007-04-20
WO2002050090A1 (en) 2002-06-27
AU2002231049B2 (en) 2006-07-20
DE60106489T2 (de) 2005-10-13
CY1106912T1 (el) 2012-09-26
DE60106489D1 (de) 2004-11-18
NO326981B1 (no) 2009-03-30
PT1593670E (pt) 2007-11-08
CA2432798C (en) 2007-02-27
ATE369334T1 (de) 2007-08-15
RU2003122520A (ru) 2005-02-27
KR100883461B1 (ko) 2009-02-16
DE60129863T2 (de) 2008-04-30
MY129148A (en) 2007-03-30
BR0116212A (pt) 2003-12-30
DK1593670T3 (da) 2007-11-05
ZA200303694B (en) 2004-08-13
EP1347987B1 (en) 2004-10-13
NZ525722A (en) 2004-11-26
HK1084945A1 (en) 2006-08-11
JP2009132745A (ja) 2009-06-18
DK1347987T3 (da) 2005-01-31
NO20032806L (no) 2003-08-19
IL155771A0 (en) 2003-12-23
ES2287826T3 (es) 2007-12-16
WO2002050090A8 (en) 2004-04-15
HUP0302269A2 (hu) 2003-10-28
CN100475829C (zh) 2009-04-08
SK7702003A3 (en) 2003-10-07
PL208242B1 (pl) 2011-04-29
ATE279425T1 (de) 2004-10-15
CA2432798A1 (en) 2002-06-27
MXPA03005671A (es) 2003-10-06
HK1056735A1 (en) 2004-02-27
PT1347987E (pt) 2005-01-31
NO20032806D0 (no) 2003-06-19
US20020137690A1 (en) 2002-09-26
DE60129863D1 (de) 2007-09-20
AR035611A1 (es) 2004-06-16
TR200402758T4 (tr) 2004-11-22
ES2230385T3 (es) 2005-05-01
ECSP034659A (es) 2003-07-25
CZ302193B6 (cs) 2010-12-08
SI1593670T1 (sl) 2007-12-31

Similar Documents

Publication Publication Date Title
MXPA03005671A (es) 2-azetidinonas sustituidas con azucares utiles como agentes hipocolesterolemicos.
MY114803A (en) Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
TWI320406B (en) Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-iv (dpp-iv)
WO2001081310A8 (en) 1-aroyl-piperidinyl benzamidines
MXPA04002167A (es) Inhibidores de la 17 beta-hidroxiesteroide deshidrogenasa tipo 3 para el tratamiento de enfermedades androgeno-dependientes.
PH12012501351A1 (en) Synthesis of eporthilones, intermediates thereto, analogues and uses thereof
YU65802A (sh) Derivati azetidina, njihovo dobivanje i farmaceutske smeše koje ih sadrže
BR0208384A (pt) Sìntese enantiosseletiva de compostos intermediários de azetidinona
EP1499590B8 (en) Piperidine derivatives as potassium channel blockers
MXPA05009503A (es) Compuestos de azetidinona sustituidos, formulaciones y usos de los mismos para el tratamiento de hipercolesterolemia.
TW200509949A (en) Pharmaceutical compositions and methods relating to inhibiting fibrous adhesions using various agents
TNSN04255A1 (en) Ring-substituted diphenyl azetidinones, method for the production thereof, medicaments containing said compounds, and use thereof.
WO2002042271A3 (en) Biphenylcarboxamides useful as lipid lowering agents
MXPA02010320A (es) Un derivado piridin-1-oxido, y procedimiento para su transformacion en compuestos farmaceuticamente efectivos.
JO2390B1 (en) Diphenylcarboxamides act as lipid-lowering agents
IL159412A0 (en) A synergistic pharmaceutical combination for the prevention or treatment of diabetes
MXPA05009502A (es) Compuestos de azetidinona sustituidos, formulaciones y usos de los mismos para el tratamiento de hipercolesterolemia.
IL173810A0 (en) Imidazopyridine derivatives and pharmaceutical compositions containing the same
AU2002339158A1 (en) 2-(3-sulfonylamino-2-oxopyrrolidin-1-yl)propanamides as factor xa inhibitors
IL156140A0 (en) Use of substituted 6-dimethylaminomethyl-1-phenyl-cyclohexane compounds for treating urinary incontinence
AU2002212241A1 (en) Method for producing chiral compounds
TH39048B (th) 2-อะเซติดิโนนที่ถูกแทนที่ด้วยน้ำตาลที่มีประ?โยชน์เป็นสารภาวะเลือดมีคลอเลสเตอรอลต่ำกว่าปกติ(Sugar-Substituted 2-Azetidinones Useful As Hypocholesterolemic Agents)
TH62472A (th) 2-อะเซติดิโนนที่ถูกแทนที่ด้วยน้ำตาลที่มีประ?โยชน์เป็นสารภาวะเลือดมีคลอเลสเตอรอลต่ำกว่าปกติ(Sugar-Substituted 2-Azetidinones Useful As Hypocholesterolemic Agents)
WO2003090737A3 (en) Methods and compositions for treatment of cancer pain
MY135292A (en) Novel piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors

Legal Events

Date Code Title Description
LAPS Decisions on the lapse of the protection rights

Effective date: 20131217